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Protein

Killer cell immunoglobulin-like receptor 2DS2

Gene

KIR2DS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS2
Alternative name(s):
CD158 antigen-like family member J
MHC class I NK cell receptor
NK receptor 183 ActI
Natural killer-associated transcript 5
Short name:
NKAT-5
p58 natural killer cell receptor clone CL-49
Short name:
p58 NK receptor CL-49
CD_antigen: CD158j
Gene namesi
Name:KIR2DS2
Synonyms:CD158J, NKAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6334 KIR2DS2
MIMi604953 gene
neXtProtiNX_P43631

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 304CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100132285
PharmGKBiPA30119

Polymorphism and mutation databases

DMDMi13124793

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508322 – 304Killer cell immunoglobulin-like receptor 2DS2Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 1001 Publication
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 1981 Publication
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP43631
PRIDEiP43631
ProteomicsDBi55645

PTM databases

iPTMnetiP43631
PhosphoSitePlusiP43631

Interactioni

Protein-protein interaction databases

BioGridi110005, 2 interactors
110008, 35 interactors

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43631
SMRiP43631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43631

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiP43631
KOiK07982
OrthoDBiEOG091G0APE

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P43631-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVRFEHFLL HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT
260 270 280 290 300
SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,502
Last modified:February 21, 2001 - v2
Checksum:i186C77DD9E86BA28
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14950Q14950_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS2
204Annotation score:
A0A0G2JPR7A0A0G2JPR7_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS2
287Annotation score:
A0A0G2JND2A0A0G2JND2_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DS2
342Annotation score:
A0A1W2PSB7A0A1W2PSB7_HUMAN
Uncharacterized protein
338Annotation score:

Sequence cautioni

The sequence AAC50338 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20W → G in CAA61983 (PubMed:8627176).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0594209A → V. Corresponds to variant dbSNP:rs189739973Ensembl.1
Natural variantiVAR_05942166Y → F. Corresponds to variant dbSNP:rs1049626616Ensembl.1
Natural variantiVAR_020090237K → E. Corresponds to variant dbSNP:rs2262065Ensembl.1
Natural variantiVAR_059422254K → N. Corresponds to variant dbSNP:rs1063326Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24079 mRNA Translation: AAC50338.1 Different initiation.
L41347 mRNA Translation: AAA65225.1
X89893 mRNA Translation: CAA61983.1
AY366243 mRNA Translation: AAR16201.1
AL133414 Genomic DNA No translation available.
RefSeqiNP_001278624.1, NM_001291695.1
NP_001278625.1, NM_001291696.1
NP_001278629.1, NM_001291700.1
NP_001278630.1, NM_001291701.1
NP_036444.1, NM_012312.4
XP_016885764.1, XM_017030275.1
UniGeneiHs.512572
Hs.731378

Genome annotation databases

EnsembliENST00000610441; ENSP00000484281; ENSG00000277885
ENST00000611495; ENSP00000484082; ENSG00000276425
ENST00000612182; ENSP00000478509; ENSG00000274438
ENST00000613378; ENSP00000482725; ENSG00000274518
ENST00000614231; ENSP00000482770; ENSG00000275253
ENST00000614727; ENSP00000483792; ENSG00000276139
ENST00000616472; ENSP00000482637; ENSG00000275452
ENST00000616541; ENSP00000484771; ENSG00000278300
ENST00000617284; ENSP00000478014; ENSG00000278300
ENST00000617984; ENSP00000477892; ENSG00000275737
ENST00000618364; ENSP00000483804; ENSG00000275735
ENST00000619473; ENSP00000484400; ENSG00000276258
ENST00000622127; ENSP00000481307; ENSG00000278152
GeneIDi100132285
KEGGihsa:100132285
UCSCiuc032izx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24079 mRNA Translation: AAC50338.1 Different initiation.
L41347 mRNA Translation: AAA65225.1
X89893 mRNA Translation: CAA61983.1
AY366243 mRNA Translation: AAR16201.1
AL133414 Genomic DNA No translation available.
RefSeqiNP_001278624.1, NM_001291695.1
NP_001278625.1, NM_001291696.1
NP_001278629.1, NM_001291700.1
NP_001278630.1, NM_001291701.1
NP_036444.1, NM_012312.4
XP_016885764.1, XM_017030275.1
UniGeneiHs.512572
Hs.731378

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4KX-ray2.30A22-221[»]
4N8VX-ray2.50G/I22-221[»]
ProteinModelPortaliP43631
SMRiP43631
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110005, 2 interactors
110008, 35 interactors

PTM databases

iPTMnetiP43631
PhosphoSitePlusiP43631

Polymorphism and mutation databases

DMDMi13124793

Proteomic databases

PeptideAtlasiP43631
PRIDEiP43631
ProteomicsDBi55645

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610441; ENSP00000484281; ENSG00000277885
ENST00000611495; ENSP00000484082; ENSG00000276425
ENST00000612182; ENSP00000478509; ENSG00000274438
ENST00000613378; ENSP00000482725; ENSG00000274518
ENST00000614231; ENSP00000482770; ENSG00000275253
ENST00000614727; ENSP00000483792; ENSG00000276139
ENST00000616472; ENSP00000482637; ENSG00000275452
ENST00000616541; ENSP00000484771; ENSG00000278300
ENST00000617284; ENSP00000478014; ENSG00000278300
ENST00000617984; ENSP00000477892; ENSG00000275737
ENST00000618364; ENSP00000483804; ENSG00000275735
ENST00000619473; ENSP00000484400; ENSG00000276258
ENST00000622127; ENSP00000481307; ENSG00000278152
GeneIDi100132285
KEGGihsa:100132285
UCSCiuc032izx.2 human

Organism-specific databases

CTDi100132285
DisGeNETi100132285
GeneCardsiKIR2DS2
HGNCiHGNC:6334 KIR2DS2
MIMi604953 gene
neXtProtiNX_P43631
PharmGKBiPA30119
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiP43631
KOiK07982
OrthoDBiEOG091G0APE

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Miscellaneous databases

EvolutionaryTraceiP43631
GenomeRNAii100132285
PROiPR:P43631
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI2S2_HUMAN
AccessioniPrimary (citable) accession number: P43631
Secondary accession number(s): Q14955, Q6H2G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 21, 2001
Last modified: July 18, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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