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Protein

Melanoma-associated antigen 11

Gene

MAGEA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.1 Publication

Keywordsi

Molecular functionTumor antigen

Enzyme and pathway databases

SIGNORiP43364

Protein family/group databases

MoonDBiP43364 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 11
Alternative name(s):
Cancer/testis antigen 1.11
Short name:
CT1.11
MAGE-11 antigen
Gene namesi
Name:MAGEA111 PublicationImported
Synonyms:MAGE11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000185247.14
HGNCiHGNC:6798 MAGEA11
MIMi300344 gene
neXtProtiNX_P43364

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4110
OpenTargetsiENSG00000185247
PharmGKBiPA30544

Polymorphism and mutation databases

BioMutaiMAGEA11
DMDMi97536722

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567101 – 429Melanoma-associated antigen 11Add BLAST429

Proteomic databases

MaxQBiP43364
PaxDbiP43364
PeptideAtlasiP43364
PRIDEiP43364
ProteomicsDBi55626
55627 [P43364-2]
TopDownProteomicsiP43364-1 [P43364-1]

PTM databases

iPTMnetiP43364
PhosphoSitePlusiP43364

Expressioni

Tissue specificityi

Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.1 Publication

Gene expression databases

BgeeiENSG00000185247 Expressed in 24 organ(s), highest expression level in corpus epididymis
CleanExiHS_MAGEA11
ExpressionAtlasiP43364 baseline and differential
GenevisibleiP43364 HS

Organism-specific databases

HPAiHPA052687

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110284, 111 interactors
IntActiP43364, 114 interactors
MINTiP43364
STRINGi9606.ENSP00000347358

Structurei

3D structure databases

ProteinModelPortaliP43364
SMRiP43364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 421MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43364
OMAiRKYRVKG
OrthoDBiEOG091G0TJ0
PhylomeDBiP43364
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030099 MAGEA11
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF71 PTHR11736:SF71, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43364-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY
60 70 80 90 100
GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT
110 120 130 140 150
VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF
160 170 180 190 200
FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ
210 220 230 240 250
EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG
260 270 280 290 300
SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD
310 320 330 340 350
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF
360 370 380 390 400
LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL
410 420
EYIANANGRD PTSYPSLYED ALREEGEGV
Length:429
Mass (Da):48,129
Last modified:May 16, 2006 - v2
Checksum:iFB399ABF47B4C49B
GO
Isoform 2 (identifier: P43364-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):44,276
Checksum:i36D7A81D8749D896
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E962G5E962_HUMAN
Melanoma antigen family A, 11, isof...
MAGEA11 hCG_1644200
400Annotation score:
C9J2X2C9J2X2_HUMAN
Melanoma-associated antigen 11
MAGEA11
295Annotation score:

Sequence cautioni

The sequence AAA68870 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08077557S → P Found in a family with intellectual disability; unknown pathological significance. 1 Publication1
Natural variantiVAR_053497191S → R. Corresponds to variant dbSNP:rs2233049Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185761 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10686 Genomic DNA Translation: AAA68870.1 Sequence problems.
AY747607 mRNA Translation: AAW71787.1
AK127849 mRNA Translation: BAC87161.1
BC004479 mRNA Translation: AAH04479.2
CCDSiCCDS48180.1 [P43364-1]
PIRiI38660
RefSeqiNP_001011544.1, NM_001011544.1
NP_005357.2, NM_005366.4 [P43364-1]
XP_016885010.1, XM_017029521.1
XP_016885011.1, XM_017029522.1 [P43364-2]
UniGeneiHs.670252

Genome annotation databases

EnsembliENST00000355220; ENSP00000347358; ENSG00000185247 [P43364-1]
GeneIDi4110
KEGGihsa:4110
UCSCiuc004fdq.4 human [P43364-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10686 Genomic DNA Translation: AAA68870.1 Sequence problems.
AY747607 mRNA Translation: AAW71787.1
AK127849 mRNA Translation: BAC87161.1
BC004479 mRNA Translation: AAH04479.2
CCDSiCCDS48180.1 [P43364-1]
PIRiI38660
RefSeqiNP_001011544.1, NM_001011544.1
NP_005357.2, NM_005366.4 [P43364-1]
XP_016885010.1, XM_017029521.1
XP_016885011.1, XM_017029522.1 [P43364-2]
UniGeneiHs.670252

3D structure databases

ProteinModelPortaliP43364
SMRiP43364
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110284, 111 interactors
IntActiP43364, 114 interactors
MINTiP43364
STRINGi9606.ENSP00000347358

Protein family/group databases

MoonDBiP43364 Predicted

PTM databases

iPTMnetiP43364
PhosphoSitePlusiP43364

Polymorphism and mutation databases

BioMutaiMAGEA11
DMDMi97536722

Proteomic databases

MaxQBiP43364
PaxDbiP43364
PeptideAtlasiP43364
PRIDEiP43364
ProteomicsDBi55626
55627 [P43364-2]
TopDownProteomicsiP43364-1 [P43364-1]

Protocols and materials databases

DNASUi4110
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355220; ENSP00000347358; ENSG00000185247 [P43364-1]
GeneIDi4110
KEGGihsa:4110
UCSCiuc004fdq.4 human [P43364-1]

Organism-specific databases

CTDi4110
DisGeNETi4110
EuPathDBiHostDB:ENSG00000185247.14
GeneCardsiMAGEA11
H-InvDBiHIX0022316
HGNCiHGNC:6798 MAGEA11
HPAiHPA052687
MIMi300344 gene
neXtProtiNX_P43364
OpenTargetsiENSG00000185247
PharmGKBiPA30544
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43364
OMAiRKYRVKG
OrthoDBiEOG091G0TJ0
PhylomeDBiP43364
TreeFamiTF328505

Enzyme and pathway databases

SIGNORiP43364

Miscellaneous databases

GeneWikiiMAGEA11
GenomeRNAii4110
PROiPR:P43364
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185247 Expressed in 24 organ(s), highest expression level in corpus epididymis
CleanExiHS_MAGEA11
ExpressionAtlasiP43364 baseline and differential
GenevisibleiP43364 HS

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030099 MAGEA11
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF71 PTHR11736:SF71, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAGAB_HUMAN
AccessioniPrimary (citable) accession number: P43364
Secondary accession number(s): Q5ETU4, Q6ZRZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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