UniProtKB - P43628 (KI2L3_HUMAN)
Protein
Killer cell immunoglobulin-like receptor 2DL3
Gene
KIR2DL3
Organism
Homo sapiens (Human)
Status
Functioni
Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
GO - Molecular functioni
- antigen binding Source: ProtInc
- identical protein binding Source: IntAct
- signaling receptor activity Source: ProtInc
GO - Biological processi
- immune response Source: ProtInc
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P43628 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Killer cell immunoglobulin-like receptor 2DL3Alternative name(s): CD158 antigen-like family member B2 KIR-023GB Killer inhibitory receptor cl 2-3 MHC class I NK cell receptor NKAT2a NKAT2b Natural killer-associated transcript 2 Short name: NKAT-2 p58 natural killer cell receptor clone CL-6 Short name: p58 NK receptor CL-6 p58.2 MHC class-I-specific NK receptor CD_antigen: CD158b2 |
Gene namesi | Name:KIR2DL3 Synonyms:CD158B2, KIRCL23, NKAT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6331, KIR2DL3 |
MIMi | 604938, gene |
neXtProti | NX_P43628 |
VEuPathDBi | HostDB:ENSG00000243772.7 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 245 | ExtracellularSequence analysisAdd BLAST | 224 | |
Transmembranei | 246 – 265 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 266 – 341 | CytoplasmicSequence analysisAdd BLAST | 76 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3804 |
OpenTargetsi | ENSG00000243772 |
PharmGKBi | PA30116 |
Miscellaneous databases
Pharosi | P43628, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3713026 |
Genetic variation databases
BioMutai | KIR2DL3 |
DMDMi | 1171727 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000015080 | 22 – 341 | Killer cell immunoglobulin-like receptor 2DL3Add BLAST | 320 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 100 | By similarity | ||
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 149 ↔ 198 | By similarity | ||
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 211 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P43628 |
MassIVEi | P43628 |
PaxDbi | P43628 |
PeptideAtlasi | P43628 |
PRIDEi | P43628 |
ProteomicsDBi | 55641 [P43628-1] 55642 [P43628-2] |
TopDownProteomicsi | P43628-1 [P43628-1] |
PTM databases
GlyGeni | P43628, 3 sites |
iPTMneti | P43628 |
PhosphoSitePlusi | P43628 |
Expressioni
Gene expression databases
Bgeei | ENSG00000243772, Expressed in blood and 40 other tissues |
ExpressionAtlasi | P43628, baseline and differential |
Genevisiblei | P43628, HS |
Organism-specific databases
HPAi | ENSG00000243772, Tissue enhanced (lung, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with ARRB2.
1 PublicationBinary interactionsi
P43628
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 110005, 63 interactors |
IntActi | P43628, 77 interactors |
MINTi | P43628 |
STRINGi | 9606.ENSP00000342215 |
Miscellaneous databases
RNActi | P43628, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P43628 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43628 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 107 | Ig-like C2-type 1Add BLAST | 66 | |
Domaini | 142 – 205 | Ig-like C2-type 2Add BLAST | 64 |
Sequence similaritiesi
Belongs to the immunoglobulin superfamily.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU21, Eukaryota |
GeneTreei | ENSGT00980000198504 |
InParanoidi | P43628 |
OMAi | VACVGEC |
PhylomeDBi | P43628 |
TreeFami | TF352669 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P43628-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
310 320 330 340
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JNW9 | A0A0G2JNW9_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL3 | 341 | Annotation score: | ||
A0A0G2JPP8 | A0A0G2JPP8_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL3 | 349 | Annotation score: | ||
A0A191URJ0 | A0A191URJ0_HUMAN | KIR2DL3 | KIR2DL3 | 341 | Annotation score: | ||
A0A0C4ZLV8 | A0A0C4ZLV8_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL3 | 341 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010313 | 9 | V → A2 PublicationsCorresponds to variant dbSNP:rs3810343Ensembl. | 1 | |
Natural variantiVAR_010314 | 32 | L → R2 PublicationsCorresponds to variant dbSNP:rs202032116Ensembl. | 1 | |
Natural variantiVAR_015967 | 34 | H → Q1 PublicationCorresponds to variant dbSNP:rs683003Ensembl. | 1 | |
Natural variantiVAR_049978 | 37 | P → R. Corresponds to variant dbSNP:rs613240Ensembl. | 1 | |
Natural variantiVAR_010315 | 56 | Q → E2 PublicationsCorresponds to variant dbSNP:rs35719984Ensembl. | 1 | |
Natural variantiVAR_049979 | 66 | F → Y. Corresponds to variant dbSNP:rs78713511Ensembl. | 1 | |
Natural variantiVAR_010316 | 71 | H → R2 PublicationsCorresponds to variant dbSNP:rs138897134Ensembl. | 1 | |
Natural variantiVAR_015968 | 229 | P → L3 PublicationsCorresponds to variant dbSNP:rs35861855Ensembl. | 1 | |
Natural variantiVAR_015969 | 242 | R → I1 Publication | 1 | |
Natural variantiVAR_015970 | 304 | A → T1 PublicationCorresponds to variant dbSNP:rs4020187Ensembl. | 1 | |
Natural variantiVAR_010317 | 318 | R → H4 PublicationsCorresponds to variant dbSNP:rs1049267Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007814 | 117 – 214 | Missing in isoform 2. 1 PublicationAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41268 mRNA Translation: AAA69869.1 U24074 mRNA Translation: AAC50333.1 L76662 mRNA Translation: AAB36590.1 L76663 mRNA Translation: AAB36591.1 AF022048 mRNA Translation: AAB95321.1 U73395 mRNA Translation: AAC51147.1 BC032422 mRNA Translation: AAH32422.1 BC050730 mRNA Translation: AAH50730.1 AH006692 Genomic DNA Translation: AAC51651.1 AH007572 Genomic DNA Translation: AAD24477.1 |
CCDSi | CCDS33107.1 [P43628-1] |
PIRi | I61725 |
RefSeqi | NP_056952.2, NM_015868.2 [P43628-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41268 mRNA Translation: AAA69869.1 U24074 mRNA Translation: AAC50333.1 L76662 mRNA Translation: AAB36590.1 L76663 mRNA Translation: AAB36591.1 AF022048 mRNA Translation: AAB95321.1 U73395 mRNA Translation: AAC51147.1 BC032422 mRNA Translation: AAH32422.1 BC050730 mRNA Translation: AAH50730.1 AH006692 Genomic DNA Translation: AAC51651.1 AH007572 Genomic DNA Translation: AAD24477.1 |
CCDSi | CCDS33107.1 [P43628-1] |
PIRi | I61725 |
RefSeqi | NP_056952.2, NM_015868.2 [P43628-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B6U | X-ray | 3.00 | A | 22-245 | [»] | |
6PAG | X-ray | 2.50 | D | 22-225 | [»] | |
SMRi | P43628 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110005, 63 interactors |
IntActi | P43628, 77 interactors |
MINTi | P43628 |
STRINGi | 9606.ENSP00000342215 |
Chemistry databases
ChEMBLi | CHEMBL3713026 |
PTM databases
GlyGeni | P43628, 3 sites |
iPTMneti | P43628 |
PhosphoSitePlusi | P43628 |
Genetic variation databases
BioMutai | KIR2DL3 |
DMDMi | 1171727 |
Proteomic databases
jPOSTi | P43628 |
MassIVEi | P43628 |
PaxDbi | P43628 |
PeptideAtlasi | P43628 |
PRIDEi | P43628 |
ProteomicsDBi | 55641 [P43628-1] 55642 [P43628-2] |
TopDownProteomicsi | P43628-1 [P43628-1] |
Protocols and materials databases
ABCDi | P43628, 1 sequenced antibody |
Antibodypediai | 35081, 530 antibodies |
DNASUi | 3804 |
Genome annotation databases
Organism-specific databases
CTDi | 3804 |
DisGeNETi | 3804 |
GeneCardsi | KIR2DL3 |
HGNCi | HGNC:6331, KIR2DL3 |
HPAi | ENSG00000243772, Tissue enhanced (lung, lymphoid tissue) |
MIMi | 604938, gene |
neXtProti | NX_P43628 |
OpenTargetsi | ENSG00000243772 |
PharmGKBi | PA30116 |
VEuPathDBi | HostDB:ENSG00000243772.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU21, Eukaryota |
GeneTreei | ENSGT00980000198504 |
InParanoidi | P43628 |
OMAi | VACVGEC |
PhylomeDBi | P43628 |
TreeFami | TF352669 |
Enzyme and pathway databases
PathwayCommonsi | P43628 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 3804, 8 hits in 898 CRISPR screens |
ChiTaRSi | KIR2DL3, human |
EvolutionaryTracei | P43628 |
GenomeRNAii | 3804 |
Pharosi | P43628, Tbio |
PROi | PR:P43628 |
RNActi | P43628, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000243772, Expressed in blood and 40 other tissues |
ExpressionAtlasi | P43628, baseline and differential |
Genevisiblei | P43628, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KI2L3_HUMAN | |
Accessioni | P43628Primary (citable) accession number: P43628 Secondary accession number(s): O43472 Q9UQ70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families