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UniProtKB - P43783 (GSHR_HAEIN)
Protein
Glutathione reductase
Gene
gor
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Maintains high levels of reduced glutathione in the cytosol.
By similarityMiscellaneous
The active site is a redox-active disulfide bond.
Catalytic activityi
- EC:1.8.1.7
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 445 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 42 | FADBy similarity | 9 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: GO_Central
- glutathione-disulfide reductase (NADPH) activity Source: GO_Central
- NADP binding Source: InterPro
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- cellular response to oxidative stress Source: GO_Central
- glutathione metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gor Ordered Locus Names:HI_0161 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067976 | 1 – 456 | Glutathione reductaseAdd BLAST | 456 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 47 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 71421.HI_0161 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | COG1249, Bacteria |
HOGENOMi | CLU_016755_2_2_6 |
OMAi | MSKHYDY |
PhylomeDBi | P43783 |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR016156, FAD/NAD-linked_Rdtase_dimer_sf IPR006322, Glutathione_Rdtase_euk/bac IPR001100, Pyr_nuc-diS_OxRdtase IPR004099, Pyr_nucl-diS_OxRdtase_dimer IPR012999, Pyr_OxRdtase_I_AS |
PANTHERi | PTHR42737, PTHR42737, 1 hit |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF02852, Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350, Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit SSF55424, SSF55424, 1 hit |
TIGRFAMsi | TIGR01421, gluta_reduc_1, 1 hit |
PROSITEi | View protein in PROSITE PS00076, PYRIDINE_REDOX_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P43783-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKHYDYIAI GGGSGGIASL NRAASYGKKC AIIEAKHLGG TCVNVGCVPK
60 70 80 90 100
KVMFYGAHIA EAINNYAPDY GFDVEVKKFD FSKLIESRQA YISRIHTSYN
110 120 130 140 150
NVLAKNNIDV INGFGKFVDA HTIEVTLADG TKEQVTADHI LIATGGRPYR
160 170 180 190 200
PNIKGQEYGI DSDGFFALTE LPKRAAVIGA GYIAVELSGV LNSLGVETHL
210 220 230 240 250
LVRRHAPMRN QDPLIVETLV EVLAQDGIQL HTNSTPSEIV KNADGSLTVR
260 270 280 290 300
CDGQSDVTVD CVIWAAGRVP TTDKIGLENA GVETNEHGYV KVDKYQNTNV
310 320 330 340 350
KGIYAVGDII ENGIELTPVA VAAGRRLSER LFNNKPTEYL DYSLVPTVVF
360 370 380 390 400
SHPPIGTVGL TEPQAIEQYG AENVKVYKSS FTAMYTAVTQ HRQPCKMKLV
410 420 430 440 450
CVGKDEKVVG LHGIGFGVDE MIQGFAVAIK MGATKADFDN TVAIHPTGSE
EFVTMR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20229 Genomic DNA Translation: AAA62137.1 L42023 Genomic DNA Translation: AAC21833.1 |
PIRi | A64052 |
RefSeqi | NP_438331.1, NC_000907.1 WP_005694117.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC21833; AAC21833; HI_0161 |
KEGGi | hin:HI_0161 |
PATRICi | fig|71421.8.peg.167 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20229 Genomic DNA Translation: AAA62137.1 L42023 Genomic DNA Translation: AAC21833.1 |
PIRi | A64052 |
RefSeqi | NP_438331.1, NC_000907.1 WP_005694117.1, NC_000907.1 |
3D structure databases
AlphaFoldDBi | P43783 |
SMRi | P43783 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI_0161 |
Genome annotation databases
EnsemblBacteriai | AAC21833; AAC21833; HI_0161 |
KEGGi | hin:HI_0161 |
PATRICi | fig|71421.8.peg.167 |
Phylogenomic databases
eggNOGi | COG1249, Bacteria |
HOGENOMi | CLU_016755_2_2_6 |
OMAi | MSKHYDY |
PhylomeDBi | P43783 |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR016156, FAD/NAD-linked_Rdtase_dimer_sf IPR006322, Glutathione_Rdtase_euk/bac IPR001100, Pyr_nuc-diS_OxRdtase IPR004099, Pyr_nucl-diS_OxRdtase_dimer IPR012999, Pyr_OxRdtase_I_AS |
PANTHERi | PTHR42737, PTHR42737, 1 hit |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF02852, Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350, Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit SSF55424, SSF55424, 1 hit |
TIGRFAMsi | TIGR01421, gluta_reduc_1, 1 hit |
PROSITEi | View protein in PROSITE PS00076, PYRIDINE_REDOX_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSHR_HAEIN | |
Accessioni | P43783Primary (citable) accession number: P43783 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families