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Entry version 167 (16 Oct 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Tumor necrosis factor receptor superfamily member 4

Gene

TNFRSF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.1 Publication
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5669034 TNFs bind their physiological receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43489

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
ACT35 antigen
OX40L receptor
TAX transcriptionally-activated glycoprotein 1 receptor
CD_antigen: CD134
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF4
Synonyms:TXGP1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11918 TNFRSF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600315 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43489

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 214ExtracellularSequence analysisAdd BLAST186
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 277CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 16 (IMD16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07094265R → C in IMD16. 1 PublicationCorresponds to variant dbSNP:rs587777075EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7293

MalaCards human disease database

More...
MalaCardsi
TNFRSF4
MIMi615593 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186827

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
431149 Combined immunodeficiency due to OX40 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P43489

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3989383

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1873

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1171933

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003455429 – 277Tumor necrosis factor receptor superfamily member 4Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 42PROSITE-ProRule annotation1 Publication
Disulfide bondi43 ↔ 56PROSITE-ProRule annotation1 Publication
Disulfide bondi46 ↔ 64PROSITE-ProRule annotation1 Publication
Disulfide bondi67 ↔ 81PROSITE-ProRule annotation1 Publication
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation1 Publication
Disulfide bondi87 ↔ 107PROSITE-ProRule annotation1 Publication
Disulfide bondi109 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 166PROSITE-ProRule annotation
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43489

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43489

PeptideAtlas

More...
PeptideAtlasi
P43489

PRoteomics IDEntifications database

More...
PRIDEi
P43489

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55637

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43489

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186827 Expressed in 83 organ(s), highest expression level in omental fat pad

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43489 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016128

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.

3 Publications

(Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF4P235102EBI-15596193,EBI-11724451

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113144, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-3024N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P43489

Protein interaction database and analysis system

More...
IntActi
P43489, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43489

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P43489

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati30 – 65TNFR-Cys 1Add BLAST36
Repeati66 – 107TNFR-Cys 2Add BLAST42
Repeati108 – 126TNFR-Cys 3; truncatedAdd BLAST19
Repeati127 – 167TNFR-Cys 4Add BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0US Eukaryota
ENOG4111DUJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111452

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049154

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43489

KEGG Orthology (KO)

More...
KOi
K05142

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPRTSQG

Database of Orthologous Groups

More...
OrthoDBi
1081476at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43489

TreeFam database of animal gene trees

More...
TreeFami
TF330135

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13406 TNFRSF4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020445 TNFR_4
IPR034022 TNFRSF4_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01921 TNFACTORR4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P43489-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCVGARRLGR GPCAALLLLG LGLSTVTGLH CVGDTYPSND RCCHECRPGN
60 70 80 90 100
GMVSRCSRSQ NTVCRPCGPG FYNDVVSSKP CKPCTWCNLR SGSERKQLCT
110 120 130 140 150
ATQDTVCRCR AGTQPLDSYK PGVDCAPCPP GHFSPGDNQA CKPWTNCTLA
160 170 180 190 200
GKHTLQPASN SSDAICEDRD PPATQPQETQ GPPARPITVQ PTEAWPRTSQ
210 220 230 240 250
GPSTRPVEVP GGRAVAAILG LGLVLGLLGP LAILLALYLL RRDQRLPPDA
260 270
HKPPGGGSFR TPIQEEQADA HSTLAKI
Length:277
Mass (Da):29,341
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49F15525941550BF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB33944 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02516410R → C1 PublicationCorresponds to variant dbSNP:rs35304565EnsemblClinVar.1
Natural variantiVAR_07094265R → C in IMD16. 1 PublicationCorresponds to variant dbSNP:rs587777075EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75962 mRNA Translation: CAA53576.1
S76792 mRNA Translation: AAB33944.1 Different initiation.
AJ277151 Genomic DNA Translation: CAB96543.1
DQ118974 Genomic DNA Translation: AAZ15374.1
AL162741 Genomic DNA No translation available.
BC105070 mRNA Translation: AAI05071.1
BC105072 mRNA Translation: AAI05073.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I37552

NCBI Reference Sequences

More...
RefSeqi
NP_003318.1, NM_003327.3
XP_016857721.1, XM_017002232.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379236; ENSP00000368538; ENSG00000186827

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7293

UCSC genome browser

More...
UCSCi
uc001ade.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75962 mRNA Translation: CAA53576.1
S76792 mRNA Translation: AAB33944.1 Different initiation.
AJ277151 Genomic DNA Translation: CAB96543.1
DQ118974 Genomic DNA Translation: AAZ15374.1
AL162741 Genomic DNA No translation available.
BC105070 mRNA Translation: AAI05071.1
BC105072 mRNA Translation: AAI05073.1
CCDSiCCDS11.1
PIRiI37552
RefSeqiNP_003318.1, NM_003327.3
XP_016857721.1, XM_017002232.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0AX-ray2.00G/H/I/J/K/L262-266[»]
2HEVX-ray2.41R29-170[»]
2HEYX-ray2.00R/T29-170[»]
6OGXX-ray2.77G29-170[»]
6OKMX-ray2.10R29-170[»]
6OKNX-ray3.25E/R29-170[»]
SMRiP43489
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113144, 8 interactors
DIPiDIP-3024N
ELMiP43489
IntActiP43489, 1 interactor
STRINGi9606.ENSP00000368538

Chemistry databases

ChEMBLiCHEMBL3989383
GuidetoPHARMACOLOGYi1873

PTM databases

iPTMnetiP43489

Polymorphism and mutation databases

BioMutaiTNFRSF4
DMDMi1171933

Proteomic databases

MassIVEiP43489
PaxDbiP43489
PeptideAtlasiP43489
PRIDEiP43489
ProteomicsDBi55637

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P43489

Genome annotation databases

EnsembliENST00000379236; ENSP00000368538; ENSG00000186827
GeneIDi7293
KEGGihsa:7293
UCSCiuc001ade.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7293
DisGeNETi7293

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFRSF4
HGNCiHGNC:11918 TNFRSF4
HPAiCAB016128
MalaCardsiTNFRSF4
MIMi600315 gene
615593 phenotype
neXtProtiNX_P43489
OpenTargetsiENSG00000186827
Orphaneti431149 Combined immunodeficiency due to OX40 deficiency
PharmGKBiPA36611

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0US Eukaryota
ENOG4111DUJ LUCA
GeneTreeiENSGT00730000111452
HOGENOMiHOG000049154
InParanoidiP43489
KOiK05142
OMAiWPRTSQG
OrthoDBi1081476at2759
PhylomeDBiP43489
TreeFamiTF330135

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
SIGNORiP43489

Miscellaneous databases

EvolutionaryTraceiP43489

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD134

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7293
PharosiP43489

Protein Ontology

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PROi
PR:P43489

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186827 Expressed in 83 organ(s), highest expression level in omental fat pad
GenevisibleiP43489 HS

Family and domain databases

CDDicd13406 TNFRSF4, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020445 TNFR_4
IPR034022 TNFRSF4_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
PRINTSiPR01921 TNFACTORR4
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43489
Secondary accession number(s): Q13663, Q2M312, Q5T7M0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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