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Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Biological processi

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1728-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr
Alternative name(s):
Histidine-containing protein
Gene namesi
Name:ptsH
Ordered Locus Names:HI_1713
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078541 – 85Phosphocarrier protein HPrAdd BLAST85

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1713

Structurei

3D structure databases

ProteinModelPortaliP43921
SMRiP43921
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 85HPrPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the HPr family.Curated

Phylogenomic databases

eggNOGiENOG4105KZ7 Bacteria
COG1925 LUCA
KOiK02784
OMAiRPGNEFV
PhylomeDBiP43921

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
IPR002114 PTS_HPr_Ser_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
PS00589 PTS_HPR_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P43921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSKDVEIIA SNGLHTRPAA QFVKEAKAFS SEITVTSGGK SASAKSLFKL
60 70 80
QTLALTQGTI LTISADGEDE QQAVEHLVAL IPTLE
Length:85
Mass (Da):9,004
Last modified:November 1, 1995 - v1
Checksum:i3D8D599742311830
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC23358.1
PIRiI64137
RefSeqiNP_439855.1, NC_000907.1
WP_005649965.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC23358; AAC23358; HI_1713
GeneIDi950527
KEGGihin:HI1713
PATRICifig|71421.8.peg.1792

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC23358.1
PIRiI64137
RefSeqiNP_439855.1, NC_000907.1
WP_005649965.1, NC_000907.1

3D structure databases

ProteinModelPortaliP43921
SMRiP43921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1713

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23358; AAC23358; HI_1713
GeneIDi950527
KEGGihin:HI1713
PATRICifig|71421.8.peg.1792

Phylogenomic databases

eggNOGiENOG4105KZ7 Bacteria
COG1925 LUCA
KOiK02784
OMAiRPGNEFV
PhylomeDBiP43921

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1728-MONOMER

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
IPR002114 PTS_HPr_Ser_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
PS00589 PTS_HPR_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTHP_HAEIN
AccessioniPrimary (citable) accession number: P43921
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
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Main funding by: National Institutes of Health

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