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Protein

Killer cell immunoglobulin-like receptor 3DL2

Gene

KIR3DL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.

GO - Biological processi

  • cellular defense response Source: ProtInc
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL2
Alternative name(s):
CD158 antigen-like family member K
MHC class I NK cell receptor
Natural killer-associated transcript 4
Short name:
NKAT-4
p70 natural killer cell receptor clone CL-5
Short name:
p70 NK receptor CL-5
CD_antigen: CD158k
Gene namesi
Name:KIR3DL2
Synonyms:CD158K, NKAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000240403.5
HGNCiHGNC:6339 KIR3DL2
MIMi604947 gene
neXtProtiNX_P43630

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 455CytoplasmicSequence analysisAdd BLAST95

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3812
OpenTargetsiENSG00000240403
PharmGKBiPA30124

Polymorphism and mutation databases

BioMutaiKIR3DL2
DMDMi1171729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001509022 – 455Killer cell immunoglobulin-like receptor 3DL2Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 95Curated
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43630
PeptideAtlasiP43630
PRIDEiP43630
ProteomicsDBi55644

PTM databases

iPTMnetiP43630
PhosphoSitePlusiP43630
SwissPalmiP43630

Expressioni

Gene expression databases

BgeeiENSG00000240403 Expressed in 23 organ(s), highest expression level in blood
ExpressionAtlasiP43630 baseline and differential
GenevisibleiP43630 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-FP305116EBI-6165894,EBI-2811134

Protein-protein interaction databases

BioGridi110013, 22 interactors
ELMiP43630
IntActiP43630, 5 interactors
STRINGi9606.ENSP00000325525

Structurei

3D structure databases

ProteinModelPortaliP43630
SMRiP43630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM Eukaryota
ENOG410ZT7K LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiP43630
KOiK07980
OMAiNLECPLA
OrthoDBiEOG091G0APE
PhylomeDBiP43630
TreeFamiTF352669

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 3 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 32 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH
60 70 80 90 100
YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP
110 120 130 140 150
HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF
160 170 180 190 200
EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP
210 220 230 240 250
HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY
260 270 280 290 300
DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL
310 320 330 340 350
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF
360 370 380 390 400
LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ
410 420 430 440 450
LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG

LEGVF
Length:455
Mass (Da):50,230
Last modified:November 1, 1995 - v1
Checksum:iDB4BA6BB6B3C2945
GO
Isoform 2 (identifier: P43630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-334: Missing.

Show »
Length:438
Mass (Da):48,517
Checksum:iF762B713D6EB916C
GO

Computationally mapped potential isoform sequencesi

There are 32 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BQU0Q9BQU0_HUMAN
Inhibitory NK receptor
KIR3DL2 kir3d
455Annotation score:
A0A0G2JP93A0A0G2JP93_HUMAN
3DL2
KIR3DL2 3DL2
455Annotation score:
Q8NHK6Q8NHK6_HUMAN
KIR3DL2
KIR3DL2
455Annotation score:
Q6H2F6Q6H2F6_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
455Annotation score:
A0A0U5GHD6A0A0U5GHD6_HUMAN
KIR3DL2
KIR3DL2
455Annotation score:
A0A0U1WNF5A0A0U1WNF5_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
455Annotation score:
A0A120N617A0A120N617_HUMAN
KIR3DL2
KIR3DL2
455Annotation score:
A0A0G2JMA3A0A0G2JMA3_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
455Annotation score:
A0A0G2JPQ5A0A0G2JPQ5_HUMAN
KIR3DL2
KIR3DL2
455Annotation score:
A0A0G2JPA6A0A0G2JPA6_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
438Annotation score:
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01032540P → A2 Publications1
Natural variantiVAR_010326113L → V2 PublicationsCorresponds to variant dbSNP:rs3188286Ensembl.1
Natural variantiVAR_010327158E → D3 PublicationsCorresponds to variant dbSNP:rs633870Ensembl.1
Natural variantiVAR_010328166R → H2 PublicationsCorresponds to variant dbSNP:rs1048271Ensembl.1
Natural variantiVAR_010329228A → P1 Publication1
Natural variantiVAR_010330252I → T1 Publication1
Natural variantiVAR_049992397T → M. Corresponds to variant dbSNP:rs3745902Ensembl.1
Natural variantiVAR_049993439K → Q. Corresponds to variant dbSNP:rs3745903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047374318 – 334Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA Translation: AAA69871.1
U30272 mRNA Translation: AAB52520.1
X93595 mRNA Translation: CAA63791.1
X93596 mRNA Translation: CAA63792.1
X94373 mRNA Translation: CAA64150.1
X94374 mRNA Translation: CAA64151.1
L76665 mRNA Translation: AAB36593.1
L76666 mRNA Translation: AAB36594.1
AY789067 mRNA Translation: AAX23112.1
CCDSiCCDS12906.1 [P43630-1]
CCDS58677.1 [P43630-2]
RefSeqiNP_001229796.1, NM_001242867.1 [P43630-2]
NP_006728.2, NM_006737.3 [P43630-1]
UniGeneiHs.645228
Hs.645532
Hs.654605

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403 [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403 [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809 [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474
ENST00000611859; ENSP00000480578; ENSG00000277181 [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722 [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442
ENST00000613612; ENSP00000482565; ENSG00000275566
ENST00000614753; ENSP00000479299; ENSG00000276357
ENST00000617354; ENSP00000482110; ENSG00000274722 [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083 [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361
ENST00000617957; ENSP00000481579; ENSG00000275083 [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739 [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626
ENST00000620817; ENSP00000479772; ENSG00000276739 [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416
ENST00000622024; ENSP00000479425; ENSG00000276004
ENST00000622453; ENSP00000477516; ENSG00000277181 [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809 [P43630-2]
ENST00000638330; ENSP00000492261; ENSG00000284381 [P43630-1]
ENST00000638726; ENSP00000492117; ENSG00000283951 [P43630-2]
ENST00000638805; ENSP00000492880; ENSG00000283975 [P43630-2]
ENST00000638891; ENSP00000491303; ENSG00000284063 [P43630-1]
ENST00000638970; ENSP00000491183; ENSG00000283975 [P43630-1]
ENST00000639252; ENSP00000491248; ENSG00000284381 [P43630-2]
ENST00000639313; ENSP00000491707; ENSG00000284063 [P43630-2]
ENST00000640782; ENSP00000491436; ENSG00000283951 [P43630-1]
GeneIDi3812
KEGGihsa:3812
UCSCiuc002qho.5 human [P43630-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA Translation: AAA69871.1
U30272 mRNA Translation: AAB52520.1
X93595 mRNA Translation: CAA63791.1
X93596 mRNA Translation: CAA63792.1
X94373 mRNA Translation: CAA64150.1
X94374 mRNA Translation: CAA64151.1
L76665 mRNA Translation: AAB36593.1
L76666 mRNA Translation: AAB36594.1
AY789067 mRNA Translation: AAX23112.1
CCDSiCCDS12906.1 [P43630-1]
CCDS58677.1 [P43630-2]
RefSeqiNP_001229796.1, NM_001242867.1 [P43630-2]
NP_006728.2, NM_006737.3 [P43630-1]
UniGeneiHs.645228
Hs.645532
Hs.654605

3D structure databases

ProteinModelPortaliP43630
SMRiP43630
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110013, 22 interactors
ELMiP43630
IntActiP43630, 5 interactors
STRINGi9606.ENSP00000325525

PTM databases

iPTMnetiP43630
PhosphoSitePlusiP43630
SwissPalmiP43630

Polymorphism and mutation databases

BioMutaiKIR3DL2
DMDMi1171729

Proteomic databases

PaxDbiP43630
PeptideAtlasiP43630
PRIDEiP43630
ProteomicsDBi55644

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403 [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403 [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809 [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474
ENST00000611859; ENSP00000480578; ENSG00000277181 [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722 [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442
ENST00000613612; ENSP00000482565; ENSG00000275566
ENST00000614753; ENSP00000479299; ENSG00000276357
ENST00000617354; ENSP00000482110; ENSG00000274722 [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083 [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361
ENST00000617957; ENSP00000481579; ENSG00000275083 [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739 [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626
ENST00000620817; ENSP00000479772; ENSG00000276739 [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416
ENST00000622024; ENSP00000479425; ENSG00000276004
ENST00000622453; ENSP00000477516; ENSG00000277181 [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809 [P43630-2]
ENST00000638330; ENSP00000492261; ENSG00000284381 [P43630-1]
ENST00000638726; ENSP00000492117; ENSG00000283951 [P43630-2]
ENST00000638805; ENSP00000492880; ENSG00000283975 [P43630-2]
ENST00000638891; ENSP00000491303; ENSG00000284063 [P43630-1]
ENST00000638970; ENSP00000491183; ENSG00000283975 [P43630-1]
ENST00000639252; ENSP00000491248; ENSG00000284381 [P43630-2]
ENST00000639313; ENSP00000491707; ENSG00000284063 [P43630-2]
ENST00000640782; ENSP00000491436; ENSG00000283951 [P43630-1]
GeneIDi3812
KEGGihsa:3812
UCSCiuc002qho.5 human [P43630-1]

Organism-specific databases

CTDi3812
DisGeNETi3812
EuPathDBiHostDB:ENSG00000240403.5
GeneCardsiKIR3DL2
HGNCiHGNC:6339 KIR3DL2
MIMi604947 gene
neXtProtiNX_P43630
OpenTargetsiENSG00000240403
PharmGKBiPA30124
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMM Eukaryota
ENOG410ZT7K LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiP43630
KOiK07980
OMAiNLECPLA
OrthoDBiEOG091G0APE
PhylomeDBiP43630
TreeFamiTF352669

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

GeneWikiiKIR3DL2
GenomeRNAii3812
PROiPR:P43630
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240403 Expressed in 23 organ(s), highest expression level in blood
ExpressionAtlasiP43630 baseline and differential
GenevisibleiP43630 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 3 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI3L2_HUMAN
AccessioniPrimary (citable) accession number: P43630
Secondary accession number(s): Q13238
, Q14947, Q14948, Q92684, Q95366, Q95367, Q95368
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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