UniProtKB - P43364 (MAGAB_HUMAN)
Protein
Melanoma-associated antigen 11
Gene
MAGEA11
Organism
Homo sapiens (Human)
Status
Functioni
Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.1 Publication
Keywordsi
Molecular function | Tumor antigen |
Enzyme and pathway databases
PathwayCommonsi | P43364 |
SIGNORi | P43364 |
Protein family/group databases
MoonDBi | P43364, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen 11Alternative name(s): Cancer/testis antigen 1.11 Short name: CT1.11 MAGE-11 antigen |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6798, MAGEA11 |
MIMi | 300344, gene |
neXtProti | NX_P43364 |
VEuPathDBi | HostDB:ENSG00000185247.14 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4110 |
OpenTargetsi | ENSG00000185247 |
PharmGKBi | PA30544 |
Miscellaneous databases
Pharosi | P43364, Tbio |
Genetic variation databases
BioMutai | MAGEA11 |
DMDMi | 97536722 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156710 | 1 – 429 | Melanoma-associated antigen 11Add BLAST | 429 |
Proteomic databases
MassIVEi | P43364 |
MaxQBi | P43364 |
PaxDbi | P43364 |
PeptideAtlasi | P43364 |
PRIDEi | P43364 |
ProteomicsDBi | 55626 [P43364-1] 55627 [P43364-2] |
TopDownProteomicsi | P43364-1 [P43364-1] |
PTM databases
iPTMneti | P43364 |
PhosphoSitePlusi | P43364 |
Expressioni
Tissue specificityi
Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.1 Publication
Gene expression databases
Bgeei | ENSG00000185247, Expressed in corpus epididymis and 36 other tissues |
ExpressionAtlasi | P43364, baseline and differential |
Genevisiblei | P43364, HS |
Organism-specific databases
HPAi | ENSG00000185247, Tissue enhanced (epididymis, testis) |
Interactioni
Binary interactionsi
P43364
Isoform 2 [P43364-2]
Protein-protein interaction databases
BioGRIDi | 110284, 139 interactors |
IntActi | P43364, 115 interactors |
MINTi | P43364 |
STRINGi | 9606.ENSP00000347358 |
Miscellaneous databases
RNActi | P43364, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 222 – 421 | MAGEPROSITE-ProRule annotationAdd BLAST | 200 |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000164167 |
InParanoidi | P43364 |
OMAi | YEEHYSV |
OrthoDBi | 1195799at2759 |
PhylomeDBi | P43364 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR021072, MAGE_N IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR030099, MAGEA11 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 1 hit PTHR11736:SF146, PTHR11736:SF146, 1 hit |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit PF12440, MAGE_N, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit SM01392, MAGE_N, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P43364-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY
60 70 80 90 100
GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT
110 120 130 140 150
VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF
160 170 180 190 200
FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ
210 220 230 240 250
EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG
260 270 280 290 300
SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD
310 320 330 340 350
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF
360 370 380 390 400
LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL
410 420
EYIANANGRD PTSYPSLYED ALREEGEGV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E962 | G5E962_HUMAN | Melanoma antigen family A, 11, isof... | MAGEA11 hCG_1644200 | 400 | Annotation score: | ||
C9J2X2 | C9J2X2_HUMAN | Melanoma-associated antigen 11 | MAGEA11 | 295 | Annotation score: |
Sequence cautioni
The sequence AAA68870 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080775 | 57 | S → P Found in a family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1557362265Ensembl. | 1 | |
Natural variantiVAR_053497 | 191 | S → R. Corresponds to variant dbSNP:rs2233049Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018576 | 1 – 35 | Missing in isoform 2. 1 PublicationAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10686 Genomic DNA Translation: AAA68870.1 Sequence problems. AY747607 mRNA Translation: AAW71787.1 AK127849 mRNA Translation: BAC87161.1 BC004479 mRNA Translation: AAH04479.2 |
CCDSi | CCDS48180.1 [P43364-1] |
PIRi | I38660 |
RefSeqi | NP_001011544.1, NM_001011544.1 NP_005357.2, NM_005366.4 [P43364-1] XP_016885010.1, XM_017029521.1 XP_016885011.1, XM_017029522.1 [P43364-2] |
Genome annotation databases
Ensembli | ENST00000355220; ENSP00000347358; ENSG00000185247 [P43364-1] |
GeneIDi | 4110 |
KEGGi | hsa:4110 |
UCSCi | uc004fdq.4, human [P43364-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10686 Genomic DNA Translation: AAA68870.1 Sequence problems. AY747607 mRNA Translation: AAW71787.1 AK127849 mRNA Translation: BAC87161.1 BC004479 mRNA Translation: AAH04479.2 |
CCDSi | CCDS48180.1 [P43364-1] |
PIRi | I38660 |
RefSeqi | NP_001011544.1, NM_001011544.1 NP_005357.2, NM_005366.4 [P43364-1] XP_016885010.1, XM_017029521.1 XP_016885011.1, XM_017029522.1 [P43364-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6WJH | X-ray | 2.19 | A/B/C/D | 218-429 | [»] | |
SMRi | P43364 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110284, 139 interactors |
IntActi | P43364, 115 interactors |
MINTi | P43364 |
STRINGi | 9606.ENSP00000347358 |
Protein family/group databases
MoonDBi | P43364, Predicted |
PTM databases
iPTMneti | P43364 |
PhosphoSitePlusi | P43364 |
Genetic variation databases
BioMutai | MAGEA11 |
DMDMi | 97536722 |
Proteomic databases
MassIVEi | P43364 |
MaxQBi | P43364 |
PaxDbi | P43364 |
PeptideAtlasi | P43364 |
PRIDEi | P43364 |
ProteomicsDBi | 55626 [P43364-1] 55627 [P43364-2] |
TopDownProteomicsi | P43364-1 [P43364-1] |
Protocols and materials databases
Antibodypediai | 30628, 225 antibodies |
DNASUi | 4110 |
Genome annotation databases
Ensembli | ENST00000355220; ENSP00000347358; ENSG00000185247 [P43364-1] |
GeneIDi | 4110 |
KEGGi | hsa:4110 |
UCSCi | uc004fdq.4, human [P43364-1] |
Organism-specific databases
CTDi | 4110 |
DisGeNETi | 4110 |
GeneCardsi | MAGEA11 |
HGNCi | HGNC:6798, MAGEA11 |
HPAi | ENSG00000185247, Tissue enhanced (epididymis, testis) |
MIMi | 300344, gene |
neXtProti | NX_P43364 |
OpenTargetsi | ENSG00000185247 |
PharmGKBi | PA30544 |
VEuPathDBi | HostDB:ENSG00000185247.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000164167 |
InParanoidi | P43364 |
OMAi | YEEHYSV |
OrthoDBi | 1195799at2759 |
PhylomeDBi | P43364 |
TreeFami | TF328505 |
Enzyme and pathway databases
PathwayCommonsi | P43364 |
SIGNORi | P43364 |
Miscellaneous databases
BioGRID-ORCSi | 4110, 6 hits in 611 CRISPR screens |
GeneWikii | MAGEA11 |
GenomeRNAii | 4110 |
Pharosi | P43364, Tbio |
PROi | PR:P43364 |
RNActi | P43364, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185247, Expressed in corpus epididymis and 36 other tissues |
ExpressionAtlasi | P43364, baseline and differential |
Genevisiblei | P43364, HS |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR021072, MAGE_N IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR030099, MAGEA11 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 1 hit PTHR11736:SF146, PTHR11736:SF146, 1 hit |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit PF12440, MAGE_N, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit SM01392, MAGE_N, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGAB_HUMAN | |
Accessioni | P43364Primary (citable) accession number: P43364 Secondary accession number(s): Q5ETU4, Q6ZRZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | May 16, 2006 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references