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Protein

CBK1 kinase activator protein MOB2

Gene

MOB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.2 Publications

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein kinase activator activity Source: SGD

GO - Biological processi

  • budding cell apical bud growth Source: SGD
  • cell cycle Source: UniProtKB-KW
  • cell separation after cytokinesis Source: SGD
  • establishment or maintenance of cell polarity Source: SGD
  • positive regulation of protein phosphorylation Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30427-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
CBK1 kinase activator protein MOB2
Alternative name(s):
MPS1 binder 2
Maintenance of ploidy protein MOB2
Gene namesi
Name:MOB2
Ordered Locus Names:YFL034C-B
ORF Names:YFL035C, YFL035C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL034C-B
SGDiS000001859 MOB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935831 – 287CBK1 kinase activator protein MOB2Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphotyrosineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei76PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43563
PaxDbiP43563
PRIDEiP43563

PTM databases

iPTMnetiP43563

Interactioni

Subunit structurei

Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CBK1P538947EBI-11125,EBI-4110

Protein-protein interaction databases

BioGridi31111, 1745 interactors
ComplexPortaliCPX-1684 CBK1-MOB2 kinase complex
DIPiDIP-1449N
IntActiP43563, 20 interactors
MINTiP43563
STRINGi4932.YFL034C-B

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni112 – 114Combined sources3
Helixi122 – 143Combined sources22
Helixi183 – 192Combined sources10
Turni196 – 198Combined sources3
Helixi211 – 231Combined sources21
Helixi234 – 237Combined sources4
Helixi238 – 240Combined sources3
Helixi243 – 259Combined sources17
Turni265 – 271Combined sources7
Helixi272 – 275Combined sources4

3D structure databases

ProteinModelPortaliP43563
SMRiP43563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

HOGENOMiHOG000164685
InParanoidiP43563
OMAiAHIYSSH
OrthoDBiEOG092C4XVR

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

Sequencei

Sequence statusi: Complete.

P43563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFNFKAFG RNSKKNKNQP LNVAQPPAMN TIYSSPHSSN SRLSLRNKHH
60 70 80 90 100
SPKRHSQTSF PAQKSTPQSQ QLTSTTPQSQ QQEASERSES QQIMFLSEPF
110 120 130 140 150
VRTALVKGSF KTIVQLPKYV DLGEWIALNV FEFFTNLNQF YGVVAEYVTP
160 170 180 190 200
DAYPTMNAGP HTDYLWLDAN NRQVSLPASQ YIDLALTWIN NKVNDKNLFP
210 220 230 240 250
TKNGLPFPQQ FSRDVQRIMV QMFRIFAHIY HHHFDKIVHL SLEAHWNSFF
260 270 280
SHFISFAKEF KIIDRKEMAP LLPLIESFEK QGKIIYN
Length:287
Mass (Da):33,276
Last modified:October 17, 2006 - v2
Checksum:iCFBA15FF83BFAA33
GO

Sequence cautioni

The sequence BAA09204 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09204.1 Sequence problems.
BK006940 Genomic DNA Translation: DAA12405.1
PIRiS58648
RefSeqiNP_116618.1, NM_001179931.1

Genome annotation databases

EnsemblFungiiBAA09204; BAA09204; BAA09204
YFL034C-B; YFL034C-B; YFL034C-B
GeneIDi850508
KEGGisce:YFL034C-B

Similar proteinsi

Entry informationi

Entry nameiMOB2_YEAST
AccessioniPrimary (citable) accession number: P43563
Secondary accession number(s): D6VTJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

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