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Protein

Killer cell immunoglobulin-like receptor 2DL3

Gene

KIR2DL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL3
Alternative name(s):
CD158 antigen-like family member B2
KIR-023GB
Killer inhibitory receptor cl 2-3
MHC class I NK cell receptor
NKAT2a
NKAT2b
Natural killer-associated transcript 2
Short name:
NKAT-2
p58 natural killer cell receptor clone CL-6
Short name:
p58 NK receptor CL-6
p58.2 MHC class-I-specific NK receptor
CD_antigen: CD158b2
Gene namesi
Name:KIR2DL3
Synonyms:CD158B2, KIRCL23, NKAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000243772.7
HGNCiHGNC:6331 KIR2DL3
MIMi604938 gene
neXtProtiNX_P43628

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 341CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3804
OpenTargetsiENSG00000243772
PharmGKBiPA30116

Chemistry databases

ChEMBLiCHEMBL3713026

Polymorphism and mutation databases

BioMutaiKIR2DL3
DMDMi1171727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508022 – 341Killer cell immunoglobulin-like receptor 2DL3Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100By similarity
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43628
PeptideAtlasiP43628
PRIDEiP43628
ProteomicsDBi55641
55642 [P43628-2]
TopDownProteomicsiP43628-1 [P43628-1]

PTM databases

iPTMnetiP43628
PhosphoSitePlusiP43628

Expressioni

Gene expression databases

BgeeiENSG00000243772 Expressed in 26 organ(s), highest expression level in blood
ExpressionAtlasiP43628 baseline and differential
GenevisibleiP43628 HS

Interactioni

Subunit structurei

Interacts with ARRB2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi110005, 2 interactors
IntActiP43628, 70 interactors
MINTiP43628
STRINGi9606.ENSP00000342215

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43628
SMRiP43628
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43628

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119033
HOVERGENiHBG074353
InParanoidiP43628
KOiK07981
OMAiEEAHESW
OrthoDBiEOG091G0APE
PhylomeDBiP43628
TreeFamiTF352669

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43628-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
310 320 330 340
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
Length:341
Mass (Da):37,886
Last modified:November 1, 1995 - v1
Checksum:iC21EAFF80EA9AAB2
GO
Isoform 2 (identifier: P43628-2) [UniParc]FASTAAdd to basket
Also known as: NKAT2a-delta-Ig2

The sequence of this isoform differs from the canonical sequence as follows:
     117-214: Missing.

Show »
Length:243
Mass (Da):27,269
Checksum:i86E3E532F7335609
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPP8A0A0G2JPP8_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL3
349Annotation score:
A0A0G2JNW9A0A0G2JNW9_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL3
341Annotation score:
A0A191URJ0A0A191URJ0_HUMAN
KIR2DL3
KIR2DL3
341Annotation score:
A0A0C4ZLV8A0A0C4ZLV8_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL3
341Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0103139V → A2 PublicationsCorresponds to variant dbSNP:rs3810343Ensembl.1
Natural variantiVAR_01031432L → R2 PublicationsCorresponds to variant dbSNP:rs202032116Ensembl.1
Natural variantiVAR_01596734H → Q1 PublicationCorresponds to variant dbSNP:rs683003Ensembl.1
Natural variantiVAR_04997837P → R. Corresponds to variant dbSNP:rs613240Ensembl.1
Natural variantiVAR_01031556Q → E2 PublicationsCorresponds to variant dbSNP:rs35719984Ensembl.1
Natural variantiVAR_04997966F → Y. Corresponds to variant dbSNP:rs78713511Ensembl.1
Natural variantiVAR_01031671H → R2 PublicationsCorresponds to variant dbSNP:rs138897134Ensembl.1
Natural variantiVAR_015968229P → L3 PublicationsCorresponds to variant dbSNP:rs35861855Ensembl.1
Natural variantiVAR_015969242R → I1 Publication1
Natural variantiVAR_015970304A → T1 PublicationCorresponds to variant dbSNP:rs4020187Ensembl.1
Natural variantiVAR_010317318R → H4 PublicationsCorresponds to variant dbSNP:rs1049267Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007814117 – 214Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41268 mRNA Translation: AAA69869.1
U24074 mRNA Translation: AAC50333.1
L76662 mRNA Translation: AAB36590.1
L76663 mRNA Translation: AAB36591.1
AF022048 mRNA Translation: AAB95321.1
U73395 mRNA Translation: AAC51147.1
BC032422 mRNA Translation: AAH32422.1
BC050730 mRNA Translation: AAH50730.1
AH006692 Genomic DNA Translation: AAC51651.1
AH007572 Genomic DNA Translation: AAD24477.1
CCDSiCCDS33107.1 [P43628-1]
PIRiI61725
RefSeqiNP_056952.2, NM_015868.2 [P43628-1]
UniGeneiHs.654608
Hs.731378

Genome annotation databases

EnsembliENST00000342376; ENSP00000342215; ENSG00000243772 [P43628-1]
ENST00000610407; ENSP00000478848; ENSG00000274830
ENST00000611207; ENSP00000478657; ENSG00000276218 [P43628-1]
ENST00000611369; ENSP00000483975; ENSG00000277484 [P43628-1]
ENST00000611821; ENSP00000484459; ENSG00000276590 [P43628-1]
ENST00000611990; ENSP00000479121; ENSG00000278327 [P43628-1]
ENST00000614792; ENSP00000481237; ENSG00000277554 [P43628-1]
ENST00000615091; ENSP00000483551; ENSG00000275658 [P43628-1]
ENST00000615739; ENSP00000478136; ENSG00000273887
ENST00000617150; ENSP00000481159; ENSG00000274952
ENST00000617242; ENSP00000483883; ENSG00000274410 [P43628-1]
ENST00000617404; ENSP00000481478; ENSG00000275008 [P43628-1]
ENST00000617593; ENSP00000483192; ENSG00000274108 [P43628-1]
ENST00000617790; ENSP00000481355; ENSG00000275623 [P43628-1]
ENST00000619702; ENSP00000480464; ENSG00000274402 [P43628-1]
ENST00000619995; ENSP00000480087; ENSG00000277317 [P43628-1]
ENST00000620549; ENSP00000483419; ENSG00000277924 [P43628-1]
ENST00000622644; ENSP00000482830; ENSG00000276459 [P43628-1]
ENST00000638813; ENSP00000492856; ENSG00000284333 [P43628-1]
ENST00000638851; ENSP00000491452; ENSG00000283708 [P43628-1]
ENST00000639089; ENSP00000491264; ENSG00000283702 [P43628-1]
ENST00000639101; ENSP00000492356; ENSG00000283790 [P43628-1]
ENST00000639176; ENSP00000491273; ENSG00000284504 [P43628-1]
ENST00000640485; ENSP00000491955; ENSG00000284510 [P43628-1]
GeneIDi3804
KEGGihsa:3804
UCSCiuc002qgx.4 human [P43628-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41268 mRNA Translation: AAA69869.1
U24074 mRNA Translation: AAC50333.1
L76662 mRNA Translation: AAB36590.1
L76663 mRNA Translation: AAB36591.1
AF022048 mRNA Translation: AAB95321.1
U73395 mRNA Translation: AAC51147.1
BC032422 mRNA Translation: AAH32422.1
BC050730 mRNA Translation: AAH50730.1
AH006692 Genomic DNA Translation: AAC51651.1
AH007572 Genomic DNA Translation: AAD24477.1
CCDSiCCDS33107.1 [P43628-1]
PIRiI61725
RefSeqiNP_056952.2, NM_015868.2 [P43628-1]
UniGeneiHs.654608
Hs.731378

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6UX-ray3.00A22-245[»]
ProteinModelPortaliP43628
SMRiP43628
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110005, 2 interactors
IntActiP43628, 70 interactors
MINTiP43628
STRINGi9606.ENSP00000342215

Chemistry databases

ChEMBLiCHEMBL3713026

PTM databases

iPTMnetiP43628
PhosphoSitePlusiP43628

Polymorphism and mutation databases

BioMutaiKIR2DL3
DMDMi1171727

Proteomic databases

PaxDbiP43628
PeptideAtlasiP43628
PRIDEiP43628
ProteomicsDBi55641
55642 [P43628-2]
TopDownProteomicsiP43628-1 [P43628-1]

Protocols and materials databases

DNASUi3804
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342376; ENSP00000342215; ENSG00000243772 [P43628-1]
ENST00000610407; ENSP00000478848; ENSG00000274830
ENST00000611207; ENSP00000478657; ENSG00000276218 [P43628-1]
ENST00000611369; ENSP00000483975; ENSG00000277484 [P43628-1]
ENST00000611821; ENSP00000484459; ENSG00000276590 [P43628-1]
ENST00000611990; ENSP00000479121; ENSG00000278327 [P43628-1]
ENST00000614792; ENSP00000481237; ENSG00000277554 [P43628-1]
ENST00000615091; ENSP00000483551; ENSG00000275658 [P43628-1]
ENST00000615739; ENSP00000478136; ENSG00000273887
ENST00000617150; ENSP00000481159; ENSG00000274952
ENST00000617242; ENSP00000483883; ENSG00000274410 [P43628-1]
ENST00000617404; ENSP00000481478; ENSG00000275008 [P43628-1]
ENST00000617593; ENSP00000483192; ENSG00000274108 [P43628-1]
ENST00000617790; ENSP00000481355; ENSG00000275623 [P43628-1]
ENST00000619702; ENSP00000480464; ENSG00000274402 [P43628-1]
ENST00000619995; ENSP00000480087; ENSG00000277317 [P43628-1]
ENST00000620549; ENSP00000483419; ENSG00000277924 [P43628-1]
ENST00000622644; ENSP00000482830; ENSG00000276459 [P43628-1]
ENST00000638813; ENSP00000492856; ENSG00000284333 [P43628-1]
ENST00000638851; ENSP00000491452; ENSG00000283708 [P43628-1]
ENST00000639089; ENSP00000491264; ENSG00000283702 [P43628-1]
ENST00000639101; ENSP00000492356; ENSG00000283790 [P43628-1]
ENST00000639176; ENSP00000491273; ENSG00000284504 [P43628-1]
ENST00000640485; ENSP00000491955; ENSG00000284510 [P43628-1]
GeneIDi3804
KEGGihsa:3804
UCSCiuc002qgx.4 human [P43628-1]

Organism-specific databases

CTDi3804
DisGeNETi3804
EuPathDBiHostDB:ENSG00000243772.7
GeneCardsiKIR2DL3
HGNCiHGNC:6331 KIR2DL3
MIMi604938 gene
neXtProtiNX_P43628
OpenTargetsiENSG00000243772
PharmGKBiPA30116
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119033
HOVERGENiHBG074353
InParanoidiP43628
KOiK07981
OMAiEEAHESW
OrthoDBiEOG091G0APE
PhylomeDBiP43628
TreeFamiTF352669

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiKIR2DL3 human
EvolutionaryTraceiP43628
GenomeRNAii3804
PROiPR:P43628
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243772 Expressed in 26 organ(s), highest expression level in blood
ExpressionAtlasiP43628 baseline and differential
GenevisibleiP43628 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI2L3_HUMAN
AccessioniPrimary (citable) accession number: P43628
Secondary accession number(s): O43472
, P78402, Q14944, Q14945, Q9UM51, Q9UQ70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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