UniProtKB - P44676 (Y380_HAEIN)
Protein
Uncharacterized tRNA/rRNA methyltransferase HI_0380
Gene
HI_0380
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 111 | S-adenosyl-L-methionine; via amide nitrogenBy similarity | 1 | |
Binding sitei | 131 | S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- RNA binding Source: InterPro
- tRNA (cytosine-2'-O-)-methyltransferase activity Source: GO_Central
- tRNA (uracil-2'-O-)-methyltransferase activity Source: GO_Central
GO - Biological processi
- tRNA nucleoside ribose methylation Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-393-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:HI_0380 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159830 | 1 – 241 | Uncharacterized tRNA/rRNA methyltransferase HI_0380Add BLAST | 241 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P44676 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P44676 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 80 | S-adenosyl-L-methionine bindingBy similarity | 3 | |
Regioni | 138 – 140 | S-adenosyl-L-methionine bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.Curated
Phylogenomic databases
eggNOGi | COG0565, Bacteria |
HOGENOMi | CLU_056931_3_0_6 |
Family and domain databases
Gene3Di | 3.40.1280.10, 1 hit |
InterProi | View protein in InterPro IPR029028, Alpha/beta_knot_MTases IPR004384, RNA_MeTrfase_TrmJ/LasT IPR001537, SpoU_MeTrfase IPR029026, tRNA_m1G_MTases_N |
PANTHERi | PTHR42786, PTHR42786, 1 hit |
Pfami | View protein in Pfam PF00588, SpoU_methylase, 1 hit |
PIRSFi | PIRSF004808, LasT, 1 hit |
SUPFAMi | SSF75217, SSF75217, 1 hit |
TIGRFAMsi | TIGR00050, rRNA_methyl_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P44676-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLENIRIVLI ETSHSGNIGS AARAMKTMGL TQLCLVSPKS VDEQSYALSA
60 70 80 90 100
GAENIVKNAR VVDSFDEAVD DCSLVIGTSA RLRHLQNTLI EPRECAEKVV
110 120 130 140 150
AYKGKIAIVF GRERIGLTNE ELLKCHYHLN IPANPDYSSL NLAMAVQLVS
160 170 180 190 200
YELRMAFLVQ NNKKNSLSLI EKNYPTTDQL AYFFDYTERI YQSLGFIQNQ
210 220 230 240
GVMRKLKRLY YRAKLEKNEL NILNGMLSAV EKRIDLTKED N
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 73 | S → P in AAC22038 (PubMed:7542800).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC22038.1 AF174385 Genomic DNA Translation: AAD54289.1 |
PIRi | G64150 |
RefSeqi | NP_438541.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC22038; AAC22038; HI_0380 |
KEGGi | hin:HI0380 |
PATRICi | fig|71421.8.peg.398 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC22038.1 AF174385 Genomic DNA Translation: AAD54289.1 |
PIRi | G64150 |
RefSeqi | NP_438541.1, NC_000907.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ILK | X-ray | 2.01 | A/B | 1-241 | [»] | |
SMRi | P44676 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI_0380 |
Protocols and materials databases
DNASUi | 949482 |
Genome annotation databases
EnsemblBacteriai | AAC22038; AAC22038; HI_0380 |
KEGGi | hin:HI0380 |
PATRICi | fig|71421.8.peg.398 |
Phylogenomic databases
eggNOGi | COG0565, Bacteria |
HOGENOMi | CLU_056931_3_0_6 |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-393-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P44676 |
Family and domain databases
Gene3Di | 3.40.1280.10, 1 hit |
InterProi | View protein in InterPro IPR029028, Alpha/beta_knot_MTases IPR004384, RNA_MeTrfase_TrmJ/LasT IPR001537, SpoU_MeTrfase IPR029026, tRNA_m1G_MTases_N |
PANTHERi | PTHR42786, PTHR42786, 1 hit |
Pfami | View protein in Pfam PF00588, SpoU_methylase, 1 hit |
PIRSFi | PIRSF004808, LasT, 1 hit |
SUPFAMi | SSF75217, SSF75217, 1 hit |
TIGRFAMsi | TIGR00050, rRNA_methyl_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y380_HAEIN | |
Accessioni | P44676Primary (citable) accession number: P44676 Secondary accession number(s): Q9RP31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | April 16, 2002 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families