Erythroid transcription factor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGD
• chromatin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Decreased expression of synapse-related genes and loss of synapses in major depressive disorder."
    Kang H.J., Voleti B., Hajszan T., Rajkowska G., Stockmeier C.A., Licznerski P., Lepack A., Majik M.S., Jeong L.S., Banasr M., Son H., Duman R.S.
    Nat Med 18:1413-1417(2012) [PubMed] [Europe PMC] [Abstract]
• chromatin DNA binding Source: UniProtKB
• cis-regulatory region sequence-specific DNA binding Source: RGD
• DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Expression of GATA-binding transcription factors in rat hepatocytes."
    Matsuda K., Kobune Y., Noda C., Ichihara A.
    FEBS Lett. 353:269-272(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• p53 binding Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Expression of GATA-binding transcription factors in rat hepatocytes."
    Matsuda K., Kobune Y., Noda C., Ichihara A.
    FEBS Lett. 353:269-272(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• sequence-specific double-stranded DNA binding Source: RGD
• transcription cis-regulatory region binding Source: RGD
• transcription coactivator binding Source: Ensembl
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• animal organ regeneration Source: RGDInferred from direct assayⁱ
  • "Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat."
    Juskeviciute E., Vadigepalli R., Hoek J.B.
    BMC Genomics 9:527-527(2008) [PubMed] [Europe PMC] [Abstract]
• basophil differentiation Source: RGD
• cell-cell signaling Source: RGD
• cell development Source: RGD
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to cAMP Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells."
    Zhang Z., Wu A.Z., Feng Z.M., Mruk D., Cheng C.Y., Chen C.L.
    Endocrinology 143:829-836(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to follicle-stimulating hormone stimulus Source: RGDInferred from expression patternⁱ
  • "Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells."
    Zhang Z., Wu A.Z., Feng Z.M., Mruk D., Cheng C.Y., Chen C.L.
    Endocrinology 143:829-836(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: RGDInferred from direct assayⁱ
  • "Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation."
    El Gazzar M.A.
    Inflamm Res 56:345-351(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to thyroid hormone stimulus Source: RGD
• dendritic cell differentiation Source: RGD
• embryonic hemopoiesis Source: RGD
• eosinophil differentiation Source: RGD
• eosinophil fate commitment Source: RGD
• erythrocyte development Source: RGD
• erythrocyte differentiation Source: RGD
• homeostasis of number of cells within a tissue Source: RGD
• in utero embryonic development Source: RGD
• male gonad development Source: RGD
• megakaryocyte differentiation Source: RGD
• myeloid cell differentiation Source: RGD
• negative regulation of apoptotic process Source: RGD
• negative regulation of bone mineralization Source: RGD
• negative regulation of cell population proliferation Source: RGD
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
• negative regulation of transcription by RNA polymerase II Source: UniProtKB
• negative regulation of transcription regulatory region DNA binding Source: RGD
• platelet aggregation Source: RGD
• platelet formation Source: RGD
• positive regulation of cytosolic calcium ion concentration Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: RGD
• positive regulation of mast cell degranulation Source: RGDInferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast proliferation Source: RGD
• positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: RGD
• regulation of definitive erythrocyte differentiation Source: RGD
• regulation of glycoprotein biosynthetic process Source: RGD
• regulation of primitive erythrocyte differentiation Source: RGD
• regulation of transcription, DNA-templated Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "Expression of GATA-binding transcription factors in rat hepatocytes."
    Matsuda K., Kobune Y., Noda C., Ichihara A.
    FEBS Lett. 353:269-272(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• Sertoli cell development Source: RGDInferred from expression patternⁱ
  • "Conserved structure, regulatory elements, and transcriptional regulation from the GATA-1 gene testis promoter."
    Onodera K., Yomogida K., Suwabe N., Takahashi S., Muraosa Y., Hayashi N., Ito E., Gu L., Rassoulzadegan M., Engel J.D., Yamamoto M.
    J Biochem 121:251-263(1997) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGD
• p53 binding Source: RGD
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• transcription coactivator binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDFPGLGALG TSEPLPQFVD SALVSSTSDS AGFFSSGPES LDTASSSTSP 
        60         70         80         90        100
NAATAAATAL AYYREAEAYR HSPVFQVYPL LNSMEGIPGS SPYASWAYSK 
       110        120        130        140        150
TALYPASTVC PSHEDAPSQT LEDPDGKNNN TFLETLKTER LSPDLLTLGT 
       160        170        180        190        200
ALPTSLPVTS SAYGGADFPS PFFSPTGSPL SSAAYSSPKF HGSLPLAPCE 
       210        220        230        240        250
ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP LIRPKKRMIV 
       260        270        280        290        300
SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD 
       310        320        330        340        350
GIQTRNRKAS GKGKKKRGSS LAGAGAAEGP AGGFMVVAGG SSSGNCGEVA 
       360        370        380        390        400
PGLTLGTAGT AHLYQGLGPV VLSGPVSHLM SFPGPLLGSP TASFPTGPVP 
       410 
TTTSTSVVSP LSS                                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ