CHRNA4

Functionⁱ

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.1 Publication

GO - Molecular functionⁱ

acetylcholine binding
Source: UniProtKB
Inferred by curatorⁱ
- 8906617
acetylcholine-gated cation-selective channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
acetylcholine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
ligand-gated ion channel activity
Source: DFLAT
Traceable author statementⁱ
- 20438829

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetylcholine receptor signaling pathway Source: Ensembl
action potential Source: UniProtKB
B cell activation Source: UniProtKB
behavioral response to nicotine
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17955458
calcium ion transport Source: UniProtKB
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cognition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14623738
DNA repair
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16332175
exploration behavior Source: Ensembl
inhibitory postsynaptic potential Source: UniProtKB
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transport
Source: UniProtKB
Non-traceable author statementⁱ
- 8906617
locomotory behavior Source: Ensembl
membrane depolarization Source: UniProtKB
nervous system process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17613539
- 7550350
neuromuscular synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of dopamine secretion Source: UniProtKB
regulation of membrane potential Source: UniProtKB
regulation of synaptic vesicle exocytosis Source: Ensembl
respiratory gaseous exchange Source: Ensembl
response to hypoxia
Source: UniProtKB
Inferred from direct assayⁱ
- 12189247
response to nicotine
Source: UniProtKB
Inferred from direct assayⁱ
- 12189247
response to oxidative stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16332175
sensory perception of pain Source: UniProtKB
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
synaptic transmission, cholinergic Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Protein family/group databases

TCDBⁱ	1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

TCDBⁱ

1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal acetylcholine receptor subunit alpha-4
Gene namesⁱ	Name:CHRNA4 Synonyms:NACRA4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101204.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1958 CHRNA4
MIMⁱ	118504 gene
neXtProtⁱ	NX_P43681

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 242	ExtracellularSequence analysisAdd BLAST	214
Transmembraneⁱ	243 – 267	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	275 – 293	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	309 – 330	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	331 – 600	CytoplasmicSequence analysisAdd BLAST	270
Transmembraneⁱ	601 – 619	HelicalSequence analysisAdd BLAST	19

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epilepsy, nocturnal frontal lobe, 1 (ENFL1)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.

Keywords - Diseaseⁱ

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1137
GeneReviewsⁱ	CHRNA4
MalaCards human disease database More...MalaCardsⁱ	CHRNA4
MIMⁱ	600513 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000101204
Orphanetⁱ	98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBⁱ	PA26490

Chemistry databases

ChEMBLⁱ	CHEMBL1882
Drug and drug target database More...DrugBankⁱ	DB05458 ABT-089 DB01351 Amobarbital DB01352 Aprobarbital DB01483 Barbital DB01496 Barbituric acid derivative DB00237 Butabarbital DB00241 Butalbital DB01353 Butethal DB09028 Cytisine DB00514 Dextromethorphan DB00898 Ethanol DB00674 Galantamine DB01354 Heptabarbital DB01355 Hexobarbital DB00463 Metharbital DB00849 Methylphenobarbital DB00184 Nicotine DB00312 Pentobarbital DB01174 Phenobarbital DB00794 Primidone DB05740 RPI-78M DB00418 Secobarbital DB00306 Talbutal DB00599 Thiopental DB01273 Varenicline
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	465

Polymorphism and mutation databases

BioMutaⁱ	CHRNA4
DMDMⁱ	1351848

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000000351	29 – 627	Neuronal acetylcholine receptor subunit alpha-4Add BLAST		599

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	57	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	107	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	161 ↔ 175	By similarity
Glycosylationⁱ	174	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	225 ↔ 226	Associated with receptor activationBy similarity
Lipidationⁱ	271	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	424	PhosphoserineBy similarity	1
Modified residueⁱ	538	PhosphoserineBy similarity	1
Modified residueⁱ	541	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	P43681
PeptideAtlas More...PeptideAtlasⁱ	P43681
PRIDEⁱ	P43681
ProteomicsDBⁱ	55649

PTM databases

iPTMnetⁱ	P43681
PhosphoSitePlusⁱ	P43681
SwissPalmⁱ	P43681

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101204 Expressed in 77 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_CHRNA4
ExpressionAtlasⁱ	P43681 baseline and differential
Genevisibleⁱ	P43681 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034064

HPAⁱ

CAB034064

Interactionⁱ

Subunit structureⁱ

Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers (PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-4-beta-2 interacts with alpha-conotoxins PnIA, GID and MII (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CHRNB2	P17787	4	EBI-20716158,EBI-9008612

With

Entry

#Exp.

IntAct

Notes

CHRNB2

P17787

4

EBI-20716158,EBI-9008612

Protein-protein interaction databases

BioGridⁱ	107559, 4 interactors
ComplexPortalⁱ	CPX-168 Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-218 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180 Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2203 Neuronal nicotinic acetylcholine receptor complex, alpha4-beta4
CORUMⁱ	P43681
IntActⁱ	P43681, 4 interactors
Molecular INTeraction database More...MINTⁱ	P43681
STRINGⁱ	9606.ENSP00000359285

Chemistry databases

BindingDBⁱ

P43681

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	33 – 44	Combined sources	12
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	56 – 59	Combined sources	4
Beta strandⁱ	62 – 77	Combined sources	16
Turnⁱ	78 – 81	Combined sources	4
Beta strandⁱ	82 – 94	Combined sources	13
Helixⁱ	102 – 104	Combined sources	3
Beta strandⁱ	111 – 114	Combined sources	4
Beta strandⁱ	123 – 126	Combined sources	4
Beta strandⁱ	128 – 131	Combined sources	4
Beta strandⁱ	140 – 143	Combined sources	4
Beta strandⁱ	145 – 151	Combined sources	7
Beta strandⁱ	154 – 159	Combined sources	6
Beta strandⁱ	166 – 170	Combined sources	5
Beta strandⁱ	172 – 183	Combined sources	12
Turnⁱ	186 – 188	Combined sources	3
Beta strandⁱ	189 – 194	Combined sources	6
Beta strandⁱ	207 – 221	Combined sources	15
Beta strandⁱ	230 – 241	Combined sources	12
Helixⁱ	244 – 247	Combined sources	4
Turnⁱ	248 – 250	Combined sources	3
Helixⁱ	251 – 257	Combined sources	7
Helixⁱ	258 – 260	Combined sources	3
Turnⁱ	261 – 263	Combined sources	3
Helixⁱ	264 – 266	Combined sources	3
Beta strandⁱ	269 – 271	Combined sources	3
Helixⁱ	274 – 292	Combined sources	19
Turnⁱ	293 – 295	Combined sources	3
Beta strandⁱ	300 – 302	Combined sources	3
Helixⁱ	305 – 331	Combined sources	27
Turnⁱ	335 – 337	Combined sources	3
Helixⁱ	342 – 348	Combined sources	7
Helixⁱ	351 – 355	Combined sources	5
Helixⁱ	586 – 617	Combined sources	32
Turnⁱ	622 – 624	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P43681
SMRⁱ	P43681
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	P43681
KEGG Orthology (KO) More...KOⁱ	K04806
OMAⁱ	YECCTEI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P43681
TreeFamⁱ	TF315605

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P43681-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK 
        60         70         80         90        100
WSRPVANISD VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW 
       110        120        130        140        150
DPADYENVTS IRIPSELIWR PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ 
       160        170        180        190        200
WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG SWTYDKAKID LVNMHSRVDQ 
       210        220        230        240        250
LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR RLPLFYTINL 
       260        270        280        290        300
IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS 
       310        320        330        340        350
LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD 
       360        370        380        390        400
IVPRLLLMKR PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS 
       410        420        430        440        450
LHPPSPSFCV PLDVPAEPGP SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR 
       460        470        480        490        500
PPHGTQAPGL AKARSLSVQH MSSPGEAVEG GVRCRSRSIQ YCVPRDDAAP 
       510        520        530        540        550
EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV SPSATVKTRS 
       560        570        580        590        600
TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR 
       610        620 
IFLWMFIIVC LLGTVGLFLP PWLAGMI

Length:627

Mass (Da):69,957

Last modified:February 1, 1996 - v2

Checksum:ⁱB3A0C0151E5A2AA8

GO

Isoform 2 (identifier: P43681-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-57: MELGGPGAPR...YNKWSRPVAN → MRMSPPSASP...VWTAGCPGEG
58-128: Missing.

« Hide

        10         20         30         40         50
MRMSPPSASP PSSSGGRTSS STTTAGEPFW AGVLFAIRPH PGLSGRIVWT 
        60         70         80         90        100
AGCPGEGADG DFAVTHLTKA HLFHDGRVQW TPPAIYKSSC SIDVTFFPFD 
       110        120        130        140        150
QQNCTMKFGS WTYDKAKIDL VNMHSRVDQL DFWESGEWVI VDAVGTYNTR 
       160        170        180        190        200
KYECCAEIYP DITYAFVIRR LPLFYTINLI IPCLLISCLT VLVFYLPSEC 
       210        220        230        240        250
GEKITLCISV LLSLTVFLLL ITEIIPSTSL VIPLIGEYLL FTMIFVTLSI 
       260        270        280        290        300
VITVFVLNVH HRSPRTHTMP TWVRRVFLDI VPRLLLMKRP SVVKDNCRRL 
       310        320        330        340        350
IESMHKMASA PRFWPEPEGE PPATSGTQSL HPPSPSFCVP LDVPAEPGPS 
       360        370        380        390        400
CKSPSDQLPP QQPLEAEKAS PHPSPGPCRP PHGTQAPGLA KARSLSVQHM 
       410        420        430        440        450
SSPGEAVEGG VRCRSRSIQY CVPRDDAAPE ADGQAAGALA SRNTHSAELP 
       460        470        480        490        500
PPDQPSPCKC TCKKEPSSVS PSATVKTRST KAPPPHLPLS PALTRAVEGV 
       510        520        530        540        550
QYIADHLKAE DTDFSVKEDW KYVAMVIDRI FLWMFIIVCL LGTVGLFLPP 

WLAGMI

Note: No experimental confirmation available.

Show »

Length:556

Mass (Da):60,994

Checksum:ⁱCE5902DBC1231CA3

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0D9SFU6	A0A0D9SFU6_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	111	Annotation score:
H0YBH1	H0YBH1_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	137	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	4	G → E in AAH96290 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_000295	280	S → F in ENFL1. 1 PublicationCorresponds to variant dbSNP:rs121909580EnsemblClinVar.	1
Natural variantⁱVAR_017531	280	S → L in ENFL1. 2 Publications	1
Natural variantⁱVAR_023402	387	E → G1 PublicationCorresponds to variant dbSNP:rs45604738EnsemblClinVar.	1
Natural variantⁱVAR_023403	517	S → L1 PublicationCorresponds to variant dbSNP:rs45622132EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054275	1 – 57	MELGG…RPVAN → MRMSPPSASPPSSSGGRTSS STTTAGEPFWAGVLFAIRPH PGLSGRIVWTAGCPGEG in isoform 2. 1 PublicationAdd BLAST		57
Alternative sequenceⁱVSP_054276	58 – 128	Missing in isoform 2. 1 PublicationAdd BLAST		71

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L35901 mRNA Translation: AAA64743.1 X89741 X89746 Genomic DNA Translation: CAA61893.1 U62433 mRNA Translation: AAB40111.1 Y08421 mRNA Translation: CAA69698.1 DQ093071 Genomic DNA Translation: AAY88737.1 AL121827 Genomic DNA No translation available. BC096290 mRNA Translation: AAH96290.1 BC096291 mRNA Translation: AAH96291.1 X87629 mRNA Translation: CAA60959.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13517.1 [P43681-1]
PIRⁱ	JC4021
NCBI Reference Sequences More...RefSeqⁱ	NP_000735.1, NM_000744.6 [P43681-1] NP_001243502.1, NM_001256573.1 XP_011526826.1, XM_011528524.1 [P43681-2]
UniGeneⁱ	Hs.10734

Genome annotation databases

Ensemblⁱ	ENST00000370263; ENSP00000359285; ENSG00000101204 [P43681-1] ENST00000615287; ENSP00000483388; ENSG00000101204 [P43681-2]
GeneIDⁱ	1137
KEGGⁱ	hsa:1137
UCSC genome browser More...UCSCⁱ	uc002yes.4 human [P43681-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43681	CHRNA4 protein		HUMAN		451	UniRef100_P43681
Neuronal acetylcholine receptor alpha 4 subunit (Fragment)		HUMAN		63
Neuronal acetylcholine receptor alpha 4 subunit (Fragment)		HUMAN		43

Protein	Similar proteins		Species	Score	Length	Source
P43681	Neuronal acetylcholine receptor subunit alpha-4		PANTR		627	UniRef90_P43681
CHRNA4 protein		HUMAN		451
Cholinergic receptor nicotinic alpha 4 subunit		GORGO		629
CHRNA4 isoform 5		PONAB		627
Uncharacterized protein		CERAT		626
+41
P43681-2	Cholinergic receptor nicotinic alpha 4 subunit		GORGO		556	UniRef90_P43681-2
Uncharacterized protein		Cebus capucinus imitator		554
CHRNA4 isoform 4		PONAB		554
Uncharacterized protein		AOTNA		554
Cholinergic receptor nicotinic alpha 4 subunit		SAIBB		552
+3

Protein	Similar proteins		Species	Score	Length	Source
P43681	Neuronal acetylcholine receptor subunit alpha-4		MOUSE		629	UniRef50_O70174
Neuronal acetylcholine receptor subunit alpha-4	)	RAT		630
Neuronal acetylcholine receptor subunit alpha-4		MUSPF		627
Neuronal acetylcholine receptor subunit alpha-4		PANTR		627
Neuronal acetylcholine receptor subunit alpha-4		CHICK		622
+462
P43681-2	Cholinergic receptor nicotinic alpha 4 subunit		GORGO		556	UniRef50_P43681-2
CHRNA4 isoform 4		PONAB		554
Uncharacterized protein		Cebus capucinus imitator		554
Uncharacterized protein		AOTNA		554
Cholinergic receptor nicotinic alpha 4 subunit		SAIBB		552
+16

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L35901 mRNA Translation: AAA64743.1 X89741 X89746 Genomic DNA Translation: CAA61893.1 U62433 mRNA Translation: AAB40111.1 Y08421 mRNA Translation: CAA69698.1 DQ093071 Genomic DNA Translation: AAY88737.1 AL121827 Genomic DNA No translation available. BC096290 mRNA Translation: AAH96290.1 BC096291 mRNA Translation: AAH96291.1 X87629 mRNA Translation: CAA60959.1
CCDSⁱ	CCDS13517.1 [P43681-1]
PIRⁱ	JC4021
RefSeqⁱ	NP_000735.1, NM_000744.6 [P43681-1] NP_001243502.1, NM_001256573.1 XP_011526826.1, XM_011528524.1 [P43681-2]
UniGeneⁱ	Hs.10734

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2GVT	model	-	A/C	38-241	[»]
	2LLY	NMR	-	A	240-339	[»]
				A	598-626	[»]
	5KXI	X-ray	3.94	A/D	27-364	[»]
				A/D	586-627	[»]
	6CNJ	electron microscopy	3.40	A/D	27-364	[»]
	6CNK	electron microscopy	3.70	A/B/D	27-364	[»]
ProteinModelPortalⁱ	P43681
SMRⁱ	P43681
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107559, 4 interactors
ComplexPortalⁱ	CPX-168 Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-218 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180 Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2203 Neuronal nicotinic acetylcholine receptor complex, alpha4-beta4
CORUMⁱ	P43681
IntActⁱ	P43681, 4 interactors
MINTⁱ	P43681
STRINGⁱ	9606.ENSP00000359285

Chemistry databases

BindingDBⁱ	P43681
ChEMBLⁱ	CHEMBL1882
DrugBankⁱ	DB05458 ABT-089 DB01351 Amobarbital DB01352 Aprobarbital DB01483 Barbital DB01496 Barbituric acid derivative DB00237 Butabarbital DB00241 Butalbital DB01353 Butethal DB09028 Cytisine DB00514 Dextromethorphan DB00898 Ethanol DB00674 Galantamine DB01354 Heptabarbital DB01355 Hexobarbital DB00463 Metharbital DB00849 Methylphenobarbital DB00184 Nicotine DB00312 Pentobarbital DB01174 Phenobarbital DB00794 Primidone DB05740 RPI-78M DB00418 Secobarbital DB00306 Talbutal DB00599 Thiopental DB01273 Varenicline
GuidetoPHARMACOLOGYⁱ	465

Protein family/group databases

TCDBⁱ	1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

TCDBⁱ

1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetⁱ	P43681
PhosphoSitePlusⁱ	P43681
SwissPalmⁱ	P43681

Polymorphism and mutation databases

BioMutaⁱ	CHRNA4
DMDMⁱ	1351848

Proteomic databases

PaxDbⁱ	P43681
PeptideAtlasⁱ	P43681
PRIDEⁱ	P43681
ProteomicsDBⁱ	55649

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370263; ENSP00000359285; ENSG00000101204 [P43681-1] ENST00000615287; ENSP00000483388; ENSG00000101204 [P43681-2]
GeneIDⁱ	1137
KEGGⁱ	hsa:1137
UCSCⁱ	uc002yes.4 human [P43681-1]

Organism-specific databases

CTDⁱ	1137
DisGeNETⁱ	1137
EuPathDBⁱ	HostDB:ENSG00000101204.15
GeneCardsⁱ	CHRNA4
GeneReviewsⁱ	CHRNA4
HGNCⁱ	HGNC:1958 CHRNA4
HPAⁱ	CAB034064
MalaCardsⁱ	CHRNA4
MIMⁱ	118504 gene 600513 phenotype
neXtProtⁱ	NX_P43681
OpenTargetsⁱ	ENSG00000101204
Orphanetⁱ	98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBⁱ	PA26490
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	P43681
KOⁱ	K04806
OMAⁱ	YECCTEI
OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P43681
TreeFamⁱ	TF315605

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

ChiTaRSⁱ	CHRNA4 human
GeneWikiⁱ	CHRNA4
GenomeRNAiⁱ	1137
Protein Ontology More...PROⁱ	PR:P43681
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101204 Expressed in 77 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_CHRNA4
ExpressionAtlasⁱ	P43681 baseline and differential
Genevisibleⁱ	P43681 HS

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACHA4_HUMAN
Accessionⁱ	P43681Primary (citable) accession number: P43681 Secondary accession number(s): Q4JGR7, Q4VAQ5, Q4VAQ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P43681 (ACHA4_HUMAN)

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Neuronal acetylcholine receptor subunit alpha-4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ