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Entry version 159 (07 Oct 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Killer cell immunoglobulin-like receptor 2DS4

Gene

KIR2DS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P43632

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2172127, DAP12 interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS4
Alternative name(s):
CD158 antigen-like family member I
MHC class I NK cell receptor
Natural killer-associated transcript 8
Short name:
NKAT-8
P58 natural killer cell receptor clones CL-39/CL-17
Short name:
p58 NK receptor CL-39/CL-17
CD_antigen: CD158i
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIR2DS41 PublicationImported
Synonyms:CD158I, KKA3, NKAT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6336, KIR2DS4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604955, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43632

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 304CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3809

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30121

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P43632, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIR2DS4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2828511

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001508522 – 304Killer cell immunoglobulin-like receptor 2DS4Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 1001 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 1981 Publication
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43632

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43632

PeptideAtlas

More...
PeptideAtlasi
P43632

PRoteomics IDEntifications database

More...
PRIDEi
P43632

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55646

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P43632, 5 sites

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HLA-F; this interaction is direct.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P43632, 8 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P43632, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43632

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P43632

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43632

KEGG Orthology (KO)

More...
KOi
K07982

Database of Orthologous Groups

More...
OrthoDBi
1000446at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43632

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047, ig, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726, SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P43632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC
110 120 130 140 150
YGSVPHSPYQ LSAPSDPLDM VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAVRSINGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT
260 270 280 290 300
SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,583
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEFDAFF3FD679A3F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JNE3A0A0G2JNE3_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS4
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A376A919A0A376A919_HUMAN
KIR2DS4 protein
KIR2DS4
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNN1A0A0G2JNN1_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS4
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ83A0A1W2PQ83_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS4
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4ZN30A0A0C4ZN30_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS4
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHK4A0A5F9ZHK4_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS4
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMV9A0A0G2JMV9_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS4
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50336 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04998065K → M. Corresponds to variant dbSNP:rs1130480Ensembl.1
Natural variantiVAR_04998168N → D. Corresponds to variant dbSNP:rs1130481Ensembl.1
Natural variantiVAR_04998271H → R. Corresponds to variant dbSNP:rs1130482Ensembl.1
Natural variantiVAR_04998389P → R. Corresponds to variant dbSNP:rs1130487Ensembl.1
Natural variantiVAR_04998492P → H. Corresponds to variant dbSNP:rs1143508Ensembl.1
Natural variantiVAR_04998593V → D. Corresponds to variant dbSNP:rs1130491Ensembl.1
Natural variantiVAR_049986103S → C. Corresponds to variant dbSNP:rs10406301Ensembl.1
Natural variantiVAR_059423178N → H. Corresponds to variant dbSNP:rs4806591Ensembl.1
Natural variantiVAR_059424205A → S. Corresponds to variant dbSNP:rs1049290Ensembl.1
Natural variantiVAR_059425254K → N. Corresponds to variant dbSNP:rs1063326Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U24077 mRNA Translation: AAC50336.1 Different initiation.
L76671 mRNA Translation: AAB36599.1
X94609 mRNA Translation: CAA64317.1
AY366245 mRNA Translation: AAR16203.1
AF002255 mRNA Translation: AAB61281.1
BC101977 mRNA Translation: AAI01978.1
BC103693 mRNA Translation: AAI03694.1

NCBI Reference Sequences

More...
RefSeqi
NP_001268900.1, NM_001281971.1
NP_001268901.1, NM_001281972.1
NP_036446.3, NM_012314.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611311; ENSP00000484123; ENSG00000276885
ENST00000612783; ENSP00000481753; ENSG00000274957
ENST00000613654; ENSP00000483112; ENSG00000276634
ENST00000614639; ENSP00000481319; ENSG00000275731
ENST00000617469; ENSP00000477744; ENSG00000276395
ENST00000617825; ENSP00000483274; ENSG00000275353
ENST00000619771; ENSP00000478241; ENSG00000274947
ENST00000620669; ENSP00000480062; ENSG00000274406
ENST00000621436; ENSP00000479843; ENSG00000276154
ENST00000638566; ENSP00000492248; ENSG00000284264
ENST00000640817; ENSP00000491676; ENSG00000283870
ENST00000640941; ENSP00000492546; ENSG00000283882
ENST00000642862; ENSP00000494622; ENSG00000283882
ENST00000644051; ENSP00000494670; ENSG00000283870
ENST00000644154; ENSP00000495680; ENSG00000284264

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3809

UCSC genome browser

More...
UCSCi
uc061emp.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24077 mRNA Translation: AAC50336.1 Different initiation.
L76671 mRNA Translation: AAB36599.1
X94609 mRNA Translation: CAA64317.1
AY366245 mRNA Translation: AAR16203.1
AF002255 mRNA Translation: AAB61281.1
BC101977 mRNA Translation: AAI01978.1
BC103693 mRNA Translation: AAI03694.1
RefSeqiNP_001268900.1, NM_001281971.1
NP_001268901.1, NM_001281972.1
NP_036446.3, NM_012314.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8NX-ray2.50A27-221[»]
SMRiP43632
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP43632, 8 interactors

PTM databases

GlyGeniP43632, 5 sites

Polymorphism and mutation databases

BioMutaiKIR2DS4
DMDMi2828511

Proteomic databases

jPOSTiP43632
MassIVEiP43632
PeptideAtlasiP43632
PRIDEiP43632
ProteomicsDBi55646

Genome annotation databases

EnsembliENST00000611311; ENSP00000484123; ENSG00000276885
ENST00000612783; ENSP00000481753; ENSG00000274957
ENST00000613654; ENSP00000483112; ENSG00000276634
ENST00000614639; ENSP00000481319; ENSG00000275731
ENST00000617469; ENSP00000477744; ENSG00000276395
ENST00000617825; ENSP00000483274; ENSG00000275353
ENST00000619771; ENSP00000478241; ENSG00000274947
ENST00000620669; ENSP00000480062; ENSG00000274406
ENST00000621436; ENSP00000479843; ENSG00000276154
ENST00000638566; ENSP00000492248; ENSG00000284264
ENST00000640817; ENSP00000491676; ENSG00000283870
ENST00000640941; ENSP00000492546; ENSG00000283882
ENST00000642862; ENSP00000494622; ENSG00000283882
ENST00000644051; ENSP00000494670; ENSG00000283870
ENST00000644154; ENSP00000495680; ENSG00000284264
GeneIDi3809
KEGGihsa:3809
UCSCiuc061emp.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3809
DisGeNETi3809

GeneCards: human genes, protein and diseases

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GeneCardsi
KIR2DS4
HGNCiHGNC:6336, KIR2DS4
MIMi604955, gene
neXtProtiNX_P43632
PharmGKBiPA30121

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

InParanoidiP43632
KOiK07982
OrthoDBi1000446at2759
PhylomeDBiP43632

Enzyme and pathway databases

PathwayCommonsiP43632
ReactomeiR-HSA-2172127, DAP12 interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3809, 1 hit in 66 CRISPR screens
EvolutionaryTraceiP43632

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIR2DS4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3809
PharosiP43632, Tdark

Protein Ontology

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PROi
PR:P43632
RNActiP43632, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin
PfamiView protein in Pfam
PF00047, ig, 2 hits
SMARTiView protein in SMART
SM00409, IG, 2 hits
SUPFAMiSSF48726, SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI2S4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43632
Secondary accession number(s): Q6H2G7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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