UniProtKB - P43885 (SERA_HAEIN)
Protein
D-3-phosphoglycerate dehydrogenase
Gene
serA
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.By similarity
Catalytic activityi
Activity regulationi
In bacteria displays feedback inhibition by L-serine.By similarity
: L-serine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- D-3-phosphoglycerate dehydrogenase (serA)
- Phosphoserine aminotransferase (serC)
- Phosphoserine phosphatase (serB)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 182 | NADBy similarity | 1 | |
Active sitei | 241 | By similarity | 1 | |
Binding sitei | 265 | NADBy similarity | 1 | |
Active sitei | 270 | By similarity | 1 | |
Active sitei | 293 | Proton donorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 162 – 163 | NADBy similarity | 2 | |
Nucleotide bindingi | 239 – 241 | NADBy similarity | 3 | |
Nucleotide bindingi | 293 – 296 | NADBy similarity | 4 |
GO - Molecular functioni
- NAD binding Source: InterPro
- phosphoglycerate dehydrogenase activity Source: GO_Central
GO - Biological processi
- L-serine biosynthetic process Source: UniProtKB-KW
- serine family amino acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Amino-acid biosynthesis, Serine biosynthesis |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-481-MONOMER |
UniPathwayi | UPA00135;UER00196 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:serA Ordered Locus Names:HI_0465 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- Gram-negative-bacterium-type cell wall Source: InterPro
- integral component of membrane Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076002 | 1 – 410 | D-3-phosphoglycerate dehydrogenaseAdd BLAST | 410 |
Proteomic databases
PRIDEi | P43885 |
Structurei
3D structure databases
ProteinModelPortali | P43885 |
SMRi | P43885 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 341 – 410 | ACTPROSITE-ProRule annotationAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
KOi | K00058 |
OMAi | YHAIGIR |
PhylomeDBi | P43885 |
Family and domain databases
InterProi | View protein in InterPro IPR002912 ACT_dom IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR010771 IgaA IPR036291 NAD(P)-bd_dom_sf IPR029015 PGDH_2 |
PANTHERi | PTHR10996:SF165 PTHR10996:SF165, 1 hit |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD147088 IgaA, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P43885-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNKVSLDKS KIKFVLFEGV HQSALDTLHA AGYTNIDYYK KALDGDELKE
60 70 80 90 100
AIKDVHFIGL RSRTHLTAEM IEAAPKLIAV GCFCIGTNQV DLNAAKARGI
110 120 130 140 150
PVFNAPFSNT RSVAELVLGE ILLLMRNVPQ ANAEVHRGVW NKSATGSHEV
160 170 180 190 200
RGKKLGIIGY GHIGSQLSII AESLGMDVYF YDIENKLPLG NAKQVRSLEE
210 220 230 240 250
LLSSCDVVSL HVPELPSTKN LMNVARIAQL KQGAILINAA RGTVVDIDAL
260 270 280 290 300
AQALKDGKLQ GAAIDVFPVE PASINEEFIS PLREFDNVIL TPHIGGSTAE
310 320 330 340 350
AQENIGFEVA GKFVKYSDNG STLSSVNFPE VSLPEHEGTK RLLHIHENRP
360 370 380 390 400
GILNKLNQIF VEANLNIAAQ YLQTDPKIGY VVVDVETNDA SPLLTKLKEI
410
DGTIRARVLY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC22124.1 |
PIRi | C64070 |
RefSeqi | NP_438626.1, NC_000907.1 WP_005693698.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC22124; AAC22124; HI_0465 |
GeneIDi | 950636 |
KEGGi | hin:HI0465 |
PATRICi | fig|71421.8.peg.485 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC22124.1 |
PIRi | C64070 |
RefSeqi | NP_438626.1, NC_000907.1 WP_005693698.1, NC_000907.1 |
3D structure databases
ProteinModelPortali | P43885 |
SMRi | P43885 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI0465 |
Proteomic databases
PRIDEi | P43885 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | AAC22124; AAC22124; HI_0465 |
GeneIDi | 950636 |
KEGGi | hin:HI0465 |
PATRICi | fig|71421.8.peg.485 |
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
KOi | K00058 |
OMAi | YHAIGIR |
PhylomeDBi | P43885 |
Enzyme and pathway databases
UniPathwayi | UPA00135;UER00196 |
BioCyci | HINF71421:G1GJ1-481-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR002912 ACT_dom IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR010771 IgaA IPR036291 NAD(P)-bd_dom_sf IPR029015 PGDH_2 |
PANTHERi | PTHR10996:SF165 PTHR10996:SF165, 1 hit |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD147088 IgaA, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | SERA_HAEIN | |
Accessioni | P43885Primary (citable) accession number: P43885 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 5, 2018 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Haemophilus influenzae
Haemophilus influenzae (strain Rd): entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways