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UniProtKB - P43548 (AGP3_YEAST)

Entry version 159 (17 Jun 2020)
Sequence version 1 (01 Nov 1995)
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Protein

General amino acid permease AGP3

Gene

AGP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

General amino acid permease with broad substrate specificity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		YEAST:G3O-30411-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P43548

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.3.10.14 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General amino acid permease AGP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGP3
Ordered Locus Names:YFL055W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:YFL055W

Saccharomyces Genome Database

More...SGDi		S000001839 AGP3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 81ExtracellularSequence analysis3
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 126CytoplasmicSequence analysisAdd BLAST24
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 168ExtracellularSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 193CytoplasmicSequence analysis4
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 241ExtracellularSequence analysisAdd BLAST27
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 280CytoplasmicSequence analysisAdd BLAST18
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 324ExtracellularSequence analysisAdd BLAST23
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 375CytoplasmicSequence analysisAdd BLAST30
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 402ExtracellularSequence analysis6
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 446CytoplasmicSequence analysisAdd BLAST23
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 480ExtracellularSequence analysisAdd BLAST13
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 558CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541441 – 558General amino acid permease AGP3Add BLAST558

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P43548

PRoteomics IDEntifications database

More...PRIDEi		P43548

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43548

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		31092, 52 interactors

Database of interacting proteins

More...DIPi		DIP-4160N

Protein interaction database and analysis system

More...IntActi		P43548, 3 interactors

Molecular INTeraction database

More...MINTi		P43548

STRING: functional protein association networks

More...STRINGi		4932.YFL055W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43548 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007946_12_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43548

KEGG Orthology (KO)

More...KOi		K16261

Identification of Orthologs from Complete Genome Data

More...OMAi		PMTIAIQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006060 AA_transporter, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43548-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLNLKRET VDIEETAKKD IKPYFASNVE AVDIDEDPDV SRYDPQTGVK 
        60         70         80         90        100
RALKNRHISL LALGGVIGPG CLVGAGNALN KGGPLALLLG FSIIGIIAFS 
       110        120        130        140        150
VMESIGEMIT LYPSGGGFTT LARRFHSDAL PAVCGYAYVV VFFAVLANEY 
       160        170        180        190        200
NTLSSILQFW GPQVPLYGYI LIFWFAFEIF QLVGVGLFGE TEYWLAWLKI 
       210        220        230        240        250
VGLVAYYIFS IVYISGDIRN RPAFGFHYWN SPGALSHGFK GIAIVFVFCS 
       260        270        280        290        300
TFYSGTESVA LAATESKNPG KAVPLAVRQT LWRILVVYIG IAVFYGATVP 
       310        320        330        340        350
FDDPNLSAST KVLKSPIAIA ISRAGWAGGA HLVNAFILIT CISAINGSLY 
       360        370        380        390        400
IGSRTLTHLA HEGLAPKILA WTDRRGVPIP AITVFNALGL ISLMNVSVGA 
       410        420        430        440        450
ANAYSYIVNL SGVGVFIVWG VISYTHLRIR KAWVAQGRSI EELPYEALFY 
       460        470        480        490        500
PWTPVLSLAA NIFLALIQGW SYFVPFDAGN FVDAYILLPV GILLYIGICV 
       510        520        530        540        550
FKSNHFRTVD LRSINLDEGR RKDMEADLSD QESSLASSET MKDYKSATFF 

RYLSNIFT
Length:558
Mass (Da):61,052
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7AE03BE36ADA1A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09186.1
BK006940 Genomic DNA Translation: DAA12385.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56200

NCBI Reference Sequences

More...RefSeqi		NP_116600.1, NM_001179912.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YFL055W_mRNA; YFL055W; YFL055W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850489

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YFL055W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09186.1
BK006940 Genomic DNA Translation: DAA12385.1
PIRiS56200
RefSeqiNP_116600.1, NM_001179912.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31092, 52 interactors
DIPiDIP-4160N
IntActiP43548, 3 interactors
MINTiP43548
STRINGi4932.YFL055W

Protein family/group databases

TCDBi2.A.3.10.14 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiP43548

Proteomic databases

PaxDbiP43548
PRIDEiP43548

Genome annotation databases

EnsemblFungiiYFL055W_mRNA; YFL055W; YFL055W
GeneIDi850489
KEGGisce:YFL055W

Organism-specific databases

EuPathDBiFungiDB:YFL055W
SGDiS000001839 AGP3

Phylogenomic databases

HOGENOMiCLU_007946_12_2_1
InParanoidiP43548
KOiK16261
OMAiPMTIAIQ

Enzyme and pathway databases

BioCyciYEAST:G3O-30411-MONOMER
SABIO-RKiP43548

Miscellaneous databases

Protein Ontology

More...PROi		PR:P43548
RNActiP43548 protein

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGP3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43548
Secondary accession number(s): D6VTH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 17, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names
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