Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysophosphatidic acid receptor 6

Gene

LPAR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.1 Publication

Miscellaneous

This is a nested gene within intron 17 of the retinoblastoma gene.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
SIGNORiP43657

Chemistry databases

SwissLipidsiSLP:000001579

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
RB intron encoded G-protein coupled receptor
Gene namesi
Name:LPAR6
Synonyms:P2RY5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139679.15
HGNCiHGNC:15520 LPAR6
MIMi609239 gene
neXtProtiNX_P43657

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 46Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini47 – 55CytoplasmicSequence analysis9
Transmembranei56 – 79Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini80 – 92ExtracellularSequence analysisAdd BLAST13
Transmembranei93 – 112Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini113 – 133CytoplasmicSequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 181ExtracellularSequence analysisAdd BLAST27
Transmembranei182 – 209Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini210 – 227CytoplasmicSequence analysisAdd BLAST18
Transmembranei228 – 253Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini254 – 272ExtracellularSequence analysisAdd BLAST19
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 344CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.
See also OMIM:278150
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04432663D → V in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs879255262EnsemblClinVar.1
Natural variantiVAR_044327188I → F in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434307EnsemblClinVar.1
Natural variantiVAR_044328189E → K in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434309EnsemblClinVar.1
Hypotrichosis 8 (HYPT8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed.
See also OMIM:278150

Keywords - Diseasei

Disease mutation, Hypotrichosis

Organism-specific databases

DisGeNETi10161
MalaCardsiLPAR6
MIMi278150 phenotype
OpenTargetsiENSG00000139679
Orphaneti55654 Hypotrichosis simplex
170 Woolly hair
PharmGKBiPA165505129

Chemistry databases

ChEMBLiCHEMBL2331058
GuidetoPHARMACOLOGYi163

Polymorphism and mutation databases

BioMutaiLPAR6
DMDMi34223726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700251 – 344Lysophosphatidic acid receptor 6Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Lipidationi284S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP43657
PeptideAtlasiP43657
PRIDEiP43657
ProteomicsDBi55648

PTM databases

iPTMnetiP43657
PhosphoSitePlusiP43657

Expressioni

Tissue specificityi

Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.3 Publications

Developmental stagei

Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.1 Publication

Gene expression databases

BgeeiENSG00000139679 Expressed in 208 organ(s), highest expression level in squamous epithelium
ExpressionAtlasiP43657 baseline and differential
GenevisibleiP43657 HS

Organism-specific databases

HPAiHPA028934
HPA076273

Interactioni

Protein-protein interaction databases

BioGridi115463, 60 interactors
IntActiP43657, 5 interactors
STRINGi9606.ENSP00000344353

Chemistry databases

BindingDBiP43657

Structurei

3D structure databases

ProteinModelPortaliP43657
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOVERGENiHBG101917
InParanoidiP43657
KOiK04273
OMAiFRIFYFA
OrthoDBiEOG091G0D67
PhylomeDBiP43657
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP
160 170 180 190 200
AVFVQSTHSQ GNNASEACFE NFPEATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF CFVPYNINLI
260 270 280 290 300
LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA
Length:344
Mass (Da):39,392
Last modified:August 22, 2003 - v3
Checksum:i699212F3C1249433
GO

Sequence cautioni

The sequence L11910 differs from that shown. Reason: Frameshift at position 31.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242F → I in BAD97109 (Ref. 6) Curated1
Sequence conflicti303K → I in CAD97680 (PubMed:17974005).Curated1
Sequence conflicti344A → G in CAD97687 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02263633I → V. Corresponds to variant dbSNP:rs1060585Ensembl.1
Natural variantiVAR_04432663D → V in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs879255262EnsemblClinVar.1
Natural variantiVAR_016253137C → W1 PublicationCorresponds to variant dbSNP:rs4151553Ensembl.1
Natural variantiVAR_044327188I → F in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434307EnsemblClinVar.1
Natural variantiVAR_044328189E → K in ARWH1. 1 PublicationCorresponds to variant dbSNP:rs121434309EnsemblClinVar.1
Natural variantiVAR_049430307W → C. Corresponds to variant dbSNP:rs17071686Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA No translation available.
L78805 Genomic DNA Translation: AAL40065.1
AF000546 mRNA Translation: AAB62190.1
BX537392 mRNA Translation: CAD97634.1
BX537438 mRNA Translation: CAD97680.1
BX537445 mRNA Translation: CAD97687.1
AK122856 mRNA Translation: BAG53764.1
AK223389 mRNA Translation: BAD97109.1
HQ995530 mRNA Translation: ADZ31975.1
JF810890 mRNA Translation: AEP43757.1
AF551763 Genomic DNA Translation: AAN64134.1
AL392048 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08796.1
BC040850 mRNA Translation: AAH40850.1
BC045651 mRNA Translation: AAH45651.1
BC070295 mRNA Translation: AAH70295.1
BC106756 mRNA Translation: AAI06757.1
CCDSiCCDS9410.1
PIRiT09508
RefSeqiNP_001155969.1, NM_001162497.1
NP_001155970.1, NM_001162498.1
NP_005758.2, NM_005767.5
UniGeneiHs.123464

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679
ENST00000378434; ENSP00000367691; ENSG00000139679
ENST00000620633; ENSP00000482660; ENSG00000139679
GeneIDi10161
KEGGihsa:10161
UCSCiuc001vce.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA No translation available.
L78805 Genomic DNA Translation: AAL40065.1
AF000546 mRNA Translation: AAB62190.1
BX537392 mRNA Translation: CAD97634.1
BX537438 mRNA Translation: CAD97680.1
BX537445 mRNA Translation: CAD97687.1
AK122856 mRNA Translation: BAG53764.1
AK223389 mRNA Translation: BAD97109.1
HQ995530 mRNA Translation: ADZ31975.1
JF810890 mRNA Translation: AEP43757.1
AF551763 Genomic DNA Translation: AAN64134.1
AL392048 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08796.1
BC040850 mRNA Translation: AAH40850.1
BC045651 mRNA Translation: AAH45651.1
BC070295 mRNA Translation: AAH70295.1
BC106756 mRNA Translation: AAI06757.1
CCDSiCCDS9410.1
PIRiT09508
RefSeqiNP_001155969.1, NM_001162497.1
NP_001155970.1, NM_001162498.1
NP_005758.2, NM_005767.5
UniGeneiHs.123464

3D structure databases

ProteinModelPortaliP43657
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115463, 60 interactors
IntActiP43657, 5 interactors
STRINGi9606.ENSP00000344353

Chemistry databases

BindingDBiP43657
ChEMBLiCHEMBL2331058
GuidetoPHARMACOLOGYi163
SwissLipidsiSLP:000001579

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP43657
PhosphoSitePlusiP43657

Polymorphism and mutation databases

BioMutaiLPAR6
DMDMi34223726

Proteomic databases

PaxDbiP43657
PeptideAtlasiP43657
PRIDEiP43657
ProteomicsDBi55648

Protocols and materials databases

DNASUi10161
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679
ENST00000378434; ENSP00000367691; ENSG00000139679
ENST00000620633; ENSP00000482660; ENSG00000139679
GeneIDi10161
KEGGihsa:10161
UCSCiuc001vce.4 human

Organism-specific databases

CTDi10161
DisGeNETi10161
EuPathDBiHostDB:ENSG00000139679.15
GeneCardsiLPAR6
HGNCiHGNC:15520 LPAR6
HPAiHPA028934
HPA076273
MalaCardsiLPAR6
MIMi278150 phenotype
609239 gene
neXtProtiNX_P43657
OpenTargetsiENSG00000139679
Orphaneti55654 Hypotrichosis simplex
170 Woolly hair
PharmGKBiPA165505129
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOVERGENiHBG101917
InParanoidiP43657
KOiK04273
OMAiFRIFYFA
OrthoDBiEOG091G0D67
PhylomeDBiP43657
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
SIGNORiP43657

Miscellaneous databases

GenomeRNAii10161
PROiPR:P43657
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139679 Expressed in 208 organ(s), highest expression level in squamous epithelium
ExpressionAtlasiP43657 baseline and differential
GenevisibleiP43657 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR6_HUMAN
AccessioniPrimary (citable) accession number: P43657
Secondary accession number(s): A4FTW9
, B3KVF2, F2YGU4, O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 22, 2003
Last modified: November 7, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again