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Entry version 182 (03 Jul 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Nicotinamide phosphoribosyltransferase

Gene

NAMPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide phosphoribosyltransferase (NAMPT), Nicotinamide phosphoribosyltransferase (PBEF1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei196Diphosphate1
Binding sitei219Nicotinamide ribonucleotide1
Binding sitei247Diphosphate1
Binding sitei311Diphosphate1
Binding sitei384Nicotinamide ribonucleotide; via amide nitrogen1
Binding sitei392Nicotinamide ribonucleotide1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Glycosyltransferase, Transferase
Biological processBiological rhythms, Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.2.12 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-197264 Nicotinamide salvaging

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P43490

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43490

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00253;UER00890

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nicotinamide phosphoribosyltransferase (EC:2.4.2.12)
Short name:
NAmPRTase
Short name:
Nampt
Alternative name(s):
Pre-B-cell colony-enhancing factor 1
Short name:
Pre-B cell-enhancing factor
Visfatin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAMPT
Synonyms:PBEF, PBEF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30092 NAMPT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608764 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43490

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi219D → N or S: No effect on activity towards nicotinamide. Alters specificity, so that the enzyme acquires activity towards nicotinic acid. 1 Publication1
Mutagenesisi247H → A: Reduces activity towards nicotinamide. 1 Publication1
Mutagenesisi311R → D: Reduces activity towards nicotinamide. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10135

Open Targets

More...
OpenTargetsi
ENSG00000105835

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162396933

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1744525

Drug and drug target database

More...
DrugBanki
DB05217 GMX1777
DB07656 N-[4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL]-3-PYRIDIN-3-YLPROPANAMIDE

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NAMPT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1172027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002058631 – 491Nicotinamide phosphoribosyltransferaseAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei188PhosphotyrosineCombined sources1
Modified residuei472PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P43490

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43490

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43490

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43490

PeptideAtlas

More...
PeptideAtlasi
P43490

PRoteomics IDEntifications database

More...
PRIDEi
P43490

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55638

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43490

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43490

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P43490

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105835 Expressed in 227 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43490 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P43490 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034349
HPA047776
HPA057722

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115438, 53 interactors

Database of interacting proteins

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DIPi
DIP-29218N

Protein interaction database and analysis system

More...
IntActi
P43490, 20 interactors

Molecular INTeraction database

More...
MINTi
P43490

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222553

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P43490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43490

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P43490

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni311 – 313Nicotinamide ribonucleotide binding3
Regioni353 – 354Nicotinamide ribonucleotide binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEB2 Eukaryota
COG1488 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153456

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216546

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43490

KEGG Orthology (KO)

More...
KOi
K03462

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWYPITV

Database of Orthologous Groups

More...
OrthoDBi
446086at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43490

TreeFam database of animal gene trees

More...
TreeFami
TF333530

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01569 PBEF_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR041529 DUF5598
IPR041525 N/Namide_PRibTrfase
IPR016471 Nicotinamide_PRibTrfase
IPR036068 Nicotinate_pribotase-like_C

The PANTHER Classification System

More...
PANTHERi
PTHR43816 PTHR43816, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18127 DUF5598, 1 hit
PF04095 NAPRTase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005943 NMPRT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51690 SSF51690, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P43490-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR
60 70 80 90 100
KVKYEETVFY GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG
110 120 130 140 150
WNYILEKYDG HLPIEIKAVP EGFVIPRGNV LFTVENTDPE CYWLTNWIET
160 170 180 190 200
ILVQSWYPIT VATNSREQKK ILAKYLLETS GNLDGLEYKL HDFGYRGVSS
210 220 230 240 250
QETAGIGASA HLVNFKGTDT VAGLALIKKY YGTKDPVPGY SVPAAEHSTI
260 270 280 290 300
TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV
310 320 330 340 350
SRSTQAPLII RPDSGNPLDT VLKVLEILGK KFPVTENSKG YKLLPPYLRV
360 370 380 390 400
IQGDGVDINT LQEIVEGMKQ KMWSIENIAF GSGGGLLQKL TRDLLNCSFK
410 420 430 440 450
CSYVVTNGLG INVFKDPVAD PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL
460 470 480 490
EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA QLNIELEAAH H
Length:491
Mass (Da):55,521
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BF07B631B589AC0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFS8A0A0C4DFS8_HUMAN
Nicotinamide phosphoribosyltransfer...
NAMPT
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG65C9JG65_HUMAN
Nicotinamide phosphoribosyltransfer...
NAMPT
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF35C9JF35_HUMAN
Nicotinamide phosphoribosyltransfer...
NAMPT
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ96862 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL24400 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036614176L → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U02020 mRNA Translation: AAA17884.1
AK292851 mRNA Translation: BAF85540.1
AC007032 Genomic DNA Translation: AAF19249.1
AC007032 Genomic DNA Translation: AAQ96862.1 Sequence problems.
CH236947 Genomic DNA Translation: EAL24399.1
CH236947 Genomic DNA Translation: EAL24400.1 Sequence problems.
CH471070 Genomic DNA Translation: EAW83382.1
BC072439 mRNA Translation: AAH72439.1
BC106046 mRNA Translation: AAI06047.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5737.1

Protein sequence database of the Protein Information Resource

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PIRi
A55927

NCBI Reference Sequences

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RefSeqi
NP_005737.1, NM_005746.2
XP_005250157.1, XM_005250100.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222553; ENSP00000222553; ENSG00000105835

Database of genes from NCBI RefSeq genomes

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GeneIDi
10135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10135

UCSC genome browser

More...
UCSCi
uc003vdq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02020 mRNA Translation: AAA17884.1
AK292851 mRNA Translation: BAF85540.1
AC007032 Genomic DNA Translation: AAF19249.1
AC007032 Genomic DNA Translation: AAQ96862.1 Sequence problems.
CH236947 Genomic DNA Translation: EAL24399.1
CH236947 Genomic DNA Translation: EAL24400.1 Sequence problems.
CH471070 Genomic DNA Translation: EAW83382.1
BC072439 mRNA Translation: AAH72439.1
BC106046 mRNA Translation: AAI06047.1
CCDSiCCDS5737.1
PIRiA55927
RefSeqiNP_005737.1, NM_005746.2
XP_005250157.1, XM_005250100.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E5BX-ray2.00A/B1-491[»]
2E5CX-ray2.20A/B1-491[»]
2E5DX-ray2.00A/B1-491[»]
2GVGX-ray2.20A/B/C/D/E/F1-491[»]
2GVJX-ray2.10A/B1-491[»]
3DGRX-ray2.10A/B1-484[»]
3DHDX-ray2.00A/B1-484[»]
3DHFX-ray1.80A/B1-484[»]
3DKJX-ray2.00A/B1-484[»]
3DKLX-ray1.89A/B1-484[»]
4JNMX-ray2.20A/B1-491[»]
4JR5X-ray1.91A/B1-491[»]
4KFNX-ray1.60A/B1-491[»]
4KFOX-ray1.60A/B1-491[»]
4KFPX-ray1.84A/B1-491[»]
4L4LX-ray2.12A/B1-491[»]
4L4MX-ray2.44A/B1-491[»]
4LTSX-ray1.69A/B1-491[»]
4LV9X-ray1.81A/B1-491[»]
4LVAX-ray1.55A/B1-491[»]
4LVBX-ray1.84A/B1-491[»]
4LVDX-ray1.75A/B1-491[»]
4LVFX-ray1.50A/B1-491[»]
4LVGX-ray1.70A/B1-491[»]
4LWWX-ray1.64A/B1-491[»]
4M6PX-ray1.75A/B1-491[»]
4M6QX-ray2.41A/B1-491[»]
4N9BX-ray2.86A/B1-491[»]
4N9CX-ray1.75A/B1-491[»]
4N9DX-ray1.70A/B1-491[»]
4N9EX-ray1.72A/B1-491[»]
4O0ZX-ray2.05A/B1-491[»]
4O10X-ray1.55A/B1-491[»]
4O12X-ray2.50A/B1-491[»]
4O13X-ray1.75A/B1-491[»]
4O14X-ray1.87A/B1-491[»]
4O15X-ray1.80A/B1-491[»]
4O16X-ray1.78A1-491[»]
4O17X-ray1.82A/B1-491[»]
4O18X-ray1.92A/B1-491[»]
4O19X-ray1.75A/B1-491[»]
4O1AX-ray1.87A/B1-491[»]
4O1BX-ray1.65A/B1-491[»]
4O1CX-ray2.09A/B1-491[»]
4O1DX-ray1.70A/B1-491[»]
4O28X-ray2.00A/B1-491[»]
4WQ6X-ray1.72A/B1-491[»]
5KITX-ray1.60A/B1-491[»]
5LX3X-ray2.10A/B1-491[»]
5LX5X-ray1.88A/B1-491[»]
5NSDX-ray2.05A/B1-491[»]
5U2MX-ray1.89A/B9-485[»]
5U2NX-ray1.73A/B9-485[»]
5UPEX-ray1.93A/B1-491[»]
5UPFX-ray1.69A/B1-491[»]
5WI0X-ray2.05A/B1-491[»]
5WI1X-ray1.99A/B1-491[»]
6ATBX-ray2.53A/B/C/D1-491[»]
6AZJX-ray2.53A/B8-485[»]
6B75X-ray2.53A/B/C/D1-491[»]
6B76X-ray2.44A/B/C/D1-491[»]
6E68X-ray1.50A/B8-487[»]
SMRiP43490
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115438, 53 interactors
DIPiDIP-29218N
IntActiP43490, 20 interactors
MINTiP43490
STRINGi9606.ENSP00000222553

Chemistry databases

BindingDBiP43490
ChEMBLiCHEMBL1744525
DrugBankiDB05217 GMX1777
DB07656 N-[4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL]-3-PYRIDIN-3-YLPROPANAMIDE

PTM databases

iPTMnetiP43490
PhosphoSitePlusiP43490
SwissPalmiP43490

Polymorphism and mutation databases

BioMutaiNAMPT
DMDMi1172027

Proteomic databases

EPDiP43490
jPOSTiP43490
MaxQBiP43490
PaxDbiP43490
PeptideAtlasiP43490
PRIDEiP43490
ProteomicsDBi55638

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10135
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222553; ENSP00000222553; ENSG00000105835
GeneIDi10135
KEGGihsa:10135
UCSCiuc003vdq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10135
DisGeNETi10135

GeneCards: human genes, protein and diseases

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GeneCardsi
NAMPT
HGNCiHGNC:30092 NAMPT
HPAiCAB034349
HPA047776
HPA057722
MIMi608764 gene
neXtProtiNX_P43490
OpenTargetsiENSG00000105835
PharmGKBiPA162396933

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEB2 Eukaryota
COG1488 LUCA
GeneTreeiENSGT00940000153456
HOGENOMiHOG000216546
InParanoidiP43490
KOiK03462
OMAiVWYPITV
OrthoDBi446086at2759
PhylomeDBiP43490
TreeFamiTF333530

Enzyme and pathway databases

UniPathwayiUPA00253;UER00890
BRENDAi2.4.2.12 2681
ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-197264 Nicotinamide salvaging
SABIO-RKiP43490
SIGNORiP43490

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NAMPT human
EvolutionaryTraceiP43490

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Nicotinamide_phosphoribosyltransferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10135

Protein Ontology

More...
PROi
PR:P43490

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105835 Expressed in 227 organ(s), highest expression level in blood
ExpressionAtlasiP43490 baseline and differential
GenevisibleiP43490 HS

Family and domain databases

CDDicd01569 PBEF_like, 1 hit
Gene3Di3.20.20.70, 2 hits
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR041529 DUF5598
IPR041525 N/Namide_PRibTrfase
IPR016471 Nicotinamide_PRibTrfase
IPR036068 Nicotinate_pribotase-like_C
PANTHERiPTHR43816 PTHR43816, 1 hit
PfamiView protein in Pfam
PF18127 DUF5598, 1 hit
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF005943 NMPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAMPT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43490
Secondary accession number(s): A4D0Q9
, A4D0R0, Q3KQV0, Q8WW95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 3, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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