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Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in galactose metabolism.By similarity

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 zinc ions per subunit.By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Zinc 1PROSITE-ProRule annotation1
Binding sitei81UDP-alpha-D-glucose; via amide nitrogenBy similarity1
Binding sitei173UDP-alpha-D-glucose; shared with dimeric partnerBy similarity1
Metal bindingi184Zinc 1PROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediatePROSITE-ProRule annotation1
Binding sitei188UDP-alpha-D-glucoseBy similarity1
Metal bindingi202Zinc 2By similarity1
Metal bindingi301Zinc 2By similarity1
Metal bindingi319Zinc 2By similarity1
Metal bindingi321Zinc 2By similarity1

GO - Molecular functioni

  • galactose binding Source: RGD
  • glucose binding Source: RGD
  • UDP-glucose:hexose-1-phosphate uridylyltransferase activity Source: RGD
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-70370 Galactose catabolism
SABIO-RKiP43424
UniPathwayi
UPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12By similarity)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:Galt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1306483 Galt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698841 – 379Galactose-1-phosphate uridylyltransferaseAdd BLAST379

Proteomic databases

PaxDbiP43424
PRIDEiP43424

Expressioni

Gene expression databases

BgeeiENSRNOG00000014766 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiP43424 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019886

Structurei

3D structure databases

ProteinModelPortaliP43424
SMRiP43424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 98UDP-alpha-D-glucose bindingBy similarity2
Regioni334 – 337UDP-alpha-D-glucose bindingBy similarity4
Regioni339 – 340UDP-alpha-D-glucose bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
HOGENOMiHOG000230490
HOVERGENiHBG051700
InParanoidiP43424
KOiK00965
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
PhylomeDBiP43424
TreeFamiTF300018

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit

Sequencei

Sequence statusi: Complete.

P43424-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPPYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPDPG PSDHPLFRVE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASNFLPDIAQ
210 220 230 240 250
REERSQQTYH NQHGKPLLLE YGHQELLRKE RLVLTSEYWI VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VQRLPELTPA ERDDLASTMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPMGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRV LPEVHYCLTQ KDKETAATA
Length:379
Mass (Da):43,314
Last modified:November 1, 1995 - v1
Checksum:iF217FA0A3A3E4665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05541 Genomic DNA Translation: AAC37609.1
BC098756 mRNA Translation: AAH98756.1
PIRiA56685
RefSeqiNP_001013107.1, NM_001013089.2
UniGeneiRn.102781

Genome annotation databases

EnsembliENSRNOT00000019886; ENSRNOP00000019886; ENSRNOG00000014766
GeneIDi298003
KEGGirno:298003
UCSCiRGD:1306483 rat

Similar proteinsi

Entry informationi

Entry nameiGALT_RAT
AccessioniPrimary (citable) accession number: P43424
Secondary accession number(s): Q4KM61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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