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Protein

Integrin alpha-V

Gene

Itgav

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF (PubMed:9827803, PubMed:10025398). They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (PubMed:9827803). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (By similarity). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398, PubMed:25127859).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi260 – 268Sequence analysis9
Calcium bindingi314 – 322Sequence analysis9
Calcium bindingi379 – 387Sequence analysis9
Calcium bindingi443 – 451Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Integrin, Receptor
Biological processAngiogenesis, Cell adhesion, Differentiation
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000170 Syndecan interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445144 Signal transduction by L1
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
CD_antigen: CD51
Cleaved into the following 2 chains:
Gene namesi
Name:Itgav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96608 Itgav

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 988ExtracellularSequence analysisAdd BLAST958
Transmembranei989 – 1012HelicalSequence analysisAdd BLAST24
Topological domaini1013 – 1044CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate, and defective development of CNS and gastrointestinal blood vessels.1 Publication

Chemistry databases

ChEMBLiCHEMBL3430891

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000001630431 – 1044Integrin alpha-VAdd BLAST1014
ChainiPRO_000001630531 – 885Integrin alpha-V heavy chainBy similarityAdd BLAST855
ChainiPRO_0000016306887 – 1044Integrin alpha-V light chainBy similarityAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi89 ↔ 97By similarity
Disulfide bondi138 ↔ 158By similarity
Disulfide bondi172 ↔ 185By similarity
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi508 ↔ 565By similarity
Glycosylationi615N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi626 ↔ 632By similarity
Disulfide bondi698 ↔ 711By similarity
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi835N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi851N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi852 ↔ 900Interchain (between heavy and light chains)By similarity
Glycosylationi869N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi905 ↔ 910By similarity
Glycosylationi941N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi969N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi976N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP43406
MaxQBiP43406
PaxDbiP43406
PeptideAtlasiP43406
PRIDEiP43406

PTM databases

iPTMnetiP43406
PhosphoSitePlusiP43406

Expressioni

Gene expression databases

BgeeiENSMUSG00000027087 Expressed in 301 organ(s), highest expression level in cumulus cell
CleanExiMM_ITGAV
ExpressionAtlasiP43406 baseline and differential
GenevisibleiP43406 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8) (Probable). Interacts with RAB25. Interacts with CIB1 (By similarity). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (PubMed:11805835). ITGAV:ITGB3 and ITGAV:ITGB5 interact with NOV (By similarity). ITGAV:ITGB3 interacts with ADGRA2 (By similarity). ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (By similarity). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1. ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3. ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1. ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (By similarity). ITGAV:ITGB3 interacts with IGF2 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 interact with FBN1 (By similarity). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (By similarity). ITGAV:ITGB6 interacts with TGFB1 (PubMed:10025398).By similarity1 Publication2 Publications

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3035 Integrin alphav-beta3 complex
CPX-3130 Integrin alphav-beta1 complex
CPX-3131 Integrin alphav-beta5 complex
CPX-3132 Integrin alphav-beta6 complex
CPX-3133 Integrin alphav-beta8 complex
CORUMiP43406
IntActiP43406, 4 interactors
MINTiP43406
STRINGi10090.ENSMUSP00000028499

Structurei

3D structure databases

ProteinModelPortaliP43406
SMRiP43406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati32 – 98FG-GAP 1PROSITE-ProRule annotationAdd BLAST67
Repeati109 – 170FG-GAP 2PROSITE-ProRule annotationAdd BLAST62
Repeati173 – 225FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati237 – 291FG-GAP 4PROSITE-ProRule annotationAdd BLAST55
Repeati292 – 357FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati358 – 415FG-GAP 6PROSITE-ProRule annotationAdd BLAST58
Repeati419 – 482FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1015 – 1019GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00930000150849
HOGENOMiHOG000231603
HOVERGENiHBG006186
InParanoidiP43406
KOiK06487
OMAiAPLYQWS
OrthoDBiEOG091G05Z4
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 3 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P43406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPGRLLLR PRPGGLLLLL PGLLLPLADA FNLDVESPAE YAGPEGSYFG
60 70 80 90 100
FAVDFFEPST SSRMFLLVGA PKANTTQPGI VEGGQVLKCE CSSSRRCQPI
110 120 130 140 150
EFDSTGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ
160 170 180 190 200
EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL
210 220 230 240 250
LGGPGSFYWQ GQLISDQVAE IISKYDPNVY SIKYNNQLAT RTAQAIFDDS
260 270 280 290 300
YLGYSVAVGD FNGDGIEDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE
310 320 330 340 350
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ
360 370 380 390 400
RAVGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK
410 420 430 440 450
GLVYIFNGRS TGLNSVPSQI LEGQWAAQSM PPSFGYSMKG ATDVDRNGYP
460 470 480 490 500
DLVVGAFGVD RAVLYRARPV VTVNAGLEVY PSILNQDNKI CPLPGTALKV
510 520 530 540 550
SCFNVRFCLK ADGKGTLPRK LHFQVELLLD KLKQKGAIRR ALFLHNRSPV
560 570 580 590 600
HSKTMTVFRG GQMQCEELVA YLRDESEFRD KLTPITIFME YRLDQRTAAD
610 620 630 640 650
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV NSDQKKIYIG
660 670 680 690 700
DDNPLTLTVK AQNQGEGAYE AELIVSIPPQ ADFIGVVRNN EALARLSCAF
710 720 730 740 750
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLKIQSS
760 770 780 790 800
NSFDNVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW EYKENPETEE
810 820 830 840 850
DVGPIVQHIY ELRNNGPSSF SKAILNLQWP YKYNNNTLLY ILHYDIDGPM
860 870 880 890 900
NCTADTEINP LRIKTPEKND TAAAGQGERN HLITKRDLTL REGDVHTLGC
910 920 930 940 950
GIAKCLQITC QVGRLDRGKS AILYVKSLLW TETFMNKENQ NHSYSLKSSA
960 970 980 990 1000
SFNIIEFPYK NLPIEDLFNS TLVTTNITWG IQPAPMPVPV WVIILAVLAG
1010 1020 1030 1040
LLLLAVLVFV MYRMGFFKRV RPPQEEQERE QLQPHENGEG NSET
Length:1,044
Mass (Da):115,360
Last modified:July 27, 2011 - v2
Checksum:i417FD73D776B5918
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AKI5A2AKI5_MOUSE
Integrin alpha-V
Itgav
1,008Annotation score:
B7ZCI9B7ZCI9_MOUSE
Integrin alpha-V
Itgav
135Annotation score:
F6W6Q6F6W6Q6_MOUSE
Integrin alpha-V
Itgav
120Annotation score:
F6RWM8F6RWM8_MOUSE
Integrin alpha-V
Itgav
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti526 – 527EL → DV in AAC52497 (PubMed:8601592).Curated2
Sequence conflicti768 – 769VL → EK in AAC52497 (PubMed:8601592).Curated2
Sequence conflicti872A → G in AAC52497 (PubMed:8601592).Curated1
Sequence conflicti880N → S in AAC52497 (PubMed:8601592).Curated1
Sequence conflicti887D → G in AAC52497 (PubMed:8601592).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14135 mRNA Translation: AAC52497.1
AL772301 Genomic DNA No translation available.
CCDSiCCDS16181.1
PIRiT10050
RefSeqiNP_032428.2, NM_008402.3
UniGeneiMm.227

Genome annotation databases

EnsembliENSMUST00000028499; ENSMUSP00000028499; ENSMUSG00000027087
GeneIDi16410
KEGGimmu:16410
UCSCiuc008kid.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14135 mRNA Translation: AAC52497.1
AL772301 Genomic DNA No translation available.
CCDSiCCDS16181.1
PIRiT10050
RefSeqiNP_032428.2, NM_008402.3
UniGeneiMm.227

3D structure databases

ProteinModelPortaliP43406
SMRiP43406
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3035 Integrin alphav-beta3 complex
CPX-3130 Integrin alphav-beta1 complex
CPX-3131 Integrin alphav-beta5 complex
CPX-3132 Integrin alphav-beta6 complex
CPX-3133 Integrin alphav-beta8 complex
CORUMiP43406
IntActiP43406, 4 interactors
MINTiP43406
STRINGi10090.ENSMUSP00000028499

Chemistry databases

ChEMBLiCHEMBL3430891

PTM databases

iPTMnetiP43406
PhosphoSitePlusiP43406

Proteomic databases

EPDiP43406
MaxQBiP43406
PaxDbiP43406
PeptideAtlasiP43406
PRIDEiP43406

Protocols and materials databases

DNASUi16410
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028499; ENSMUSP00000028499; ENSMUSG00000027087
GeneIDi16410
KEGGimmu:16410
UCSCiuc008kid.2 mouse

Organism-specific databases

CTDi3685
MGIiMGI:96608 Itgav

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00930000150849
HOGENOMiHOG000231603
HOVERGENiHBG006186
InParanoidiP43406
KOiK06487
OMAiAPLYQWS
OrthoDBiEOG091G05Z4
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000170 Syndecan interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445144 Signal transduction by L1
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiItgav mouse
PROiPR:P43406
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027087 Expressed in 301 organ(s), highest expression level in cumulus cell
CleanExiMM_ITGAV
ExpressionAtlasiP43406 baseline and differential
GenevisibleiP43406 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 3 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITAV_MOUSE
AccessioniPrimary (citable) accession number: P43406
Secondary accession number(s): A2AKI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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