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Protein

Melanoma-associated antigen B1

Gene

MAGEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen B1
Alternative name(s):
Cancer/testis antigen 3.1
Short name:
CT3.1
DSS-AHC critical interval MAGE superfamily 10
Short name:
DAM10
MAGE-B1 antigen
MAGE-XP antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEB1
Synonyms:MAGEL1, MAGEXP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000214107.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6808 MAGEB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300097 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43366

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4112

Open Targets

More...
OpenTargetsi
ENSG00000214107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30554

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGEB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17380136

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567121 – 347Melanoma-associated antigen B1Add BLAST347

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P43366

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43366

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43366

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43366

PeptideAtlas

More...
PeptideAtlasi
P43366

PRoteomics IDEntifications database

More...
PRIDEi
P43366

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55629

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43366

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43366

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214107 Expressed in 12 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAGEB1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43366 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001193
HPA002820

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110286, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P43366, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368264

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P43366

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43366

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 307MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562 Eukaryota
ENOG4111S70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231161

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006315

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43366

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWKFMNM

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43366

TreeFam database of animal gene trees

More...
TreeFami
TF328505

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11736 PTHR11736, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838 MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT
60 70 80 90 100
SSPAAGIPQK PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST
110 120 130 140 150
ESSVKDPVAW EAGMLMHFIL RKYKMREPIM KADMLKVVDE KYKDHFTEIL
160 170 180 190 200
NGASRRLELV FGLDLKEDNP SGHTYTLVSK LNLTNDGNLS NDWDFPRNGL
210 220 230 240 250
LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE PRKFITQDLV
260 270 280 290 300
QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF
310 320 330 340
PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM
Length:347
Mass (Da):39,037
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i538A65E02DC34155
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5Q → E in CAG46562 (Ref. 3) Curated1
Sequence conflicti23 – 24QG → HY in AAH13772 (PubMed:15489334).Curated2
Sequence conflicti28A → R in CAA57889 (PubMed:7761436).Curated1
Sequence conflicti144 – 145DH → EY in AAH13772 (PubMed:15489334).Curated2
Sequence conflicti172G → S in CAA57889 (PubMed:7761436).Curated1
Sequence conflicti327T → I in AAC97145 (PubMed:8535061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053499267R → C. Corresponds to variant dbSNP:rs7062640Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82539 mRNA Translation: CAA57889.1
S80936 Genomic DNA Translation: AAC97145.1
CR541762 mRNA Translation: CAG46562.1
AK314977 mRNA Translation: BAG37476.1
AC005185 Genomic DNA Translation: AAD10634.1
CH471074 Genomic DNA Translation: EAW99049.1
BC013772 mRNA Translation: AAH13772.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14222.1

NCBI Reference Sequences

More...
RefSeqi
NP_002354.2, NM_002363.4
NP_796379.1, NM_177404.2
NP_803134.1, NM_177415.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.73021

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378981; ENSP00000368264; ENSG00000214107
ENST00000397548; ENSP00000380681; ENSG00000214107
ENST00000397550; ENSP00000380683; ENSG00000214107

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4112

UCSC genome browser

More...
UCSCi
uc004dcc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82539 mRNA Translation: CAA57889.1
S80936 Genomic DNA Translation: AAC97145.1
CR541762 mRNA Translation: CAG46562.1
AK314977 mRNA Translation: BAG37476.1
AC005185 Genomic DNA Translation: AAD10634.1
CH471074 Genomic DNA Translation: EAW99049.1
BC013772 mRNA Translation: AAH13772.1
CCDSiCCDS14222.1
RefSeqiNP_002354.2, NM_002363.4
NP_796379.1, NM_177404.2
NP_803134.1, NM_177415.2
UniGeneiHs.73021

3D structure databases

ProteinModelPortaliP43366
SMRiP43366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110286, 7 interactors
IntActiP43366, 2 interactors
STRINGi9606.ENSP00000368264

PTM databases

iPTMnetiP43366
PhosphoSitePlusiP43366

Polymorphism and mutation databases

BioMutaiMAGEB1
DMDMi17380136

Proteomic databases

EPDiP43366
jPOSTiP43366
MaxQBiP43366
PaxDbiP43366
PeptideAtlasiP43366
PRIDEiP43366
ProteomicsDBi55629

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4112
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378981; ENSP00000368264; ENSG00000214107
ENST00000397548; ENSP00000380681; ENSG00000214107
ENST00000397550; ENSP00000380683; ENSG00000214107
GeneIDi4112
KEGGihsa:4112
UCSCiuc004dcc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4112
DisGeNETi4112
EuPathDBiHostDB:ENSG00000214107.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAGEB1
HGNCiHGNC:6808 MAGEB1
HPAiHPA001193
HPA002820
MIMi300097 gene
neXtProtiNX_P43366
OpenTargetsiENSG00000214107
PharmGKBiPA30554

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00940000166106
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43366
OMAiIWKFMNM
OrthoDBi1195799at2759
PhylomeDBiP43366
TreeFamiTF328505

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4112

Protein Ontology

More...
PROi
PR:P43366

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000214107 Expressed in 12 organ(s), highest expression level in right testis
CleanExiHS_MAGEB1
GenevisibleiP43366 HS

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43366
Secondary accession number(s): B2RC79
, O00601, O75862, Q6FHJ0, Q96CW8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 26, 2001
Last modified: January 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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