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Protein

Syndecan-2

Gene

Sdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • dendrite morphogenesis Source: GO_Central
  • regulation of dendrite morphogenesis Source: UniProtKB

Keywordsi

Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name:
HSPG
CD_antigen: CD362
Gene namesi
Name:Sdc2
Synonyms:Hspg1, Synd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1349165 Sdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 145ExtracellularSequence analysisAdd BLAST127
Transmembranei146 – 170HelicalSequence analysisAdd BLAST25
Topological domaini171 – 202CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003350419 – 202Syndecan-2Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi57O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Modified residuei116PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiP43407
PaxDbiP43407
PeptideAtlasiP43407
PRIDEiP43407

PTM databases

iPTMnetiP43407
PhosphoSitePlusiP43407

Expressioni

Tissue specificityi

Preferential expression in cells of mesenchymal origin.

Gene expression databases

BgeeiENSMUSG00000022261 Expressed in 292 organ(s), highest expression level in pituitary gland
CleanExiMM_SDC2
GenevisibleiP43407 MM

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1 (PubMed:21555464). Forms a complex with SDCBP and PDCD6IP (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PCOLCEQ151134EBI-11578890,EBI-8869614From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP43407
IntActiP43407, 1 interactor
STRINGi10090.ENSMUSP00000022871

Structurei

3D structure databases

ProteinModelPortaliP43407
SMRiP43407
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiP43407
KOiK16336
OMAiMQRAWIL
OrthoDBiEOG091G0OOE
PhylomeDBiP43407
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD
60 70 80 90 100
YSSASGSGAD EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA
110 120 130 140 150
QTESPEETDK EEVDISEAEE KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV
160 170 180 190 200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF

YA
Length:202
Mass (Da):22,131
Last modified:November 1, 1995 - v1
Checksum:iC213D1B64D88376F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00674 mRNA Translation: AAA17781.1
AK011042 mRNA Translation: BAB27354.1
BC047144 mRNA Translation: AAH47144.1
CCDSiCCDS27413.1
PIRiI53137
RefSeqiNP_032330.1, NM_008304.2
UniGeneiMm.234266

Genome annotation databases

EnsembliENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261
GeneIDi15529
KEGGimmu:15529
UCSCiuc007vkx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00674 mRNA Translation: AAA17781.1
AK011042 mRNA Translation: BAB27354.1
BC047144 mRNA Translation: AAH47144.1
CCDSiCCDS27413.1
PIRiI53137
RefSeqiNP_032330.1, NM_008304.2
UniGeneiMm.234266

3D structure databases

ProteinModelPortaliP43407
SMRiP43407
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP43407
IntActiP43407, 1 interactor
STRINGi10090.ENSMUSP00000022871

PTM databases

iPTMnetiP43407
PhosphoSitePlusiP43407

Proteomic databases

MaxQBiP43407
PaxDbiP43407
PeptideAtlasiP43407
PRIDEiP43407

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261
GeneIDi15529
KEGGimmu:15529
UCSCiuc007vkx.1 mouse

Organism-specific databases

CTDi6383
MGIiMGI:1349165 Sdc2

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiP43407
KOiK16336
OMAiMQRAWIL
OrthoDBiEOG091G0OOE
PhylomeDBiP43407
TreeFamiTF320463

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-3000170 Syndecan interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSiSdc2 mouse
PROiPR:P43407
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022261 Expressed in 292 organ(s), highest expression level in pituitary gland
CleanExiMM_SDC2
GenevisibleiP43407 MM

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDC2_MOUSE
AccessioniPrimary (citable) accession number: P43407
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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