UniProtKB - P43407 (SDC2_MOUSE)
Protein
Syndecan-2
Gene
Sdc2
Organism
Mus musculus (Mouse)
Status
Functioni
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.1 Publication
GO - Molecular functioni
- identical protein binding Source: MGI
- PDZ domain binding Source: MGI
GO - Biological processi
- cell migration Source: GO_Central
- dendrite morphogenesis Source: GO_Central
- regulation of dendrite morphogenesis Source: UniProtKB
Keywordsi
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928, HS-GAG biosynthesis R-MMU-2024096, HS-GAG degradation R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-3000170, Syndecan interactions R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-3928662, EPHB-mediated forward signaling R-MMU-8957275, Post-translational protein phosphorylation R-MMU-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syndecan-2Short name: SYND2 Alternative name(s): Fibroglycan Heparan sulfate proteoglycan core protein Short name: HSPG CD_antigen: CD362 |
Gene namesi | Name:Sdc2 Synonyms:Hspg1, Synd2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349165, Sdc2 |
Subcellular locationi
Other locations
Golgi apparatus
- Golgi lumen Source: Reactome
Other locations
- cell surface Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: MGI
- synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 145 | ExtracellularSequence analysisAdd BLAST | 127 | |
Transmembranei | 146 – 170 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 171 – 202 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000033504 | 19 – 202 | Syndecan-2Add BLAST | 184 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 41 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 55 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 57 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Modified residuei | 116 | PhosphoserineBy similarity | 1 | |
Modified residuei | 188 | PhosphoserineBy similarity | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 143 – 144 | Cleavage of ectodomainSequence analysis | 2 |
Keywords - PTMi
Glycoprotein, Heparan sulfate, Phosphoprotein, ProteoglycanProteomic databases
MaxQBi | P43407 |
PaxDbi | P43407 |
PeptideAtlasi | P43407 |
PRIDEi | P43407 |
ProteomicsDBi | 256718 |
PTM databases
GlyGeni | P43407, 3 sites |
iPTMneti | P43407 |
PhosphoSitePlusi | P43407 |
Expressioni
Tissue specificityi
Preferential expression in cells of mesenchymal origin.
Gene expression databases
Bgeei | ENSMUSG00000022261, Expressed in pituitary gland and 307 other tissues |
Genevisiblei | P43407, MM |
Interactioni
Subunit structurei
Interacts (via cytoplasmic domain) with SARM1 (PubMed:21555464).
Forms a complex with SDCBP and PDCD6IP (By similarity).
By similarity1 PublicationBinary interactionsi
P43407
With | #Exp. | IntAct |
---|---|---|
PCOLCE [Q15113] from Homo sapiens. | 4 | EBI-11578890,EBI-8869614 |
GO - Molecular functioni
- identical protein binding Source: MGI
- PDZ domain binding Source: MGI
Protein-protein interaction databases
CORUMi | P43407 |
IntActi | P43407, 1 interactor |
STRINGi | 10090.ENSMUSP00000022871 |
Miscellaneous databases
RNActi | P43407, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the syndecan proteoglycan family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZ6V, Eukaryota |
GeneTreei | ENSGT00940000157222 |
HOGENOMi | CLU_046599_2_1_1 |
InParanoidi | P43407 |
OMAi | MNPAEEN |
OrthoDBi | 1362808at2759 |
PhylomeDBi | P43407 |
TreeFami | TF320463 |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031201, Syndecan-2 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF6, PTHR10915:SF6, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P43407-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD
60 70 80 90 100
YSSASGSGAD EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA
110 120 130 140 150
QTESPEETDK EEVDISEAEE KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV
160 170 180 190 200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF
YA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00674 mRNA Translation: AAA17781.1 AK011042 mRNA Translation: BAB27354.1 BC047144 mRNA Translation: AAH47144.1 |
CCDSi | CCDS27413.1 |
PIRi | I53137 |
RefSeqi | NP_032330.1, NM_008304.2 |
Genome annotation databases
Ensembli | ENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261 |
GeneIDi | 15529 |
KEGGi | mmu:15529 |
UCSCi | uc007vkx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00674 mRNA Translation: AAA17781.1 AK011042 mRNA Translation: BAB27354.1 BC047144 mRNA Translation: AAH47144.1 |
CCDSi | CCDS27413.1 |
PIRi | I53137 |
RefSeqi | NP_032330.1, NM_008304.2 |
3D structure databases
SMRi | P43407 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | P43407 |
IntActi | P43407, 1 interactor |
STRINGi | 10090.ENSMUSP00000022871 |
PTM databases
GlyGeni | P43407, 3 sites |
iPTMneti | P43407 |
PhosphoSitePlusi | P43407 |
Proteomic databases
MaxQBi | P43407 |
PaxDbi | P43407 |
PeptideAtlasi | P43407 |
PRIDEi | P43407 |
ProteomicsDBi | 256718 |
Protocols and materials databases
Antibodypediai | 25987, 284 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261 |
GeneIDi | 15529 |
KEGGi | mmu:15529 |
UCSCi | uc007vkx.1, mouse |
Organism-specific databases
CTDi | 6383 |
MGIi | MGI:1349165, Sdc2 |
Phylogenomic databases
eggNOGi | ENOG502RZ6V, Eukaryota |
GeneTreei | ENSGT00940000157222 |
HOGENOMi | CLU_046599_2_1_1 |
InParanoidi | P43407 |
OMAi | MNPAEEN |
OrthoDBi | 1362808at2759 |
PhylomeDBi | P43407 |
TreeFami | TF320463 |
Enzyme and pathway databases
Reactomei | R-MMU-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928, HS-GAG biosynthesis R-MMU-2024096, HS-GAG degradation R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-3000170, Syndecan interactions R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-3928662, EPHB-mediated forward signaling R-MMU-8957275, Post-translational protein phosphorylation R-MMU-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 15529, 1 hit in 52 CRISPR screens |
ChiTaRSi | Sdc2, mouse |
PROi | PR:P43407 |
RNActi | P43407, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022261, Expressed in pituitary gland and 307 other tissues |
Genevisiblei | P43407, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031201, Syndecan-2 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF6, PTHR10915:SF6, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SDC2_MOUSE | |
Accessioni | P43407Primary (citable) accession number: P43407 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families