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Protein

Melanoma-associated antigen B1

Gene

MAGEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B1
Alternative name(s):
Cancer/testis antigen 3.1
Short name:
CT3.1
DSS-AHC critical interval MAGE superfamily 10
Short name:
DAM10
MAGE-B1 antigen
MAGE-XP antigen
Gene namesi
Name:MAGEB1
Synonyms:MAGEL1, MAGEXP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000214107.7
HGNCiHGNC:6808 MAGEB1
MIMi300097 gene
neXtProtiNX_P43366

Pathology & Biotechi

Organism-specific databases

DisGeNETi4112
OpenTargetsiENSG00000214107
PharmGKBiPA30554

Polymorphism and mutation databases

BioMutaiMAGEB1
DMDMi17380136

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567121 – 347Melanoma-associated antigen B1Add BLAST347

Proteomic databases

EPDiP43366
MaxQBiP43366
PaxDbiP43366
PeptideAtlasiP43366
PRIDEiP43366
ProteomicsDBi55629

PTM databases

iPTMnetiP43366
PhosphoSitePlusiP43366

Expressioni

Tissue specificityi

Expressed only in testis.

Gene expression databases

BgeeiENSG00000214107 Expressed in 12 organ(s), highest expression level in right testis
CleanExiHS_MAGEB1
GenevisibleiP43366 HS

Organism-specific databases

HPAiHPA001193
HPA002820

Interactioni

Protein-protein interaction databases

BioGridi110286, 7 interactors
IntActiP43366, 2 interactors
STRINGi9606.ENSP00000368264

Structurei

3D structure databases

ProteinModelPortaliP43366
SMRiP43366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 307MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43366
OMAiREPIMKA
OrthoDBiEOG091G0TJ0
PhylomeDBiP43366
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P43366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT
60 70 80 90 100
SSPAAGIPQK PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST
110 120 130 140 150
ESSVKDPVAW EAGMLMHFIL RKYKMREPIM KADMLKVVDE KYKDHFTEIL
160 170 180 190 200
NGASRRLELV FGLDLKEDNP SGHTYTLVSK LNLTNDGNLS NDWDFPRNGL
210 220 230 240 250
LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE PRKFITQDLV
260 270 280 290 300
QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF
310 320 330 340
PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM
Length:347
Mass (Da):39,037
Last modified:September 26, 2001 - v2
Checksum:i538A65E02DC34155
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5Q → E in CAG46562 (Ref. 3) Curated1
Sequence conflicti23 – 24QG → HY in AAH13772 (PubMed:15489334).Curated2
Sequence conflicti28A → R in CAA57889 (PubMed:7761436).Curated1
Sequence conflicti144 – 145DH → EY in AAH13772 (PubMed:15489334).Curated2
Sequence conflicti172G → S in CAA57889 (PubMed:7761436).Curated1
Sequence conflicti327T → I in AAC97145 (PubMed:8535061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053499267R → C. Corresponds to variant dbSNP:rs7062640Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82539 mRNA Translation: CAA57889.1
S80936 Genomic DNA Translation: AAC97145.1
CR541762 mRNA Translation: CAG46562.1
AK314977 mRNA Translation: BAG37476.1
AC005185 Genomic DNA Translation: AAD10634.1
CH471074 Genomic DNA Translation: EAW99049.1
BC013772 mRNA Translation: AAH13772.1
CCDSiCCDS14222.1
RefSeqiNP_002354.2, NM_002363.4
NP_796379.1, NM_177404.2
NP_803134.1, NM_177415.2
UniGeneiHs.73021

Genome annotation databases

EnsembliENST00000378981; ENSP00000368264; ENSG00000214107
ENST00000397548; ENSP00000380681; ENSG00000214107
ENST00000397550; ENSP00000380683; ENSG00000214107
GeneIDi4112
KEGGihsa:4112
UCSCiuc004dcc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGB1_HUMAN
AccessioniPrimary (citable) accession number: P43366
Secondary accession number(s): B2RC79
, O00601, O75862, Q6FHJ0, Q96CW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 26, 2001
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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