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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

frmA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Zinc 1; catalyticBy similarity1
Metal bindingi71Zinc 1; catalyticBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-195-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Alternative name(s):
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
Gene namesi
Name:frmA
Synonyms:adhC
Ordered Locus Names:HI_0185
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607761 – 378S-(hydroxymethyl)glutathione dehydrogenaseAdd BLAST378

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0185

Structurei

3D structure databases

ProteinModelPortaliP44557
SMRiP44557
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QPD Bacteria
COG1062 LUCA
KOiK00121
OMAiCNVCKHP
PhylomeDBiP44557

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P44557-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIKQINSTI KSRAAVAFAP NQPLQIVEID VEMPRKGEVL IRNTHTGVCH
60 70 80 90 100
TDAFTLSGSD PEGVFPVVLG HEGAGVVVAV GEGVLSVKPG DHVIPLYTAE
110 120 130 140 150
CGECEFCRSG KTNLCVSVRD TQGKGLMPDC TTRFSYQGQP IYHYMGCSTF
160 170 180 190 200
SEYSVVAEVS LAKINPEANH EQVCLLGCGV TTGIGAVHNT AKVQEGDSVA
210 220 230 240 250
VFGLGAIGLA VVQGARQAKA GRIIAIDTNP AKFELAKQFG ATDCLNPNDY
260 270 280 290 300
DKPIKDVLLD INKWGIDHTF ECIGNVNVMR QALESAHRGW GQSIIIGVAG
310 320 330 340 350
AGQEISTRPF QLVTGRVWKG SAFGGVKGRS ELPQMVEDSM KGDIQLEPFV
360 370
THTMPLDKIN EAFELMHEGK SIRTVIHY
Length:378
Mass (Da):40,651
Last modified:November 1, 1995 - v1
Checksum:iA68677243681165E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21854.1
PIRiH64052
RefSeqiNP_438353.1, NC_000907.1
WP_005694101.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21854; AAC21854; HI_0185
GeneIDi951091
KEGGihin:HI0185
PATRICifig|71421.8.peg.189

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21854.1
PIRiH64052
RefSeqiNP_438353.1, NC_000907.1
WP_005694101.1, NC_000907.1

3D structure databases

ProteinModelPortaliP44557
SMRiP44557
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0185

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21854; AAC21854; HI_0185
GeneIDi951091
KEGGihin:HI0185
PATRICifig|71421.8.peg.189

Phylogenomic databases

eggNOGiENOG4107QPD Bacteria
COG1062 LUCA
KOiK00121
OMAiCNVCKHP
PhylomeDBiP44557

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-195-MONOMER

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRMA_HAEIN
AccessioniPrimary (citable) accession number: P44557
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
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Main funding by: National Institutes of Health

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