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Protein

Type-2 restriction enzyme HindIII

Gene

hindIIIR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes the double-stranded sequence AAGCTT and cleaves after A-1.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processRestriction system

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1421-MONOMER

Protein family/group databases

REBASEi1151 HindIII

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HindIII (EC:3.1.21.4)
Short name:
R.HindIII
Alternative name(s):
Endonuclease HindIII
Type II restriction enzyme HindIII
Gene namesi
Name:hindIIIR
Ordered Locus Names:HI_1393
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773211 – 300Type-2 restriction enzyme HindIIIAdd BLAST300

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1393

Chemistry databases

BindingDBiP43870

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43870
SMRiP43870
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43870

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105S7Q Bacteria
ENOG4111XCG LUCA
KOiK01155
OMAiDINMSSK

Family and domain databases

Gene3Di3.40.91.70, 1 hit
InterProiView protein in InterPro
IPR019043 Restrct_endonuc_II_HindIII
IPR038373 Restrct_endonuc_II_HindIII_sf
PfamiView protein in Pfam
PF09518 RE_HindIII, 1 hit

Sequencei

Sequence statusi: Complete.

P43870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKSALEKLL SLIENLTNQE FKQATNSLIS FIYKLNRNEV IELVRSIGIL
60 70 80 90 100
PEAIKPSSTQ EKLFSKAGDI VLAKAFQLLN LNSKPLEQRG NAGDVIALSK
110 120 130 140 150
EFNYGLVADA KSFRLSRTAK NQKDFKVKAL SEWREDKDYA VLTAPFFQYP
160 170 180 190 200
TTKSQIFKQS LDENVLLFSW EHLAILLQLD LEETNIFSFE QLWNFPKKQS
210 220 230 240 250
KKTSVSDAEN NFMRDFNKYF MDLFKIDKDT LNQLLQKEIN FIEERSLIEK
260 270 280 290 300
EYWKKQINII KNFTREEAIE ALLKDINMSS KIETIDSFIK GIKSNDRLYL
Length:300
Mass (Da):34,952
Last modified:November 1, 1995 - v1
Checksum:i62F62AC4B18E841B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15391 Genomic DNA Translation: AAA61958.1
L42023 Genomic DNA Translation: AAC23040.1
PIRiH64121
RefSeqiNP_439547.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC23040; AAC23040; HI_1393
GeneIDi950303
KEGGihin:HI1393
PATRICifig|71421.8.peg.1452

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15391 Genomic DNA Translation: AAA61958.1
L42023 Genomic DNA Translation: AAC23040.1
PIRiH64121
RefSeqiNP_439547.1, NC_000907.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E52X-ray2.00A/B/C/D1-300[»]
3A4KX-ray2.17A/B/C/D1-300[»]
3WVGX-ray2.25A/B/C/D1-300[»]
3WVHX-ray2.54A/B/C/D1-300[»]
3WVIX-ray2.55A/B/C/D1-300[»]
3WVKX-ray2.00A/B/C/D1-300[»]
3WVPX-ray2.30A/B/C/D1-300[»]
ProteinModelPortaliP43870
SMRiP43870
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1393

Chemistry databases

BindingDBiP43870
ChEMBLiCHEMBL5004

Protein family/group databases

REBASEi1151 HindIII

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23040; AAC23040; HI_1393
GeneIDi950303
KEGGihin:HI1393
PATRICifig|71421.8.peg.1452

Phylogenomic databases

eggNOGiENOG4105S7Q Bacteria
ENOG4111XCG LUCA
KOiK01155
OMAiDINMSSK

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1421-MONOMER

Miscellaneous databases

EvolutionaryTraceiP43870
PROiPR:P43870

Family and domain databases

Gene3Di3.40.91.70, 1 hit
InterProiView protein in InterPro
IPR019043 Restrct_endonuc_II_HindIII
IPR038373 Restrct_endonuc_II_HindIII_sf
PfamiView protein in Pfam
PF09518 RE_HindIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT2D3_HAEIN
AccessioniPrimary (citable) accession number: P43870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
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Main funding by: National Institutes of Health

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