KIR2DL1

Functionⁱ

Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functionⁱ

signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7749980

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

immune response
Source: ProtInc
Traceable author statementⁱ
- 7749980
natural killer cell inhibitory signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 18604210
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Killer cell immunoglobulin-like receptor 2DL1 Alternative name(s): CD158 antigen-like family member A MHC class I NK cell receptor Natural killer-associated transcript 1 Short name: NKAT-1 p58 natural killer cell receptor clones CL-42/47.11 Short name: p58 NK receptor CL-42/47.11 p58.1 MHC class-I-specific NK receptor CD_antigen: CD158a
Gene namesⁱ	Name:KIR2DL1 Synonyms:CD158A, NKAT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125498.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6329 KIR2DL1
MIMⁱ	604936 gene
neXtProtⁱ	NX_P43626

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 245	ExtracellularSequence analysisAdd BLAST	224
Transmembraneⁱ	246 – 264	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	265 – 348	CytoplasmicSequence analysisAdd BLAST	84

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	302	Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. 1 Publication		1
Mutagenesisⁱ	332	Y → A: Abolishes interaction with ARRB2; when associated with A-302. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3802
PharmGKBⁱ	PA30114

Chemistry databases

ChEMBLⁱ	CHEMBL3712912

ChEMBLⁱ

CHEMBL3712912

Polymorphism and mutation databases

BioMutaⁱ	KIR2DL1
DMDMⁱ	1171726

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000015078	22 – 348	Killer cell immunoglobulin-like receptor 2DL1Add BLAST		327

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 100	Combined sources1 Publication
Glycosylationⁱ	67	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	84	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	144	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	149 ↔ 198	Combined sources1 Publication
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P43626
PeptideAtlas More...PeptideAtlasⁱ	P43626
PRIDEⁱ	P43626
ProteomicsDBⁱ	55639

PTM databases

iPTMnetⁱ	P43626
PhosphoSitePlusⁱ	P43626

Expressionⁱ

Tissue specificityⁱ

Expressed by NK cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000125498 Expressed in 49 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_KIR2DL1
ExpressionAtlasⁱ	P43626 baseline and differential
Genevisibleⁱ	P43626 HS

Interactionⁱ

Subunit structureⁱ

Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HLA-C	P30501	3	EBI-8684277,EBI-9978392
HLA-C	P30504	3	EBI-8684277,EBI-1051396
HLA-C	Q07000	2	EBI-8684277,EBI-1058803
HLA-C	Q29865	2	EBI-8684277,EBI-13917304
HLA-C	Q29963	3	EBI-8684277,EBI-4400689
HLA-C	Q95604	2	EBI-8684277,EBI-6163558
HLA-C	Q9TNN7	3	EBI-8684277,EBI-13916949
PTPN6	P29350	4	EBI-8684277,EBI-78260

Protein-protein interaction databases

BioGridⁱ	110003, 25 interactors
IntActⁱ	P43626, 19 interactors
Molecular INTeraction database More...MINTⁱ	P43626
STRINGⁱ	9606.ENSP00000336769

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 35	Combined sources	6
Beta strandⁱ	37 – 40	Combined sources	4
Beta strandⁱ	45 – 53	Combined sources	9
Beta strandⁱ	56 – 66	Combined sources	11
Beta strandⁱ	68 – 73	Combined sources	6
Beta strandⁱ	75 – 77	Combined sources	3
Beta strandⁱ	80 – 89	Combined sources	10
Helixⁱ	92 – 94	Combined sources	3
Beta strandⁱ	96 – 104	Combined sources	9
Beta strandⁱ	118 – 123	Combined sources	6
Beta strandⁱ	130 – 135	Combined sources	6
Beta strandⁱ	137 – 140	Combined sources	4
Beta strandⁱ	144 – 153	Combined sources	10
Beta strandⁱ	156 – 162	Combined sources	7
Beta strandⁱ	169 – 172	Combined sources	4
Beta strandⁱ	174 – 177	Combined sources	4
Beta strandⁱ	180 – 189	Combined sources	10
Beta strandⁱ	194 – 202	Combined sources	9
Beta strandⁱ	205 – 209	Combined sources	5
Beta strandⁱ	216 – 221	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P43626
SMRⁱ	P43626
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P43626

EvolutionaryTraceⁱ

P43626

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	42 – 107	Ig-like C2-type 1Add BLAST		66
Domainⁱ	142 – 205	Ig-like C2-type 2Add BLAST		64

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410KCDN Eukaryota ENOG4110P2R LUCA
HOGENOMⁱ	HOG000234396
HOVERGENⁱ	HBG074353
InParanoidⁱ	P43626
KEGG Orthology (KO) More...KOⁱ	K07981
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0APE
PhylomeDBⁱ	P43626
TreeFamⁱ	TF352669

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047 ig, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P43626-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW 
        60         70         80         90        100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC 
       110        120        130        140        150
YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS 
       160        170        180        190        200
SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG 
       210        220        230        240        250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT 
       260        270        280        290        300
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV 
       310        320        330        340 
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP

Length:348

Mass (Da):38,505

Last modified:November 1, 1995 - v1

Checksum:ⁱ3DFBF2D6FDCE1D1E

GO

Isoform 2 (identifier: P43626-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
238-239: TG → TERMFHHVGQACLKLPTSSDPTVSACQS

« Hide

        10         20         30         40         50
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW 
        60         70         80         90        100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC 
       110        120        130        140        150
YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS 
       160        170        180        190        200
SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG 
       210        220        230        240        250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTER MFHHVGQACL 
       260        270        280        290        300
KLPTSSDPTV SACQSNPRHL HILIGTSVVI ILFILLFFLL HRWCSNKKNA 
       310        320        330        340        350
AVMDQESAGN RTANSEDSDE QDPQEVTYTQ LNHCVFTQRK ITRPSQRPKT 
       360        370 
PPTDIIVYTE LPNAESRSKV VSCP

Note: No experimental confirmation available.

Show »

Length:374

Mass (Da):41,360

Checksum:ⁱ80C18B19F3A5B394

GO

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	Q6H2H3	Q6H2H3_HUMAN	KIR2DL1 KIR2DL1 (KIR2DL1 Killer-cell Immunoglobulin-like Receptor) (Killer cell immunoglobulin-like receptor 2DL1) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1) (Killer-cell immunoglobulin-like receptor) (Natural killer cell inhibitory receptor)	KIR2DL1 KIR-2DL1	348	Annotation score:
	Q6H2H2	Q6H2H2_HUMAN	KIR2DL1 KIR2DL1 (KIR2DL1 Killer-cell Immunoglobulin-like Receptor) (Killer cell immunoglobulin-like receptor 2DL1) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1) (Natural killer cell inhibitory receptor)	KIR2DL1	348	Annotation score:
	E7BWR8	E7BWR8_HUMAN	HCG2043595, isoform CRA_a HCG2043595, isoform CRA_a (KIR2DL1) (Killer cell immunoglobulin-like receptor 2DL1)	KIR2DL1 hCG_2043595	348	Annotation score:
	A0A0G2JQ35	A0A0G2JQ35_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL1	KIR2DL1	348	Annotation score:
	A0A1W2PRZ1	A0A1W2PRZ1_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL1	KIR2DL1	374	Annotation score:
	A0A0G2JND8	A0A0G2JND8_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL1	KIR2DL1	374	Annotation score:
	A0A0G2JQ06	A0A0G2JQ06_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL1	KIR2DL1	348	Annotation score:
	A0A0G2JPY8	A0A0G2JPY8_HUMAN	Killer cell immunoglobulin-like rec... Killer cell immunoglobulin-like receptor 2DL1	KIR2DL1	348	Annotation score:
	A0A0G2JQ05	A0A0G2JQ05_HUMAN	KIR2DL1 protein KIR2DL1 protein (Killer cell immunoglobulin-like receptor 2DL1)	KIR2DL1	374	Annotation score:
	A0A0C4ZNX3	A0A0C4ZNX3_HUMAN	KIR2DL1 Killer-cell Immunoglobulin-... KIR2DL1 Killer-cell Immunoglobulin-like Receptor (Killer cell immunoglobulin-like receptor 2DL1) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1)	KIR2DL1	348	Annotation score:
There is more potential isoformShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_003949	5	V → F1 PublicationCorresponds to variant dbSNP:rs2304224Ensembl.	1
Natural variantⁱVAR_061332	9	A → V. Corresponds to variant dbSNP:rs3810343Ensembl.	1
Natural variantⁱVAR_003950	37	P → R1 PublicationCorresponds to variant dbSNP:rs35509911Ensembl.	1
Natural variantⁱVAR_056091	66	F → Y. Corresponds to variant dbSNP:rs673568Ensembl.	1
Natural variantⁱVAR_061333	111	V → L. Corresponds to variant dbSNP:rs687885Ensembl.	1
Natural variantⁱVAR_003951	135	P → L1 Publication	1
Natural variantⁱVAR_010331	175	P → T.	1
Natural variantⁱVAR_010332	184	D → N.	1
Natural variantⁱVAR_010333	203	H → R.	1
Natural variantⁱVAR_010334	237	K → E.	1
Natural variantⁱVAR_010335	266	R → C.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056314	238 – 239	TG → TERMFHHVGQACLKLPTSSD PTVSACQS in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41267 mRNA Translation: AAA69868.1 U24076 mRNA Translation: AAC50335.1 U24078 mRNA Translation: AAC50337.1 AF022045 mRNA Translation: AAB95318.1 AY789055 mRNA Translation: AAX23100.1 AC011501 Genomic DNA No translation available. BC069344 mRNA Translation: AAH69344.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12904.1 [P43626-1]
PIRⁱ	A56247
NCBI Reference Sequences More...RefSeqⁱ	NP_055033.2, NM_014218.2
UniGeneⁱ	Hs.654605 Hs.690615

Genome annotation databases

Ensemblⁱ	ENST00000291633; ENSP00000291633; ENSG00000125498 ENST00000611611; ENSP00000478232; ENSG00000278738 ENST00000615920; ENSP00000482120; ENSG00000273794 ENST00000617376; ENSP00000484559; ENSG00000278821 ENST00000618563; ENSP00000484361; ENSG00000276625 ENST00000620449; ENSP00000478263; ENSG00000277833 ENST00000622463; ENSP00000479363; ENSG00000278495
GeneIDⁱ	3802
KEGGⁱ	hsa:3802
UCSC genome browser More...UCSCⁱ	uc010erz.2 human [P43626-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P43626	KIR2DL1		HUMAN		348	UniRef100_P43626

Protein	Similar proteins		Species	Score	Length	Source
P43626	Killer cell immunoglobulin-like receptor 2DL3	)	HUMAN		341	UniRef90_P43626
Killer-cell Ig-like receptor KIR2DLc		western gorilla		353
KIR2DL7		PANTR		349
Killer cell immunoglobulin-like receptor 2DS2	)	HUMAN		304
Killer cell immunoglobulin-like receptor 2DS1		HUMAN		304
+122
P43626-2	Uncharacterized protein		PANTR		375	UniRef90_P43626-2
Killer cell immunoglobulin-like receptor 2DL1		HUMAN		374
Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 1		HUMAN		206
KIR2DL1 (Fragment)		HUMAN		123
Killer cell immunoglobulin-like receptor 2DL1		HUMAN		374
+6

Protein	Similar proteins		Species	Score	Length	Source
P43626	Killer cell immunoglobulin-like receptor 2DL3	)	HUMAN		341	UniRef50_P43626
Killer-cell Ig-like receptor KIR2DLc		western gorilla		353
Uncharacterized protein		PANTR		349
killer cell immunoglobulin-like receptor 2DS2 isoform X2		ODORO		341
Uncharacterized protein		RHIRO		341
+289
P43626-2	Killer cell immunoglobulin-like receptor 2DS3		HUMAN		304	UniRef50_P43626-2
Uncharacterized protein		PANTR		375
Uncharacterized protein		PROCO		319
Uncharacterized protein		PAPAN		370
Killer cell immunoglobulin-like receptor 2DS5		HUMAN		304
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L41267 mRNA Translation: AAA69868.1 U24076 mRNA Translation: AAC50335.1 U24078 mRNA Translation: AAC50337.1 AF022045 mRNA Translation: AAB95318.1 AY789055 mRNA Translation: AAX23100.1 AC011501 Genomic DNA No translation available. BC069344 mRNA Translation: AAH69344.1
CCDSⁱ	CCDS12904.1 [P43626-1]
PIRⁱ	A56247
RefSeqⁱ	NP_055033.2, NM_014218.2
UniGeneⁱ	Hs.654605 Hs.690615

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IM9	X-ray	2.80	D	22-245	[»]
	1NKR	X-ray	1.70	A	22-221	[»]
ProteinModelPortalⁱ	P43626
SMRⁱ	P43626
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110003, 25 interactors
IntActⁱ	P43626, 19 interactors
MINTⁱ	P43626
STRINGⁱ	9606.ENSP00000336769

Chemistry databases

ChEMBLⁱ	CHEMBL3712912

ChEMBLⁱ

CHEMBL3712912

PTM databases

iPTMnetⁱ	P43626
PhosphoSitePlusⁱ	P43626

Polymorphism and mutation databases

BioMutaⁱ	KIR2DL1
DMDMⁱ	1171726

Proteomic databases

PaxDbⁱ	P43626
PeptideAtlasⁱ	P43626
PRIDEⁱ	P43626
ProteomicsDBⁱ	55639

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3802
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000291633; ENSP00000291633; ENSG00000125498 ENST00000611611; ENSP00000478232; ENSG00000278738 ENST00000615920; ENSP00000482120; ENSG00000273794 ENST00000617376; ENSP00000484559; ENSG00000278821 ENST00000618563; ENSP00000484361; ENSG00000276625 ENST00000620449; ENSP00000478263; ENSG00000277833 ENST00000622463; ENSP00000479363; ENSG00000278495
GeneIDⁱ	3802
KEGGⁱ	hsa:3802
UCSCⁱ	uc010erz.2 human [P43626-1]

Organism-specific databases

CTDⁱ	3802
DisGeNETⁱ	3802
EuPathDBⁱ	HostDB:ENSG00000125498.19
GeneCardsⁱ	KIR2DL1
HGNCⁱ	HGNC:6329 KIR2DL1
MIMⁱ	604936 gene
neXtProtⁱ	NX_P43626
PharmGKBⁱ	PA30114
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KCDN Eukaryota ENOG4110P2R LUCA
HOGENOMⁱ	HOG000234396
HOVERGENⁱ	HBG074353
InParanoidⁱ	P43626
KOⁱ	K07981
OrthoDBⁱ	EOG091G0APE
PhylomeDBⁱ	P43626
TreeFamⁱ	TF352669

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSⁱ	KIR2DL1 human
EvolutionaryTraceⁱ	P43626
GeneWikiⁱ	KIR2DL1
GenomeRNAiⁱ	3802
Protein Ontology More...PROⁱ	PR:P43626
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125498 Expressed in 49 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_KIR2DL1
ExpressionAtlasⁱ	P43626 baseline and differential
Genevisibleⁱ	P43626 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013151 Immunoglobulin
Pfamⁱ	View protein in Pfam PF00047 ig, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KI2L1_HUMAN
Accessionⁱ	P43626Primary (citable) accession number: P43626 Secondary accession number(s): O43470, Q32WE6, Q6IST4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	September 12, 2018
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

UniProtKB

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Supporting data

UniProtKB - P43626 (KI2L1_HUMAN)

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Killer cell immunoglobulin-like receptor 2DL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ