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UniProtKB - P43553 (ALR2_YEAST)
Protein
Magnesium transporter ALR2
Gene
ALR2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Plasma membrane magnesium transporter.
1 PublicationMiscellaneous
Present with 2130 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- inorganic cation transmembrane transporter activity Source: SGD
- magnesium ion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cation transport Source: SGD
- cellular magnesium ion homeostasis Source: GO_Central
- magnesium ion transport Source: SGD
- transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Ligand | Magnesium |
Enzyme and pathway databases
BRENDAi | 7.2.2.14, 984 |
Names & Taxonomyi
Protein namesi | Recommended name: Magnesium transporter ALR2Alternative name(s): Aluminum resistance protein 2 |
Gene namesi | Name:ALR2 Ordered Locus Names:YFL050C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001844, ALR2 |
VEuPathDBi | FungiDB:YFL050C |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 741 | CytoplasmicSequence analysisAdd BLAST | 741 | |
Transmembranei | 742 – 762 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 763 – 771 | ExtracellularSequence analysis | 9 | |
Transmembranei | 772 – 792 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 793 – 858 | CytoplasmicSequence analysisAdd BLAST | 66 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201536 | 1 – 858 | Magnesium transporter ALR2Add BLAST | 858 |
Proteomic databases
MaxQBi | P43553 |
PaxDbi | P43553 |
PRIDEi | P43553 |
PTM databases
iPTMneti | P43553 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 31097, 39 interactors |
DIPi | DIP-4581N |
STRINGi | 4932.YFL050C |
Miscellaneous databases
RNActi | P43553, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 81 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 318 – 337 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 365 – 396 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 26 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 50 – 67 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 322 – 337 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QPTQ, Eukaryota |
GeneTreei | ENSGT00940000176664 |
HOGENOMi | CLU_007127_6_0_1 |
InParanoidi | P43553 |
OMAi | REHIRIN |
Family and domain databases
CDDi | cd12829, Alr1p-like, 1 hit |
InterProi | View protein in InterPro IPR044089, Alr1-like IPR045861, CorA_cytoplasmic_dom IPR045863, CorA_TM1_TM2 IPR002523, MgTranspt_CorA/ZnTranspt_ZntB |
Pfami | View protein in Pfam PF01544, CorA, 1 hit |
SUPFAMi | SSF143865, SSF143865, 1 hit SSF144083, SSF144083, 1 hit |
i Sequence
Sequence statusi: Complete.
P43553-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSLSTSFDS SSDLPRSKSV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE
60 70 80 90 100
ALALKVDETK DSRHKFSSSN GENSGVENGG YVEKTNISTS GRMDFEGEAE
110 120 130 140 150
AEAVKRYQLR SFALLSSNAR PSRLAKSETH QKQIHVESIA PSLPKNAALE
160 170 180 190 200
RGHDTALPAG TSSNRCNLEA SSSARTFTSA RKASLVSAIF ETSAESEHGT
210 220 230 240 250
HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND TRRIKPLRMD
260 270 280 290 300
SRVSFHSEIS QASRDSQETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS
310 320 330 340 350
NAERNLSLAN HQRHSERTYN HTDQDTGFTN SASTSGSSAA LKYTPEISRT
360 370 380 390 400
LEKNCSVNEM YVSENNESVR EDDKPDLHPD VTFGRNKIEG EKEGNDSSYS
410 420 430 440 450
RAYYTLQNTE YQIPSRFSFF RSESDETVHA SDIPSLISEG QTFYELFKGG
460 470 480 490 500
DPTWWLDCSC PTDDEMRCIA KTFGIHPLTA EDIRMQETRE KVELFKSYYF
510 520 530 540 550
VCFHTFENDK ESENYLEPIN VYIVVFRSGV LTFHFDPISH CANVRRRVRQ
560 570 580 590 600
LRDYVSVNSD WLCYALIDDI TDSFAPVIQS IEYEADSIDD SVFMTRDMDF
610 620 630 640 650
AAMLQRIGES RRKTMTLMRL LSGKADVIKM FAKRCQDETN GIGPVLKSQT
660 670 680 690 700
NMVNLQAEQE NVNQNNSNNQ ISLSNSYMQT TSQPRGDIAL YLGDIQDHLL
710 720 730 740 750
TMFQNLLAYE KIFSRSHANY LAQLQVESFN SNNKVTEMLG KVTMLGTMLV
760 770 780 790 800
PLNVITGLFG MNVKVPGRNG SIAWWYGILG VLLLLAVISW FLASYWIKKI
810 820 830 840 850
DPPATLNEAA GSGAKSVISS FLPKRDKRFN DDSKNGNARV GVRRKSTVSL
PSRYSRYN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50617 Genomic DNA Translation: BAA09191.1 BK006940 Genomic DNA Translation: DAA12390.1 |
PIRi | S56205 |
RefSeqi | NP_116604.1, NM_001179917.1 |
Genome annotation databases
EnsemblFungii | YFL050C_mRNA; YFL050C; YFL050C |
GeneIDi | 850494 |
KEGGi | sce:YFL050C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50617 Genomic DNA Translation: BAA09191.1 BK006940 Genomic DNA Translation: DAA12390.1 |
PIRi | S56205 |
RefSeqi | NP_116604.1, NM_001179917.1 |
3D structure databases
SMRi | P43553 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31097, 39 interactors |
DIPi | DIP-4581N |
STRINGi | 4932.YFL050C |
PTM databases
iPTMneti | P43553 |
Proteomic databases
MaxQBi | P43553 |
PaxDbi | P43553 |
PRIDEi | P43553 |
Genome annotation databases
EnsemblFungii | YFL050C_mRNA; YFL050C; YFL050C |
GeneIDi | 850494 |
KEGGi | sce:YFL050C |
Organism-specific databases
SGDi | S000001844, ALR2 |
VEuPathDBi | FungiDB:YFL050C |
Phylogenomic databases
eggNOGi | ENOG502QPTQ, Eukaryota |
GeneTreei | ENSGT00940000176664 |
HOGENOMi | CLU_007127_6_0_1 |
InParanoidi | P43553 |
OMAi | REHIRIN |
Enzyme and pathway databases
BRENDAi | 7.2.2.14, 984 |
Miscellaneous databases
PROi | PR:P43553 |
RNActi | P43553, protein |
Family and domain databases
CDDi | cd12829, Alr1p-like, 1 hit |
InterProi | View protein in InterPro IPR044089, Alr1-like IPR045861, CorA_cytoplasmic_dom IPR045863, CorA_TM1_TM2 IPR002523, MgTranspt_CorA/ZnTranspt_ZntB |
Pfami | View protein in Pfam PF01544, CorA, 1 hit |
SUPFAMi | SSF143865, SSF143865, 1 hit SSF144083, SSF144083, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALR2_YEAST | |
Accessioni | P43553Primary (citable) accession number: P43553 Secondary accession number(s): D6VTI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VI
Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names - SIMILARITY comments
Index of protein domains and families