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Protein

Formate dehydrogenase iron-sulfur subunit

Gene

fdxH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi47Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi50Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi54Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi106Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi109Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi114Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi118Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi139Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi142Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi145Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi149Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi166Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi169Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi181Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi185Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-7-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase iron-sulfur subunit
Alternative name(s):
Formate dehydrogenase subunit beta
Short name:
FDH subunit beta
Gene namesi
Name:fdxH
Ordered Locus Names:HI_0007
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592521 – 312Formate dehydrogenase iron-sulfur subunitAdd BLAST312

Proteomic databases

PRIDEiP44450

Interactioni

Subunit structurei

Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.

Protein-protein interaction databases

STRINGi71421.HI0007

Structurei

3D structure databases

ProteinModelPortaliP44450
SMRiP44450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini97 – 1294Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST33
Domaini130 – 1594Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini164 – 1954Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Transmembrane

Phylogenomic databases

eggNOGiENOG4105QA4 Bacteria
COG0437 LUCA
KOiK00124
OMAiCVDRIQN
PhylomeDBiP44450

Family and domain databases

CDDicd10558 FDH-N, 1 hit
Gene3Di1.20.5.480, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR006470 Formate_DH_bsu_Proteobacteria
IPR038384 Formate_DH_C_sf
IPR014603 Formate_DH_Fe-S_su
IPR015246 Formate_DH_TM
PfamiView protein in Pfam
PF13247 Fer4_11, 1 hit
PF09163 Form-deh_trans, 1 hit
PIRSFiPIRSF036298 FDH_4Fe4S, 1 hit
TIGRFAMsiTIGR01582 FDH-beta, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 4 hits

Sequencei

Sequence statusi: Complete.

P44450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTAQGVQT QDVIKISATS GLTPAPQARD HKVEIAKLID VSTCIGCKAC
60 70 80 90 100
QVGCSEWNDI RSDINAQCVG VYDNPVDLDA KAWTVMRFNE VEENDRLEWL
110 120 130 140 150
IRKDGCMHCT EPGCLKACPA PGAIIQYANG IVDFQSDKCI GCGYCIAGCP
160 170 180 190 200
FNIPRMNPED NRVYKCTLCV DRVSVGQEPA CVKTCPTGAI RFGSKEEMKI
210 220 230 240 250
YAEQRVADLK SRGYENAGLY DPPGVGGTHV MYVLHHADKP ELYNGLPKDP
260 270 280 290 300
QIDLSVTLWK DVLKPVAAVA MGGLALAEVA HYLTVGPNVE EDVEDHHHEF
310
EENKPSKGEN NE
Length:312
Mass (Da):34,069
Last modified:November 1, 1995 - v1
Checksum:iAA49DD3C17064866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21685.1
PIRiA64042
RefSeqiNP_438180.1, NC_000907.1
WP_005693893.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21685; AAC21685; HI_0007
GeneIDi950904
KEGGihin:HI0007
PATRICifig|71421.8.peg.7

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21685.1
PIRiA64042
RefSeqiNP_438180.1, NC_000907.1
WP_005693893.1, NC_000907.1

3D structure databases

ProteinModelPortaliP44450
SMRiP44450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0007

Proteomic databases

PRIDEiP44450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21685; AAC21685; HI_0007
GeneIDi950904
KEGGihin:HI0007
PATRICifig|71421.8.peg.7

Phylogenomic databases

eggNOGiENOG4105QA4 Bacteria
COG0437 LUCA
KOiK00124
OMAiCVDRIQN
PhylomeDBiP44450

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-7-MONOMER

Family and domain databases

CDDicd10558 FDH-N, 1 hit
Gene3Di1.20.5.480, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR006470 Formate_DH_bsu_Proteobacteria
IPR038384 Formate_DH_C_sf
IPR014603 Formate_DH_Fe-S_su
IPR015246 Formate_DH_TM
PfamiView protein in Pfam
PF13247 Fer4_11, 1 hit
PF09163 Form-deh_trans, 1 hit
PIRSFiPIRSF036298 FDH_4Fe4S, 1 hit
TIGRFAMsiTIGR01582 FDH-beta, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFDXH_HAEIN
AccessioniPrimary (citable) accession number: P44450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
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Main funding by: National Institutes of Health

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