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UniProtKB - P43628 (KI2L3_HUMAN)

Entry version 200 (25 May 2022)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
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Protein

Killer cell immunoglobulin-like receptor 2DL3

Gene

KIR2DL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P43628

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P43628

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL3Curated
Alternative name(s):
CD158 antigen-like family member B2
KIR-023GB
Killer inhibitory receptor cl 2-3
NKAT2a
NKAT2b
Natural killer-associated transcript 2
Short name:
NKAT-2
p58 natural killer cell receptor clone CL-6
Short name:
p58 NK receptor CL-6
p58.2 MHC class-I-specific NK receptor
CD_antigen: CD158b2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIR2DL3Imported
Synonyms:CD158B2, KIRCL23, NKAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6331, KIR2DL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604938, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P43628

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000243772

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 341CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3804

Open Targets

More...OpenTargetsi		ENSG00000243772

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30116

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P43628, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3713026

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIR2DL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		1171727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001508022 – 341Killer cell immunoglobulin-like receptor 2DL3Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 100By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P43628

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P43628

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P43628

PeptideAtlas

More...PeptideAtlasi		P43628

PRoteomics IDEntifications database

More...PRIDEi		P43628

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55641 [P43628-1]
55642 [P43628-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P43628-1 [P43628-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P43628, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43628

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P43628

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000243772, Expressed in blood and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P43628, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P43628, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000243772, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARRB2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P43628
With#Exp.IntAct
ADGRE2 [Q9UHX3]3EBI-8632435,EBI-11277970
AGTRAP - isoform 2 [Q6RW13-2]3EBI-8632435,EBI-11522760
AIG1 - isoform 1 [Q9NVV5-2]3EBI-8632435,EBI-11957045
ANKRD46 - isoform 1 [Q86W74-2]3EBI-8632435,EBI-12109402
APOA2 [P02652]3EBI-8632435,EBI-1171525
APOD [P05090]3EBI-8632435,EBI-715495
AQP10 [Q96PS8]3EBI-8632435,EBI-12820279
ASGR1 [P07306]3EBI-8632435,EBI-1172335
ATP6V0E1 [O15342]3EBI-8632435,EBI-12935759
BMP10 [O95393]3EBI-8632435,EBI-3922513
BRICD5 - isoform 2 [Q6PL45-2]3EBI-8632435,EBI-12244618
BTN2A2 [Q8WVV5]3EBI-8632435,EBI-8648738
CDIPT [O14735]3EBI-8632435,EBI-358858
CISD2 [Q8N5K1]3EBI-8632435,EBI-1045797
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-8632435,EBI-12256978
CLN6 [Q9NWW5]3EBI-8632435,EBI-6165897
COQ9 [O75208]3EBI-8632435,EBI-724524
CXCL9 [Q07325]3EBI-8632435,EBI-3911467
CYB5B [O43169]3EBI-8632435,EBI-1058710
CYBC1 [Q9BQA9]3EBI-8632435,EBI-2680384
EMD [P50402]3EBI-8632435,EBI-489887
FAM209A [Q5JX71]3EBI-8632435,EBI-18304435
FAM3C [Q92520]3EBI-8632435,EBI-2876774
FUNDC2 [Q9BWH2]3EBI-8632435,EBI-714482
GAST [P01350]3EBI-8632435,EBI-3436637
GJA8 [P48165]3EBI-8632435,EBI-17458373
GPR108 [Q9NPR9]3EBI-8632435,EBI-11343451
GPX8 [Q8TED1]3EBI-8632435,EBI-11721746
HLA-B [P01889]2EBI-8632435,EBI-1046513
HLA-C [P10321]9EBI-8632435,EBI-1051396
HLA-C [Q53YP1]2EBI-8632435,EBI-13917186
IFITM3 [Q01628]3EBI-8632435,EBI-7932862
INSIG2 [Q9Y5U4]3EBI-8632435,EBI-8503746
ITGAM [P11215]3EBI-8632435,EBI-2568251
JAGN1 [Q8N5M9]3EBI-8632435,EBI-10266796
itself3EBI-8632435,EBI-8632435
KTN1 - isoform 3 [Q86UP2-3]3EBI-8632435,EBI-12007212
LAT - isoform 2 [O43561-2]3EBI-8632435,EBI-8070286
LEUTX [A8MZ59]3EBI-8632435,EBI-17490413
LHFPL5 [Q8TAF8]3EBI-8632435,EBI-2820517
NINJ2 [Q9NZG7]3EBI-8632435,EBI-10317425
NRM [Q8IXM6]3EBI-8632435,EBI-10262547
NSG1 [P42857]3EBI-8632435,EBI-6380741
OLFM4 [Q6UX06]3EBI-8632435,EBI-2804156
PLN [P26678]3EBI-8632435,EBI-692836
PLPPR2 [Q96GM1]3EBI-8632435,EBI-12955265
PTPN11 [Q06124]4EBI-8632435,EBI-297779
PTPN6 [P29350]13EBI-8632435,EBI-78260
RNF152 [Q8N8N0]3EBI-8632435,EBI-2129725
RTP2 [Q5QGT7]3EBI-8632435,EBI-10244780
SEC22B [O75396]3EBI-8632435,EBI-1058865
SLC38A7 [Q9NVC3]3EBI-8632435,EBI-10314552
SMIM1 [B2RUZ4]3EBI-8632435,EBI-12188413
SNORC [Q6UX34]3EBI-8632435,EBI-11957067
THBD [P07204]3EBI-8632435,EBI-941422
TMEM218 [A2RU14]3EBI-8632435,EBI-10173151
TMEM222 [Q9H0R3]3EBI-8632435,EBI-347385
TMEM243 [Q9BU79]3EBI-8632435,EBI-12887458
TMEM86B [Q8N661]3EBI-8632435,EBI-2548832
TMEM97 [Q5BJF2]3EBI-8632435,EBI-12111910
TRAF3IP3 [Q9Y228]3EBI-8632435,EBI-765817
TTMP [Q5BVD1]3EBI-8632435,EBI-10243654
UPK1B [O75841]3EBI-8632435,EBI-12237619
UPK2 [O00526]3EBI-8632435,EBI-10179682
VAMP5 [O95183]3EBI-8632435,EBI-10191195

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110005, 63 interactors

Protein interaction database and analysis system

More...IntActi		P43628, 76 interactors

Molecular INTeraction database

More...MINTi		P43628

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000342215

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43628, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P43628

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43628

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P43628

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni220 – 239DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RU21, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00980000198504

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43628

Identification of Orthologs from Complete Genome Data

More...OMAi		PELHGHH

Database for complete collections of gene phylogenies

More...PhylomeDBi		P43628

TreeFam database of animal gene trees

More...TreeFami		TF352669

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00047, ig, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43628-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW 
        60         70         80         90        100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC 
       110        120        130        140        150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS 
       160        170        180        190        200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG 
       210        220        230        240        250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT 
       260        270        280        290        300
SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE 
       310        320        330        340 
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
Length:341
Mass (Da):37,886
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC21EAFF80EA9AAB2
GO
Isoform 2 (identifier: P43628-2) [UniParc]FASTAAdd to basket
Also known as: NKAT2a-delta-Ig2

The sequence of this isoform differs from the canonical sequence as follows:
     117-214: Missing.

Show »
Length:243
Mass (Da):27,269
Checksum:i86E3E532F7335609
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A191URJ0A0A191URJ0_HUMAN
KIR2DL3
KIR2DL3 KIR2DL32DL3*00501_extension_1
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNW9A0A0G2JNW9_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL3
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPP8A0A0G2JPP8_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL3
349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4ZLV8A0A0C4ZLV8_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL3
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0103139V → A2 PublicationsCorresponds to variant dbSNP:rs3810343Ensembl.1
Natural variantiVAR_01031432L → R2 PublicationsCorresponds to variant dbSNP:rs202032116Ensembl.1
Natural variantiVAR_01596734H → Q1 PublicationCorresponds to variant dbSNP:rs683003Ensembl.1
Natural variantiVAR_04997837P → R. Corresponds to variant dbSNP:rs613240Ensembl.1
Natural variantiVAR_01031556Q → E2 PublicationsCorresponds to variant dbSNP:rs35719984Ensembl.1
Natural variantiVAR_04997966F → Y. Corresponds to variant dbSNP:rs78713511Ensembl.1
Natural variantiVAR_01031671H → R2 PublicationsCorresponds to variant dbSNP:rs138897134Ensembl.1
Natural variantiVAR_015968229P → L3 PublicationsCorresponds to variant dbSNP:rs35861855Ensembl.1
Natural variantiVAR_015969242R → I1 Publication1
Natural variantiVAR_015970304A → T1 PublicationCorresponds to variant dbSNP:rs4020187Ensembl.1
Natural variantiVAR_010317318R → H4 PublicationsCorresponds to variant dbSNP:rs1049267Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007814117 – 214Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L41268 mRNA Translation: AAA69869.1
U24074 mRNA Translation: AAC50333.1
L76662 mRNA Translation: AAB36590.1
L76663 mRNA Translation: AAB36591.1
AF022048 mRNA Translation: AAB95321.1
U73395 mRNA Translation: AAC51147.1
BC032422 mRNA Translation: AAH32422.1
BC050730 mRNA Translation: AAH50730.1
AH006692 Genomic DNA Translation: AAC51651.1
AH007572 Genomic DNA Translation: AAD24477.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33107.1 [P43628-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I61725

NCBI Reference Sequences

More...RefSeqi		NP_056952.2, NM_015868.2 [P43628-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342376.4; ENSP00000342215.3; ENSG00000243772.8
ENST00000610407.4; ENSP00000478848.1; ENSG00000274830.5
ENST00000611207.4; ENSP00000478657.1; ENSG00000276218.5
ENST00000611369.4; ENSP00000483975.1; ENSG00000277484.5
ENST00000611821.4; ENSP00000484459.1; ENSG00000276590.5
ENST00000611990.4; ENSP00000479121.1; ENSG00000278327.5
ENST00000614792.4; ENSP00000481237.1; ENSG00000277554.5
ENST00000615091.4; ENSP00000483551.1; ENSG00000275658.5
ENST00000615739.1; ENSP00000478136.1; ENSG00000273887.1
ENST00000617150.4; ENSP00000481159.1; ENSG00000274952.5
ENST00000617242.4; ENSP00000483883.1; ENSG00000274410.5
ENST00000617404.1; ENSP00000481478.1; ENSG00000275008.1
ENST00000617593.4; ENSP00000483192.1; ENSG00000274108.5
ENST00000617790.4; ENSP00000481355.1; ENSG00000275623.5
ENST00000619702.1; ENSP00000480464.1; ENSG00000274402.1
ENST00000619995.4; ENSP00000480087.1; ENSG00000277317.5
ENST00000620549.4; ENSP00000483419.1; ENSG00000277924.5
ENST00000622644.4; ENSP00000482830.1; ENSG00000276459.5
ENST00000638813.2; ENSP00000492856.1; ENSG00000284333.2
ENST00000638851.2; ENSP00000491452.1; ENSG00000283708.2
ENST00000639089.2; ENSP00000491264.1; ENSG00000283702.2
ENST00000639101.2; ENSP00000492356.1; ENSG00000283790.2
ENST00000639176.2; ENSP00000491273.1; ENSG00000284504.2
ENST00000640485.2; ENSP00000491955.1; ENSG00000284510.2

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3804

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000342376.4; ENSP00000342215.3; NM_015868.3; NP_056952.2

UCSC genome browser

More...UCSCi		uc002qgx.4, human [P43628-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41268 mRNA Translation: AAA69869.1
U24074 mRNA Translation: AAC50333.1
L76662 mRNA Translation: AAB36590.1
L76663 mRNA Translation: AAB36591.1
AF022048 mRNA Translation: AAB95321.1
U73395 mRNA Translation: AAC51147.1
BC032422 mRNA Translation: AAH32422.1
BC050730 mRNA Translation: AAH50730.1
AH006692 Genomic DNA Translation: AAC51651.1
AH007572 Genomic DNA Translation: AAD24477.1
CCDSiCCDS33107.1 [P43628-1]
PIRiI61725
RefSeqiNP_056952.2, NM_015868.2 [P43628-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6UX-ray3.00A22-245[»]
6PAGX-ray2.50D22-225[»]
AlphaFoldDBiP43628
SMRiP43628
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110005, 63 interactors
IntActiP43628, 76 interactors
MINTiP43628
STRINGi9606.ENSP00000342215

Chemistry databases

ChEMBLiCHEMBL3713026

PTM databases

GlyGeniP43628, 3 sites
iPTMnetiP43628
PhosphoSitePlusiP43628

Genetic variation databases

BioMutaiKIR2DL3
DMDMi1171727

Proteomic databases

jPOSTiP43628
MassIVEiP43628
PaxDbiP43628
PeptideAtlasiP43628
PRIDEiP43628
ProteomicsDBi55641 [P43628-1]
55642 [P43628-2]
TopDownProteomicsiP43628-1 [P43628-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P43628, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35081, 544 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		3804

Genome annotation databases

EnsembliENST00000342376.4; ENSP00000342215.3; ENSG00000243772.8
ENST00000610407.4; ENSP00000478848.1; ENSG00000274830.5
ENST00000611207.4; ENSP00000478657.1; ENSG00000276218.5
ENST00000611369.4; ENSP00000483975.1; ENSG00000277484.5
ENST00000611821.4; ENSP00000484459.1; ENSG00000276590.5
ENST00000611990.4; ENSP00000479121.1; ENSG00000278327.5
ENST00000614792.4; ENSP00000481237.1; ENSG00000277554.5
ENST00000615091.4; ENSP00000483551.1; ENSG00000275658.5
ENST00000615739.1; ENSP00000478136.1; ENSG00000273887.1
ENST00000617150.4; ENSP00000481159.1; ENSG00000274952.5
ENST00000617242.4; ENSP00000483883.1; ENSG00000274410.5
ENST00000617404.1; ENSP00000481478.1; ENSG00000275008.1
ENST00000617593.4; ENSP00000483192.1; ENSG00000274108.5
ENST00000617790.4; ENSP00000481355.1; ENSG00000275623.5
ENST00000619702.1; ENSP00000480464.1; ENSG00000274402.1
ENST00000619995.4; ENSP00000480087.1; ENSG00000277317.5
ENST00000620549.4; ENSP00000483419.1; ENSG00000277924.5
ENST00000622644.4; ENSP00000482830.1; ENSG00000276459.5
ENST00000638813.2; ENSP00000492856.1; ENSG00000284333.2
ENST00000638851.2; ENSP00000491452.1; ENSG00000283708.2
ENST00000639089.2; ENSP00000491264.1; ENSG00000283702.2
ENST00000639101.2; ENSP00000492356.1; ENSG00000283790.2
ENST00000639176.2; ENSP00000491273.1; ENSG00000284504.2
ENST00000640485.2; ENSP00000491955.1; ENSG00000284510.2
GeneIDi3804
KEGGihsa:3804
MANE-SelectiENST00000342376.4; ENSP00000342215.3; NM_015868.3; NP_056952.2
UCSCiuc002qgx.4, human [P43628-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3804
DisGeNETi3804

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIR2DL3
HGNCiHGNC:6331, KIR2DL3
HPAiENSG00000243772, Tissue enhanced (lymphoid)
MIMi604938, gene
neXtProtiNX_P43628
OpenTargetsiENSG00000243772
PharmGKBiPA30116
VEuPathDBiHostDB:ENSG00000243772

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RU21, Eukaryota
GeneTreeiENSGT00980000198504
InParanoidiP43628
OMAiPELHGHH
PhylomeDBiP43628
TreeFamiTF352669

Enzyme and pathway databases

PathwayCommonsiP43628
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkiP43628

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3804, 16 hits in 976 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIR2DL3, human
EvolutionaryTraceiP43628

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3804
PharosiP43628, Tbio

Protein Ontology

More...PROi		PR:P43628
RNActiP43628, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000243772, Expressed in blood and 41 other tissues
ExpressionAtlasiP43628, baseline and differential
GenevisibleiP43628, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin
PfamiView protein in Pfam
PF00047, ig, 2 hits
SMARTiView protein in SMART
SM00409, IG, 2 hits
SUPFAMiSSF48726, SSF48726, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI2L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43628
Secondary accession number(s): O43472
, P78402, Q14944, Q14945, Q9UM51, Q9UQ70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 25, 2022
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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