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UniProtKB - P43639 (CSK2B_YEAST)
Protein
Casein kinase II subunit beta
Gene
CKB1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Regulatory subunit of casein kinase II/CK2 (By similarity).
As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
By similarityMiscellaneous
Present with 8120 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- protein kinase regulator activity Source: SGD
- protein serine/threonine kinase inhibitor activity Source: SGD
GO - Biological processi
- cellular response to DNA damage stimulus Source: SGD
- nucleolar large rRNA transcription by RNA polymerase I Source: ComplexPortal
- peptidyl-serine phosphorylation Source: SGD
- peptidyl-threonine phosphorylation Source: SGD
- protein phosphorylation Source: SGD
- regulation of cell cycle Source: ComplexPortal
- regulation of protein serine/threonine phosphatase activity Source: GO_Central
- regulation of ribosomal protein gene transcription by RNA polymerase II Source: ComplexPortal
- regulation of transcription by RNA polymerase I Source: SGD
- regulation of transcription by RNA polymerase III Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaShort name: CK II beta |
Gene namesi | Name:CKB1 Ordered Locus Names:YGL019W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002987, CKB1 |
VEuPathDBi | FungiDB:YGL019W |
Subcellular locationi
Nucleus
- CURI complex Source: ComplexPortal
- nucleolus Source: ComplexPortal
- nucleoplasm Source: Reactome
- UTP-C complex Source: SGD
Other locations
- cytoplasm Source: GO_Central
- protein kinase CK2 complex Source: SGD
- small-subunit processome Source: ComplexPortal
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000068257 | 2 – 278 | Casein kinase II subunit betaAdd BLAST | 277 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by alpha subunit.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P43639 |
PaxDbi | P43639 |
PRIDEi | P43639 |
PTM databases
iPTMneti | P43639 |
Interactioni
Subunit structurei
Binary interactionsi
P43639
With | #Exp. | IntAct |
---|---|---|
CKA1 [P15790] | 11 | EBI-9563,EBI-9533 |
CKA2 [P19454] | 11 | EBI-9563,EBI-9548 |
CKB2 [P38930] | 6 | EBI-9563,EBI-9578 |
UTP22 [P53254] | 3 | EBI-9563,EBI-1878 |
Protein-protein interaction databases
BioGRIDi | 33227, 553 interactors |
ComplexPortali | CPX-581, Protein kinase CK2 variant 1 CPX-769, Protein kinase CK2 variant 2 CPX-770, Protein kinase CK2 variant 3 CPX-771, UTP-C complex variant 2 CPX-772, UTP-C complex variant 1 CPX-773, UTP-C complex variant 3 CPX-774, CURI complex variant 1 CPX-775, CURI complex variant 2 CPX-776, CURI complex variant 3 |
DIPi | DIP-282N |
IntActi | P43639, 79 interactors |
MINTi | P43639 |
STRINGi | 4932.YGL019W |
Miscellaneous databases
RNActi | P43639, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 78 – 111 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 78 – 97 | Acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the casein kinase 2 subunit beta family.Curated
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
GeneTreei | ENSGT00390000003781 |
HOGENOMi | CLU_034027_3_0_1 |
InParanoidi | P43639 |
OMAi | QNGSPMA |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 2 hits |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P43639-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQEFVEDYS RTGSSDDEDS GAYDEWIPSF CSRFGHEYFC QVPTEFIEDD
60 70 80 90 100
FNMTSLSQEV PHYRKALDLI LDLEAMSDEE EDEDDVVEED EVDQEMQSND
110 120 130 140 150
GHDEGKRRNK SPVVNKSIIE HAAEQLYGLI HARFILTKPG LQAMAEKFDH
160 170 180 190 200
KEFGTCPRYY CNGMQLLPCG LSDTVGKHTV RLYCPSCQDL YLPQSSRFLC
210 220 230 240 250
LEGAFWGTSF PGVFLKHFKE LEEYVERKSK ESYELKVFGF RINDEAVSGP
260 270
RMKWLRQYPS TEEDWEEFAK CEFETPAV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21283 Genomic DNA Translation: AAA86829.1 Z72541 Genomic DNA Translation: CAA96719.1 BK006941 Genomic DNA Translation: DAA08079.1 |
PIRi | A56421 |
RefSeqi | NP_011496.3, NM_001180884.3 |
Genome annotation databases
EnsemblFungii | YGL019W_mRNA; YGL019W; YGL019W |
GeneIDi | 852865 |
KEGGi | sce:YGL019W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21283 Genomic DNA Translation: AAA86829.1 Z72541 Genomic DNA Translation: CAA96719.1 BK006941 Genomic DNA Translation: DAA08079.1 |
PIRi | A56421 |
RefSeqi | NP_011496.3, NM_001180884.3 |
3D structure databases
SMRi | P43639 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33227, 553 interactors |
ComplexPortali | CPX-581, Protein kinase CK2 variant 1 CPX-769, Protein kinase CK2 variant 2 CPX-770, Protein kinase CK2 variant 3 CPX-771, UTP-C complex variant 2 CPX-772, UTP-C complex variant 1 CPX-773, UTP-C complex variant 3 CPX-774, CURI complex variant 1 CPX-775, CURI complex variant 2 CPX-776, CURI complex variant 3 |
DIPi | DIP-282N |
IntActi | P43639, 79 interactors |
MINTi | P43639 |
STRINGi | 4932.YGL019W |
PTM databases
iPTMneti | P43639 |
Proteomic databases
MaxQBi | P43639 |
PaxDbi | P43639 |
PRIDEi | P43639 |
Genome annotation databases
EnsemblFungii | YGL019W_mRNA; YGL019W; YGL019W |
GeneIDi | 852865 |
KEGGi | sce:YGL019W |
Organism-specific databases
SGDi | S000002987, CKB1 |
VEuPathDBi | FungiDB:YGL019W |
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
GeneTreei | ENSGT00390000003781 |
HOGENOMi | CLU_034027_3_0_1 |
InParanoidi | P43639 |
OMAi | QNGSPMA |
Miscellaneous databases
PROi | PR:P43639 |
RNActi | P43639, protein |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 2 hits |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSK2B_YEAST | |
Accessioni | P43639Primary (citable) accession number: P43639 Secondary accession number(s): D6VUB8, Q9URG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families