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UniProtKB - P44600 (HXUC1_HAEIN)

Entry version 131 (23 Feb 2022)
Sequence version 1 (01 Nov 1995)
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Protein

Heme/hemopexin utilization protein C

Gene

hxuC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for utilization of free heme at low concentrations.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Protein family/group databases

Transport Classification Database

More...TCDBi		1.B.14.2.11, the outer membrane receptor (omr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heme/hemopexin utilization protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hxuC
Ordered Locus Names:HI_0262
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri71421 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000579 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003479222 – 723Heme/hemopexin utilization protein CAdd BLAST702

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		71421.HI_0262

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P44600

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi706 – 723TonB C-terminal boxAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG4771, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008287_19_3_6

Identification of Orthologs from Complete Genome Data

More...OMAi		AWEVGFN

Database for complete collections of gene phylogenies

More...PhylomeDBi		P44600

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.170.130.10, 1 hit
2.40.170.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039426, BtuB-like
IPR012910, Plug_dom
IPR037066, Plug_dom_sf
IPR000531, TonB-dep_rcpt_b-brl
IPR011276, TonB_haem/Hb_rcpt
IPR010949, TonB_Hb/transfer/lactofer_rcpt
IPR036942, TonB_rcpt_b-brl_sf
IPR010917, TonB_rcpt_CS

The PANTHER Classification System

More...PANTHERi		PTHR30069, PTHR30069, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07715, Plug, 1 hit
PF00593, TonB_dep_Rec, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01785, TonB-hemin, 1 hit
TIGR01786, TonB-hemlactrns, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01156, TONB_DEPENDENT_REC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P44600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFSKLSLAI TTTLVTANAL AQSVELDSIN VIATRDPSRF AYTPEKQSKD 
        60         70         80         90        100
SLLSKQATSV ADALEDIPNV DVRGGSRSIA QKPNIRGLSD NRVVQVIDGV 
       110        120        130        140        150
RQNFDLAHRG SYFLPMSLIQ EIEVIKGPSS SLWGSGALGG VVAMRTPNAL 
       160        170        180        190        200
DLLKNNDKFG VKIRQGYQTA NNLSEKDVSV FAANDKFDVL ISGFYNNADN 
       210        220        230        240        250
LRTGKGNKLN NTAYKQFGGL AKFGWQINDA NRVELSHRET RFKQTAPSNN 
       260        270        280        290        300
EVENELTNEQ ITDQIKKFHG QKDDLLPPTT QPSPSERSEF YSKVKTRLGS 
       310        320        330        340        350
VSYLTDQQIP DQSTVFNYYL TPDNPYLNTH IALYNNKTIE KEQRKVSGVK 
       360        370        380        390        400
DQTKLTTRGI NLRNSSELSH ISFVYGVDYM RDKIRTERGT NGSDAKFRAD 
       410        420        430        440        450
PYNANSNTTG VYLIAHIPLF GEKLLVSPSV RYDHYDTSSK TVKYKDNHLS 
       460        470        480        490        500
PATKLTWIVT NWLDFTAKYN EAFRAPSMQE RFVSGAHFGA NTLGLDHINR 
       510        520        530        540        550
FVANPNLRPE TAKNKEITAN LHFDSLFKQG DKFKIEATYF RNDVKDFINL 
       560        570        580        590        600
KIFNDAKTSA SAGANPNTNG ALLPKNSQYQ NITNARLSGI ELQAQYQTER 
       610        620        630        640        650
LTLFTNYGST KGKDKDSGEA LSNIAASKIG VGVNYALVKD KFTVGATVTH 
       660        670        680        690        700
YAAQRRVPKD HSVTYPSYIL TDLRATYAPL KGEWKNLRLD FALENLFDRK 
       710        720 
YQPAFSLMEG TGRNAKISAV YSF
Length:723
Mass (Da):80,776
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91EB3AB0FFEA2984
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21927.1

Protein sequence database of the Protein Information Resource

More...PIRi		C64058

NCBI Reference Sequences

More...RefSeqi		NP_438431.1, NC_000907.1
WP_005694042.1, NC_000907.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC21927; AAC21927; HI_0262

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hin:HI_0262

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|71421.8.peg.277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21927.1
PIRiC64058
RefSeqiNP_438431.1, NC_000907.1
WP_005694042.1, NC_000907.1

3D structure databases

SMRiP44600
ModBaseiSearch...

Protein-protein interaction databases

STRINGi71421.HI_0262

Protein family/group databases

TCDBi1.B.14.2.11, the outer membrane receptor (omr) family

Genome annotation databases

EnsemblBacteriaiAAC21927; AAC21927; HI_0262
KEGGihin:HI_0262
PATRICifig|71421.8.peg.277

Phylogenomic databases

eggNOGiCOG4771, Bacteria
HOGENOMiCLU_008287_19_3_6
OMAiAWEVGFN
PhylomeDBiP44600

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR039426, BtuB-like
IPR012910, Plug_dom
IPR037066, Plug_dom_sf
IPR000531, TonB-dep_rcpt_b-brl
IPR011276, TonB_haem/Hb_rcpt
IPR010949, TonB_Hb/transfer/lactofer_rcpt
IPR036942, TonB_rcpt_b-brl_sf
IPR010917, TonB_rcpt_CS
PANTHERiPTHR30069, PTHR30069, 1 hit
PfamiView protein in Pfam
PF07715, Plug, 1 hit
PF00593, TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01785, TonB-hemin, 1 hit
TIGR01786, TonB-hemlactrns, 1 hit
PROSITEiView protein in PROSITE
PS01156, TONB_DEPENDENT_REC_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXUC1_HAEIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P44600
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 23, 2022
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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