UniProtKB - P43626 (KI2L1_HUMAN)
Protein
Killer cell immunoglobulin-like receptor 2DL1
Gene
KIR2DL1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication
GO - Molecular functioni
- signaling receptor activity Source: ProtInc
GO - Biological processi
- immune response Source: ProtInc
- natural killer cell inhibitory signaling pathway Source: UniProtKB
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P43626 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Killer cell immunoglobulin-like receptor 2DL1Alternative name(s): CD158 antigen-like family member A MHC class I NK cell receptor Natural killer-associated transcript 1 Short name: NKAT-1 p58 natural killer cell receptor clones CL-42/47.11 Short name: p58 NK receptor CL-42/47.11 p58.1 MHC class-I-specific NK receptor CD_antigen: CD158a |
Gene namesi | Name:KIR2DL1 Synonyms:CD158A, NKAT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125498.19 |
HGNCi | HGNC:6329, KIR2DL1 |
MIMi | 604936, gene |
neXtProti | NX_P43626 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 245 | ExtracellularSequence analysisAdd BLAST | 224 | |
Transmembranei | 246 – 264 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 265 – 348 | CytoplasmicSequence analysisAdd BLAST | 84 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 302 | Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. 1 Publication | 1 | |
Mutagenesisi | 332 | Y → A: Abolishes interaction with ARRB2; when associated with A-302. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3802 |
PharmGKBi | PA30114 |
Miscellaneous databases
Pharosi | P43626, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712912 |
Polymorphism and mutation databases
BioMutai | KIR2DL1 |
DMDMi | 1171726 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000015078 | 22 – 348 | Killer cell immunoglobulin-like receptor 2DL1Add BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 100 | Combined sources1 Publication | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 149 ↔ 198 | Combined sources1 Publication | ||
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P43626 |
MassIVEi | P43626 |
PaxDbi | P43626 |
PeptideAtlasi | P43626 |
PRIDEi | P43626 |
ProteomicsDBi | 55639 [P43626-1] 66496 |
PTM databases
GlyGeni | P43626, 4 sites |
iPTMneti | P43626 |
PhosphoSitePlusi | P43626 |
Expressioni
Tissue specificityi
Expressed by NK cells.1 Publication
Gene expression databases
Bgeei | ENSG00000125498, Expressed in amniotic fluid and 58 other tissues |
ExpressionAtlasi | P43626, baseline and differential |
Genevisiblei | P43626, HS |
Organism-specific databases
HPAi | ENSG00000125498, Tissue enhanced (endometrium, lung, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with ARRB2.
Interacts with PTPN6; the interaction is enhanced by ARRB2.
Interacts with PTPN11; the interaction is enhanced by ARRB2.
1 PublicationBinary interactionsi
Hide detailsP43626
Protein-protein interaction databases
BioGRIDi | 110003, 25 interactors |
IntActi | P43626, 16 interactors |
MINTi | P43626 |
STRINGi | 9606.ENSP00000336769 |
Miscellaneous databases
RNActi | P43626, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P43626 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43626 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 107 | Ig-like C2-type 1Add BLAST | 66 | |
Domaini | 142 – 205 | Ig-like C2-type 2Add BLAST | 64 |
Sequence similaritiesi
Belongs to the immunoglobulin superfamily.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU21, Eukaryota |
InParanoidi | P43626 |
OrthoDBi | 1055520at2759 |
PhylomeDBi | P43626 |
TreeFami | TF352669 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P43626-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT
260 270 280 290 300
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
310 320 330 340
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6H2H3 | Q6H2H3_HUMAN | KIR2DL1 | KIR2DL1 KIR-2DL1 | 348 | Annotation score: | ||
Q6H2H2 | Q6H2H2_HUMAN | KIR2DL1 | KIR2DL1 | 348 | Annotation score: | ||
A0A0G2JPY8 | A0A0G2JPY8_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL1 | 348 | Annotation score: | ||
A0A0G2JQ35 | A0A0G2JQ35_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL1 | 348 | Annotation score: | ||
E7BWR8 | E7BWR8_HUMAN | HCG2043595, isoform CRA_a | KIR2DL1 hCG_2043595 | 348 | Annotation score: | ||
A0A0G2JQ06 | A0A0G2JQ06_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL1 | 348 | Annotation score: | ||
A0A0C4ZNX3 | A0A0C4ZNX3_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL1 | 348 | Annotation score: | ||
A0A0G2JQ05 | A0A0G2JQ05_HUMAN | KIR2DL1 protein | KIR2DL1 | 374 | Annotation score: | ||
A0A1W2PRZ1 | A0A1W2PRZ1_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL1 | 374 | Annotation score: | ||
A0A0G2JND8 | A0A0G2JND8_HUMAN | Killer cell immunoglobulin-like rec... | KIR2DL1 | 374 | Annotation score: | ||
There is more potential isoformShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003949 | 5 | V → F1 PublicationCorresponds to variant dbSNP:rs2304224Ensembl. | 1 | |
Natural variantiVAR_061332 | 9 | A → V. Corresponds to variant dbSNP:rs3810343Ensembl. | 1 | |
Natural variantiVAR_003950 | 37 | P → R1 PublicationCorresponds to variant dbSNP:rs35509911Ensembl. | 1 | |
Natural variantiVAR_056091 | 66 | F → Y. Corresponds to variant dbSNP:rs673568Ensembl. | 1 | |
Natural variantiVAR_061333 | 111 | V → L. Corresponds to variant dbSNP:rs687885Ensembl. | 1 | |
Natural variantiVAR_003951 | 135 | P → L1 PublicationCorresponds to variant dbSNP:rs11673144Ensembl. | 1 | |
Natural variantiVAR_010331 | 175 | P → T. Corresponds to variant dbSNP:rs111799279Ensembl. | 1 | |
Natural variantiVAR_010332 | 184 | D → N. Corresponds to variant dbSNP:rs147072532Ensembl. | 1 | |
Natural variantiVAR_010333 | 203 | H → R. Corresponds to variant dbSNP:rs666590Ensembl. | 1 | |
Natural variantiVAR_010334 | 237 | K → E. Corresponds to variant dbSNP:rs75232650Ensembl. | 1 | |
Natural variantiVAR_010335 | 266 | R → C. Corresponds to variant dbSNP:rs34721508Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056314 | 238 – 239 | TG → TERMFHHVGQACLKLPTSSD PTVSACQS in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41267 mRNA Translation: AAA69868.1 U24076 mRNA Translation: AAC50335.1 U24078 mRNA Translation: AAC50337.1 AF022045 mRNA Translation: AAB95318.1 AY789055 mRNA Translation: AAX23100.1 AC011501 Genomic DNA No translation available. BC069344 mRNA Translation: AAH69344.1 |
CCDSi | CCDS12904.1 [P43626-1] |
PIRi | A56247 |
RefSeqi | NP_055033.2, NM_014218.2 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L41267 mRNA Translation: AAA69868.1 U24076 mRNA Translation: AAC50335.1 U24078 mRNA Translation: AAC50337.1 AF022045 mRNA Translation: AAB95318.1 AY789055 mRNA Translation: AAX23100.1 AC011501 Genomic DNA No translation available. BC069344 mRNA Translation: AAH69344.1 |
CCDSi | CCDS12904.1 [P43626-1] |
PIRi | A56247 |
RefSeqi | NP_055033.2, NM_014218.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IM9 | X-ray | 2.80 | D | 22-245 | [»] | |
1NKR | X-ray | 1.70 | A | 22-221 | [»] | |
SMRi | P43626 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110003, 25 interactors |
IntActi | P43626, 16 interactors |
MINTi | P43626 |
STRINGi | 9606.ENSP00000336769 |
Chemistry databases
ChEMBLi | CHEMBL3712912 |
PTM databases
GlyGeni | P43626, 4 sites |
iPTMneti | P43626 |
PhosphoSitePlusi | P43626 |
Polymorphism and mutation databases
BioMutai | KIR2DL1 |
DMDMi | 1171726 |
Proteomic databases
jPOSTi | P43626 |
MassIVEi | P43626 |
PaxDbi | P43626 |
PeptideAtlasi | P43626 |
PRIDEi | P43626 |
ProteomicsDBi | 55639 [P43626-1] 66496 |
Protocols and materials databases
ABCDi | P43626, 1 sequenced antibody |
Antibodypediai | 21559, 707 antibodies |
DNASUi | 3802 |
Genome annotation databases
Organism-specific databases
CTDi | 3802 |
DisGeNETi | 3802 |
EuPathDBi | HostDB:ENSG00000125498.19 |
GeneCardsi | KIR2DL1 |
HGNCi | HGNC:6329, KIR2DL1 |
HPAi | ENSG00000125498, Tissue enhanced (endometrium, lung, lymphoid tissue) |
MIMi | 604936, gene |
neXtProti | NX_P43626 |
PharmGKBi | PA30114 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU21, Eukaryota |
InParanoidi | P43626 |
OrthoDBi | 1055520at2759 |
PhylomeDBi | P43626 |
TreeFami | TF352669 |
Enzyme and pathway databases
PathwayCommonsi | P43626 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 3802, 5 hits in 814 CRISPR screens |
EvolutionaryTracei | P43626 |
GeneWikii | KIR2DL1 |
GenomeRNAii | 3802 |
Pharosi | P43626, Tbio |
PROi | PR:P43626 |
RNActi | P43626, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125498, Expressed in amniotic fluid and 58 other tissues |
ExpressionAtlasi | P43626, baseline and differential |
Genevisiblei | P43626, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KI2L1_HUMAN | |
Accessioni | P43626Primary (citable) accession number: P43626 Secondary accession number(s): O43470, Q32WE6, Q6IST4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries