UniProtKB - P44501 (DDH_HAEIN)
Protein
2-hydroxyacid dehydrogenase homolog
Gene
ddh
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 234 | By similarity | 1 | |
Binding sitei | 258 | NADBy similarity | 1 | |
Active sitei | 263 | By similarity | 1 | |
Active sitei | 295 | Proton donorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 154 – 155 | NADBy similarity | 2 | |
Nucleotide bindingi | 232 – 234 | NADBy similarity | 3 | |
Nucleotide bindingi | 295 – 298 | NADBy similarity | 4 |
GO - Molecular functioni
- D-lactate dehydrogenase activity Source: GO_Central
- NAD binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-86-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ddh Ordered Locus Names:HI_0085 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076021 | 1 – 331 | 2-hydroxyacid dehydrogenase homologAdd BLAST | 331 |
Proteomic databases
PRIDEi | P44501 |
Structurei
3D structure databases
ProteinModelPortali | P44501 |
SMRi | P44501 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | ENOG4105C5I Bacteria COG1052 LUCA |
KOi | K03778 |
OMAi | THKAYNR |
PhylomeDBi | P44501 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P44501-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIAIYSTKS YDRKYIELIN AKYNFDLEFF DFMLNESTVR LAEHCEVVCI
60 70 80 90 100
FVNDNGSRKV LEKLAALGVK IVALRCAGFN NVDLKAAQEL GIQVVRVPAY
110 120 130 140 150
SPEAVAEHTI GLMMTLNRRI HRAYQRTREA NFSLEGLIGF NMYGRTVGVI
160 170 180 190 200
GTGKIGIAVM RILKGFGMNI LAYDPFKNPV VEELGGQYVE LDELYAKSHV
210 220 230 240 250
ITLHCPATPE NYHLLNCEAF AKMKDGVMIV NTSRGSLIDT QAAIDALKQR
260 270 280 290 300
KIGALGMDVY ENERDLFFED KSNEVIQDDI FRRLSSCHNV LLTGHQAFLT
310 320 330
EEALTNIADV TLSNIYKLKS GKVCENIVLP S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC21763.1 |
PIRi | F64047 |
RefSeqi | NP_438258.1, NC_000907.1 WP_005693834.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC21763; AAC21763; HI_0085 |
GeneIDi | 950977 |
KEGGi | hin:HI0085 |
PATRICi | fig|71421.8.peg.86 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC21763.1 |
PIRi | F64047 |
RefSeqi | NP_438258.1, NC_000907.1 WP_005693834.1, NC_000907.1 |
3D structure databases
ProteinModelPortali | P44501 |
SMRi | P44501 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI0085 |
Proteomic databases
PRIDEi | P44501 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | AAC21763; AAC21763; HI_0085 |
GeneIDi | 950977 |
KEGGi | hin:HI0085 |
PATRICi | fig|71421.8.peg.86 |
Phylogenomic databases
eggNOGi | ENOG4105C5I Bacteria COG1052 LUCA |
KOi | K03778 |
OMAi | THKAYNR |
PhylomeDBi | P44501 |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-86-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | DDH_HAEIN | |
Accessioni | P44501Primary (citable) accession number: P44501 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | November 7, 2018 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Haemophilus influenzae
Haemophilus influenzae (strain Rd): entries and gene names