UniProtKB - P43897 (EFTS_HUMAN)
Elongation factor Ts, mitochondrial
TSFM
Functioni
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
UniRule annotation1 PublicationGO - Molecular functioni
- RNA binding Source: UniProtKB
- translation elongation factor activity Source: GO_Central
GO - Biological processi
- mitochondrial translational elongation Source: GO_Central
- regulation of DNA-templated transcription, elongation Source: ProtInc
- regulation of mitochondrial translation Source: UniProtKB
- translational elongation Source: GO_Central
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | P43897 |
Reactomei | R-HSA-5389840, Mitochondrial translation elongation |
SignaLinki | P43897 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor Ts, mitochondrialUniRule annotationShort name: EF-TsUniRule annotation Short name: EF-TsMtUniRule annotation |
Gene namesi | Name:TSFMUniRule annotation |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12367, TSFM |
MIMi | 604723, gene |
neXtProti | NX_P43897 |
VEuPathDBi | HostDB:ENSG00000123297 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: GO_Central
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Combined oxidative phosphorylation deficiency 3 (COXPD3)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077697 | 240 | C → S in COXPD3; decreased protein abundance; decreased mitochondrial translation products; patient fibroblast phenotype can be rescued by coexpression with wild-type TSFM. 1 PublicationCorresponds to variant dbSNP:rs750799705Ensembl. | 1 | |
Natural variantiVAR_068973 | 312 | R → W in COXPD3. 2 PublicationsCorresponds to variant dbSNP:rs121909485EnsemblClinVar. | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variant, Primary mitochondrial diseaseOrganism-specific databases
DisGeNETi | 10102 |
MalaCardsi | TSFM |
MIMi | 610505, phenotype |
OpenTargetsi | ENSG00000123297 |
Orphaneti | 168566, Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3 |
PharmGKBi | PA37037 |
Miscellaneous databases
Pharosi | P43897, Tbio |
Genetic variation databases
BioMutai | TSFM |
DMDMi | 12644268 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 45 | MitochondrionUniRule annotationAdd BLAST | 45 | |
ChainiPRO_0000007468 | 46 – 325 | Elongation factor Ts, mitochondrialAdd BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 133 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 192 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 270 | PhosphoserineCombined sources | 1 | |
Modified residuei | 324 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P43897 |
jPOSTi | P43897 |
MassIVEi | P43897 |
MaxQBi | P43897 |
PeptideAtlasi | P43897 |
PRIDEi | P43897 |
ProteomicsDBi | 26068 55655 [P43897-1] 55656 [P43897-2] 55657 [P43897-3] |
PTM databases
GlyGeni | P43897, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P43897 |
MetOSitei | P43897 |
PhosphoSitePlusi | P43897 |
SwissPalmi | P43897 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000123297, Expressed in right adrenal gland and 243 other tissues |
ExpressionAtlasi | P43897, baseline and differential |
Genevisiblei | P43897, HS |
Organism-specific databases
HPAi | ENSG00000123297, Low tissue specificity |
Interactioni
Binary interactionsi
P43897
Protein-protein interaction databases
BioGRIDi | 115409, 385 interactors |
IntActi | P43897, 38 interactors |
MINTi | P43897 |
STRINGi | 9606.ENSP00000313877 |
Miscellaneous databases
RNActi | P43897, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P43897 |
SMRi | P43897 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43897 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1071, Eukaryota |
GeneTreei | ENSGT00390000016293 |
HOGENOMi | CLU_047155_4_0_1 |
InParanoidi | P43897 |
OMAi | HTTRQLC |
OrthoDBi | 1048278at2759 |
PhylomeDBi | P43897 |
TreeFami | TF314154 |
Family and domain databases
Gene3Di | 3.30.479.20, 2 hits |
HAMAPi | MF_00050, EF_Ts, 1 hit |
InterProi | View protein in InterPro IPR036402, EF-Ts_dimer_sf IPR001816, Transl_elong_EFTs/EF1B IPR014039, Transl_elong_EFTs/EF1B_dimer IPR018101, Transl_elong_Ts_CS IPR009060, UBA-like_sf |
PANTHERi | PTHR11741, PTHR11741, 1 hit |
Pfami | View protein in Pfam PF00889, EF_TS, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit SSF54713, SSF54713, 2 hits |
PROSITEi | View protein in PROSITE PS01126, EF_TS_1, 1 hit PS01127, EF_TS_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLRSLRVF LVARTGSYPA GSLLRQSPQP RHTFYAGPRL SASASSKELL
60 70 80 90 100
MKLRRKTGYS FVNCKKALET CGGDLKQAEI WLHKEAQKEG WSKAAKLQGR
110 120 130 140 150
KTKEGLIGLL QEGNTTVLVE VNCETDFVSR NLKFQLLVQQ VALGTMMHCQ
160 170 180 190 200
TLKDQPSAYS KGFLNSSELS GLPAGPDREG SLKDQLALAI GKLGENMILK
210 220 230 240 250
RAAWVKVPSG FYVGSYVHGA MQSPSLHKLV LGKYGALVIC ETSEQKTNLE
260 270 280 290 300
DVGRRLGQHV VGMAPLSVGS LDDEPGGEAE TKMLSQPYLL DPSITLGQYV
310 320
QPQGVSVVDF VRFECGEGEE AAETE
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VPA7 | F8VPA7_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 200 | Annotation score: | ||
F8VS27 | F8VS27_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 230 | Annotation score: | ||
C9JT21 | C9JT21_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 168 | Annotation score: | ||
C9JG32 | C9JG32_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 140 | Annotation score: | ||
A0A494C1D5 | A0A494C1D5_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 129 | Annotation score: | ||
F8WCK2 | F8WCK2_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 89 | Annotation score: | ||
A0A494C1M9 | A0A494C1M9_HUMAN | Elongation factor Ts, mitochondrial | TSFM | 137 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 – 34 | HTF → ARV in AAC37577 (PubMed:7615523).Curated | 3 | |
Sequence conflicti | 196 | N → T in AAH93068 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077697 | 240 | C → S in COXPD3; decreased protein abundance; decreased mitochondrial translation products; patient fibroblast phenotype can be rescued by coexpression with wild-type TSFM. 1 PublicationCorresponds to variant dbSNP:rs750799705Ensembl. | 1 | |
Natural variantiVAR_068973 | 312 | R → W in COXPD3. 2 PublicationsCorresponds to variant dbSNP:rs121909485EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001364 | 161 | K → KVQWLTPVNLALWEAEAGGS LE in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_043517 | 162 – 167 | GFLNSS → ENWEKT in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_043518 | 168 – 325 | Missing in isoform 3. 1 PublicationAdd BLAST | 158 | |
Alternative sequenceiVSP_045283 | 192 – 215 | KLGEN…FYVGS → LPFQIGAVSELQLPESNFLQ NTSS in isoform 4. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_045284 | 216 – 325 | Missing in isoform 4. 1 PublicationAdd BLAST | 110 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110399 mRNA Translation: AAD20224.1 AK304621 mRNA Translation: BAG65403.1 AK308981 mRNA No translation available. AC025165 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97075.1 BC022862 mRNA Translation: AAH22862.1 BC093068 mRNA Translation: AAH93068.1 L37936 mRNA Translation: AAC37577.1 |
CCDSi | CCDS53809.1 [P43897-2] CCDS53810.1 [P43897-4] CCDS53811.1 [P43897-3] CCDS8958.2 [P43897-1] |
PIRi | I84606 |
RefSeqi | NP_001166166.1, NM_001172695.1 [P43897-3] NP_001166167.1, NM_001172696.1 [P43897-2] NP_001166168.1, NM_001172697.1 [P43897-4] NP_005717.3, NM_005726.5 [P43897-1] |
Genome annotation databases
Ensembli | ENST00000323833.12; ENSP00000313877.8; ENSG00000123297.20 [P43897-2] ENST00000540550.6; ENSP00000440987.1; ENSG00000123297.20 [P43897-3] ENST00000543727.5; ENSP00000439342.1; ENSG00000123297.20 [P43897-4] ENST00000652027.2; ENSP00000499171.2; ENSG00000123297.20 |
GeneIDi | 10102 |
KEGGi | hsa:10102 |
MANE-Selecti | ENST00000652027.2; ENSP00000499171.2; NM_005726.6; NP_005717.3 |
UCSCi | uc001sqh.4, human [P43897-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110399 mRNA Translation: AAD20224.1 AK304621 mRNA Translation: BAG65403.1 AK308981 mRNA No translation available. AC025165 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97075.1 BC022862 mRNA Translation: AAH22862.1 BC093068 mRNA Translation: AAH93068.1 L37936 mRNA Translation: AAC37577.1 |
CCDSi | CCDS53809.1 [P43897-2] CCDS53810.1 [P43897-4] CCDS53811.1 [P43897-3] CCDS8958.2 [P43897-1] |
PIRi | I84606 |
RefSeqi | NP_001166166.1, NM_001172695.1 [P43897-3] NP_001166167.1, NM_001172696.1 [P43897-2] NP_001166168.1, NM_001172697.1 [P43897-4] NP_005717.3, NM_005726.5 [P43897-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CP9 | NMR | - | A | 45-95 | [»] | |
AlphaFoldDBi | P43897 | |||||
SMRi | P43897 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115409, 385 interactors |
IntActi | P43897, 38 interactors |
MINTi | P43897 |
STRINGi | 9606.ENSP00000313877 |
PTM databases
GlyGeni | P43897, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P43897 |
MetOSitei | P43897 |
PhosphoSitePlusi | P43897 |
SwissPalmi | P43897 |
Genetic variation databases
BioMutai | TSFM |
DMDMi | 12644268 |
Proteomic databases
EPDi | P43897 |
jPOSTi | P43897 |
MassIVEi | P43897 |
MaxQBi | P43897 |
PeptideAtlasi | P43897 |
PRIDEi | P43897 |
ProteomicsDBi | 26068 55655 [P43897-1] 55656 [P43897-2] 55657 [P43897-3] |
Protocols and materials databases
Antibodypediai | 1781, 148 antibodies from 25 providers |
DNASUi | 10102 |
Genome annotation databases
Ensembli | ENST00000323833.12; ENSP00000313877.8; ENSG00000123297.20 [P43897-2] ENST00000540550.6; ENSP00000440987.1; ENSG00000123297.20 [P43897-3] ENST00000543727.5; ENSP00000439342.1; ENSG00000123297.20 [P43897-4] ENST00000652027.2; ENSP00000499171.2; ENSG00000123297.20 |
GeneIDi | 10102 |
KEGGi | hsa:10102 |
MANE-Selecti | ENST00000652027.2; ENSP00000499171.2; NM_005726.6; NP_005717.3 |
UCSCi | uc001sqh.4, human [P43897-1] |
Organism-specific databases
CTDi | 10102 |
DisGeNETi | 10102 |
GeneCardsi | TSFM |
HGNCi | HGNC:12367, TSFM |
HPAi | ENSG00000123297, Low tissue specificity |
MalaCardsi | TSFM |
MIMi | 604723, gene 610505, phenotype |
neXtProti | NX_P43897 |
OpenTargetsi | ENSG00000123297 |
Orphaneti | 168566, Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3 |
PharmGKBi | PA37037 |
VEuPathDBi | HostDB:ENSG00000123297 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1071, Eukaryota |
GeneTreei | ENSGT00390000016293 |
HOGENOMi | CLU_047155_4_0_1 |
InParanoidi | P43897 |
OMAi | HTTRQLC |
OrthoDBi | 1048278at2759 |
PhylomeDBi | P43897 |
TreeFami | TF314154 |
Enzyme and pathway databases
PathwayCommonsi | P43897 |
Reactomei | R-HSA-5389840, Mitochondrial translation elongation |
SignaLinki | P43897 |
Miscellaneous databases
BioGRID-ORCSi | 10102, 369 hits in 1089 CRISPR screens |
ChiTaRSi | TSFM, human |
EvolutionaryTracei | P43897 |
GeneWikii | TSFM |
GenomeRNAii | 10102 |
Pharosi | P43897, Tbio |
PROi | PR:P43897 |
RNActi | P43897, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123297, Expressed in right adrenal gland and 243 other tissues |
ExpressionAtlasi | P43897, baseline and differential |
Genevisiblei | P43897, HS |
Family and domain databases
Gene3Di | 3.30.479.20, 2 hits |
HAMAPi | MF_00050, EF_Ts, 1 hit |
InterProi | View protein in InterPro IPR036402, EF-Ts_dimer_sf IPR001816, Transl_elong_EFTs/EF1B IPR014039, Transl_elong_EFTs/EF1B_dimer IPR018101, Transl_elong_Ts_CS IPR009060, UBA-like_sf |
PANTHERi | PTHR11741, PTHR11741, 1 hit |
Pfami | View protein in Pfam PF00889, EF_TS, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit SSF54713, SSF54713, 2 hits |
PROSITEi | View protein in PROSITE PS01126, EF_TS_1, 1 hit PS01127, EF_TS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EFTS_HUMAN | |
Accessioni | P43897Primary (citable) accession number: P43897 Secondary accession number(s): B4E391 Q9UQK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 11, 2001 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families