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Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

PTPN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei470SubstrateBy similarity1
Active sitei515Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei559SubstrateBy similarity1

GO - Molecular functioni

  • non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cellular response to cytokine stimulus Source: Reactome
  • negative regulation of neuron projection development Source: MGI
  • peptidyl-tyrosine dephosphorylation Source: MGI
  • positive regulation of protein localization to plasma membrane Source: MGI
  • protein dephosphorylation Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-9008059 Interleukin-37 signaling
SIGNORiP43378

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name:
PTPase MEG2
Gene namesi
Name:PTPN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169410.9
HGNCiHGNC:9661 PTPN9
MIMi600768 gene
neXtProtiNX_P43378

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5780
OpenTargetsiENSG00000169410
PharmGKBiPA34005

Chemistry databases

ChEMBLiCHEMBL6117

Polymorphism and mutation databases

DMDMi1172724

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947641 – 593Tyrosine-protein phosphatase non-receptor type 9Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP43378
MaxQBiP43378
PaxDbiP43378
PeptideAtlasiP43378
PRIDEiP43378
ProteomicsDBi55630

PTM databases

DEPODiP43378
iPTMnetiP43378
PhosphoSitePlusiP43378

Expressioni

Gene expression databases

BgeeiENSG00000169410
CleanExiHS_PTPN9
ExpressionAtlasiP43378 baseline and differential
GenevisibleiP43378 HS

Organism-specific databases

HPAiHPA041922

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111744, 40 interactors
IntActiP43378, 19 interactors
MINTiP43378
STRINGi9606.ENSP00000303554

Chemistry databases

BindingDBiP43378

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi288 – 312Combined sources25
Helixi320 – 323Combined sources4
Turni325 – 327Combined sources3
Helixi328 – 330Combined sources3
Turni340 – 342Combined sources3
Beta strandi343 – 345Combined sources3
Beta strandi350 – 352Combined sources3
Beta strandi359 – 365Combined sources7
Beta strandi368 – 375Combined sources8
Helixi380 – 382Combined sources3
Helixi383 – 392Combined sources10
Beta strandi397 – 400Combined sources4
Beta strandi404 – 406Combined sources3
Beta strandi423 – 426Combined sources4
Beta strandi429 – 438Combined sources10
Beta strandi440 – 451Combined sources12
Turni452 – 455Combined sources4
Beta strandi456 – 465Combined sources10
Beta strandi470 – 472Combined sources3
Helixi478 – 497Combined sources20
Beta strandi511 – 514Combined sources4
Beta strandi516 – 519Combined sources4
Helixi520 – 538Combined sources19
Beta strandi539 – 541Combined sources3
Helixi543 – 550Combined sources8
Turni551 – 553Combined sources3
Helixi561 – 577Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PA5X-ray1.60A/B277-582[»]
4GE2X-ray1.80A/B277-582[»]
4GE5X-ray2.00A/B277-582[»]
4GE6X-ray1.40A/B277-582[»]
4ICZX-ray1.90A277-582[»]
ProteinModelPortaliP43378
SMRiP43378
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43378

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 243CRAL-TRIOPROSITE-ProRule annotationAdd BLAST160
Domaini303 – 574Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni515 – 521Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF2N Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785
HOGENOMiHOG000006971
HOVERGENiHBG006880
InParanoidiP43378
KOiK18038
OMAiNKCRAGR
OrthoDBiEOG091G0JWX
PhylomeDBiP43378
TreeFamiTF351975

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P43378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF
60 70 80 90 100
LMARKFDVLR AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN
110 120 130 140 150
VRDPTGASIA LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV
160 170 180 190 200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS
210 220 230 240 250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF
260 270 280 290 300
LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK
310 320 330 340 350
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS
360 370 380 390 400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM
410 420 430 440 450
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH
460 470 480 490 500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSLAVSNMGA
510 520 530 540 550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM
560 570 580 590
RTQRAFSIQT PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ
Length:593
Mass (Da):68,020
Last modified:November 1, 1995 - v1
Checksum:i9BD75A5A986DDA0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83738 mRNA Translation: AAA60226.1
BT007405 mRNA Translation: AAP36073.1
BC010863 mRNA Translation: AAH10863.1
CCDSiCCDS10280.1
PIRiA42690
RefSeqiNP_002824.1, NM_002833.3
UniGeneiHs.445775

Genome annotation databases

EnsembliENST00000618819; ENSP00000482732; ENSG00000169410
GeneIDi5780
KEGGihsa:5780
UCSCiuc002bal.5 human

Similar proteinsi

Entry informationi

Entry nameiPTN9_HUMAN
AccessioniPrimary (citable) accession number: P43378
Secondary accession number(s): Q53XR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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