Sdc2

Functionⁱ

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.1 Publication

GO - Molecular functionⁱ

identical protein binding Source: MGI
PDZ domain binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dendrite morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of dendrite morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21555464

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation, Neurogenesis

Biological process

Differentiation, Neurogenesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928 HS-GAG biosynthesis R-MMU-2024096 HS-GAG degradation R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-3000170 Syndecan interactions R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-3928662 EPHB-mediated forward signaling R-MMU-8957275 Post-translational protein phosphorylation R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syndecan-2 Short name: SYND2 Alternative name(s): Fibroglycan Heparan sulfate proteoglycan core protein Short name: HSPG CD_antigen: CD362
Gene namesⁱ	Name:Sdc2 Synonyms:Hspg1, Synd2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1349165 Sdc2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 145	ExtracellularSequence analysisAdd BLAST	127
Transmembraneⁱ	146 – 170	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	171 – 202	CytoplasmicSequence analysisAdd BLAST	32

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000033504	19 – 202	Syndecan-2Add BLAST		184

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	41	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Glycosylationⁱ	55	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Glycosylationⁱ	57	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Modified residueⁱ	116	PhosphoserineBy similarity	1
Modified residueⁱ	188	PhosphoserineBy similarity	1

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	143 – 144	Cleavage of ectodomainSequence analysis		2

Keywords - PTMⁱ

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P43407
PaxDbⁱ	P43407
PeptideAtlas More...PeptideAtlasⁱ	P43407
PRIDEⁱ	P43407

PTM databases

iPTMnetⁱ	P43407
PhosphoSitePlusⁱ	P43407

Expressionⁱ

Tissue specificityⁱ

Preferential expression in cells of mesenchymal origin.

Gene expression databases

Bgeeⁱ	ENSMUSG00000022261 Expressed in 292 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_SDC2
Genevisibleⁱ	P43407 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via cytoplasmic domain) with SARM1 (PubMed:21555464). Forms a complex with SDCBP and PDCD6IP (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PCOLCE	Q15113	4	EBI-11578890,EBI-8869614	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

PCOLCE

Q15113

4

EBI-11578890,EBI-8869614

From Homo sapiens.

GO - Molecular functionⁱ

identical protein binding Source: MGI
PDZ domain binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	P43407
IntActⁱ	P43407, 1 interactor
STRINGⁱ	10090.ENSMUSP00000022871

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P43407
SMRⁱ	P43407
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IW5I Eukaryota ENOG4111QSA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063116
HOGENOMⁱ	HOG000263414
HOVERGENⁱ	HBG004501
InParanoidⁱ	P43407
KEGG Orthology (KO) More...KOⁱ	K16336
OMAⁱ	MQRAWIL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OOE
PhylomeDBⁱ	P43407
TreeFamⁱ	TF320463

Family and domain databases

InterProⁱ	View protein in InterPro IPR003585 Neurexin-like IPR001050 Syndecan IPR031201 Syndecan-2 IPR027789 Syndecan/Neurexin_dom IPR030479 Syndecan_CS
PANTHERⁱ	PTHR10915 PTHR10915, 1 hit PTHR10915:SF6 PTHR10915:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit
PROSITEⁱ	View protein in PROSITE PS00964 SYNDECAN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P43407-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD 
        60         70         80         90        100
YSSASGSGAD EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA 
       110        120        130        140        150
QTESPEETDK EEVDISEAEE KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV 
       160        170        180        190        200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF 

YA

Length:202

Mass (Da):22,131

Last modified:November 1, 1995 - v1

Checksum:ⁱC213D1B64D88376F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00674 mRNA Translation: AAA17781.1 AK011042 mRNA Translation: BAB27354.1 BC047144 mRNA Translation: AAH47144.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27413.1
PIRⁱ	I53137
NCBI Reference Sequences More...RefSeqⁱ	NP_032330.1, NM_008304.2
UniGeneⁱ	Mm.234266

Genome annotation databases

Ensemblⁱ	ENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261
GeneIDⁱ	15529
KEGGⁱ	mmu:15529
UCSC genome browser More...UCSCⁱ	uc007vkx.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43407	Syndecan (Fragment)		MOUSE		175	UniRef100_P43407

Protein	Similar proteins		Species	Score	Length	Source
P43407	Syndecan-2		RAT		201	UniRef90_P43407
Syndecan (Fragment)		MOUSE		175
UPI000A307044		MUSPA		202
UPI000A317BCC		MUSCR		202
UPI00038BD0D6		MICOH		201
+4

Protein	Similar proteins		Species	Score	Length	Source
P43407	Syndecan-2		HUMAN		201	UniRef50_P34741
Syndecan-2		BOVIN		202
Syndecan-2		RAT		201
Syndecan		HETGA		202
syndecan-2		BALAS		202
+333

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00674 mRNA Translation: AAA17781.1 AK011042 mRNA Translation: BAB27354.1 BC047144 mRNA Translation: AAH47144.1
CCDSⁱ	CCDS27413.1
PIRⁱ	I53137
RefSeqⁱ	NP_032330.1, NM_008304.2
UniGeneⁱ	Mm.234266

3D structure databases

ProteinModelPortalⁱ	P43407
SMRⁱ	P43407
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P43407
IntActⁱ	P43407, 1 interactor
STRINGⁱ	10090.ENSMUSP00000022871

PTM databases

iPTMnetⁱ	P43407
PhosphoSitePlusⁱ	P43407

Proteomic databases

MaxQBⁱ	P43407
PaxDbⁱ	P43407
PeptideAtlasⁱ	P43407
PRIDEⁱ	P43407

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261
GeneIDⁱ	15529
KEGGⁱ	mmu:15529
UCSCⁱ	uc007vkx.1 mouse

Organism-specific databases

CTDⁱ	6383
MGIⁱ	MGI:1349165 Sdc2

Phylogenomic databases

eggNOGⁱ	ENOG410IW5I Eukaryota ENOG4111QSA LUCA
GeneTreeⁱ	ENSGT00530000063116
HOGENOMⁱ	HOG000263414
HOVERGENⁱ	HBG004501
InParanoidⁱ	P43407
KOⁱ	K16336
OMAⁱ	MQRAWIL
OrthoDBⁱ	EOG091G0OOE
PhylomeDBⁱ	P43407
TreeFamⁱ	TF320463

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-MMU-2022928 HS-GAG biosynthesis R-MMU-2024096 HS-GAG degradation R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-3000170 Syndecan interactions R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-3928662 EPHB-mediated forward signaling R-MMU-8957275 Post-translational protein phosphorylation R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	Sdc2 mouse
Protein Ontology More...PROⁱ	PR:P43407
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022261 Expressed in 292 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_SDC2
Genevisibleⁱ	P43407 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003585 Neurexin-like IPR001050 Syndecan IPR031201 Syndecan-2 IPR027789 Syndecan/Neurexin_dom IPR030479 Syndecan_CS
PANTHERⁱ	PTHR10915 PTHR10915, 1 hit PTHR10915:SF6 PTHR10915:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit
PROSITEⁱ	View protein in PROSITE PS00964 SYNDECAN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SDC2_MOUSE
Accessionⁱ	P43407Primary (citable) accession number: P43407
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P43407 (SDC2_MOUSE)

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Syndecan-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ