KIR2DL3

Functionⁱ

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

GO - Molecular functionⁱ

antigen binding
Source: ProtInc
Traceable author statementⁱ
- 9059894
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7749980

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

immune response
Source: ProtInc
Traceable author statementⁱ
- 7749980
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Killer cell immunoglobulin-like receptor 2DL3 Alternative name(s): CD158 antigen-like family member B2 KIR-023GB Killer inhibitory receptor cl 2-3 MHC class I NK cell receptor NKAT2a NKAT2b Natural killer-associated transcript 2 Short name: NKAT-2 p58 natural killer cell receptor clone CL-6 Short name: p58 NK receptor CL-6 p58.2 MHC class-I-specific NK receptor CD_antigen: CD158b2
Gene namesⁱ	Name:KIR2DL3 Synonyms:CD158B2, KIRCL23, NKAT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000243772.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6331 KIR2DL3
MIMⁱ	604938 gene
neXtProtⁱ	NX_P43628

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 245	ExtracellularSequence analysisAdd BLAST	224
Transmembraneⁱ	246 – 265	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	266 – 341	CytoplasmicSequence analysisAdd BLAST	76

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3804
Open Targets More...OpenTargetsⁱ	ENSG00000243772
PharmGKBⁱ	PA30116

Chemistry databases

ChEMBLⁱ	CHEMBL3713026

ChEMBLⁱ

CHEMBL3713026

Polymorphism and mutation databases

BioMutaⁱ	KIR2DL3
DMDMⁱ	1171727

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	By similarityAdd BLAST		21
ChainⁱPRO_0000015080	22 – 341	Killer cell immunoglobulin-like receptor 2DL3Add BLAST		320

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 100	By similarity
Glycosylationⁱ	84	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	149 ↔ 198	By similarity
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	211	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P43628
PeptideAtlas More...PeptideAtlasⁱ	P43628
PRIDEⁱ	P43628
ProteomicsDBⁱ	55641 55642 [P43628-2]
TopDownProteomicsⁱ	P43628-1 [P43628-1]

PTM databases

iPTMnetⁱ	P43628
PhosphoSitePlusⁱ	P43628

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000243772 Expressed in 26 organ(s), highest expression level in blood
ExpressionAtlasⁱ	P43628 baseline and differential
Genevisibleⁱ	P43628 HS

Interactionⁱ

Subunit structureⁱ

Interacts with ARRB2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HLA-B	P30484	2	EBI-8632435,EBI-6163582
HLA-B	Q31612	2	EBI-8632435,EBI-9978548
HLA-C	P04222	3	EBI-8632435,EBI-13917186
HLA-C	P10321	2	EBI-8632435,EBI-9978491
HLA-C	P30499	2	EBI-8632435,EBI-13916865
HLA-C	P30501	2	EBI-8632435,EBI-9978392
HLA-C	P30505	2	EBI-8632435,EBI-6163567
HLA-C	Q29960	2	EBI-8632435,EBI-6163576
PTPN11	Q06124	4	EBI-8632435,EBI-297779
PTPN6	P29350	13	EBI-8632435,EBI-78260

Protein-protein interaction databases

BioGridⁱ	110005, 2 interactors
IntActⁱ	P43628, 70 interactors
Molecular INTeraction database More...MINTⁱ	P43628
STRINGⁱ	9606.ENSP00000342215

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 42	Combined sources	6
Beta strandⁱ	45 – 53	Combined sources	9
Beta strandⁱ	56 – 64	Combined sources	9
Beta strandⁱ	68 – 73	Combined sources	6
Beta strandⁱ	81 – 87	Combined sources	7
Turnⁱ	92 – 94	Combined sources	3
Beta strandⁱ	96 – 103	Combined sources	8
Beta strandⁱ	118 – 123	Combined sources	6
Beta strandⁱ	130 – 132	Combined sources	3
Beta strandⁱ	144 – 150	Combined sources	7
Beta strandⁱ	156 – 162	Combined sources	7
Beta strandⁱ	177 – 179	Combined sources	3
Beta strandⁱ	182 – 189	Combined sources	8
Beta strandⁱ	194 – 201	Combined sources	8
Beta strandⁱ	216 – 218	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P43628
SMRⁱ	P43628
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P43628

EvolutionaryTraceⁱ

P43628

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	42 – 107	Ig-like C2-type 1Add BLAST		66
Domainⁱ	142 – 205	Ig-like C2-type 2Add BLAST		64

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119033
HOVERGENⁱ	HBG074353
InParanoidⁱ	P43628
KEGG Orthology (KO) More...KOⁱ	K07981
OMAⁱ	EEAHESW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0APE
PhylomeDBⁱ	P43628
TreeFamⁱ	TF352669

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047 ig, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P43628-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW 
        60         70         80         90        100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC 
       110        120        130        140        150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS 
       160        170        180        190        200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG 
       210        220        230        240        250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT 
       260        270        280        290        300
SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE 
       310        320        330        340 
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P

Length:341

Mass (Da):37,886

Last modified:November 1, 1995 - v1

Checksum:ⁱC21EAFF80EA9AAB2

GO

Isoform 2 (identifier: P43628-2) [UniParc]FASTA Add to basket

Also known as: NKAT2a-delta-Ig2

The sequence of this isoform differs from the canonical sequence as follows:
117-214: Missing.

« Hide

        10         20         30         40         50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW 
        60         70         80         90        100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC 
       110        120        130        140        150
YGSVTHSPYQ LSAPSDPLLV SVTGNPSNSW PSPTEPSSET GNPRHLHVLI 
       160        170        180        190        200
GTSVVIILFI LLLFFLLHRW CCNKKNAVVM DQEPAGNRTV NREDSDEQDP 
       210        220        230        240 
QEVTYAQLNH CVFTQRKITR PSQRPKTPPT DIIVYTELPN AEP

Show »

Length:243

Mass (Da):27,269

Checksum:ⁱ86E3E532F7335609

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2JPP8	A0A0G2JPP8_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL3	KIR2DL3	349	Annotation score:
A0A0G2JNW9	A0A0G2JNW9_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL3	KIR2DL3	341	Annotation score:
A0A191URJ0	A0A191URJ0_HUMAN	KIR2DL3 KIR2DL3 (Killer cell immunoglobulin-like receptor 2DL3) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3)	KIR2DL3	341	Annotation score:
A0A0C4ZLV8	A0A0C4ZLV8_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL3 (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3)	KIR2DL3	341	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_010313	9	V → A2 PublicationsCorresponds to variant dbSNP:rs3810343Ensembl.	1
Natural variantⁱVAR_010314	32	L → R2 PublicationsCorresponds to variant dbSNP:rs202032116Ensembl.	1
Natural variantⁱVAR_015967	34	H → Q1 PublicationCorresponds to variant dbSNP:rs683003Ensembl.	1
Natural variantⁱVAR_049978	37	P → R. Corresponds to variant dbSNP:rs613240Ensembl.	1
Natural variantⁱVAR_010315	56	Q → E2 PublicationsCorresponds to variant dbSNP:rs35719984Ensembl.	1
Natural variantⁱVAR_049979	66	F → Y. Corresponds to variant dbSNP:rs78713511Ensembl.	1
Natural variantⁱVAR_010316	71	H → R2 PublicationsCorresponds to variant dbSNP:rs138897134Ensembl.	1
Natural variantⁱVAR_015968	229	P → L3 PublicationsCorresponds to variant dbSNP:rs35861855Ensembl.	1
Natural variantⁱVAR_015969	242	R → I1 Publication	1
Natural variantⁱVAR_015970	304	A → T1 PublicationCorresponds to variant dbSNP:rs4020187Ensembl.	1
Natural variantⁱVAR_010317	318	R → H4 PublicationsCorresponds to variant dbSNP:rs1049267Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_007814	117 – 214	Missing in isoform 2. 1 PublicationAdd BLAST		98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41268 mRNA Translation: AAA69869.1 U24074 mRNA Translation: AAC50333.1 L76662 mRNA Translation: AAB36590.1 L76663 mRNA Translation: AAB36591.1 AF022048 mRNA Translation: AAB95321.1 U73395 mRNA Translation: AAC51147.1 BC032422 mRNA Translation: AAH32422.1 BC050730 mRNA Translation: AAH50730.1 AH006692 Genomic DNA Translation: AAC51651.1 AH007572 Genomic DNA Translation: AAD24477.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33107.1 [P43628-1]
PIRⁱ	I61725
NCBI Reference Sequences More...RefSeqⁱ	NP_056952.2, NM_015868.2 [P43628-1]
UniGeneⁱ	Hs.654608 Hs.731378

Genome annotation databases

Ensemblⁱ	ENST00000342376; ENSP00000342215; ENSG00000243772 [P43628-1] ENST00000610407; ENSP00000478848; ENSG00000274830 ENST00000611207; ENSP00000478657; ENSG00000276218 [P43628-1] ENST00000611369; ENSP00000483975; ENSG00000277484 [P43628-1] ENST00000611821; ENSP00000484459; ENSG00000276590 [P43628-1] ENST00000611990; ENSP00000479121; ENSG00000278327 [P43628-1] ENST00000614792; ENSP00000481237; ENSG00000277554 [P43628-1] ENST00000615091; ENSP00000483551; ENSG00000275658 [P43628-1] ENST00000615739; ENSP00000478136; ENSG00000273887 ENST00000617150; ENSP00000481159; ENSG00000274952 ENST00000617242; ENSP00000483883; ENSG00000274410 [P43628-1] ENST00000617404; ENSP00000481478; ENSG00000275008 [P43628-1] ENST00000617593; ENSP00000483192; ENSG00000274108 [P43628-1] ENST00000617790; ENSP00000481355; ENSG00000275623 [P43628-1] ENST00000619702; ENSP00000480464; ENSG00000274402 [P43628-1] ENST00000619995; ENSP00000480087; ENSG00000277317 [P43628-1] ENST00000620549; ENSP00000483419; ENSG00000277924 [P43628-1] ENST00000622644; ENSP00000482830; ENSG00000276459 [P43628-1] ENST00000638813; ENSP00000492856; ENSG00000284333 [P43628-1] ENST00000638851; ENSP00000491452; ENSG00000283708 [P43628-1] ENST00000639089; ENSP00000491264; ENSG00000283702 [P43628-1] ENST00000639101; ENSP00000492356; ENSG00000283790 [P43628-1] ENST00000639176; ENSP00000491273; ENSG00000284504 [P43628-1] ENST00000640485; ENSP00000491955; ENSG00000284510 [P43628-1]
GeneIDⁱ	3804
KEGGⁱ	hsa:3804
UCSC genome browser More...UCSCⁱ	uc002qgx.4 human [P43628-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43628	KIR2DL3		HUMAN		341	UniRef100_P43628
KIR2DL3 (Fragment)		HUMAN		337
KIR2DL3 (Fragment)		HUMAN		273

Protein	Similar proteins		Species	Score	Length	Source
P43628	Killer cell immunoglobulin-like receptor 2DL1	)	HUMAN		348	UniRef90_P43626
Killer-cell Ig-like receptor KIR2DLc		western gorilla		353
KIR2DL7		PANTR		349
Killer cell immunoglobulin-like receptor 2DS2	)	HUMAN		304
Killer cell immunoglobulin-like receptor 2DS1		HUMAN		304
+122
P43628-2	KIR2DL2 protein		HUMAN		250	UniRef90_P43628-2
Natural killer-associated transcript 2a protein		HUMAN		243
KIR2DL3 protein		HUMAN		243

Protein	Similar proteins		Species	Score	Length	Source
P43628	Killer cell immunoglobulin-like receptor 2DL1	)	HUMAN		348	UniRef50_P43626
Killer-cell Ig-like receptor KIR2DLc		western gorilla		353
Uncharacterized protein		PANTR		349
killer cell immunoglobulin-like receptor 2DS2 isoform X2		ODORO		341
Uncharacterized protein		RHIRO		341
+289
P43628-2	KIR2DL2 protein		HUMAN		250	UniRef50_P43628-2
Uncharacterized protein		CERAT		267
Killer immunoglobulin-like receptor 2DL4 splice variant		MACFA		279
Uncharacterized protein		GORGO		248
Uncharacterized protein		PANPA		257
+44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41268 mRNA Translation: AAA69869.1 U24074 mRNA Translation: AAC50333.1 L76662 mRNA Translation: AAB36590.1 L76663 mRNA Translation: AAB36591.1 AF022048 mRNA Translation: AAB95321.1 U73395 mRNA Translation: AAC51147.1 BC032422 mRNA Translation: AAH32422.1 BC050730 mRNA Translation: AAH50730.1 AH006692 Genomic DNA Translation: AAC51651.1 AH007572 Genomic DNA Translation: AAD24477.1
CCDSⁱ	CCDS33107.1 [P43628-1]
PIRⁱ	I61725
RefSeqⁱ	NP_056952.2, NM_015868.2 [P43628-1]
UniGeneⁱ	Hs.654608 Hs.731378

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1B6U	X-ray	3.00	A	22-245	[»]
ProteinModelPortalⁱ	P43628
SMRⁱ	P43628
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110005, 2 interactors
IntActⁱ	P43628, 70 interactors
MINTⁱ	P43628
STRINGⁱ	9606.ENSP00000342215

Chemistry databases

ChEMBLⁱ	CHEMBL3713026

ChEMBLⁱ

CHEMBL3713026

PTM databases

iPTMnetⁱ	P43628
PhosphoSitePlusⁱ	P43628

Polymorphism and mutation databases

BioMutaⁱ	KIR2DL3
DMDMⁱ	1171727

Proteomic databases

PaxDbⁱ	P43628
PeptideAtlasⁱ	P43628
PRIDEⁱ	P43628
ProteomicsDBⁱ	55641 55642 [P43628-2]
TopDownProteomicsⁱ	P43628-1 [P43628-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3804
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000342376; ENSP00000342215; ENSG00000243772 [P43628-1] ENST00000610407; ENSP00000478848; ENSG00000274830 ENST00000611207; ENSP00000478657; ENSG00000276218 [P43628-1] ENST00000611369; ENSP00000483975; ENSG00000277484 [P43628-1] ENST00000611821; ENSP00000484459; ENSG00000276590 [P43628-1] ENST00000611990; ENSP00000479121; ENSG00000278327 [P43628-1] ENST00000614792; ENSP00000481237; ENSG00000277554 [P43628-1] ENST00000615091; ENSP00000483551; ENSG00000275658 [P43628-1] ENST00000615739; ENSP00000478136; ENSG00000273887 ENST00000617150; ENSP00000481159; ENSG00000274952 ENST00000617242; ENSP00000483883; ENSG00000274410 [P43628-1] ENST00000617404; ENSP00000481478; ENSG00000275008 [P43628-1] ENST00000617593; ENSP00000483192; ENSG00000274108 [P43628-1] ENST00000617790; ENSP00000481355; ENSG00000275623 [P43628-1] ENST00000619702; ENSP00000480464; ENSG00000274402 [P43628-1] ENST00000619995; ENSP00000480087; ENSG00000277317 [P43628-1] ENST00000620549; ENSP00000483419; ENSG00000277924 [P43628-1] ENST00000622644; ENSP00000482830; ENSG00000276459 [P43628-1] ENST00000638813; ENSP00000492856; ENSG00000284333 [P43628-1] ENST00000638851; ENSP00000491452; ENSG00000283708 [P43628-1] ENST00000639089; ENSP00000491264; ENSG00000283702 [P43628-1] ENST00000639101; ENSP00000492356; ENSG00000283790 [P43628-1] ENST00000639176; ENSP00000491273; ENSG00000284504 [P43628-1] ENST00000640485; ENSP00000491955; ENSG00000284510 [P43628-1]
GeneIDⁱ	3804
KEGGⁱ	hsa:3804
UCSCⁱ	uc002qgx.4 human [P43628-1]

Organism-specific databases

CTDⁱ	3804
DisGeNETⁱ	3804
EuPathDBⁱ	HostDB:ENSG00000243772.7
GeneCardsⁱ	KIR2DL3
HGNCⁱ	HGNC:6331 KIR2DL3
MIMⁱ	604938 gene
neXtProtⁱ	NX_P43628
OpenTargetsⁱ	ENSG00000243772
PharmGKBⁱ	PA30116
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119033
HOVERGENⁱ	HBG074353
InParanoidⁱ	P43628
KOⁱ	K07981
OMAⁱ	EEAHESW
OrthoDBⁱ	EOG091G0APE
PhylomeDBⁱ	P43628
TreeFamⁱ	TF352669

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSⁱ	KIR2DL3 human
EvolutionaryTraceⁱ	P43628
GenomeRNAiⁱ	3804
Protein Ontology More...PROⁱ	PR:P43628
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000243772 Expressed in 26 organ(s), highest expression level in blood
ExpressionAtlasⁱ	P43628 baseline and differential
Genevisibleⁱ	P43628 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013151 Immunoglobulin
Pfamⁱ	View protein in Pfam PF00047 ig, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KI2L3_HUMAN
Accessionⁱ	P43628Primary (citable) accession number: P43628 Secondary accession number(s): O43472 , P78402, Q14944, Q14945, Q9UM51, Q9UQ70
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P43628 (KI2L3_HUMAN)

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Killer cell immunoglobulin-like receptor 2DL3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ