Erythroid transcription factor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Decreased expression of synapse-related genes and loss of synapses in major depressive disorder."
    Kang H.J., Voleti B., Hajszan T., Rajkowska G., Stockmeier C.A., Licznerski P., Lepack A., Majik M.S., Jeong L.S., Banasr M., Son H., Duman R.S.
    Nat. Med. 18:1413-1417(2012) [PubMed] [Europe PMC] [Abstract]
• chromatin DNA binding Source: UniProtKB
• DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Expression of GATA-binding transcription factors in rat hepatocytes."
    Matsuda K., Kobune Y., Noda C., Ichihara A.
    FEBS Lett. 353:269-272(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• DNA binding, bending Source: RGDInferred from sequence orthologyⁱ
  • "Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis."
    Wu D., Molofsky A.B., Liang H.E., Ricardo-Gonzalez R.R., Jouihan H.A., Bando J.K., Chawla A., Locksley R.M.
    Science 332:243-247(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
  • "ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells."
    Qamar I., Park E., Gong E.Y., Lee H.J., Lee K.
    J. Biol. Chem. 284:18021-18032(2009) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1."
    Crossley M., Tsang A.P., Bieker J.J., Orkin S.H.
    J. Biol. Chem. 269:15440-15444(1994) [PubMed] [Europe PMC] [Abstract]
  • "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor."
    Martin D.I., Tsai S.F., Orkin S.H.
    Nature 338:435-438(1989) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor."
    Calligaris R., Bottardi S., Cogoi S., Apezteguia I., Santoro C.
    Proc. Natl. Acad. Sci. U.S.A. 92:11598-11602(1995) [PubMed] [Europe PMC] [Abstract]
• p53 binding Source: RGDInferred from sequence orthologyⁱ
  • "GATA-1 associates with and inhibits p53."
    Trainor C.D., Mas C., Archambault P., Di Lello P., Omichinski J.G.
    Blood 114:165-173(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor."
    Martin D.I., Tsai S.F., Orkin S.H.
    Nature 338:435-438(1989) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "X-linked thrombocytopenia caused by a novel mutation of GATA-1."
    Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G.
    Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
  • "Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation."
    Sugiyama D., Tanaka M., Kitajima K., Zheng J., Yen H., Murotani T., Yamatodani A., Nakano T.
    Blood 111:1924-1932(2008) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Expression of GATA-binding transcription factors in rat hepatocytes."
    Matsuda K., Kobune Y., Noda C., Ichihara A.
    FEBS Lett. 353:269-272(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• transcription regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."
    Nichols K.E., Crispino J.D., Poncz M., White J.G., Orkin S.H., Maris J.M., Weiss M.J.
    Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• animal organ regeneration Source: RGDInferred from direct assayⁱ
  • "Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat."
    Juskeviciute E., Vadigepalli R., Hoek J.B.
    BMC Genomics 9:527-527(2008) [PubMed] [Europe PMC] [Abstract]
• basophil differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Expression of tal-1 and GATA-binding proteins during human hematopoiesis."
    Mouthon M.A., Bernard O., Mitjavila M.T., Romeo P.H., Vainchenker W., Mathieu-Mahul D.
    Blood 81:647-655(1993) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: RGDInferred from sequence orthologyⁱ
  • "Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2."
    Kacena M.A., Shivdasani R.A., Wilson K., Xi Y., Troiano N., Nazarian A., Gundberg C.M., Bouxsein M.L., Lorenzo J.A., Horowitz M.C.
    J. Bone Miner. Res. 19:652-660(2004) [PubMed] [Europe PMC] [Abstract]
• cell development Source: RGDInferred from sequence orthologyⁱ
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J. 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to cAMP Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells."
    Zhang Z., Wu A.Z., Feng Z.M., Mruk D., Cheng C.Y., Chen C.L.
    Endocrinology 143:829-836(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to follicle-stimulating hormone stimulus Source: RGDInferred from expression patternⁱ
  • "Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells."
    Zhang Z., Wu A.Z., Feng Z.M., Mruk D., Cheng C.Y., Chen C.L.
    Endocrinology 143:829-836(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: RGDInferred from direct assayⁱ
  • "Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation."
    El Gazzar M.A.
    Inflamm. Res. 56:345-351(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to thyroid hormone stimulus Source: RGDInferred from sequence orthologyⁱ
  • "GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells."
    Gamper I., Koh K.R., Ruau D., Ullrich K., Bartunkova J., Piroth D., Hacker C., Bartunek P., Zenke M.
    Exp. Hematol. 37:539-548.e4(2009) [PubMed] [Europe PMC] [Abstract]
• dendritic cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Gata1 regulates dendritic-cell development and survival."
    Gutierrez L., Nikolic T., van Dijk T.B., Hammad H., Vos N., Willart M., Grosveld F., Philipsen S., Lambrecht B.N.
    Blood 110:1933-1941(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic hemopoiesis Source: RGDInferred from sequence orthologyⁱ
  • "Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells."
    Tsai F.Y., Browne C.P., Orkin S.H.
    Dev. Biol. 196:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• eosinophil differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription."
    Zon L.I., Yamaguchi Y., Yee K., Albee E.A., Kimura A., Bennett J.C., Orkin S.H., Ackerman S.J.
    Blood 81:3234-3241(1993) [PubMed] [Europe PMC] [Abstract]
• eosinophil fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "Essential and instructive roles of GATA factors in eosinophil development."
    Hirasawa R., Shimizu R., Takahashi S., Osawa M., Takayanagi S., Kato Y., Onodera M., Minegishi N., Yamamoto M., Fukao K., Taniguchi H., Nakauchi H., Iwama A.
    J. Exp. Med. 195:1379-1386(2002) [PubMed] [Europe PMC] [Abstract]
• erythrocyte development Source: RGDInferred from sequence orthologyⁱ
  • "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."
    Nichols K.E., Crispino J.D., Poncz M., White J.G., Orkin S.H., Maris J.M., Weiss M.J.
    Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
• erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."
    Nichols K.E., Crispino J.D., Poncz M., White J.G., Orkin S.H., Maris J.M., Weiss M.J.
    Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
  • "Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells."
    Simon M.C., Pevny L., Wiles M.V., Keller G., Costantini F., Orkin S.H.
    Nat. Genet. 1:92-98(1992) [PubMed] [Europe PMC] [Abstract]
  • "Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1."
    Pevny L., Simon M.C., Robertson E., Klein W.H., Tsai S.F., D'Agati V., Orkin S.H., Costantini F.
    Nature 349:257-260(1991) [PubMed] [Europe PMC] [Abstract]
  • "Expression of tal-1 and GATA-binding proteins during human hematopoiesis."
    Mouthon M.A., Bernard O., Mitjavila M.T., Romeo P.H., Vainchenker W., Mathieu-Mahul D.
    Blood 81:647-655(1993) [PubMed] [Europe PMC] [Abstract]
  • "Development of hematopoietic cells lacking transcription factor GATA-1."
    Pevny L., Lin C.S., D'Agati V., Simon M.C., Orkin S.H., Costantini F.
    Development 121:163-172(1995) [PubMed] [Europe PMC] [Abstract]
  • "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
  • "Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells."
    Tsai F.Y., Browne C.P., Orkin S.H.
    Dev. Biol. 196:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• homeostasis of number of cells within a tissue Source: RGDInferred from sequence orthologyⁱ
  • "Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development."
    Fujiwara Y., Chang A.N., Williams A.M., Orkin S.H.
    Blood 103:583-585(2004) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGDInferred from sequence orthologyⁱ
  • "Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells."
    Tsai F.Y., Browne C.P., Orkin S.H.
    Dev. Biol. 196:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: RGDInferred from sequence orthologyⁱ
  • "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."
    Nichols K.E., Crispino J.D., Poncz M., White J.G., Orkin S.H., Maris J.M., Weiss M.J.
    Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
• megakaryocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."
    Nichols K.E., Crispino J.D., Poncz M., White J.G., Orkin S.H., Maris J.M., Weiss M.J.
    Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
  • "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J. 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
• myeloid cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1."
    Fujiwara Y., Browne C.P., Cunniff K., Goff S.C., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 93:12355-12358(1996) [PubMed] [Europe PMC] [Abstract]
  • "Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene."
    Takahashi S., Onodera K., Motohashi H., Suwabe N., Hayashi N., Yanai N., Nabesima Y., Yamamoto M.
    J. Biol. Chem. 272:12611-12615(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1."
    Ribeil J.A., Zermati Y., Vandekerckhove J., Cathelin S., Kersual J., Dussiot M., Coulon S., Moura I.C., Zeuner A., Kirkegaard-Sorensen T., Varet B., Solary E., Garrido C., Hermine O.
    Nature 445:102-105(2007) [PubMed] [Europe PMC] [Abstract]
  • "Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis."
    Weiss M.J., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 92:9623-9627(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of bone mineralization Source: RGDInferred from sequence orthologyⁱ
  • "Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2."
    Kacena M.A., Shivdasani R.A., Wilson K., Xi Y., Troiano N., Nazarian A., Gundberg C.M., Bouxsein M.L., Lorenzo J.A., Horowitz M.C.
    J. Bone Miner. Res. 19:652-660(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J. 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGDInferred from sequence orthologyⁱ
  • "Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1."
    Ribeil J.A., Zermati Y., Vandekerckhove J., Cathelin S., Kersual J., Dussiot M., Coulon S., Moura I.C., Zeuner A., Kirkegaard-Sorensen T., Varet B., Solary E., Garrido C., Hermine O.
    Nature 445:102-105(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: UniProtKB
• negative regulation of transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• platelet aggregation Source: RGDInferred from sequence orthologyⁱ
  • "Selective impairment of platelet activation to collagen in the absence of GATA1."
    Hughan S.C., Senis Y., Best D., Thomas A., Frampton J., Vyas P., Watson S.P.
    Blood 105:4369-4376(2005) [PubMed] [Europe PMC] [Abstract]
• platelet formation Source: RGDInferred from sequence orthologyⁱ
  • "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."
    Nichols K.E., Crispino J.D., Poncz M., White J.G., Orkin S.H., Maris J.M., Weiss M.J.
    Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
  • "X-linked thrombocytopenia caused by a novel mutation of GATA-1."
    Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G.
    Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
  • "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J. 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1."
    Ribeil J.A., Zermati Y., Vandekerckhove J., Cathelin S., Kersual J., Dussiot M., Coulon S., Moura I.C., Zeuner A., Kirkegaard-Sorensen T., Varet B., Solary E., Garrido C., Hermine O.
    Nature 445:102-105(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mast cell degranulation Source: RGDInferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2."
    Kacena M.A., Shivdasani R.A., Wilson K., Xi Y., Troiano N., Nazarian A., Gundberg C.M., Bouxsein M.L., Lorenzo J.A., Horowitz M.C.
    J. Bone Miner. Res. 19:652-660(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "Selective impairment of platelet activation to collagen in the absence of GATA1."
    Hughan S.C., Senis Y., Best D., Thomas A., Frampton J., Vyas P., Watson S.P.
    Blood 105:4369-4376(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction."
    Yu C., Niakan K.K., Matsushita M., Stamatoyannopoulos G., Orkin S.H., Raskind W.H.
    Blood 100:2040-2045(2002) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
  • "Gata1 regulates dendritic-cell development and survival."
    Gutierrez L., Nikolic T., van Dijk T.B., Hammad H., Vos N., Willart M., Grosveld F., Philipsen S., Lambrecht B.N.
    Blood 110:1933-1941(2007) [PubMed] [Europe PMC] [Abstract]
  • "SCL and associated proteins distinguish active from repressive GATA transcription factor complexes."
    Tripic T., Deng W., Cheng Y., Zhang Y., Vakoc C.R., Gregory G.D., Hardison R.C., Blobel G.A.
    Blood 113:2191-2201(2009) [PubMed] [Europe PMC] [Abstract]
  • "ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells."
    Qamar I., Park E., Gong E.Y., Lee H.J., Lee K.
    J. Biol. Chem. 284:18021-18032(2009) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 associates with and inhibits p53."
    Trainor C.D., Mas C., Archambault P., Di Lello P., Omichinski J.G.
    Blood 114:165-173(2009) [PubMed] [Europe PMC] [Abstract]
  • "Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1."
    Chen R.L., Chou Y.C., Lan Y.J., Huang T.S., Shen C.K.
    J. Biol. Chem. 285:10189-10197(2010) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1."
    Crossley M., Tsang A.P., Bieker J.J., Orkin S.H.
    J. Biol. Chem. 269:15440-15444(1994) [PubMed] [Europe PMC] [Abstract]
  • "Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor."
    Calligaris R., Bottardi S., Cogoi S., Apezteguia I., Santoro C.
    Proc. Natl. Acad. Sci. U.S.A. 92:11598-11602(1995) [PubMed] [Europe PMC] [Abstract]
  • "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of definitive erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction."
    Yu C., Niakan K.K., Matsushita M., Stamatoyannopoulos G., Orkin S.H., Raskind W.H.
    Blood 100:2040-2045(2002) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of glycoprotein biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "Selective impairment of platelet activation to collagen in the absence of GATA1."
    Hughan S.C., Senis Y., Best D., Thomas A., Frampton J., Vyas P., Watson S.P.
    Blood 105:4369-4376(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of primitive erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development."
    Fujiwara Y., Chang A.N., Williams A.M., Orkin S.H.
    Blood 103:583-585(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "Expression of GATA-binding transcription factors in rat hepatocytes."
    Matsuda K., Kobune Y., Noda C., Ichihara A.
    FEBS Lett. 353:269-272(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• Sertoli cell development Source: RGDInferred from expression patternⁱ
  • "Conserved structure, regulatory elements, and transcriptional regulation from the GATA-1 gene testis promoter."
    Onodera K., Yomogida K., Suwabe N., Takahashi S., Muraosa Y., Hayashi N., Ito E., Gu L., Rassoulzadegan M., Engel J.D., Yamamoto M.
    J. Biochem. 121:251-263(1997) [PubMed] [Europe PMC] [Abstract]
• transcriptional activation by promoter-enhancer looping Source: RGDInferred from sequence orthologyⁱ
  • "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction."
    Liew C.K., Simpson R.J., Kwan A.H., Crofts L.A., Loughlin F.E., Matthews J.M., Crossley M., Mackay J.P.
    Proc. Natl. Acad. Sci. U.S.A. 102:583-588(2005) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor."
    Martin D.I., Tsai S.F., Orkin S.H.
    Nature 338:435-438(1989) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
• p53 binding Source: RGDInferred from sequence orthologyⁱ
  • "GATA-1 associates with and inhibits p53."
    Trainor C.D., Mas C., Archambault P., Di Lello P., Omichinski J.G.
    Blood 114:165-173(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "X-linked thrombocytopenia caused by a novel mutation of GATA-1."
    Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G.
    Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
  • "Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation."
    Sugiyama D., Tanaka M., Kitajima K., Zheng J., Yen H., Murotani T., Yamatodani A., Nakano T.
    Blood 111:1924-1932(2008) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDFPGLGALG TSEPLPQFVD SALVSSTSDS AGFFSSGPES LDTASSSTSP 
        60         70         80         90        100
NAATAAATAL AYYREAEAYR HSPVFQVYPL LNSMEGIPGS SPYASWAYSK 
       110        120        130        140        150
TALYPASTVC PSHEDAPSQT LEDPDGKNNN TFLETLKTER LSPDLLTLGT 
       160        170        180        190        200
ALPTSLPVTS SAYGGADFPS PFFSPTGSPL SSAAYSSPKF HGSLPLAPCE 
       210        220        230        240        250
ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP LIRPKKRMIV 
       260        270        280        290        300
SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD 
       310        320        330        340        350
GIQTRNRKAS GKGKKKRGSS LAGAGAAEGP AGGFMVVAGG SSSGNCGEVA 
       360        370        380        390        400
PGLTLGTAGT AHLYQGLGPV VLSGPVSHLM SFPGPLLGSP TASFPTGPVP 
       410 
TTTSTSVVSP LSS                                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ