frmA

Functionⁱ

Catalytic activityⁱ

S-(hydroxymethyl)glutathione + NAD(P)⁺ = S-formylglutathione + NAD(P)H.

A primary alcohol + NAD⁺ = an aldehyde + NADH.

A secondary alcohol + NAD⁺ = a ketone + NADH.

Cofactorⁱ

Zn²⁺By similarityNote: Binds 2 Zn²⁺ ions per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	49	Zinc 1; catalyticBy similarity	1
Metal bindingⁱ	71	Zinc 1; catalyticBy similarity	1
Metal bindingⁱ	101	Zinc 2By similarity	1
Metal bindingⁱ	104	Zinc 2By similarity	1
Metal bindingⁱ	107	Zinc 2By similarity	1
Metal bindingⁱ	115	Zinc 2By similarity	1
Metal bindingⁱ	178	Zinc 1; catalyticBy similarity	1

GO - Molecular functionⁱ

alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
S-(hydroxymethyl)glutathione dehydrogenase activity Source: UniProtKB-EC
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ethanol oxidation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCycⁱ	HINF71421:G1GJ1-195-MONOMER

BioCycⁱ

HINF71421:G1GJ1-195-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284) Alternative name(s): Alcohol dehydrogenase class-3 (EC:1.1.1.1) Alcohol dehydrogenase class-III Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-) Short name: FALDH Short name: FDH Short name: GSH-FDH
Gene namesⁱ	Name:frmA Synonyms:adhC Ordered Locus Names:HI_0185
Organismⁱ	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifierⁱ	71421 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae
Proteomesⁱ	UP000000579 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm Curated

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000160776	1 – 378	S-(hydroxymethyl)glutathione dehydrogenaseAdd BLAST		378

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	71421.HI0185

STRINGⁱ

71421.HI0185

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P44557
SMRⁱ	P44557
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4107QPD Bacteria COG1062 LUCA
KEGG Orthology (KO) More...KOⁱ	K00121
OMAⁱ	CNVCKHP
PhylomeDBⁱ	P44557

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08300 alcohol_DH_class_III, 1 hit
InterProⁱ	View protein in InterPro IPR014183 ADH_3 IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf IPR020843 PKS_ER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SMARTⁱ	View protein in SMART SM00829 PKS_ER, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 2 hits SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR02818 adh_III_F_hyde, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P44557-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEIKQINSTI KSRAAVAFAP NQPLQIVEID VEMPRKGEVL IRNTHTGVCH 
        60         70         80         90        100
TDAFTLSGSD PEGVFPVVLG HEGAGVVVAV GEGVLSVKPG DHVIPLYTAE 
       110        120        130        140        150
CGECEFCRSG KTNLCVSVRD TQGKGLMPDC TTRFSYQGQP IYHYMGCSTF 
       160        170        180        190        200
SEYSVVAEVS LAKINPEANH EQVCLLGCGV TTGIGAVHNT AKVQEGDSVA 
       210        220        230        240        250
VFGLGAIGLA VVQGARQAKA GRIIAIDTNP AKFELAKQFG ATDCLNPNDY 
       260        270        280        290        300
DKPIKDVLLD INKWGIDHTF ECIGNVNVMR QALESAHRGW GQSIIIGVAG 
       310        320        330        340        350
AGQEISTRPF QLVTGRVWKG SAFGGVKGRS ELPQMVEDSM KGDIQLEPFV 
       360        370 
THTMPLDKIN EAFELMHEGK SIRTVIHY

Length:378

Mass (Da):40,651

Last modified:November 1, 1995 - v1

Checksum:ⁱA68677243681165E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L42023 Genomic DNA Translation: AAC21854.1
PIRⁱ	H64052
NCBI Reference Sequences More...RefSeqⁱ	NP_438353.1, NC_000907.1 WP_005694101.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC21854; AAC21854; HI_0185
GeneIDⁱ	951091
KEGGⁱ	hin:HI0185
PATRICⁱ	fig\|71421.8.peg.189

Protein	Similar proteins		Species	Score	Length	Source
P44557	Alcohol dehydrogenase (Fragment)		HAEIF		195	UniRef100_P44557
Alcohol dehydrogenase (Fragment)		HAEIF		132
Alcohol dehydrogenase (Fragment)		HAEIF		181

Protein	Similar proteins		Species	Score	Length	Source
P44557	Alcohol dehydrogenase (Fragment)		HAEIF		195	UniRef90_P44557
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria cinerea ATCC 14685		403
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria polysaccharea ATCC 43768		394
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria meningitidis ATCC 13091		394
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria lactamica ATCC 23970		394
+247

Protein	Similar proteins		Species	Score	Length	Source
P44557	Probable S-(hydroxymethyl)glutathione dehydrogenase 1		SCHPO		378	UniRef50_P44557
Alcohol dehydrogenase (Fragment)		HAEIF		195
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria cinerea ATCC 14685		403
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria meningitidis ATCC 13091		394
S-(hydroxymethyl)glutathione dehydrogenase		Neisseria lactamica ATCC 23970		394
+405

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L42023 Genomic DNA Translation: AAC21854.1
PIRⁱ	H64052
RefSeqⁱ	NP_438353.1, NC_000907.1 WP_005694101.1, NC_000907.1

3D structure databases

ProteinModelPortalⁱ	P44557
SMRⁱ	P44557
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	71421.HI0185

STRINGⁱ

71421.HI0185

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC21854; AAC21854; HI_0185
GeneIDⁱ	951091
KEGGⁱ	hin:HI0185
PATRICⁱ	fig\|71421.8.peg.189

Phylogenomic databases

eggNOGⁱ	ENOG4107QPD Bacteria COG1062 LUCA
KOⁱ	K00121
OMAⁱ	CNVCKHP
PhylomeDBⁱ	P44557

Enzyme and pathway databases

BioCycⁱ	HINF71421:G1GJ1-195-MONOMER

BioCycⁱ

HINF71421:G1GJ1-195-MONOMER

Family and domain databases

CDDⁱ	cd08300 alcohol_DH_class_III, 1 hit
InterProⁱ	View protein in InterPro IPR014183 ADH_3 IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf IPR020843 PKS_ER
Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SMARTⁱ	View protein in SMART SM00829 PKS_ER, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 2 hits SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR02818 adh_III_F_hyde, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FRMA_HAEIN
Accessionⁱ	P44557Primary (citable) accession number: P44557
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	February 28, 2018
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Haemophilus influenzae
Haemophilus influenzae (strain Rd): entries and gene names

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P44557 (FRMA_HAEIN)

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S-(hydroxymethyl)glutathione dehydrogenase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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GO - Cellular componenti

Keywords - Cellular componenti

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Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

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Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ