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Protein

Transcription factor SOX-18

Gene

Sox18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi79 – 147HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-18
Gene namesi
Name:Sox18
Synonyms:Sox-18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:103559 Sox18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487681 – 377Transcription factor SOX-18Add BLAST377

Proteomic databases

MaxQBiP43680
PaxDbiP43680
PRIDEiP43680

PTM databases

iPTMnetiP43680
PhosphoSitePlusiP43680

Expressioni

Tissue specificityi

Expressed only in lung, heart and skeletal muscles.

Gene expression databases

BgeeiENSMUSG00000046470 Expressed in 233 organ(s), highest expression level in brain blood vessel
CleanExiMM_SOX18
GenevisibleiP43680 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203404, 1 interactor
STRINGi10090.ENSMUSP00000062759

Chemistry databases

BindingDBiP43680

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43680
SMRiP43680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini256 – 376Sox C-terminalPROSITE-ProRule annotationAdd BLAST121

Phylogenomic databases

eggNOGiENOG410IPYV Eukaryota
ENOG410Y4NM LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000069999
HOVERGENiHBG000517
InParanoidiP43680
KOiK09270
OMAiYLNCSRT
OrthoDBiEOG091G0CYU
PhylomeDBiP43680

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033392 Sox7/17/18_central
IPR021934 Sox_C
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12067 Sox17_18_mid, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS51516 SOX_C, 1 hit

Sequencei

Sequence statusi: Complete.

P43680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRSPPGYGA QDDPPSRRDC AWAPGIGAAA EARGLPVTNV SPTSPASPSS
60 70 80 90 100
LPRSPPRSPE SGRYGFGRGE RQTADELRIR RPMNAFMVWA KDERKRLAQQ
110 120 130 140 150
NPDLHNAVLS KMLGKAWKEL NTAEKRPFVE EAERLRVQHL RDHPNYKYRP
160 170 180 190 200
RRKKQARKVR RLEPGLLLPG LVQPSAPPEA FAAASGSARS FRELPTLGAE
210 220 230 240 250
FDGLGLPTPE RSPLDGLEPG EASFFPPPLA PEDCALRAFR APYAPELARD
260 270 280 290 300
PSFCYGAPLA EALRTAPPAA PLAGLYYGTL GTPGPFPNPL SPPPESPSLE
310 320 330 340 350
GTEQLEPTAD LWADVDLTEF DQYLNCSRTR PDATTLPYHV ALAKLGPRAM
360 370
SCPEESSLIS ALSDASSAVY YSACISG
Length:377
Mass (Da):40,898
Last modified:October 10, 2002 - v3
Checksum:i29F4C9B9D50F94D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156A → E in AAB18615 (PubMed:7665083).Curated1
Sequence conflicti260A → G in AAB18615 (PubMed:7665083).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35032 mRNA Translation: AAB18615.1
AF288518 Genomic DNA Translation: AAG48578.1
BC006612 mRNA Translation: AAH06612.1
L29086 mRNA Translation: AAA56844.1
CCDSiCCDS17218.1
RefSeqiNP_033262.2, NM_009236.2
UniGeneiMm.264904

Genome annotation databases

EnsembliENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470
GeneIDi20672
KEGGimmu:20672
UCSCiuc008ona.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35032 mRNA Translation: AAB18615.1
AF288518 Genomic DNA Translation: AAG48578.1
BC006612 mRNA Translation: AAH06612.1
L29086 mRNA Translation: AAA56844.1
CCDSiCCDS17218.1
RefSeqiNP_033262.2, NM_009236.2
UniGeneiMm.264904

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y60X-ray1.75C77-155[»]
ProteinModelPortaliP43680
SMRiP43680
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203404, 1 interactor
STRINGi10090.ENSMUSP00000062759

Chemistry databases

BindingDBiP43680

PTM databases

iPTMnetiP43680
PhosphoSitePlusiP43680

Proteomic databases

MaxQBiP43680
PaxDbiP43680
PRIDEiP43680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470
GeneIDi20672
KEGGimmu:20672
UCSCiuc008ona.1 mouse

Organism-specific databases

CTDi54345
MGIiMGI:103559 Sox18

Phylogenomic databases

eggNOGiENOG410IPYV Eukaryota
ENOG410Y4NM LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000069999
HOVERGENiHBG000517
InParanoidiP43680
KOiK09270
OMAiYLNCSRT
OrthoDBiEOG091G0CYU
PhylomeDBiP43680

Miscellaneous databases

PROiPR:P43680
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046470 Expressed in 233 organ(s), highest expression level in brain blood vessel
CleanExiMM_SOX18
GenevisibleiP43680 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033392 Sox7/17/18_central
IPR021934 Sox_C
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12067 Sox17_18_mid, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS51516 SOX_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX18_MOUSE
AccessioniPrimary (citable) accession number: P43680
Secondary accession number(s): Q9EQ73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2002
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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