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Protein

Metallothionein-like protein 1A

Gene

MT1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn). Plays a role in Cu homeostasis in the roots under elevated Cu concentration. Functions cooperatively with the phytochelatin synthase PCS1 to protect plants from Cu and cadmium (Cd) toxicity (PubMed:18287486). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development (PubMed:24635746). Confers tolerance to Cd and plays a role in Cd and Zn homeostasis (PubMed:16240177).Curated3 Publications

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • metal ion binding Source: TAIR

GO - Biological processi

  • response to copper ion Source: TAIR
  • response to high light intensity Source: TAIR

Keywordsi

Biological processStress response
LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 1A
Short name:
MT-1A
Alternative name(s):
MT-2
MT-Q
Protein LIGHT STRESS-REGULATED 41 Publication
Gene namesi
Name:MT1A
Synonyms:LSR41 Publication
Ordered Locus Names:At1g07600
ORF Names:F22G5_33, F24B9.34
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G07600
TAIRilocus:2025082 AT1G07600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974191 – 45Metallothionein-like protein 1AAdd BLAST45

Proteomic databases

PaxDbiP43392

Expressioni

Tissue specificityi

Expressed in phloem and mesophyll cells of leaves, vascular tissues of cotyledons, sepals and petals. Expressed in anthers. Expressed in root endodermis and at lower levels in cortex of mature region of roots.1 Publication

Inductioni

By light stress, drought and salt stress.1 Publication

Gene expression databases

GenevisibleiP43392 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G07600.1

Structurei

3D structure databases

ProteinModelPortaliP43392
SMRiP43392
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000113674

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P43392-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MADSNCGCGS SCKCGDSCSC EKNYNKECDN CSCGSNCSCG SNCNC
Length:45
Mass (Da):4,580
Last modified:November 1, 1995 - v1
Checksum:iB8AD2C9A030325D2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9LNV2Q9LNV2_ARATH
Dentin sialophosphoprotein
At1g07330, F22G5.33, F22G5_33
753Annotation score:
F4HQL7F4HQL7_ARATH
Dentin sialophosphoprotein
At1g07330, F22G5.33, F22G5_33
685Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15130 mRNA Translation: AAA50251.1
U11253 Genomic DNA Translation: AAA82209.1
AC007583 Genomic DNA Translation: AAF75098.1
CP002684 Genomic DNA Translation: AEE28147.1
AF332449 mRNA Translation: AAG48812.1
AF386921 mRNA Translation: AAK62366.1
AY128916 mRNA Translation: AAM91316.1
AK230254 mRNA Translation: BAF02056.1
AY086003 mRNA Translation: AAM63212.1
PIRiS57858
RefSeqiNP_172239.1, NM_100633.2
UniGeneiAt.23699
At.48120

Genome annotation databases

EnsemblPlantsiAT1G07600.1; AT1G07600.1; AT1G07600
GeneIDi837273
GrameneiAT1G07600.1; AT1G07600.1; AT1G07600
KEGGiath:AT1G07600

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15130 mRNA Translation: AAA50251.1
U11253 Genomic DNA Translation: AAA82209.1
AC007583 Genomic DNA Translation: AAF75098.1
CP002684 Genomic DNA Translation: AEE28147.1
AF332449 mRNA Translation: AAG48812.1
AF386921 mRNA Translation: AAK62366.1
AY128916 mRNA Translation: AAM91316.1
AK230254 mRNA Translation: BAF02056.1
AY086003 mRNA Translation: AAM63212.1
PIRiS57858
RefSeqiNP_172239.1, NM_100633.2
UniGeneiAt.23699
At.48120

3D structure databases

ProteinModelPortaliP43392
SMRiP43392
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G07600.1

Proteomic databases

PaxDbiP43392

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07600.1; AT1G07600.1; AT1G07600
GeneIDi837273
GrameneiAT1G07600.1; AT1G07600.1; AT1G07600
KEGGiath:AT1G07600

Organism-specific databases

AraportiAT1G07600
TAIRilocus:2025082 AT1G07600

Phylogenomic databases

HOGENOMiHOG000113674

Miscellaneous databases

PROiPR:P43392

Gene expression databases

GenevisibleiP43392 AT

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMT1A_ARATH
AccessioniPrimary (citable) accession number: P43392
Secondary accession number(s): Q0WLF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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