UniProtKB - P43702 (PARC_HAEIN)
Protein
DNA topoisomerase 4 subunit A
Gene
parC
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Functioni
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation
Catalytic activityi
- ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation EC:5.6.2.2
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 123 | Transition state stabilizerUniRule annotation | 1 | |
Active sitei | 124 | O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: GO_Central
- DNA binding Source: GO_Central
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Source: UniProtKB-UniRule
GO - Biological processi
- chromosome segregation Source: GO_Central
- DNA topological change Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Isomerase, Topoisomerase |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-1551-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA topoisomerase 4 subunit AUniRule annotation (EC:5.6.2.2UniRule annotation)Alternative name(s): Topoisomerase IV subunit AUniRule annotation |
Gene namesi | Name:parCUniRule annotation Ordered Locus Names:HI_1529 |
Organismi | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Taxonomic identifieri | 71421 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation
Plasma Membrane
- extrinsic component of plasma membrane Source: UniProtKB-UniRule
Other locations
- chromosome Source: InterPro
- cytoplasm Source: GO_Central
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
DrugBanki | DB06771, Besifloxacin DB00537, Ciprofloxacin DB00467, Enoxacin DB09047, Finafloxacin DB04576, Fleroxacin DB01155, Gemifloxacin DB00365, Grepafloxacin DB01137, Levofloxacin DB00978, Lomefloxacin DB00218, Moxifloxacin DB01059, Norfloxacin DB01165, Ofloxacin DB00487, Pefloxacin DB01208, Sparfloxacin DB01405, Temafloxacin DB00685, Trovafloxacin |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145400 | 1 – 747 | DNA topoisomerase 4 subunit AAdd BLAST | 747 |
Interactioni
Subunit structurei
Heterotetramer composed of ParC and ParE.
UniRule annotationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 43 | Interaction with DNAUniRule annotation | 1 | |
Sitei | 79 | Interaction with DNAUniRule annotation | 1 | |
Sitei | 81 | Interaction with DNAUniRule annotation | 1 |
Protein-protein interaction databases
STRINGi | 71421.HI_1529 |
Family & Domainsi
Sequence similaritiesi
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | COG0188, Bacteria |
HOGENOMi | CLU_002977_4_1_6 |
OMAi | PRSNRID |
PhylomeDBi | P43702 |
Family and domain databases
CDDi | cd00187, TOP4c, 1 hit |
Gene3Di | 1.10.268.10, 1 hit 2.120.10.90, 1 hit 3.90.199.10, 1 hit |
HAMAPi | MF_00936, ParC_type1, 1 hit |
InterProi | View protein in InterPro IPR006691, GyrA/parC_rep IPR035516, Gyrase/topoIV_suA_C IPR013760, Topo_IIA-like_dom_sf IPR002205, Topo_IIA_A/C IPR013758, Topo_IIA_A/C_ab IPR013757, Topo_IIA_A_a_sf IPR005742, TopoIV_A_Gneg |
Pfami | View protein in Pfam PF03989, DNA_gyraseA_C, 2 hits PF00521, DNA_topoisoIV, 1 hit |
SMARTi | View protein in SMART SM00434, TOP4c, 1 hit |
SUPFAMi | SSF101904, SSF101904, 1 hit SSF56719, SSF56719, 1 hit |
i Sequence
Sequence statusi: Complete.
P43702-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNINYEGIE QMPLRTFTEK AYLNYSMYVI MDRALPFIGD GLKPVQRRIV
60 70 80 90 100
YAMSELGLNA TAKYKKSART VGDVLGKFHP HGDSACYEAM VLMAQPFSYR
110 120 130 140 150
YPLVDGQGNW GAPDDPKSFA AMRYTESRLS KISEILLNEL GQGTVDYQPN
160 170 180 190 200
FDGTLAEPQY LPARLPHILL NGTTGIAVGM ATDIPPHNIN EIADAAVMLL
210 220 230 240 250
DNPKAGLDDV LEIVQGPDFP TEAEIISPKS EIRKIYEQGR GSIKMRATWK
260 270 280 290 300
KEDGEIIISA LPHQSSPSKV IAQIAEQMTA KKLPMLEDIR DEADHENPIR
310 320 330 340 350
IVLVPRSNRV DTDALMAHLF ATTDLEKSYR VNMNMIGLDH KPAVKGLLEI
360 370 380 390 400
LNEWLDFRRT TVTRRLQYRL DKVLSRLHIL EGLMIAFLNI DEVIEIIRHE
410 420 430 440 450
DDPKAELMAR FNLSDEQADA ILNLRLRHLA KLEENQLKAE QDELEKERLN
460 470 480 490 500
LEAILGSERR LNTLIKKEIQ EDAKKYANPR MSQLVEREEA KMISESDMTP
510 520 530 540 550
AEPVTVILSE MGWVRCAKGH DIDPKSLSYK AGDSYLAHAC GKSNQAVVFI
560 570 580 590 600
DSTGRSYALD PLSLPSARSQ GEPLTGKLNL PTGATIEYVV MASEQQELLM
610 620 630 640 650
ASDAGYGFIC KFEDLIARNK AGKALISLPE NAKVLKPKTL INSTALVVAI
660 670 680 690 700
TSAGRMLIFP AQDLPVLSKG KGNKMITIPA ANAKDRSELL TKLLLISDQA
710 720 730 740
SLEFYSGKRK IVLKPEDLQK FRAERGRKGS TLPRGLHTNL EIMVIEP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC23175.1 |
PIRi | F64127 |
RefSeqi | NP_439678.1, NC_000907.1 WP_005693555.1, NC_000907.1 |
Genome annotation databases
EnsemblBacteriai | AAC23175; AAC23175; HI_1529 |
KEGGi | hin:HI_1529 |
PATRICi | fig|71421.8.peg.1600 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42023 Genomic DNA Translation: AAC23175.1 |
PIRi | F64127 |
RefSeqi | NP_439678.1, NC_000907.1 WP_005693555.1, NC_000907.1 |
3D structure databases
SMRi | P43702 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 71421.HI_1529 |
Chemistry databases
DrugBanki | DB06771, Besifloxacin DB00537, Ciprofloxacin DB00467, Enoxacin DB09047, Finafloxacin DB04576, Fleroxacin DB01155, Gemifloxacin DB00365, Grepafloxacin DB01137, Levofloxacin DB00978, Lomefloxacin DB00218, Moxifloxacin DB01059, Norfloxacin DB01165, Ofloxacin DB00487, Pefloxacin DB01208, Sparfloxacin DB01405, Temafloxacin DB00685, Trovafloxacin |
Genome annotation databases
EnsemblBacteriai | AAC23175; AAC23175; HI_1529 |
KEGGi | hin:HI_1529 |
PATRICi | fig|71421.8.peg.1600 |
Phylogenomic databases
eggNOGi | COG0188, Bacteria |
HOGENOMi | CLU_002977_4_1_6 |
OMAi | PRSNRID |
PhylomeDBi | P43702 |
Enzyme and pathway databases
BioCyci | HINF71421:G1GJ1-1551-MONOMER |
Family and domain databases
CDDi | cd00187, TOP4c, 1 hit |
Gene3Di | 1.10.268.10, 1 hit 2.120.10.90, 1 hit 3.90.199.10, 1 hit |
HAMAPi | MF_00936, ParC_type1, 1 hit |
InterProi | View protein in InterPro IPR006691, GyrA/parC_rep IPR035516, Gyrase/topoIV_suA_C IPR013760, Topo_IIA-like_dom_sf IPR002205, Topo_IIA_A/C IPR013758, Topo_IIA_A/C_ab IPR013757, Topo_IIA_A_a_sf IPR005742, TopoIV_A_Gneg |
Pfami | View protein in Pfam PF03989, DNA_gyraseA_C, 2 hits PF00521, DNA_topoisoIV, 1 hit |
SMARTi | View protein in SMART SM00434, TOP4c, 1 hit |
SUPFAMi | SSF101904, SSF101904, 1 hit SSF56719, SSF56719, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARC_HAEIN | |
Accessioni | P43702Primary (citable) accession number: P43702 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families