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UniProtKB - P44557 (FRMA_HAEIN)
Protein
S-(hydroxymethyl)glutathione dehydrogenase
Gene
frmA
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Catalytic activityi
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 49 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 71 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 101 | Zinc 2By similarity | 1 | |
Metal bindingi | 104 | Zinc 2By similarity | 1 | |
Metal bindingi | 107 | Zinc 2By similarity | 1 | |
Metal bindingi | 115 | Zinc 2By similarity | 1 | |
Metal bindingi | 178 | Zinc 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- alcohol dehydrogenase activity, zinc-dependent Source: GO_Central
- S-(hydroxymethyl)glutathione dehydrogenase activity Source: GO_Central
- S-(hydroxymethyl)glutathione dehydrogenase NAD activity Source: UniProtKB-EC
- S-(hydroxymethyl)glutathione dehydrogenase NADP activity Source: UniProtKB-EC
- zinc ion binding Source: GO_Central
GO - Biological processi
- ethanol oxidation Source: InterPro
- formaldehyde catabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:frmA Synonyms:adhC Ordered Locus Names:HI_0185 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160776 | 1 – 378 | S-(hydroxymethyl)glutathione dehydrogenaseAdd BLAST | 378 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1062, Bacteria |
HOGENOMi | CLU_026673_14_0_6 |
OMAi | LNWAPSC |
PhylomeDBi | P44557 |
Family and domain databases
CDDi | cd08300, alcohol_DH_class_III, 1 hit |
InterProi | View protein in InterPro IPR014183, ADH_3 IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02818, adh_III_F_hyde, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
P44557-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIKQINSTI KSRAAVAFAP NQPLQIVEID VEMPRKGEVL IRNTHTGVCH
60 70 80 90 100
TDAFTLSGSD PEGVFPVVLG HEGAGVVVAV GEGVLSVKPG DHVIPLYTAE
110 120 130 140 150
CGECEFCRSG KTNLCVSVRD TQGKGLMPDC TTRFSYQGQP IYHYMGCSTF
160 170 180 190 200
SEYSVVAEVS LAKINPEANH EQVCLLGCGV TTGIGAVHNT AKVQEGDSVA
210 220 230 240 250
VFGLGAIGLA VVQGARQAKA GRIIAIDTNP AKFELAKQFG ATDCLNPNDY
260 270 280 290 300
DKPIKDVLLD INKWGIDHTF ECIGNVNVMR QALESAHRGW GQSIIIGVAG
310 320 330 340 350
AGQEISTRPF QLVTGRVWKG SAFGGVKGRS ELPQMVEDSM KGDIQLEPFV
360 370
THTMPLDKIN EAFELMHEGK SIRTVIHY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC21854.1 |
PIRi | H64052 |
RefSeqi | NP_438353.1, NC_000907.1 WP_005694101.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC21854; AAC21854; HI_0185 |
KEGGi | hin:HI_0185 |
PATRICi | fig|71421.8.peg.189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC21854.1 |
PIRi | H64052 |
RefSeqi | NP_438353.1, NC_000907.1 WP_005694101.1, NC_000907.1 |
3D structure databases
SMRi | P44557 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI_0185 |
Genome annotation databases
EnsemblBacteriai | AAC21854; AAC21854; HI_0185 |
KEGGi | hin:HI_0185 |
PATRICi | fig|71421.8.peg.189 |
Phylogenomic databases
eggNOGi | COG1062, Bacteria |
HOGENOMi | CLU_026673_14_0_6 |
OMAi | LNWAPSC |
PhylomeDBi | P44557 |
Family and domain databases
CDDi | cd08300, alcohol_DH_class_III, 1 hit |
InterProi | View protein in InterPro IPR014183, ADH_3 IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02818, adh_III_F_hyde, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FRMA_HAEIN | |
Accessioni | P44557Primary (citable) accession number: P44557 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families