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UniProtKB - P43897 (EFTS_HUMAN)

Entry version 206 (25 May 2022)
Sequence version 2 (11 Jan 2001)
Previous versions | rss
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Protein

Elongation factor Ts, mitochondrial

Gene

TSFM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.

UniRule annotation1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P43897

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5389840, Mitochondrial translation elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P43897

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongation factor Ts, mitochondrialUniRule annotation
Short name:
EF-TsUniRule annotation
Short name:
EF-TsMtUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSFMUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12367, TSFM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604723, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P43897

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123297

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 3 (COXPD3)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA mitochondrial disease resulting in severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077697240C → S in COXPD3; decreased protein abundance; decreased mitochondrial translation products; patient fibroblast phenotype can be rescued by coexpression with wild-type TSFM. 1 PublicationCorresponds to variant dbSNP:rs750799705Ensembl.1
Natural variantiVAR_068973312R → W in COXPD3. 2 PublicationsCorresponds to variant dbSNP:rs121909485EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		10102

MalaCards human disease database

More...MalaCardsi		TSFM
MIMi610505, phenotype

Open Targets

More...OpenTargetsi		ENSG00000123297

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		168566, Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37037

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P43897, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSFM

Domain mapping of disease mutations (DMDM)

More...DMDMi		12644268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 45MitochondrionUniRule annotationAdd BLAST45
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000746846 – 325Elongation factor Ts, mitochondrialAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76N6-succinyllysineBy similarity1
Modified residuei133N6-succinyllysineBy similarity1
Modified residuei192N6-succinyllysineBy similarity1
Modified residuei270PhosphoserineCombined sources1
Modified residuei324PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P43897

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P43897

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P43897

MaxQB - The MaxQuant DataBase

More...MaxQBi		P43897

PeptideAtlas

More...PeptideAtlasi		P43897

PRoteomics IDEntifications database

More...PRIDEi		P43897

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		26068
55655 [P43897-1]
55656 [P43897-2]
55657 [P43897-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P43897, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43897

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P43897

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P43897

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P43897

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123297, Expressed in right adrenal gland and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P43897, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P43897, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123297, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115409, 385 interactors

Protein interaction database and analysis system

More...IntActi		P43897, 38 interactors

Molecular INTeraction database

More...MINTi		P43897

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000313877

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43897, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P43897

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43897

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P43897

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EF-Ts family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1071, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047155_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43897

Identification of Orthologs from Complete Genome Data

More...OMAi		HTTRQLC

Database of Orthologous Groups

More...OrthoDBi		1048278at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P43897

TreeFam database of animal gene trees

More...TreeFami		TF314154

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.479.20, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_00050, EF_Ts, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036402, EF-Ts_dimer_sf
IPR001816, Transl_elong_EFTs/EF1B
IPR014039, Transl_elong_EFTs/EF1B_dimer
IPR018101, Transl_elong_Ts_CS
IPR009060, UBA-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR11741, PTHR11741, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00889, EF_TS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46934, SSF46934, 1 hit
SSF54713, SSF54713, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01126, EF_TS_1, 1 hit
PS01127, EF_TS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLLRSLRVF LVARTGSYPA GSLLRQSPQP RHTFYAGPRL SASASSKELL 
        60         70         80         90        100
MKLRRKTGYS FVNCKKALET CGGDLKQAEI WLHKEAQKEG WSKAAKLQGR 
       110        120        130        140        150
KTKEGLIGLL QEGNTTVLVE VNCETDFVSR NLKFQLLVQQ VALGTMMHCQ 
       160        170        180        190        200
TLKDQPSAYS KGFLNSSELS GLPAGPDREG SLKDQLALAI GKLGENMILK 
       210        220        230        240        250
RAAWVKVPSG FYVGSYVHGA MQSPSLHKLV LGKYGALVIC ETSEQKTNLE 
       260        270        280        290        300
DVGRRLGQHV VGMAPLSVGS LDDEPGGEAE TKMLSQPYLL DPSITLGQYV 
       310        320 
QPQGVSVVDF VRFECGEGEE AAETE
Length:325
Mass (Da):35,391
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i671645764A9CB31C
GO
Isoform 2 (identifier: P43897-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: K → KVQWLTPVNLALWEAEAGGSLE

Show »
Length:346
Mass (Da):37,656
Checksum:i15E85F6DF0FE8714
GO
Isoform 3 (identifier: P43897-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-167: GFLNSS → ENWEKT
     168-325: Missing.

Show »
Length:167
Mass (Da):18,748
Checksum:i32E5D247199AF171
GO
Isoform 4 (identifier: P43897-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-215: KLGENMILKRAAWVKVPSGFYVGS → LPFQIGAVSELQLPESNFLQNTSS
     216-325: Missing.

Show »
Length:215
Mass (Da):23,557
Checksum:i018E9C1CD7458EBD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPA7F8VPA7_HUMAN
Elongation factor Ts, mitochondrial
TSFM
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS27F8VS27_HUMAN
Elongation factor Ts, mitochondrial
TSFM
230Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JT21C9JT21_HUMAN
Elongation factor Ts, mitochondrial
TSFM
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG32C9JG32_HUMAN
Elongation factor Ts, mitochondrial
TSFM
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1D5A0A494C1D5_HUMAN
Elongation factor Ts, mitochondrial
TSFM
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCK2F8WCK2_HUMAN
Elongation factor Ts, mitochondrial
TSFM
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1M9A0A494C1M9_HUMAN
Elongation factor Ts, mitochondrial
TSFM
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32 – 34HTF → ARV in AAC37577 (PubMed:7615523).Curated3
Sequence conflicti196N → T in AAH93068 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077697240C → S in COXPD3; decreased protein abundance; decreased mitochondrial translation products; patient fibroblast phenotype can be rescued by coexpression with wild-type TSFM. 1 PublicationCorresponds to variant dbSNP:rs750799705Ensembl.1
Natural variantiVAR_068973312R → W in COXPD3. 2 PublicationsCorresponds to variant dbSNP:rs121909485EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001364161K → KVQWLTPVNLALWEAEAGGS LE in isoform 2. 1 Publication1
Alternative sequenceiVSP_043517162 – 167GFLNSS → ENWEKT in isoform 3. 1 Publication6
Alternative sequenceiVSP_043518168 – 325Missing in isoform 3. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_045283192 – 215KLGEN…FYVGS → LPFQIGAVSELQLPESNFLQ NTSS in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_045284216 – 325Missing in isoform 4. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF110399 mRNA Translation: AAD20224.1
AK304621 mRNA Translation: BAG65403.1
AK308981 mRNA No translation available.
AC025165 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97075.1
BC022862 mRNA Translation: AAH22862.1
BC093068 mRNA Translation: AAH93068.1
L37936 mRNA Translation: AAC37577.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53809.1 [P43897-2]
CCDS53810.1 [P43897-4]
CCDS53811.1 [P43897-3]
CCDS8958.2 [P43897-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I84606

NCBI Reference Sequences

More...RefSeqi		NP_001166166.1, NM_001172695.1 [P43897-3]
NP_001166167.1, NM_001172696.1 [P43897-2]
NP_001166168.1, NM_001172697.1 [P43897-4]
NP_005717.3, NM_005726.5 [P43897-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000323833.12; ENSP00000313877.8; ENSG00000123297.20 [P43897-2]
ENST00000540550.6; ENSP00000440987.1; ENSG00000123297.20 [P43897-3]
ENST00000543727.5; ENSP00000439342.1; ENSG00000123297.20 [P43897-4]
ENST00000652027.2; ENSP00000499171.2; ENSG00000123297.20

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10102

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000652027.2; ENSP00000499171.2; NM_005726.6; NP_005717.3

UCSC genome browser

More...UCSCi		uc001sqh.4, human [P43897-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110399 mRNA Translation: AAD20224.1
AK304621 mRNA Translation: BAG65403.1
AK308981 mRNA No translation available.
AC025165 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97075.1
BC022862 mRNA Translation: AAH22862.1
BC093068 mRNA Translation: AAH93068.1
L37936 mRNA Translation: AAC37577.1
CCDSiCCDS53809.1 [P43897-2]
CCDS53810.1 [P43897-4]
CCDS53811.1 [P43897-3]
CCDS8958.2 [P43897-1]
PIRiI84606
RefSeqiNP_001166166.1, NM_001172695.1 [P43897-3]
NP_001166167.1, NM_001172696.1 [P43897-2]
NP_001166168.1, NM_001172697.1 [P43897-4]
NP_005717.3, NM_005726.5 [P43897-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CP9NMR-A45-95[»]
AlphaFoldDBiP43897
SMRiP43897
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115409, 385 interactors
IntActiP43897, 38 interactors
MINTiP43897
STRINGi9606.ENSP00000313877

PTM databases

GlyGeniP43897, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP43897
MetOSiteiP43897
PhosphoSitePlusiP43897
SwissPalmiP43897

Genetic variation databases

BioMutaiTSFM
DMDMi12644268

Proteomic databases

EPDiP43897
jPOSTiP43897
MassIVEiP43897
MaxQBiP43897
PeptideAtlasiP43897
PRIDEiP43897
ProteomicsDBi26068
55655 [P43897-1]
55656 [P43897-2]
55657 [P43897-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1781, 148 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		10102

Genome annotation databases

EnsembliENST00000323833.12; ENSP00000313877.8; ENSG00000123297.20 [P43897-2]
ENST00000540550.6; ENSP00000440987.1; ENSG00000123297.20 [P43897-3]
ENST00000543727.5; ENSP00000439342.1; ENSG00000123297.20 [P43897-4]
ENST00000652027.2; ENSP00000499171.2; ENSG00000123297.20
GeneIDi10102
KEGGihsa:10102
MANE-SelectiENST00000652027.2; ENSP00000499171.2; NM_005726.6; NP_005717.3
UCSCiuc001sqh.4, human [P43897-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10102
DisGeNETi10102

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSFM
HGNCiHGNC:12367, TSFM
HPAiENSG00000123297, Low tissue specificity
MalaCardsiTSFM
MIMi604723, gene
610505, phenotype
neXtProtiNX_P43897
OpenTargetsiENSG00000123297
Orphaneti168566, Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3
PharmGKBiPA37037
VEuPathDBiHostDB:ENSG00000123297

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1071, Eukaryota
GeneTreeiENSGT00390000016293
HOGENOMiCLU_047155_4_0_1
InParanoidiP43897
OMAiHTTRQLC
OrthoDBi1048278at2759
PhylomeDBiP43897
TreeFamiTF314154

Enzyme and pathway databases

PathwayCommonsiP43897
ReactomeiR-HSA-5389840, Mitochondrial translation elongation
SignaLinkiP43897

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10102, 369 hits in 1089 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TSFM, human
EvolutionaryTraceiP43897

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TSFM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10102
PharosiP43897, Tbio

Protein Ontology

More...PROi		PR:P43897
RNActiP43897, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123297, Expressed in right adrenal gland and 243 other tissues
ExpressionAtlasiP43897, baseline and differential
GenevisibleiP43897, HS

Family and domain databases

Gene3Di3.30.479.20, 2 hits
HAMAPiMF_00050, EF_Ts, 1 hit
InterProiView protein in InterPro
IPR036402, EF-Ts_dimer_sf
IPR001816, Transl_elong_EFTs/EF1B
IPR014039, Transl_elong_EFTs/EF1B_dimer
IPR018101, Transl_elong_Ts_CS
IPR009060, UBA-like_sf
PANTHERiPTHR11741, PTHR11741, 1 hit
PfamiView protein in Pfam
PF00889, EF_TS, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF54713, SSF54713, 2 hits
PROSITEiView protein in PROSITE
PS01126, EF_TS_1, 1 hit
PS01127, EF_TS_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFTS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43897
Secondary accession number(s): B4E391
, F5H2T7, Q561V7, Q8TBC2, Q9UQK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2001
Last modified: May 25, 2022
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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