UniProtKB - P43681 (ACHA4_HUMAN)
Neuronal acetylcholine receptor subunit alpha-4
CHRNA4
Functioni
GO - Molecular functioni
- acetylcholine binding Source: UniProtKB
- acetylcholine-gated cation-selective channel activity Source: UniProtKB
- acetylcholine receptor activity Source: UniProtKB
- ligand-gated ion channel activity Source: DFLAT
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- acetylcholine receptor signaling pathway Source: Ensembl
- action potential Source: UniProtKB
- B cell activation Source: UniProtKB
- behavioral response to nicotine Source: UniProtKB
- calcium ion transport Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- cognition Source: UniProtKB
- DNA repair Source: UniProtKB
- exploration behavior Source: Ensembl
- inhibitory postsynaptic potential Source: UniProtKB
- ion transmembrane transport Source: GO_Central
- ion transport Source: UniProtKB
- locomotory behavior Source: Ensembl
- membrane depolarization Source: UniProtKB
- nervous system process Source: UniProtKB
- regulation of dopamine secretion Source: UniProtKB
- regulation of membrane potential Source: UniProtKB
- respiratory gaseous exchange by respiratory system Source: Ensembl
- response to hypoxia Source: UniProtKB
- response to nicotine Source: UniProtKB
- response to oxidative stress Source: UniProtKB
- sensory perception of pain Source: UniProtKB
- signal transduction Source: UniProtKB
- synaptic transmission, cholinergic Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P43681 |
Reactomei | R-HSA-629587, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Protein family/group databases
TCDBi | 1.A.9.1.6, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal acetylcholine receptor subunit alpha-4 |
Gene namesi | Name:CHRNA4 Synonyms:NACRA4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101204.15 |
HGNCi | HGNC:1958, CHRNA4 |
MIMi | 118504, gene |
neXtProti | NX_P43681 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ; Multi-pass membrane protein
- Cell membrane ; Multi-pass membrane protein
- Cell membrane By similarity; Lipid-anchor By similarity
Plasma Membrane
- acetylcholine-gated channel complex Source: UniProtKB
- external side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- dendrite Source: UniProtKB
- dopaminergic synapse Source: Ensembl
- integral component of membrane Source: UniProtKB
- membrane Source: UniProtKB
- neuron projection Source: GO_Central
- neuronal cell body Source: UniProtKB
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 242 | ExtracellularSequence analysisAdd BLAST | 214 | |
Transmembranei | 243 – 267 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 275 – 293 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 309 – 330 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 331 – 600 | CytoplasmicSequence analysisAdd BLAST | 270 | |
Transmembranei | 601 – 619 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Epilepsy, nocturnal frontal lobe, 1 (ENFL1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_000295 | 280 | S → F in ENFL1. 1 PublicationCorresponds to variant dbSNP:rs121909580EnsemblClinVar. | 1 | |
Natural variantiVAR_017531 | 280 | S → L in ENFL1. 2 Publications | 1 |
Keywords - Diseasei
Disease mutation, EpilepsyOrganism-specific databases
DisGeNETi | 1137 |
GeneReviewsi | CHRNA4 |
MalaCardsi | CHRNA4 |
MIMi | 600513, phenotype |
OpenTargetsi | ENSG00000101204 |
Orphaneti | 98784, Autosomal dominant nocturnal frontal lobe epilepsy |
PharmGKBi | PA26490 |
Miscellaneous databases
Pharosi | P43681, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1882 |
DrugBanki | DB00915, Amantadine DB01351, Amobarbital DB01352, Aprobarbital DB00572, Atropine DB01483, Barbital DB00237, Butabarbital DB00241, Butalbital DB01353, Butobarbital DB00564, Carbamazepine DB09028, Cytisine DB01245, Decamethonium DB00514, Dextromethorphan DB01496, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione DB07720, Epibatidine DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00898, Ethanol DB01354, Heptabarbital DB01355, Hexobarbital DB00753, Isoflurane DB00657, Mecamylamine DB00333, Methadone DB00463, Metharbital DB00849, Methylphenobarbital DB00184, Nicotine DB00312, Pentobarbital DB01174, Phenobarbital DB00981, Physostigmine DB05458, Pozanicline DB00794, Primidone DB05740, RPI-78M DB00747, Scopolamine DB00418, Secobarbital DB00306, Talbutal DB00599, Thiopental DB01273, Varenicline |
DrugCentrali | P43681 |
GuidetoPHARMACOLOGYi | 465 |
Polymorphism and mutation databases
BioMutai | CHRNA4 |
DMDMi | 1351848 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000000351 | 29 – 627 | Neuronal acetylcholine receptor subunit alpha-4Add BLAST | 599 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 107 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 161 ↔ 175 | By similarity | ||
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 225 ↔ 226 | Associated with receptor activationBy similarity | ||
Lipidationi | 271 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 424 | PhosphoserineBy similarity | 1 | |
Modified residuei | 538 | PhosphoserineBy similarity | 1 | |
Modified residuei | 541 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MassIVEi | P43681 |
PaxDbi | P43681 |
PeptideAtlasi | P43681 |
PRIDEi | P43681 |
ProteomicsDBi | 55649 [P43681-1] 62290 |
PTM databases
GlyGeni | P43681, 3 sites |
iPTMneti | P43681 |
PhosphoSitePlusi | P43681 |
SwissPalmi | P43681 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101204, Expressed in right lobe of liver and 100 other tissues |
ExpressionAtlasi | P43681, baseline and differential |
Genevisiblei | P43681, HS |
Organism-specific databases
HPAi | ENSG00000101204, Group enriched (brain, liver, parathyroid gland) |
Interactioni
Subunit structurei
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers (PubMed:22361591).
Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769).
Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-4-beta-2 interacts with alpha-conotoxins PnIA, GID and MII (By similarity).
By similarity3 PublicationsBinary interactionsi
Hide detailsP43681
With | #Exp. | IntAct |
---|---|---|
CRELD2 - isoform 1 [Q6UXH1-1] | 3 | EBI-7132379,EBI-21348071 |
CRELD2 - isoform 3 [Q6UXH1-3] | 3 | EBI-7132379,EBI-21348090 |
Isoform 1 [P43681-1]
With | #Exp. | IntAct |
---|---|---|
CHRNB2 [P17787] | 4 | EBI-20716158,EBI-9008612 |
Protein-protein interaction databases
BioGRIDi | 107559, 4 interactors |
ComplexPortali | CPX-168, Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-218, Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180, Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2203, Neuronal nicotinic acetylcholine receptor complex, alpha4-beta4 |
CORUMi | P43681 |
IntActi | P43681, 6 interactors |
MINTi | P43681 |
STRINGi | 9606.ENSP00000359285 |
Chemistry databases
BindingDBi | P43681 |
Miscellaneous databases
RNActi | P43681, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P43681 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000159329 |
HOGENOMi | CLU_018074_1_1_1 |
InParanoidi | P43681 |
OMAi | QMYSPNK |
PhylomeDBi | P43681 |
TreeFami | TF315605 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK
60 70 80 90 100
WSRPVANISD VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW
110 120 130 140 150
DPADYENVTS IRIPSELIWR PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ
160 170 180 190 200
WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG SWTYDKAKID LVNMHSRVDQ
210 220 230 240 250
LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR RLPLFYTINL
260 270 280 290 300
IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS
310 320 330 340 350
LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD
360 370 380 390 400
IVPRLLLMKR PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS
410 420 430 440 450
LHPPSPSFCV PLDVPAEPGP SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR
460 470 480 490 500
PPHGTQAPGL AKARSLSVQH MSSPGEAVEG GVRCRSRSIQ YCVPRDDAAP
510 520 530 540 550
EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV SPSATVKTRS
560 570 580 590 600
TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR
610 620
IFLWMFIIVC LLGTVGLFLP PWLAGMI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0D9SFU6 | A0A0D9SFU6_HUMAN | Neuronal acetylcholine receptor sub... | CHRNA4 | 111 | Annotation score: | ||
H0YBH1 | H0YBH1_HUMAN | Neuronal acetylcholine receptor sub... | CHRNA4 | 137 | Annotation score: | ||
A0A6Q8PG41 | A0A6Q8PG41_HUMAN | Neuronal acetylcholine receptor sub... | CHRNA4 | 91 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | G → E in AAH96290 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_000295 | 280 | S → F in ENFL1. 1 PublicationCorresponds to variant dbSNP:rs121909580EnsemblClinVar. | 1 | |
Natural variantiVAR_017531 | 280 | S → L in ENFL1. 2 Publications | 1 | |
Natural variantiVAR_023402 | 387 | E → G1 PublicationCorresponds to variant dbSNP:rs45604738EnsemblClinVar. | 1 | |
Natural variantiVAR_023403 | 517 | S → L1 PublicationCorresponds to variant dbSNP:rs45622132EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054275 | 1 – 57 | MELGG…RPVAN → MRMSPPSASPPSSSGGRTSS STTTAGEPFWAGVLFAIRPH PGLSGRIVWTAGCPGEG in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_054276 | 58 – 128 | Missing in isoform 2. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35901 mRNA Translation: AAA64743.1 X89741 , X89742, X89743, X89744, X89745, X89746 Genomic DNA Translation: CAA61893.1 U62433 mRNA Translation: AAB40111.1 Y08421 mRNA Translation: CAA69698.1 DQ093071 Genomic DNA Translation: AAY88737.1 AL121827 Genomic DNA No translation available. BC096290 mRNA Translation: AAH96290.1 BC096291 mRNA Translation: AAH96291.1 X87629 mRNA Translation: CAA60959.1 |
CCDSi | CCDS13517.1 [P43681-1] |
PIRi | JC4021 |
RefSeqi | NP_000735.1, NM_000744.6 [P43681-1] NP_001243502.1, NM_001256573.1 XP_011526826.1, XM_011528524.1 [P43681-2] |
Genome annotation databases
Ensembli | ENST00000370263; ENSP00000359285; ENSG00000101204 [P43681-1] ENST00000615287; ENSP00000483388; ENSG00000101204 [P43681-2] |
GeneIDi | 1137 |
KEGGi | hsa:1137 |
UCSCi | uc002yes.4, human [P43681-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35901 mRNA Translation: AAA64743.1 X89741 , X89742, X89743, X89744, X89745, X89746 Genomic DNA Translation: CAA61893.1 U62433 mRNA Translation: AAB40111.1 Y08421 mRNA Translation: CAA69698.1 DQ093071 Genomic DNA Translation: AAY88737.1 AL121827 Genomic DNA No translation available. BC096290 mRNA Translation: AAH96290.1 BC096291 mRNA Translation: AAH96291.1 X87629 mRNA Translation: CAA60959.1 |
CCDSi | CCDS13517.1 [P43681-1] |
PIRi | JC4021 |
RefSeqi | NP_000735.1, NM_000744.6 [P43681-1] NP_001243502.1, NM_001256573.1 XP_011526826.1, XM_011528524.1 [P43681-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GVT | model | - | A/C | 38-241 | [»] | |
2LLY | NMR | - | A | 240-339 | [»] | |
A | 598-626 | [»] | ||||
5KXI | X-ray | 3.94 | A/D | 27-364 | [»] | |
A/D | 586-627 | [»] | ||||
6CNJ | electron microscopy | 3.40 | A/D | 27-364 | [»] | |
6CNK | electron microscopy | 3.70 | A/B/D | 27-364 | [»] | |
6UR8 | electron microscopy | 3.71 | A/D | 27-364 | [»] | |
A/D | 589-627 | [»] | ||||
6USF | electron microscopy | 3.87 | A/D | 27-358 | [»] | |
A/D | 589-627 | [»] | ||||
SMRi | P43681 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107559, 4 interactors |
ComplexPortali | CPX-168, Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-218, Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180, Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2203, Neuronal nicotinic acetylcholine receptor complex, alpha4-beta4 |
CORUMi | P43681 |
IntActi | P43681, 6 interactors |
MINTi | P43681 |
STRINGi | 9606.ENSP00000359285 |
Chemistry databases
BindingDBi | P43681 |
ChEMBLi | CHEMBL1882 |
DrugBanki | DB00915, Amantadine DB01351, Amobarbital DB01352, Aprobarbital DB00572, Atropine DB01483, Barbital DB00237, Butabarbital DB00241, Butalbital DB01353, Butobarbital DB00564, Carbamazepine DB09028, Cytisine DB01245, Decamethonium DB00514, Dextromethorphan DB01496, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione DB07720, Epibatidine DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00898, Ethanol DB01354, Heptabarbital DB01355, Hexobarbital DB00753, Isoflurane DB00657, Mecamylamine DB00333, Methadone DB00463, Metharbital DB00849, Methylphenobarbital DB00184, Nicotine DB00312, Pentobarbital DB01174, Phenobarbital DB00981, Physostigmine DB05458, Pozanicline DB00794, Primidone DB05740, RPI-78M DB00747, Scopolamine DB00418, Secobarbital DB00306, Talbutal DB00599, Thiopental DB01273, Varenicline |
DrugCentrali | P43681 |
GuidetoPHARMACOLOGYi | 465 |
Protein family/group databases
TCDBi | 1.A.9.1.6, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
PTM databases
GlyGeni | P43681, 3 sites |
iPTMneti | P43681 |
PhosphoSitePlusi | P43681 |
SwissPalmi | P43681 |
Polymorphism and mutation databases
BioMutai | CHRNA4 |
DMDMi | 1351848 |
Proteomic databases
MassIVEi | P43681 |
PaxDbi | P43681 |
PeptideAtlasi | P43681 |
PRIDEi | P43681 |
ProteomicsDBi | 55649 [P43681-1] 62290 |
Protocols and materials databases
Antibodypediai | 29717, 277 antibodies |
Genome annotation databases
Ensembli | ENST00000370263; ENSP00000359285; ENSG00000101204 [P43681-1] ENST00000615287; ENSP00000483388; ENSG00000101204 [P43681-2] |
GeneIDi | 1137 |
KEGGi | hsa:1137 |
UCSCi | uc002yes.4, human [P43681-1] |
Organism-specific databases
CTDi | 1137 |
DisGeNETi | 1137 |
EuPathDBi | HostDB:ENSG00000101204.15 |
GeneCardsi | CHRNA4 |
GeneReviewsi | CHRNA4 |
HGNCi | HGNC:1958, CHRNA4 |
HPAi | ENSG00000101204, Group enriched (brain, liver, parathyroid gland) |
MalaCardsi | CHRNA4 |
MIMi | 118504, gene 600513, phenotype |
neXtProti | NX_P43681 |
OpenTargetsi | ENSG00000101204 |
Orphaneti | 98784, Autosomal dominant nocturnal frontal lobe epilepsy |
PharmGKBi | PA26490 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000159329 |
HOGENOMi | CLU_018074_1_1_1 |
InParanoidi | P43681 |
OMAi | QMYSPNK |
PhylomeDBi | P43681 |
TreeFami | TF315605 |
Enzyme and pathway databases
PathwayCommonsi | P43681 |
Reactomei | R-HSA-629587, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Miscellaneous databases
BioGRID-ORCSi | 1137, 3 hits in 845 CRISPR screens |
GeneWikii | CHRNA4 |
GenomeRNAii | 1137 |
Pharosi | P43681, Tclin |
PROi | PR:P43681 |
RNActi | P43681, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101204, Expressed in right lobe of liver and 100 other tissues |
ExpressionAtlasi | P43681, baseline and differential |
Genevisiblei | P43681, HS |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACHA4_HUMAN | |
Accessioni | P43681Primary (citable) accession number: P43681 Secondary accession number(s): Q4JGR7, Q4VAQ5, Q4VAQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations