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Protein

Killer cell immunoglobulin-like receptor 2DL1

Gene

KIR2DL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL1
Alternative name(s):
CD158 antigen-like family member A
MHC class I NK cell receptor
Natural killer-associated transcript 1
Short name:
NKAT-1
p58 natural killer cell receptor clones CL-42/47.11
Short name:
p58 NK receptor CL-42/47.11
p58.1 MHC class-I-specific NK receptor
CD_antigen: CD158a
Gene namesi
Name:KIR2DL1
Synonyms:CD158A, NKAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000125498.19
HGNCiHGNC:6329 KIR2DL1
MIMi604936 gene
neXtProtiNX_P43626

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 348CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi302Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. 1 Publication1
Mutagenesisi332Y → A: Abolishes interaction with ARRB2; when associated with A-302. 1 Publication1

Organism-specific databases

DisGeNETi3802
PharmGKBiPA30114

Chemistry databases

ChEMBLiCHEMBL3712912

Polymorphism and mutation databases

BioMutaiKIR2DL1
DMDMi1171726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001507822 – 348Killer cell immunoglobulin-like receptor 2DL1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100Combined sources1 Publication
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198Combined sources1 Publication
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43626
PeptideAtlasiP43626
PRIDEiP43626
ProteomicsDBi55639

PTM databases

iPTMnetiP43626
PhosphoSitePlusiP43626

Expressioni

Tissue specificityi

Expressed by NK cells.1 Publication

Gene expression databases

BgeeiENSG00000125498 Expressed in 49 organ(s), highest expression level in amniotic fluid
CleanExiHS_KIR2DL1
ExpressionAtlasiP43626 baseline and differential
GenevisibleiP43626 HS

Interactioni

Subunit structurei

Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi110003, 25 interactors
IntActiP43626, 19 interactors
MINTiP43626
STRINGi9606.ENSP00000336769

Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43626
SMRiP43626
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43626

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCDN Eukaryota
ENOG4110P2R LUCA
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiP43626
KOiK07981
OrthoDBiEOG091G0APE
PhylomeDBiP43626
TreeFamiTF352669

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT
260 270 280 290 300
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
310 320 330 340
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP
Length:348
Mass (Da):38,505
Last modified:November 1, 1995 - v1
Checksum:i3DFBF2D6FDCE1D1E
GO
Isoform 2 (identifier: P43626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: TG → TERMFHHVGQACLKLPTSSDPTVSACQS

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):41,360
Checksum:i80C18B19F3A5B394
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6H2H3Q6H2H3_HUMAN
KIR2DL1
KIR2DL1 KIR-2DL1
348Annotation score:
Q6H2H2Q6H2H2_HUMAN
KIR2DL1
KIR2DL1
348Annotation score:
E7BWR8E7BWR8_HUMAN
HCG2043595, isoform CRA_a
KIR2DL1 hCG_2043595
348Annotation score:
A0A0G2JQ35A0A0G2JQ35_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL1
348Annotation score:
A0A1W2PRZ1A0A1W2PRZ1_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL1
374Annotation score:
A0A0G2JND8A0A0G2JND8_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL1
374Annotation score:
A0A0G2JQ06A0A0G2JQ06_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL1
348Annotation score:
A0A0G2JPY8A0A0G2JPY8_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL1
348Annotation score:
A0A0G2JQ05A0A0G2JQ05_HUMAN
KIR2DL1 protein
KIR2DL1
374Annotation score:
A0A0C4ZNX3A0A0C4ZNX3_HUMAN
KIR2DL1 Killer-cell Immunoglobulin-...
KIR2DL1
348Annotation score:
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0039495V → F1 PublicationCorresponds to variant dbSNP:rs2304224Ensembl.1
Natural variantiVAR_0613329A → V. Corresponds to variant dbSNP:rs3810343Ensembl.1
Natural variantiVAR_00395037P → R1 PublicationCorresponds to variant dbSNP:rs35509911Ensembl.1
Natural variantiVAR_05609166F → Y. Corresponds to variant dbSNP:rs673568Ensembl.1
Natural variantiVAR_061333111V → L. Corresponds to variant dbSNP:rs687885Ensembl.1
Natural variantiVAR_003951135P → L1 Publication1
Natural variantiVAR_010331175P → T. 1
Natural variantiVAR_010332184D → N. 1
Natural variantiVAR_010333203H → R. 1
Natural variantiVAR_010334237K → E. 1
Natural variantiVAR_010335266R → C. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056314238 – 239TG → TERMFHHVGQACLKLPTSSD PTVSACQS in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41267 mRNA Translation: AAA69868.1
U24076 mRNA Translation: AAC50335.1
U24078 mRNA Translation: AAC50337.1
AF022045 mRNA Translation: AAB95318.1
AY789055 mRNA Translation: AAX23100.1
AC011501 Genomic DNA No translation available.
BC069344 mRNA Translation: AAH69344.1
CCDSiCCDS12904.1 [P43626-1]
PIRiA56247
RefSeqiNP_055033.2, NM_014218.2
UniGeneiHs.654605
Hs.690615

Genome annotation databases

EnsembliENST00000291633; ENSP00000291633; ENSG00000125498
ENST00000611611; ENSP00000478232; ENSG00000278738
ENST00000615920; ENSP00000482120; ENSG00000273794
ENST00000617376; ENSP00000484559; ENSG00000278821
ENST00000618563; ENSP00000484361; ENSG00000276625
ENST00000620449; ENSP00000478263; ENSG00000277833
ENST00000622463; ENSP00000479363; ENSG00000278495
GeneIDi3802
KEGGihsa:3802
UCSCiuc010erz.2 human [P43626-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41267 mRNA Translation: AAA69868.1
U24076 mRNA Translation: AAC50335.1
U24078 mRNA Translation: AAC50337.1
AF022045 mRNA Translation: AAB95318.1
AY789055 mRNA Translation: AAX23100.1
AC011501 Genomic DNA No translation available.
BC069344 mRNA Translation: AAH69344.1
CCDSiCCDS12904.1 [P43626-1]
PIRiA56247
RefSeqiNP_055033.2, NM_014218.2
UniGeneiHs.654605
Hs.690615

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IM9X-ray2.80D22-245[»]
1NKRX-ray1.70A22-221[»]
ProteinModelPortaliP43626
SMRiP43626
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110003, 25 interactors
IntActiP43626, 19 interactors
MINTiP43626
STRINGi9606.ENSP00000336769

Chemistry databases

ChEMBLiCHEMBL3712912

PTM databases

iPTMnetiP43626
PhosphoSitePlusiP43626

Polymorphism and mutation databases

BioMutaiKIR2DL1
DMDMi1171726

Proteomic databases

PaxDbiP43626
PeptideAtlasiP43626
PRIDEiP43626
ProteomicsDBi55639

Protocols and materials databases

DNASUi3802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291633; ENSP00000291633; ENSG00000125498
ENST00000611611; ENSP00000478232; ENSG00000278738
ENST00000615920; ENSP00000482120; ENSG00000273794
ENST00000617376; ENSP00000484559; ENSG00000278821
ENST00000618563; ENSP00000484361; ENSG00000276625
ENST00000620449; ENSP00000478263; ENSG00000277833
ENST00000622463; ENSP00000479363; ENSG00000278495
GeneIDi3802
KEGGihsa:3802
UCSCiuc010erz.2 human [P43626-1]

Organism-specific databases

CTDi3802
DisGeNETi3802
EuPathDBiHostDB:ENSG00000125498.19
GeneCardsiKIR2DL1
HGNCiHGNC:6329 KIR2DL1
MIMi604936 gene
neXtProtiNX_P43626
PharmGKBiPA30114
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCDN Eukaryota
ENOG4110P2R LUCA
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiP43626
KOiK07981
OrthoDBiEOG091G0APE
PhylomeDBiP43626
TreeFamiTF352669

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiKIR2DL1 human
EvolutionaryTraceiP43626
GeneWikiiKIR2DL1
GenomeRNAii3802
PROiPR:P43626
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125498 Expressed in 49 organ(s), highest expression level in amniotic fluid
CleanExiHS_KIR2DL1
ExpressionAtlasiP43626 baseline and differential
GenevisibleiP43626 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI2L1_HUMAN
AccessioniPrimary (citable) accession number: P43626
Secondary accession number(s): O43470, Q32WE6, Q6IST4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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