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Protein

Killer cell immunoglobulin-like receptor 2DL2

Gene

KIR2DL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL2
Alternative name(s):
CD158 antigen-like family member B1
MHC class I NK cell receptor
Natural killer-associated transcript 6
Short name:
NKAT-6
p58 natural killer cell receptor clone CL-43
Short name:
p58 NK receptor CL-43
CD_antigen: CD158b1
Gene namesi
Name:KIR2DL2
Synonyms:CD158B1, NKAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6330 KIR2DL2
MIMi604937 gene
neXtProtiNX_P43627

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 348CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3803
PharmGKBiPA30115

Chemistry databases

ChEMBLiCHEMBL3833441

Polymorphism and mutation databases

DMDMi1171725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001507922 – 348Killer cell immunoglobulin-like receptor 2DL2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100Combined sources2 Publications
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198Combined sources2 Publications
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP43627
PRIDEiP43627
ProteomicsDBi55640

PTM databases

iPTMnetiP43627
PhosphoSitePlusiP43627

Expressioni

Gene expression databases

CleanExiHS_KIR2DL2

Interactioni

Protein-protein interaction databases

BioGridi110004, 4 interactors
IntActiP43627, 17 interactors

Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43627
SMRiP43627
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43627

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiP43627
KOiK07981
OrthoDBiEOG091G0APE

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P43627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW
60 70 80 90 100
SDVRFEHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHECR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN PRHLHILIGT
260 270 280 290 300
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
310 320 330 340
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP
Length:348
Mass (Da):38,472
Last modified:November 1, 1995 - v1
Checksum:i5B54C548F5CF3FBF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N742Q8N742_HUMAN
KIR2DL2
KIR2DL2 KIR2DL3
348Annotation score:
A0A0G2JPG1A0A0G2JPG1_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL2
248Annotation score:
A0A0G2JML6A0A0G2JML6_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL2
331Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289 – 290SE → RQ in AAB36597 (PubMed:8662091).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0594179A → V. Corresponds to variant dbSNP:rs3810343Ensembl.1
Natural variantiVAR_02192937R → P. Corresponds to variant dbSNP:rs613240Ensembl.1
Natural variantiVAR_05941866F → Y. Corresponds to variant dbSNP:rs673568Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24075 mRNA Translation: AAC50334.1
L76669 mRNA Translation: AAB36597.1
EU791544 Genomic DNA Translation: ACI49715.1
RefSeqiNP_055034.2, NM_014219.2
UniGeneiHs.743949

Genome annotation databases

EnsembliENST00000611724; ENSP00000482519; ENSG00000275546
ENST00000613410; ENSP00000483373; ENSG00000276731
ENST00000616831; ENSP00000482201; ENSG00000278731
ENST00000618388; ENSP00000480161; ENSG00000275914
ENST00000618796; ENSP00000481907; ENSG00000275407
ENST00000619621; ENSP00000483052; ENSG00000276011
ENST00000638623; ENSP00000492136; ENSG00000284225
ENST00000638818; ENSP00000491858; ENSG00000283716
ENST00000643115; ENSP00000496379; ENSG00000284225
ENST00000646347; ENSP00000494464; ENSG00000283716
GeneIDi3803
KEGGihsa:3803
UCSCiuc032lsh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24075 mRNA Translation: AAC50334.1
L76669 mRNA Translation: AAB36597.1
EU791544 Genomic DNA Translation: ACI49715.1
RefSeqiNP_055034.2, NM_014219.2
UniGeneiHs.743949

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EFXX-ray3.00D/E22-221[»]
2DL2X-ray3.00A26-221[»]
2DLIX-ray2.90A25-221[»]
ProteinModelPortaliP43627
SMRiP43627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110004, 4 interactors
IntActiP43627, 17 interactors

Chemistry databases

ChEMBLiCHEMBL3833441

PTM databases

iPTMnetiP43627
PhosphoSitePlusiP43627

Polymorphism and mutation databases

DMDMi1171725

Proteomic databases

PeptideAtlasiP43627
PRIDEiP43627
ProteomicsDBi55640

Protocols and materials databases

DNASUi3803
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611724; ENSP00000482519; ENSG00000275546
ENST00000613410; ENSP00000483373; ENSG00000276731
ENST00000616831; ENSP00000482201; ENSG00000278731
ENST00000618388; ENSP00000480161; ENSG00000275914
ENST00000618796; ENSP00000481907; ENSG00000275407
ENST00000619621; ENSP00000483052; ENSG00000276011
ENST00000638623; ENSP00000492136; ENSG00000284225
ENST00000638818; ENSP00000491858; ENSG00000283716
ENST00000643115; ENSP00000496379; ENSG00000284225
ENST00000646347; ENSP00000494464; ENSG00000283716
GeneIDi3803
KEGGihsa:3803
UCSCiuc032lsh.2 human

Organism-specific databases

CTDi3803
DisGeNETi3803
GeneCardsiKIR2DL2
HGNCiHGNC:6330 KIR2DL2
MIMi604937 gene
neXtProtiNX_P43627
PharmGKBiPA30115
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiP43627
KOiK07981
OrthoDBiEOG091G0APE

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

EvolutionaryTraceiP43627
GenomeRNAii3803
PROiPR:P43627
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIR2DL2

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI2L2_HUMAN
AccessioniPrimary (citable) accession number: P43627
Secondary accession number(s): C6EVR8, Q14951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 10, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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