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Entry version 153 (07 Apr 2021)
Sequence version 1 (01 Nov 1995)
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Protein

GPI inositol-deacylase

Gene

BST1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. Required for the transport of misfolded protein to the Golgi, although dipensable for the transport of many normal proteins.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei236By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol deacylase activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
yeast-BST1, PGAP1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GPI inositol-deacylase (EC:3.1.-.-)
Alternative name(s):
Bypass of SEC30 protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BST1
Ordered Locus Names:YFL025C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001869, BST1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YFL025C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei708 – 728HelicalSequence analysisAdd BLAST21
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Transmembranei804 – 824HelicalSequence analysisAdd BLAST21
Transmembranei872 – 892HelicalSequence analysisAdd BLAST21
Transmembranei920 – 940HelicalSequence analysisAdd BLAST21
Transmembranei957 – 977HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1005HelicalSequence analysisAdd BLAST21
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002026761 – 1029GPI inositol-deacylaseAdd BLAST1029

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi668N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi694N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi918N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43571

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43571

PRoteomics IDEntifications database

More...
PRIDEi
P43571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43571

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31121, 389 interactors

Database of interacting proteins

More...
DIPi
DIP-7407N

Protein interaction database and analysis system

More...
IntActi
P43571, 4 interactors

Molecular INTeraction database

More...
MINTi
P43571

STRING: functional protein association networks

More...
STRINGi
4932.YFL025C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P43571, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GPI inositol-deacylase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3724, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167854

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006103_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43571

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRFASKY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR012908, PGAP1-like
IPR039529, PGAP1/BST1

The PANTHER Classification System

More...
PANTHERi
PTHR15495, PTHR15495, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07819, PGAP1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00120, LIPASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43571-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIRRLVSVI TRPIINKVNS SGQYSRVLAT REDQDKASPK YMNNDKIAKK
60 70 80 90 100
PYTYRLFSIL GILSICSLLL ISLLKPFNGA DAPQCESIYM FPSYARIDGF
110 120 130 140 150
DERYTPLAHK YHLYLYREQS VDREPLNGDE LQLDGIPVLF IPGNAGSFRQ
160 170 180 190 200
CRSIASACSN IYFDSNTRAT LRNENVRNLD FFTADFNEDF TAFHGETMLD
210 220 230 240 250
QAEYLNDAIK YILSLYERTP DYPHPKPQSV IIVGHSMGGI VSRVMLTLKN
260 270 280 290 300
HVPGSISTIL TLSSPHAASP VTFDGDILKL YKNTNEYWRK QLSQNDSFFS
310 320 330 340 350
KNISLVSITG GILDTTLPAD YASVEDLVSL ENGFTSFTTT IPDVWTPIDH
360 370 380 390 400
LAIVWCKQLR EVLARLLLES IDASKPEKVK PLNQRLQIAR KLLLSGFEDY
410 420 430 440 450
SWMNSKLNYP QENLQEFSDN FFSDYATLEM NDVLDFEMFN LEKWHNNYTK
460 470 480 490 500
INIPSNISST EHLHFTLLTS LDMPMIYFCT ESRVNLSCIT AVDSILTVPR
510 520 530 540 550
SSKDTQFAAD SSFGEAKNPF KAVSVGKNIL QKYDYLMISK PTYGEFSEQE
560 570 580 590 600
GMEDNQGFLL ALLRNVSNVQ IVNTTPSQIL LFGEQLHLDG KDIEQVISFS
610 620 630 640 650
NLWDSLLSYK LETKIEASNE GIASEETLFQ PFIRQWVYEP FESKWHLNII
660 670 680 690 700
NKSLDINMHN VAPFIPLNES EPRSLQLSFF IPPGMSLEAK MTINWSLTLK
710 720 730 740 750
MLFIRYRLAL ASFPVAFIAL VLSYQFYWYN KTSEFPSFDS TLGYILRKHG
760 770 780 790 800
ILMFFTLFLA SPVVNNKLVQ RILYLLDPVG LNYPFLLSER NMHANFYYLG
810 820 830 840 850
IRDWFMSTIG ILFGVMTVGL LALVSKIFGS LEILVIFLQR KLSKKNTEDK
860 870 880 890 900
EAFDTIEHKA YGKGRLMASV LLLLLVFFHI PYQMAFVISL VIQIATCIRV
910 920 930 940 950
ALLKLSNNEQ KLNLLNYNMT LLLLLLFVSA INIPIIIVFL HNVAIKWETS
960 970 980 990 1000
FRSHHNILAV APIIFLVGNN SIFKMPNSVP LDTWDGKVTI ILFVYLTVFS
1010 1020
FIYGIRNLYW IHHLVNIICA WLLFFETIH
Length:1,029
Mass (Da):117,755
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10B77B212E5AD686
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09213.1
BK006940 Genomic DNA Translation: DAA12415.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S56229

NCBI Reference Sequences

More...
RefSeqi
NP_116628.1, NM_001179941.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YFL025C_mRNA; YFL025C; YFL025C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850519

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YFL025C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09213.1
BK006940 Genomic DNA Translation: DAA12415.1
PIRiS56229
RefSeqiNP_116628.1, NM_001179941.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31121, 389 interactors
DIPiDIP-7407N
IntActiP43571, 4 interactors
MINTiP43571
STRINGi4932.YFL025C

Protein family/group databases

ESTHERiyeast-BST1, PGAP1

PTM databases

iPTMnetiP43571

Proteomic databases

MaxQBiP43571
PaxDbiP43571
PRIDEiP43571

Genome annotation databases

EnsemblFungiiYFL025C_mRNA; YFL025C; YFL025C
GeneIDi850519
KEGGisce:YFL025C

Organism-specific databases

SGDiS000001869, BST1
VEuPathDBiFungiDB:YFL025C

Phylogenomic databases

eggNOGiKOG3724, Eukaryota
GeneTreeiENSGT00940000167854
HOGENOMiCLU_006103_0_0_1
InParanoidiP43571
OMAiTRFASKY

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P43571
RNActiP43571, protein

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR012908, PGAP1-like
IPR039529, PGAP1/BST1
PANTHERiPTHR15495, PTHR15495, 1 hit
PfamiView protein in Pfam
PF07819, PGAP1, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120, LIPASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBST1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43571
Secondary accession number(s): D6VTK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 7, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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