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UniProtKB - P44776 (FUCP_HAEIN)
Protein
L-fucose-proton symporter
Gene
fucP
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
By similarityCatalytic activityi
- This reaction proceeds in the backwardBy similarity direction.
GO - Molecular functioni
- fucose:proton symporter activity Source: InterPro
GO - Biological processi
- fucose metabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Carbohydrate metabolism, Fucose metabolism, Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: L-fucose-proton symporterBy similarityAlternative name(s): L-fucose-H(+) symport proteinBy similarity |
Gene namesi | Name:fucP Ordered Locus Names:HI_0610 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 250 – 270 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 288 – 308 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 311 – 331 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 339 – 359 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094502 | 1 – 428 | L-fucose-proton symporterAdd BLAST | 428 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0738, Bacteria |
HOGENOMi | CLU_028452_0_1_6 |
OMAi | TWGFAYG |
PhylomeDBi | P44776 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR005275, Lfuc_symporter_FucP IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00885, fucP, 1 hit |
i Sequence
Sequence statusi: Complete.
P44776-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAKVLEKKF IVPFVLITSL FALWGFANDI TNPMVAVFQT VMEIPASEAA
60 70 80 90 100
LVQLAFYGGY GTMAIPAALF ASRYSYKAGI LLGLALYAIG AFLFWPAAQY
110 120 130 140 150
EIFNFFLVSL YILTFGLAFL ETTANPYILA MGDPQTATRR LNFAQSFNPL
160 170 180 190 200
GSITGMFVAS QLVLTNLESD KRDAAGNLIF HTLSEAEKMS IRTHDLAEIR
210 220 230 240 250
DPYIALGFVV VAVFIIIGLK KMPAVKIEEA GQISFKTAVS RLAQKAKYRE
260 270 280 290 300
GVIAQAFYVG VQIMCWTFIV QYAERLGFTK AEGQNFNIIA MAIFISSRFI
310 320 330 340 350
STALMKYLKA EFMLMLFAIG GFLSILGVIF IDGVWGLYCL ILTSGFMPLM
360 370 380 390 400
FPTIYGIALY GLKEESTLGA AGLVMAIVGG ALMPPLQGMI IDQGEVMGLP
410 420
AVNFSFILPL ICFVVIAIYG FRAWKILK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC22269.1 |
PIRi | B64081 |
RefSeqi | NP_438768.1, NC_000907.1 WP_005694544.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC22269; AAC22269; HI_0610 |
KEGGi | hin:HI_0610 |
PATRICi | fig|71421.8.peg.634 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC22269.1 |
PIRi | B64081 |
RefSeqi | NP_438768.1, NC_000907.1 WP_005694544.1, NC_000907.1 |
3D structure databases
SMRi | P44776 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI_0610 |
Genome annotation databases
EnsemblBacteriai | AAC22269; AAC22269; HI_0610 |
KEGGi | hin:HI_0610 |
PATRICi | fig|71421.8.peg.634 |
Phylogenomic databases
eggNOGi | COG0738, Bacteria |
HOGENOMi | CLU_028452_0_1_6 |
OMAi | TWGFAYG |
PhylomeDBi | P44776 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR005275, Lfuc_symporter_FucP IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00885, fucP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FUCP_HAEIN | |
Accessioni | P44776Primary (citable) accession number: P44776 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families