UniProtKB - P43630 (KI3L2_HUMAN)
Protein
Killer cell immunoglobulin-like receptor 3DL2
Gene
KIR3DL2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).3 Publications
GO - Molecular functioni
- MHC class Ib protein binding Source: UniProtKB
GO - Biological processi
- cellular defense response Source: ProtInc
- negative regulation of neuron death Source: UniProtKB
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P43630 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Killer cell immunoglobulin-like receptor 3DL2Alternative name(s): CD158 antigen-like family member K MHC class I NK cell receptor Natural killer-associated transcript 4 Short name: NKAT-4 p70 natural killer cell receptor clone CL-5 Short name: p70 NK receptor CL-5 CD_antigen: CD158k |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6339, KIR3DL2 |
MIMi | 604947, gene |
neXtProti | NX_P43630 |
VEuPathDBi | HostDB:ENSG00000240403.5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 340 | ExtracellularSequence analysisAdd BLAST | 319 | |
Transmembranei | 341 – 360 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 361 – 455 | CytoplasmicSequence analysisAdd BLAST | 95 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3812 |
OpenTargetsi | ENSG00000240403 |
PharmGKBi | PA30124 |
Miscellaneous databases
Pharosi | P43630, Tbio |
Genetic variation databases
BioMutai | KIR3DL2 |
DMDMi | 1171729 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000015090 | 22 – 455 | Killer cell immunoglobulin-like receptor 3DL2Add BLAST | 434 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 95 | Curated | ||
Disulfide bondi | 144 ↔ 195 | By similarity | ||
Glycosylationi | 179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 244 ↔ 293 | By similarity | ||
Glycosylationi | 273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P43630 |
PaxDbi | P43630 |
PeptideAtlasi | P43630 |
PRIDEi | P43630 |
ProteomicsDBi | 55644 [P43630-1] |
PTM databases
GlyGeni | P43630, 4 sites |
iPTMneti | P43630 |
PhosphoSitePlusi | P43630 |
SwissPalmi | P43630 |
Expressioni
Tissue specificityi
Expressed in astrocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000240403, Expressed in blood and 34 other tissues |
ExpressionAtlasi | P43630, baseline and differential |
Genevisiblei | P43630, HS |
Organism-specific databases
HPAi | ENSG00000240403, Tissue enhanced (heart muscle, lymphoid tissue, salivary gland) |
Interactioni
Subunit structurei
Interacts with peptide-free HLA-F open conformer.
2 PublicationsBinary interactionsi
P43630
With | #Exp. | IntAct |
---|---|---|
HLA-F [P30511] | 6 | EBI-6165894,EBI-2811134 |
GO - Molecular functioni
- MHC class Ib protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110013, 22 interactors |
ELMi | P43630 |
IntActi | P43630, 24 interactors |
STRINGi | 9606.ENSP00000325525 |
Miscellaneous databases
RNActi | P43630, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 102 | Ig-like C2-type 1Add BLAST | 61 | |
Domaini | 137 – 202 | Ig-like C2-type 2Add BLAST | 66 | |
Domaini | 237 – 300 | Ig-like C2-type 3Add BLAST | 64 |
Sequence similaritiesi
Belongs to the immunoglobulin superfamily.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU21, Eukaryota |
GeneTreei | ENSGT01000000214458 |
HOGENOMi | CLU_021100_2_1_1 |
InParanoidi | P43630 |
OMAi | NLECPLA |
PhylomeDBi | P43630 |
TreeFami | TF352669 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 3 hits |
SMARTi | View protein in SMART SM00409, IG, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 32 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P43630-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH
60 70 80 90 100
YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP
110 120 130 140 150
HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF
160 170 180 190 200
EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP
210 220 230 240 250
HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY
260 270 280 290 300
DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL
310 320 330 340 350
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF
360 370 380 390 400
LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ
410 420 430 440 450
LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG
LEGVF
Computationally mapped potential isoform sequencesi
There are 32 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BQU0 | Q9BQU0_HUMAN | Inhibitory NK receptor | KIR3DL2 kir3d | 455 | Annotation score: | ||
A0A0G2JPA6 | A0A0G2JPA6_HUMAN | Killer cell immunoglobulin-like rec... | KIR3DL2 | 438 | Annotation score: | ||
A0A0G2JP93 | A0A0G2JP93_HUMAN | 3DL2 | KIR3DL2 3DL2 | 455 | Annotation score: | ||
Q8NHK6 | Q8NHK6_HUMAN | KIR3DL2 | KIR3DL2 | 455 | Annotation score: | ||
Q6H2F6 | Q6H2F6_HUMAN | Killer cell immunoglobulin-like rec... | KIR3DL2 | 455 | Annotation score: | ||
A0A0G2JLU7 | A0A0G2JLU7_HUMAN | Killer cell immunoglobulin-like rec... | KIR3DL2 | 455 | Annotation score: | ||
A0A0G2JM36 | A0A0G2JM36_HUMAN | KIR3DL2 protein | KIR3DL2 | 438 | Annotation score: | ||
A0A0G2JN45 | A0A0G2JN45_HUMAN | Killer cell immunoglobulin-like rec... | KIR3DL2 | 438 | Annotation score: | ||
A0A0G2JPQ5 | A0A0G2JPQ5_HUMAN | KIR3DL2 | KIR3DL2 | 455 | Annotation score: | ||
A0A0U1WNF5 | A0A0U1WNF5_HUMAN | Killer cell immunoglobulin-like rec... | KIR3DL2 | 455 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010325 | 40 | P → A2 Publications | 1 | |
Natural variantiVAR_010326 | 113 | L → V2 PublicationsCorresponds to variant dbSNP:rs3188286Ensembl. | 1 | |
Natural variantiVAR_010327 | 158 | E → D3 PublicationsCorresponds to variant dbSNP:rs633870Ensembl. | 1 | |
Natural variantiVAR_010328 | 166 | R → H2 PublicationsCorresponds to variant dbSNP:rs1048271Ensembl. | 1 | |
Natural variantiVAR_010329 | 228 | A → P1 PublicationCorresponds to variant dbSNP:rs1377032475Ensembl. | 1 | |
Natural variantiVAR_010330 | 252 | I → T1 Publication | 1 | |
Natural variantiVAR_049992 | 397 | T → M. Corresponds to variant dbSNP:rs3745902Ensembl. | 1 | |
Natural variantiVAR_049993 | 439 | K → Q. Corresponds to variant dbSNP:rs3745903Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047374 | 318 – 334 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41270 mRNA Translation: AAA69871.1 U30272 mRNA Translation: AAB52520.1 X93595 mRNA Translation: CAA63791.1 X93596 mRNA Translation: CAA63792.1 X94373 mRNA Translation: CAA64150.1 X94374 mRNA Translation: CAA64151.1 L76665 mRNA Translation: AAB36593.1 L76666 mRNA Translation: AAB36594.1 AY789067 mRNA Translation: AAX23112.1 |
CCDSi | CCDS12906.1 [P43630-1] CCDS58677.1 [P43630-2] |
RefSeqi | NP_001229796.1, NM_001242867.1 [P43630-2] NP_006728.2, NM_006737.3 [P43630-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41270 mRNA Translation: AAA69871.1 U30272 mRNA Translation: AAB52520.1 X93595 mRNA Translation: CAA63791.1 X93596 mRNA Translation: CAA63792.1 X94373 mRNA Translation: CAA64150.1 X94374 mRNA Translation: CAA64151.1 L76665 mRNA Translation: AAB36593.1 L76666 mRNA Translation: AAB36594.1 AY789067 mRNA Translation: AAX23112.1 |
CCDSi | CCDS12906.1 [P43630-1] CCDS58677.1 [P43630-2] |
RefSeqi | NP_001229796.1, NM_001242867.1 [P43630-2] NP_006728.2, NM_006737.3 [P43630-1] |
3D structure databases
SMRi | P43630 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110013, 22 interactors |
ELMi | P43630 |
IntActi | P43630, 24 interactors |
STRINGi | 9606.ENSP00000325525 |
PTM databases
GlyGeni | P43630, 4 sites |
iPTMneti | P43630 |
PhosphoSitePlusi | P43630 |
SwissPalmi | P43630 |
Genetic variation databases
BioMutai | KIR3DL2 |
DMDMi | 1171729 |
Proteomic databases
MassIVEi | P43630 |
PaxDbi | P43630 |
PeptideAtlasi | P43630 |
PRIDEi | P43630 |
ProteomicsDBi | 55644 [P43630-1] |
Protocols and materials databases
ABCDi | P43630, 12 sequenced antibodies |
Antibodypediai | 52684, 130 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 3812 |
DisGeNETi | 3812 |
GeneCardsi | KIR3DL2 |
HGNCi | HGNC:6339, KIR3DL2 |
HPAi | ENSG00000240403, Tissue enhanced (heart muscle, lymphoid tissue, salivary gland) |
MIMi | 604947, gene |
neXtProti | NX_P43630 |
OpenTargetsi | ENSG00000240403 |
PharmGKBi | PA30124 |
VEuPathDBi | HostDB:ENSG00000240403.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU21, Eukaryota |
GeneTreei | ENSGT01000000214458 |
HOGENOMi | CLU_021100_2_1_1 |
InParanoidi | P43630 |
OMAi | NLECPLA |
PhylomeDBi | P43630 |
TreeFami | TF352669 |
Enzyme and pathway databases
PathwayCommonsi | P43630 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 3812, 3 hits in 865 CRISPR screens |
GeneWikii | KIR3DL2 |
GenomeRNAii | 3812 |
Pharosi | P43630, Tbio |
PROi | PR:P43630 |
RNActi | P43630, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000240403, Expressed in blood and 34 other tissues |
ExpressionAtlasi | P43630, baseline and differential |
Genevisiblei | P43630, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 3 hits |
SMARTi | View protein in SMART SM00409, IG, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KI3L2_HUMAN | |
Accessioni | P43630Primary (citable) accession number: P43630 Secondary accession number(s): Q13238 Q95368 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries