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Protein

Killer cell immunoglobulin-like receptor 3DL1

Gene

KIR3DL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functioni

  • HLA-B specific inhibitory MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiP43629

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
CD158 antigen-like family member E
HLA-BW4-specific inhibitory NK cell receptor
MHC class I NK cell receptor
Natural killer-associated transcript 3
Short name:
NKAT-3
p70 natural killer cell receptor clones CL-2/CL-11
Short name:
p70 NK receptor CL-2/CL-11
CD_antigen: CD158e
Gene namesi
Name:KIR3DL1
Synonyms:CD158E, NKAT3, NKB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167633.17
HGNCiHGNC:6338 KIR3DL1
MIMi604946 gene
neXtProtiNX_P43629

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 444CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3811
MalaCardsiKIR3DL1
OpenTargetsiENSG00000167633
PharmGKBiPA30123

Polymorphism and mutation databases

BioMutaiKIR3DL1
DMDMi1171728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508722 – 444Killer cell immunoglobulin-like receptor 3DL1Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 951 Publication
Glycosylationi92N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi144 ↔ 1951 Publication
Glycosylationi179N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi244 ↔ 2931 Publication
Glycosylationi273N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43629
PeptideAtlasiP43629
PRIDEiP43629
ProteomicsDBi55643

PTM databases

iPTMnetiP43629
PhosphoSitePlusiP43629

Expressioni

Gene expression databases

BgeeiENSG00000167633 Expressed in 24 organ(s), highest expression level in blood
CleanExiHS_KIR3DL1
ExpressionAtlasiP43629 baseline and differential
GenevisibleiP43629 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110012, 6 interactors
IntActiP43629, 11 interactors
STRINGi9606.ENSP00000375608

Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43629
SMRiP43629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Domaini

Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.1 Publication

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM Eukaryota
ENOG410ZT7K LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiP43629
KOiK07980
OMAiYEELNIN
PhylomeDBiP43629
TreeFamiTF352669

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 3 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 36 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH
60 70 80 90 100
YRHRFNNFML YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP
110 120 130 140 150
HSPTGWSAPS NPVVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF
160 170 180 190 200
EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT
210 220 230 240 250
HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY
260 270 280 290 300
DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
310 320 330 340 350
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII
360 370 380 390 400
LFILLLFFLL HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ
410 420 430 440
LDHCVFTQRK ITRPSQRPKT PPTDTILYTE LPNAKPRSKV VSCP
Length:444
Mass (Da):49,098
Last modified:November 1, 1995 - v1
Checksum:i47DEA12BBAFDEC53
GO
Isoform 2 (identifier: P43629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.

Show »
Length:349
Mass (Da):38,403
Checksum:i250F6C7D25DC0A13
GO

Computationally mapped potential isoform sequencesi

There are 36 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W5QJC1W5QJC1_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL1
427Annotation score:
Q6H2G3Q6H2G3_HUMAN
KIR3DL1
KIR3DL1
444Annotation score:
Q15702Q15702_HUMAN
Killer cell Ig-like receptor varian...
KIR3DL1
427Annotation score:
Q5UCD8Q5UCD8_HUMAN
KIR3DL1/S1
KIR3DL1
444Annotation score:
C4N360C4N360_HUMAN
KIR3DL1/S1
KIR3DL1
444Annotation score:
Q5UCE1Q5UCE1_HUMAN
KIR3DL1
KIR3DL1
444Annotation score:
Q6H2G1Q6H2G1_HUMAN
KIR3DL1
KIR3DL1
444Annotation score:
Q8NHK7Q8NHK7_HUMAN
KIR3DL1
KIR3DL1
444Annotation score:
Q5UCD9Q5UCD9_HUMAN
KIR3DL1
KIR3DL1
444Annotation score:
Q8N152Q8N152_HUMAN
KIR3DL1
KIR3DL1
444Annotation score:
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0103192S → L. Corresponds to variant dbSNP:rs605219Ensembl.1
Natural variantiVAR_01032013L → F. Corresponds to variant dbSNP:rs1142881Ensembl.1
Natural variantiVAR_01032123M → V. Corresponds to variant dbSNP:rs1142882Ensembl.1
Natural variantiVAR_01032268I → V. Corresponds to variant dbSNP:rs643347Ensembl.1
Natural variantiVAR_01032375I → L. Corresponds to variant dbSNP:rs1049150Ensembl.1
Natural variantiVAR_049987203P → S. Corresponds to variant dbSNP:rs2273731Ensembl.1
Natural variantiVAR_049988220P → L. Corresponds to variant dbSNP:rs680891Ensembl.1
Natural variantiVAR_010336259G → R. Corresponds to variant dbSNP:rs1049215Ensembl.1
Natural variantiVAR_010324333S → C. 1
Natural variantiVAR_049989362L → R. Corresponds to variant dbSNP:rs1130468Ensembl.1
Natural variantiVAR_049990394E → Q. Corresponds to variant dbSNP:rs1130513Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04763325 – 119Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41269 mRNA Translation: AAA69870.1
U30273 mRNA Translation: AAB52521.1
U30274 mRNA Translation: AAB52522.1
X94262 mRNA Translation: CAA63938.1
U31416 mRNA Translation: AAC23725.1
AF022049 mRNA Translation: AAB95322.1
L76664 mRNA Translation: AAB36592.1
AC006293 Genomic DNA No translation available.
AC011501 Genomic DNA No translation available.
CCDSiCCDS42621.1 [P43629-1]
PIRiG01924
G01925
RefSeqiNP_001309097.1, NM_001322168.1
NP_037421.2, NM_013289.2 [P43629-1]
UniGeneiHs.645228

Genome annotation databases

EnsembliENST00000358178; ENSP00000350901; ENSG00000167633 [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633 [P43629-1]
ENST00000612668; ENSP00000484488; ENSG00000274036 [P43629-1]
ENST00000616188; ENSP00000484036; ENSG00000275288 [P43629-1]
ENST00000621353; ENSP00000484972; ENSG00000276423 [P43629-1]
ENST00000639353; ENSP00000492794; ENSG00000284342 [P43629-1]
ENST00000639813; ENSP00000492173; ENSG00000284426 [P43629-2]
ENST00000640111; ENSP00000491437; ENSG00000284342 [P43629-2]
ENST00000640788; ENSP00000491550; ENSG00000284426 [P43629-1]
GeneIDi3811
KEGGihsa:3811
UCSCiuc010esf.4 human [P43629-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41269 mRNA Translation: AAA69870.1
U30273 mRNA Translation: AAB52521.1
U30274 mRNA Translation: AAB52522.1
X94262 mRNA Translation: CAA63938.1
U31416 mRNA Translation: AAC23725.1
AF022049 mRNA Translation: AAB95322.1
L76664 mRNA Translation: AAB36592.1
AC006293 Genomic DNA No translation available.
AC011501 Genomic DNA No translation available.
CCDSiCCDS42621.1 [P43629-1]
PIRiG01924
G01925
RefSeqiNP_001309097.1, NM_001322168.1
NP_037421.2, NM_013289.2 [P43629-1]
UniGeneiHs.645228

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VH8X-ray1.80G/H22-320[»]
3WUWX-ray2.00G28-313[»]
5B38X-ray2.30G22-320[»]
5B39X-ray2.50G22-320[»]
5T6ZX-ray2.00G22-320[»]
5T70X-ray2.10G22-320[»]
ProteinModelPortaliP43629
SMRiP43629
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110012, 6 interactors
IntActiP43629, 11 interactors
STRINGi9606.ENSP00000375608

PTM databases

iPTMnetiP43629
PhosphoSitePlusiP43629

Polymorphism and mutation databases

BioMutaiKIR3DL1
DMDMi1171728

Proteomic databases

PaxDbiP43629
PeptideAtlasiP43629
PRIDEiP43629
ProteomicsDBi55643

Protocols and materials databases

DNASUi3811
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358178; ENSP00000350901; ENSG00000167633 [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633 [P43629-1]
ENST00000612668; ENSP00000484488; ENSG00000274036 [P43629-1]
ENST00000616188; ENSP00000484036; ENSG00000275288 [P43629-1]
ENST00000621353; ENSP00000484972; ENSG00000276423 [P43629-1]
ENST00000639353; ENSP00000492794; ENSG00000284342 [P43629-1]
ENST00000639813; ENSP00000492173; ENSG00000284426 [P43629-2]
ENST00000640111; ENSP00000491437; ENSG00000284342 [P43629-2]
ENST00000640788; ENSP00000491550; ENSG00000284426 [P43629-1]
GeneIDi3811
KEGGihsa:3811
UCSCiuc010esf.4 human [P43629-1]

Organism-specific databases

CTDi3811
DisGeNETi3811
EuPathDBiHostDB:ENSG00000167633.17
GeneCardsiKIR3DL1
HGNCiHGNC:6338 KIR3DL1
MalaCardsiKIR3DL1
MIMi604946 gene
neXtProtiNX_P43629
OpenTargetsiENSG00000167633
PharmGKBiPA30123
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMM Eukaryota
ENOG410ZT7K LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiP43629
KOiK07980
OMAiYEELNIN
PhylomeDBiP43629
TreeFamiTF352669

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiP43629

Miscellaneous databases

GeneWikiiKIR3DL1
GenomeRNAii3811
PROiPR:P43629
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167633 Expressed in 24 organ(s), highest expression level in blood
CleanExiHS_KIR3DL1
ExpressionAtlasiP43629 baseline and differential
GenevisibleiP43629 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 3 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI3L1_HUMAN
AccessioniPrimary (citable) accession number: P43629
Secondary accession number(s): O43473, Q14946, Q16541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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