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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gapA)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateBy similarity1
Binding sitei112SubstrateBy similarity1
Binding sitei145SubstrateBy similarity1
Binding sitei196ATPBy similarity1
Binding sitei313ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi339 – 342ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-538-MONOMER
UniPathwayi
UPA00109;UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:HI_0525
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001459482 – 386Phosphoglycerate kinaseAdd BLAST385

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0525

Structurei

3D structure databases

ProteinModelPortaliP43726
SMRiP43726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingBy similarity3
Regioni59 – 62Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
KOiK00927
OMAiDMIFDIG
PhylomeDBiP43726

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43726-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVIKMTDLD LAGKRVFIRA DLNVPVKDGK VTSDARIRAT IPTLKLALEK
60 70 80 90 100
GAKVMVTSHL GRPTEGEFKP EDSLQPVVDY LKNAGFNVRL EQDYLNGVDV
110 120 130 140 150
KDGEIVVLEN VRVNKGEKKN DPELGKKYAA LCDVFVMDAF GTAHRAQAST
160 170 180 190 200
YGVAEFAPIA CAGPLLAAEL DALGKALKEP ARPMVAIVGG SKVSTKLEVL
210 220 230 240 250
NSLSKIADQI IVGGGIANTF IAAAGHNVGK SLYEADLIPV AKELAANTDI
260 270 280 290 300
PVPVDVRVGL EFSETAAATE KVVNEVKDDE SIFDIGDKSA EQLAEIIKNA
310 320 330 340 350
KTVLWNGPVG VFEFPHFRKG TEIISHAIAN SDAFSIAGGG DTLAAIDLFG
360 370 380
IADKISYIST GGGAFLEFVE GKVLPAVEIL EKRAKN
Length:386
Mass (Da):40,983
Last modified:January 23, 2007 - v2
Checksum:i9029D21368DEB66D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22183.1
PIRiD64074
RefSeqiNP_438683.1, NC_000907.1
WP_005694128.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22183; AAC22183; HI_0525
GeneIDi949587
KEGGihin:HI0525
PATRICifig|71421.8.peg.544

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22183.1
PIRiD64074
RefSeqiNP_438683.1, NC_000907.1
WP_005694128.1, NC_000907.1

3D structure databases

ProteinModelPortaliP43726
SMRiP43726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0525

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22183; AAC22183; HI_0525
GeneIDi949587
KEGGihin:HI0525
PATRICifig|71421.8.peg.544

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
KOiK00927
OMAiDMIFDIG
PhylomeDBiP43726

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

BioCyciHINF71421:G1GJ1-538-MONOMER

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_HAEIN
AccessioniPrimary (citable) accession number: P43726
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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