Transcription factor GATA-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: BHF-UCL
• chromatin binding Source: GO_Central
• co-SMAD binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 21330551
• DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 24000169
• enhancer sequence-specific DNA binding Source: Ensembl
• NFAT protein binding Source: Ensembl
• protein kinase binding Source: Ensembl
• RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 21330551
• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
• RNA polymerase II transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • 21330551
• sequence-specific DNA binding Source: BHF-UCL
• transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCLInferred from genetic interactionⁱ
  • 21330551
• transcription coactivator activity Source: UniProtKBInferred from direct assayⁱ
  • 21220346
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • 9858576
• transcription regulatory region DNA binding Source: UniProtKBInferred from direct assayⁱ
  • 21220346
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• aortic valve morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 29325903
• atrial septum morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 12845333
• atrial septum primum morphogenesis Source: BHF-UCL
• atrial septum secundum morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20347099
• blood coagulation Source: Reactome
• cardiac right ventricle morphogenesis Source: BHF-UCL
• cardiac ventricle morphogenesis Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 20347099
• cell-cell signaling Source: BHF-UCL
• cell growth involved in cardiac muscle cell development Source: Ensembl
• cellular response to glucose stimulus Source: Ensembl
• embryonic foregut morphogenesis Source: BHF-UCL
• embryonic heart tube anterior/posterior pattern specification Source: BHF-UCL
• endocardial cushion development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 21330551
• endoderm development Source: BHF-UCLTraceable author statementⁱ
  • 20347099
• heart looping Source: BHF-UCL
• intestinal epithelial cell differentiation Source: MGIInferred from direct assayⁱ
  • 9566909
• male gonad development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 21220346
• negative regulation of autophagy Source: Ensembl
• positive regulation of angiogenesis Source: BHF-UCL
• positive regulation of BMP signaling pathway Source: Ensembl
• positive regulation of cardioblast differentiation Source: BHF-UCL
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 24000169
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • 21330551
  • 29325903
• positive regulation of vascular endothelial growth factor production Source: BHF-UCL
• regulation of cardiac muscle cell contraction Source: Ensembl
• regulation of transcription, DNA-templated Source: BHF-UCL
• response to drug Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20585342
• response to mechanical stimulus Source: Ensembl
• response to vitamin A Source: Ensembl
• transcription by RNA polymerase II Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 12845333
• transdifferentiation Source: Ensembl
• ventricular septum development Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: BHF-UCL
• co-SMAD binding Source: BHF-UCLInferred from physical interactionⁱ
  • 21330551
• NFAT protein binding Source: Ensembl
• protein kinase binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • 21330551
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • 9858576

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG 
        60         70         80         90        100
LSYLQGGGAG SASGGASGGS SGGAASGAGP GTQQGSPGWS QAGADGAAYT 
       110        120        130        140        150
PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYSSGGGAAG AGLAGREQYG 
       160        170        180        190        200
RAGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPAA 
       210        220        230        240        250
RHPNLDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA CGLYHKMNGI 
       260        270        280        290        300
NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK 
       310        320        330        340        350
LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAAPSGSESL PPASGASSNS 
       360        370        380        390        400
SNATTSSSEE MRPIKTEPGL SSHYGHSSSV SQTFSVSAMS GHGPSIHPVL 
       410        420        430        440 
SALKLSPQGY ASPVSQSPQT SSKQDSWNSL VLADSHGDII TA         

        10         20         30         40         50
MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG 
        60         70         80         90        100
LSYLQGGGAG SASGGASGGS SGGAASGAGP GTQQGSPGWS QAGADGAAYT 
       110        120        130        140        150
PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYSSGGGAAG AGLAGREQYG 
       160        170        180        190        200
RAGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPAA 
       210        220        230        240        250
RHPNLVDMFD DFSEGRECVN CGAMSTPLWR RDGTGHYLCN ACGLYHKMNG 
       260        270        280        290        300
INRPLIKPQR RLSASRRVGL SCANCQTTTT TLWRRNAEGE PVCNACGLYM 
       310        320        330        340        350
KLHGVPRPLA MRKEGIQTRK RKPKNLNKSK TPAAPSGSES LPPASGASSN 
       360        370        380        390        400
SSNATTSSSE EMRPIKTEPG LSSHYGHSSS VSQTFSVSAM SGHGPSIHPV 
       410        420        430        440 
LSALKLSPQG YASPVSQSPQ TSSKQDSWNS LVLADSHGDI ITA        

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 8
   Human chromosome 8: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot