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UniProtKB - P43630 (KI3L2_HUMAN)

Entry version 194 (02 Jun 2021)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
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Protein

Killer cell immunoglobulin-like receptor 3DL2

Gene

KIR3DL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952).

Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270).

Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P43630

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL2
Alternative name(s):
CD158 antigen-like family member K
MHC class I NK cell receptor
Natural killer-associated transcript 4
Short name:
NKAT-4
p70 natural killer cell receptor clone CL-5
Short name:
p70 NK receptor CL-5
CD_antigen: CD158k
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIR3DL21 PublicationImported
Synonyms:CD158K, NKAT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6339, KIR3DL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604947, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P43630

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000240403.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 455CytoplasmicSequence analysisAdd BLAST95

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3812

Open Targets

More...OpenTargetsi		ENSG00000240403

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30124

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P43630, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIR3DL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1171729

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001509022 – 455Killer cell immunoglobulin-like receptor 3DL2Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 95Curated
Disulfide bondi144 ↔ 195By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P43630

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P43630

PeptideAtlas

More...PeptideAtlasi		P43630

PRoteomics IDEntifications database

More...PRIDEi		P43630

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55644 [P43630-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P43630, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43630

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P43630

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P43630

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in astrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000240403, Expressed in blood and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P43630, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P43630, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000240403, Tissue enhanced (heart muscle, lymphoid tissue, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with peptide-free HLA-F open conformer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110013, 22 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P43630

Protein interaction database and analysis system

More...IntActi		P43630, 24 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325525

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43630, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43630

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RU21, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00980000198504

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021100_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43630

Identification of Orthologs from Complete Genome Data

More...OMAi		NLECPLA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P43630

TreeFam database of animal gene trees

More...TreeFami		TF352669

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00047, ig, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 32 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH 
        60         70         80         90        100
YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP 
       110        120        130        140        150
HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF 
       160        170        180        190        200
EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP 
       210        220        230        240        250
HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY 
       260        270        280        290        300
DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL 
       310        320        330        340        350
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF 
       360        370        380        390        400
LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ 
       410        420        430        440        450
LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG 

LEGVF
Length:455
Mass (Da):50,230
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB4BA6BB6B3C2945
GO
Isoform 2 (identifier: P43630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-334: Missing.

Show »
Length:438
Mass (Da):48,517
Checksum:iF762B713D6EB916C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 32 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BQU0Q9BQU0_HUMAN
Inhibitory NK receptor
KIR3DL2 kir3d
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPA6A0A0G2JPA6_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JP93A0A0G2JP93_HUMAN
3DL2
KIR3DL2 3DL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8NHK6Q8NHK6_HUMAN
KIR3DL2
KIR3DL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM36A0A0G2JM36_HUMAN
KIR3DL2 protein
KIR3DL2
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPQ5A0A0G2JPQ5_HUMAN
KIR3DL2
KIR3DL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6H2F6Q6H2F6_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLU7A0A0G2JLU7_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM59A0A0G2JM59_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMA3A0A0G2JMA3_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01032540P → A2 Publications1
Natural variantiVAR_010326113L → V2 PublicationsCorresponds to variant dbSNP:rs3188286Ensembl.1
Natural variantiVAR_010327158E → D3 PublicationsCorresponds to variant dbSNP:rs633870Ensembl.1
Natural variantiVAR_010328166R → H2 PublicationsCorresponds to variant dbSNP:rs1048271Ensembl.1
Natural variantiVAR_010329228A → P1 PublicationCorresponds to variant dbSNP:rs1377032475Ensembl.1
Natural variantiVAR_010330252I → T1 Publication1
Natural variantiVAR_049992397T → M. Corresponds to variant dbSNP:rs3745902Ensembl.1
Natural variantiVAR_049993439K → Q. Corresponds to variant dbSNP:rs3745903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047374318 – 334Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L41270 mRNA Translation: AAA69871.1
U30272 mRNA Translation: AAB52520.1
X93595 mRNA Translation: CAA63791.1
X93596 mRNA Translation: CAA63792.1
X94373 mRNA Translation: CAA64150.1
X94374 mRNA Translation: CAA64151.1
L76665 mRNA Translation: AAB36593.1
L76666 mRNA Translation: AAB36594.1
AY789067 mRNA Translation: AAX23112.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12906.1 [P43630-1]
CCDS58677.1 [P43630-2]

NCBI Reference Sequences

More...RefSeqi		NP_001229796.1, NM_001242867.1 [P43630-2]
NP_006728.2, NM_006737.3 [P43630-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000270442; ENSP00000270442; ENSG00000240403 [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403 [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809 [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474
ENST00000611859; ENSP00000480578; ENSG00000277181 [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722 [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442
ENST00000613612; ENSP00000482565; ENSG00000275566
ENST00000614753; ENSP00000479299; ENSG00000276357
ENST00000617354; ENSP00000482110; ENSG00000274722 [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083 [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361
ENST00000617957; ENSP00000481579; ENSG00000275083 [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739 [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626
ENST00000620817; ENSP00000479772; ENSG00000276739 [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416
ENST00000622024; ENSP00000479425; ENSG00000276004
ENST00000622453; ENSP00000477516; ENSG00000277181 [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809 [P43630-2]
ENST00000638330; ENSP00000492261; ENSG00000284381 [P43630-1]
ENST00000638726; ENSP00000492117; ENSG00000283951 [P43630-2]
ENST00000638805; ENSP00000492880; ENSG00000283975 [P43630-2]
ENST00000638891; ENSP00000491303; ENSG00000284063 [P43630-1]
ENST00000638970; ENSP00000491183; ENSG00000283975 [P43630-1]
ENST00000639252; ENSP00000491248; ENSG00000284381 [P43630-2]
ENST00000639313; ENSP00000491707; ENSG00000284063 [P43630-2]
ENST00000640782; ENSP00000491436; ENSG00000283951 [P43630-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3812

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3812

UCSC genome browser

More...UCSCi		uc002qho.5, human [P43630-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA Translation: AAA69871.1
U30272 mRNA Translation: AAB52520.1
X93595 mRNA Translation: CAA63791.1
X93596 mRNA Translation: CAA63792.1
X94373 mRNA Translation: CAA64150.1
X94374 mRNA Translation: CAA64151.1
L76665 mRNA Translation: AAB36593.1
L76666 mRNA Translation: AAB36594.1
AY789067 mRNA Translation: AAX23112.1
CCDSiCCDS12906.1 [P43630-1]
CCDS58677.1 [P43630-2]
RefSeqiNP_001229796.1, NM_001242867.1 [P43630-2]
NP_006728.2, NM_006737.3 [P43630-1]

3D structure databases

SMRiP43630
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110013, 22 interactors
ELMiP43630
IntActiP43630, 24 interactors
STRINGi9606.ENSP00000325525

PTM databases

GlyGeniP43630, 4 sites
iPTMnetiP43630
PhosphoSitePlusiP43630
SwissPalmiP43630

Genetic variation databases

BioMutaiKIR3DL2
DMDMi1171729

Proteomic databases

MassIVEiP43630
PaxDbiP43630
PeptideAtlasiP43630
PRIDEiP43630
ProteomicsDBi55644 [P43630-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P43630, 12 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52684, 157 antibodies

The DNASU plasmid repository

More...DNASUi		3812

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403 [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403 [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809 [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474
ENST00000611859; ENSP00000480578; ENSG00000277181 [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722 [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442
ENST00000613612; ENSP00000482565; ENSG00000275566
ENST00000614753; ENSP00000479299; ENSG00000276357
ENST00000617354; ENSP00000482110; ENSG00000274722 [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083 [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361
ENST00000617957; ENSP00000481579; ENSG00000275083 [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739 [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626
ENST00000620817; ENSP00000479772; ENSG00000276739 [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416
ENST00000622024; ENSP00000479425; ENSG00000276004
ENST00000622453; ENSP00000477516; ENSG00000277181 [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809 [P43630-2]
ENST00000638330; ENSP00000492261; ENSG00000284381 [P43630-1]
ENST00000638726; ENSP00000492117; ENSG00000283951 [P43630-2]
ENST00000638805; ENSP00000492880; ENSG00000283975 [P43630-2]
ENST00000638891; ENSP00000491303; ENSG00000284063 [P43630-1]
ENST00000638970; ENSP00000491183; ENSG00000283975 [P43630-1]
ENST00000639252; ENSP00000491248; ENSG00000284381 [P43630-2]
ENST00000639313; ENSP00000491707; ENSG00000284063 [P43630-2]
ENST00000640782; ENSP00000491436; ENSG00000283951 [P43630-1]
GeneIDi3812
KEGGihsa:3812
UCSCiuc002qho.5, human [P43630-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3812
DisGeNETi3812

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIR3DL2
HGNCiHGNC:6339, KIR3DL2
HPAiENSG00000240403, Tissue enhanced (heart muscle, lymphoid tissue, salivary gland)
MIMi604947, gene
neXtProtiNX_P43630
OpenTargetsiENSG00000240403
PharmGKBiPA30124
VEuPathDBiHostDB:ENSG00000240403.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RU21, Eukaryota
GeneTreeiENSGT00980000198504
HOGENOMiCLU_021100_2_1_1
InParanoidiP43630
OMAiNLECPLA
PhylomeDBiP43630
TreeFamiTF352669

Enzyme and pathway databases

PathwayCommonsiP43630
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3812, 4 hits in 973 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KIR3DL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3812
PharosiP43630, Tbio

Protein Ontology

More...PROi		PR:P43630
RNActiP43630, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000240403, Expressed in blood and 34 other tissues
ExpressionAtlasiP43630, baseline and differential
GenevisibleiP43630, HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin
PfamiView protein in Pfam
PF00047, ig, 3 hits
SMARTiView protein in SMART
SM00409, IG, 3 hits
SUPFAMiSSF48726, SSF48726, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI3L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43630
Secondary accession number(s): Q13238
, Q14947, Q14948, Q92684, Q95366, Q95367, Q95368
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 2, 2021
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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