UniProtKB - P43487 (RANG_HUMAN)
Ran-specific GTPase-activating protein
RANBP1
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- GDP-dissociation inhibitor activity Source: GO_Central
- GTPase activator activity Source: UniProtKB-KW
- small GTPase binding Source: ProtInc
GO - Biological processi
- intracellular transport Source: InterPro
- positive regulation of mitotic centrosome separation Source: GO_Central
- signal transduction Source: UniProtKB
- viral process Source: Reactome
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | P43487 |
Reactomei | R-HSA-165054, Rev-mediated nuclear export of HIV RNA |
Names & Taxonomyi
Protein namesi | Recommended name: Ran-specific GTPase-activating proteinAlternative name(s): Ran-binding protein 1 Short name: RanBP1 |
Gene namesi | Name:RANBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9847, RANBP1 |
MIMi | 601180, gene |
neXtProti | NX_P43487 |
VEuPathDBi | HostDB:ENSG00000099901.16 |
Subcellular locationi
Cytoskeleton
- centrosome Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear envelope Source: Reactome
- nuclear pore Source: GO_Central
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: BHF-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5902 |
OpenTargetsi | ENSG00000099901 |
PharmGKBi | PA34206 |
Miscellaneous databases
Pharosi | P43487, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | RANBP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000213667 | 2 – 201 | Ran-specific GTPase-activating proteinAdd BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 13 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 18 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 150 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 150 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 183 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 | |
Cross-linki | 190 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P43487 |
jPOSTi | P43487 |
MassIVEi | P43487 |
MaxQBi | P43487 |
PaxDbi | P43487 |
PeptideAtlasi | P43487 |
PRIDEi | P43487 |
ProteomicsDBi | 55636 [P43487-1] |
TopDownProteomicsi | P43487-1 [P43487-1] |
2D gel databases
DOSAC-COBS-2DPAGEi | P43487 |
OGPi | P43487 |
REPRODUCTION-2DPAGEi | IPI00414127 |
PTM databases
iPTMneti | P43487 |
PhosphoSitePlusi | P43487 |
SwissPalmi | P43487 |
Expressioni
Gene expression databases
Bgeei | ENSG00000099901, Expressed in subventricular zone (inner) (primate) and 159 other tissues |
ExpressionAtlasi | P43487, baseline and differential |
Genevisiblei | P43487, HS |
Organism-specific databases
HPAi | ENSG00000099901, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:7882974, PubMed:7891706, PubMed:8896452).
Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860, PubMed:11832950).
Identified in a complex that contains TNPO1, RAN and RANBP1.
Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (By similarity).
Identified in a complex with nucleotide-free RAN and RCC1 (PubMed:7882974, PubMed:7616957).
By similarity6 PublicationsGO - Molecular functioni
- cadherin binding Source: BHF-UCL
- small GTPase binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 111838, 71 interactors |
CORUMi | P43487 |
DIPi | DIP-35058N |
IntActi | P43487, 27 interactors |
MINTi | P43487 |
STRINGi | 9606.ENSP00000401564 |
Miscellaneous databases
RNActi | P43487, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P43487 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43487 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 164 | RanBD1PROSITE-ProRule annotationAdd BLAST | 139 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
GeneTreei | ENSGT00900000141073 |
InParanoidi | P43487 |
OMAi | PKDQEDH |
OrthoDBi | 1154500at2759 |
PhylomeDBi | P43487 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID00337 |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAKDTHED HDTSTENTDE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK
60 70 80 90 100
MRAKLFRFAS ENDLPEWKER GTGDVKLLKH KEKGAIRLLM RRDKTLKICA
110 120 130 140 150
NHYITPMMEL KPNAGSDRAW VWNTHADFAD ECPKPELLAI RFLNAENAQK
160 170 180 190 200
FKTKFEECRK EIEEREKKAG SGKNDHAEKV AEKLEALSVK EETKEDAEEK
Q
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6WQW2 | F6WQW2_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 278 | Annotation score: | ||
C9JDM3 | C9JDM3_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 165 | Annotation score: | ||
C9JJ34 | C9JJ34_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 163 | Annotation score: | ||
C9JXG8 | C9JXG8_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 145 | Annotation score: | ||
C9JGV6 | C9JGV6_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 204 | Annotation score: | ||
C9JIC6 | C9JIC6_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 53 | Annotation score: | ||
F8WCY3 | F8WCY3_HUMAN | Ran-specific GTPase-activating prot... | RANBP1 | 73 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | E → V in BAD97226 (PubMed:10591208).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036567 | 16 | E → D in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_053629 | 145 | A → V. Corresponds to variant dbSNP:rs5746863Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055104 | 169 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83617 mRNA Translation: CAA58592.1 D38076 mRNA Translation: BAA07269.1 CR456556 mRNA Translation: CAG30442.1 AK223506 mRNA Translation: BAD97226.1 AC006547 Genomic DNA No translation available. |
CCDSi | CCDS13775.1 [P43487-1] CCDS63408.1 [P43487-2] |
PIRi | S54290 |
RefSeqi | NP_001265568.1, NM_001278639.1 NP_001265569.1, NM_001278640.1 [P43487-2] NP_002873.1, NM_002882.3 [P43487-1] |
Genome annotation databases
Ensembli | ENST00000331821; ENSP00000327583; ENSG00000099901 [P43487-1] ENST00000402752; ENSP00000384925; ENSG00000099901 [P43487-2] |
GeneIDi | 5902 |
KEGGi | hsa:5902 |
UCSCi | uc002zro.3, human [P43487-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83617 mRNA Translation: CAA58592.1 D38076 mRNA Translation: BAA07269.1 CR456556 mRNA Translation: CAG30442.1 AK223506 mRNA Translation: BAD97226.1 AC006547 Genomic DNA No translation available. |
CCDSi | CCDS13775.1 [P43487-1] CCDS63408.1 [P43487-2] |
PIRi | S54290 |
RefSeqi | NP_001265568.1, NM_001278639.1 NP_001265569.1, NM_001278640.1 [P43487-2] NP_002873.1, NM_002882.3 [P43487-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K5D | X-ray | 2.70 | B/E/H/K | 1-201 | [»] | |
1K5G | X-ray | 3.10 | B/E/H/K | 1-201 | [»] | |
SMRi | P43487 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111838, 71 interactors |
CORUMi | P43487 |
DIPi | DIP-35058N |
IntActi | P43487, 27 interactors |
MINTi | P43487 |
STRINGi | 9606.ENSP00000401564 |
Chemistry databases
DrugBanki | DB09130, Copper DB12695, Phenethyl Isothiocyanate |
PTM databases
iPTMneti | P43487 |
PhosphoSitePlusi | P43487 |
SwissPalmi | P43487 |
Genetic variation databases
BioMutai | RANBP1 |
2D gel databases
DOSAC-COBS-2DPAGEi | P43487 |
OGPi | P43487 |
REPRODUCTION-2DPAGEi | IPI00414127 |
Proteomic databases
EPDi | P43487 |
jPOSTi | P43487 |
MassIVEi | P43487 |
MaxQBi | P43487 |
PaxDbi | P43487 |
PeptideAtlasi | P43487 |
PRIDEi | P43487 |
ProteomicsDBi | 55636 [P43487-1] |
TopDownProteomicsi | P43487-1 [P43487-1] |
Protocols and materials databases
Antibodypediai | 23138, 273 antibodies |
DNASUi | 5902 |
Genome annotation databases
Ensembli | ENST00000331821; ENSP00000327583; ENSG00000099901 [P43487-1] ENST00000402752; ENSP00000384925; ENSG00000099901 [P43487-2] |
GeneIDi | 5902 |
KEGGi | hsa:5902 |
UCSCi | uc002zro.3, human [P43487-1] |
Organism-specific databases
CTDi | 5902 |
DisGeNETi | 5902 |
GeneCardsi | RANBP1 |
HGNCi | HGNC:9847, RANBP1 |
HPAi | ENSG00000099901, Low tissue specificity |
MIMi | 601180, gene |
neXtProti | NX_P43487 |
OpenTargetsi | ENSG00000099901 |
PharmGKBi | PA34206 |
VEuPathDBi | HostDB:ENSG00000099901.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
GeneTreei | ENSGT00900000141073 |
InParanoidi | P43487 |
OMAi | PKDQEDH |
OrthoDBi | 1154500at2759 |
PhylomeDBi | P43487 |
Enzyme and pathway databases
PathwayCommonsi | P43487 |
Reactomei | R-HSA-165054, Rev-mediated nuclear export of HIV RNA |
Miscellaneous databases
BioGRID-ORCSi | 5902, 192 hits in 996 CRISPR screens |
ChiTaRSi | RANBP1, human |
EvolutionaryTracei | P43487 |
GeneWikii | RANBP1 |
GenomeRNAii | 5902 |
Pharosi | P43487, Tbio |
PROi | PR:P43487 |
RNActi | P43487, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000099901, Expressed in subventricular zone (inner) (primate) and 159 other tissues |
ExpressionAtlasi | P43487, baseline and differential |
Genevisiblei | P43487, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID00337 |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RANG_HUMAN | |
Accessioni | P43487Primary (citable) accession number: P43487 Secondary accession number(s): Q53EY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families