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UniProtKB - P43364 (MAGAB_HUMAN)

Entry version 163 (02 Dec 2020)
Sequence version 2 (16 May 2006)
Previous versions | rss
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Protein

Melanoma-associated antigen 11

Gene

MAGEA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P43364

SIGNOR Signaling Network Open Resource

More...SIGNORi		P43364

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P43364, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen 11
Alternative name(s):
Cancer/testis antigen 1.11
Short name:
CT1.11
MAGE-11 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEA111 PublicationImported
Synonyms:MAGE11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000185247.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:6798, MAGEA11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300344, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P43364

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4110

Open Targets

More...OpenTargetsi		ENSG00000185247

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30544

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P43364, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAGEA11

Domain mapping of disease mutations (DMDM)

More...DMDMi		97536722

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567101 – 429Melanoma-associated antigen 11Add BLAST429

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P43364

MaxQB - The MaxQuant DataBase

More...MaxQBi		P43364

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P43364

PeptideAtlas

More...PeptideAtlasi		P43364

PRoteomics IDEntifications database

More...PRIDEi		P43364

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55626 [P43364-1]
55627 [P43364-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P43364-1 [P43364-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43364

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P43364

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185247, Expressed in corpus epididymis and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P43364, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P43364, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185247, Tissue enhanced (epididymis, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P43364
With#Exp.IntAct
ACSM2B [Q68CK6]3EBI-739552,EBI-2880280
BRD1 [O95696]3EBI-739552,EBI-714754
C22orf39 [Q6P5X5]3EBI-739552,EBI-7317823
CASP7 [P55210]3EBI-739552,EBI-523958
CAVIN3 [Q969G5]3EBI-739552,EBI-3893101
CCDC105 [Q8IYK2]3EBI-739552,EBI-10818513
CCDC106 [Q9BWC9]3EBI-739552,EBI-711501
CCDC14 - isoform 3 [Q49A88-3]3EBI-739552,EBI-12105646
CCDC146 [Q8IYE0]3EBI-739552,EBI-10749669
CCDC27 [Q2M243]3EBI-739552,EBI-12314269
CDKN2B [P42772]4EBI-739552,EBI-711280
CLUAP1 [Q96AJ1]5EBI-739552,EBI-739780
CORO1A [P31146]3EBI-739552,EBI-1046676
CTTNBP2 [Q8WZ74]3EBI-739552,EBI-1774260
DLGAP1 [Q6IS01]3EBI-739552,EBI-11961832
DOCK10 [Q96BY6]3EBI-739552,EBI-748520
FAM161A [Q3B820]3EBI-739552,EBI-719941
GADD45GIP1 [Q8TAE8]3EBI-739552,EBI-372506
GCSH [P23434]3EBI-739552,EBI-715444
HOXB5 [P09067]3EBI-739552,EBI-3893317
IFI44 [Q8TCB0]3EBI-739552,EBI-2831730
IL11 [P20809]4EBI-739552,EBI-751694
IL6ST [P40189]3EBI-739552,EBI-1030834
JADE3 [Q92613]3EBI-739552,EBI-10278909
LAS2 [Q8IYD9]4EBI-739552,EBI-749878
LMBR1L [A0A0S2Z5F8]3EBI-739552,EBI-16434477
MLF1 [P58340]5EBI-739552,EBI-721328
NDUFB9 [Q9Y6M9]4EBI-739552,EBI-713654
NOL4 - isoform 2 [O94818-2]3EBI-739552,EBI-10190763
NTAQ1 [Q96HA8]3EBI-739552,EBI-741158
PCBD2 [Q9H0N5]3EBI-739552,EBI-634289
PHYH [O14832]4EBI-739552,EBI-721853
PIK3IP1 [Q96FE7]3EBI-739552,EBI-10285708
PIN4 - isoform 2 [Q9Y237-2]3EBI-739552,EBI-11749201
PLCXD3 [Q63HM9]3EBI-739552,EBI-12105500
PPIF [P30405]3EBI-739552,EBI-5544229
PPM1K [Q8N3J5]3EBI-739552,EBI-3923368
RANBP10 [Q6VN20]3EBI-739552,EBI-310569
REX1BD [Q96EN9]3EBI-739552,EBI-745810
SH2D4A [Q9H788]2EBI-739552,EBI-747035
SNX20 - isoform 3 [Q7Z614-3]3EBI-739552,EBI-12336127
STAR [P49675]6EBI-739552,EBI-722932
SUCLA2 [Q9P2R7]3EBI-739552,EBI-2269898
SUOX [P51687]3EBI-739552,EBI-3921347
TCEA2 [Q15560]5EBI-739552,EBI-710310
TCF25 [Q9BQ70]5EBI-739552,EBI-745182
TMEM123 [Q8N131]4EBI-739552,EBI-749248
TRMT1 [Q9NXH9]5EBI-739552,EBI-748900
UBE3D [Q7Z6J8]3EBI-739552,EBI-9379147
WTAP [Q15007]4EBI-739552,EBI-751647
Isoform 2 [P43364-2]
With#Exp.IntAct
ACMSD [Q8TDX5]3EBI-10178634,EBI-749859
B9838V1 [I7GY12]3EBI-10178634,EBI-10178638
BCL2L11 [O43521]3EBI-10178634,EBI-526406
BEX2 [Q9BXY8]3EBI-10178634,EBI-745073
CCDC14 [Q49A88]3EBI-10178634,EBI-751035
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-10178634,EBI-10247802
CDC20B [Q86Y33]3EBI-10178634,EBI-10260504
CLUAP1 [Q96AJ1]3EBI-10178634,EBI-739780
CSNK2A1 [P68400]3EBI-10178634,EBI-347804
DIEXF [Q68CQ4]3EBI-10178634,EBI-747711
DNAJC10 - isoform 2 [Q8IXB1-2]3EBI-10178634,EBI-10262451
DOCK10 - isoform 3 [Q96BY6-3]3EBI-10178634,EBI-10282566
ENOX2 - isoform 2 [Q16206-2]3EBI-10178634,EBI-10179508
GNPDA1 [P46926]3EBI-10178634,EBI-749356
HOXB5 [P09067]3EBI-10178634,EBI-3893317
IL11 [P20809]3EBI-10178634,EBI-751694
IL6ST [Q17RA0]3EBI-10178634,EBI-10238517
JADE3 [Q92613]3EBI-10178634,EBI-10278909
MTA1 [Q13330]3EBI-10178634,EBI-714236
NDUFB9 [Q9Y6M9]3EBI-10178634,EBI-713654
NOS3 [P29474]3EBI-10178634,EBI-1391623
NTAQ1 [Q96HA8]3EBI-10178634,EBI-741158
PCBD2 [Q9H0N5]3EBI-10178634,EBI-634289
PIN4 [Q9Y237]3EBI-10178634,EBI-714599
PNKD [Q8N490]3EBI-10178634,EBI-746368
RADIL [Q96JH8]3EBI-10178634,EBI-744267
RBM23 [Q86U06]3EBI-10178634,EBI-780319
RBM23 - isoform 2 [Q86U06-2]3EBI-10178634,EBI-10258579
SNX20 [Q7Z614]3EBI-10178634,EBI-744896
STAR [P49675]3EBI-10178634,EBI-722932
TCF25 [Q9BQ70]3EBI-10178634,EBI-745182
THEM5 [Q8N1Q8]3EBI-10178634,EBI-10264970
TMEM123 [Q8N131]3EBI-10178634,EBI-749248
TPM3 [Q5VU62]3EBI-10178634,EBI-10184033
TRMT1 [Q9NXH9]3EBI-10178634,EBI-748900
TXN2 [Q99757]3EBI-10178634,EBI-2932492
USP20 [Q9Y2K6]3EBI-10178634,EBI-2511991
ZCCHC12 [Q6PEW1]3EBI-10178634,EBI-748373

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110284, 139 interactors

Protein interaction database and analysis system

More...IntActi		P43364, 113 interactors

Molecular INTeraction database

More...MINTi		P43364

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347358

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43364, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43364

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 421MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4562, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164167

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43364

Identification of Orthologs from Complete Genome Data

More...OMAi		YEEHYSV

Database of Orthologous Groups

More...OrthoDBi		1195799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P43364

TreeFam database of animal gene trees

More...TreeFami		TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR030099, MAGEA11
IPR002190, MHD_dom

The PANTHER Classification System

More...PANTHERi		PTHR11736, PTHR11736, 1 hit
PTHR11736:SF146, PTHR11736:SF146, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50838, MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43364-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY 
        60         70         80         90        100
GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT 
       110        120        130        140        150
VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF 
       160        170        180        190        200
FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ 
       210        220        230        240        250
EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG 
       260        270        280        290        300
SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD 
       310        320        330        340        350
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF 
       360        370        380        390        400
LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL 
       410        420 
EYIANANGRD PTSYPSLYED ALREEGEGV
Length:429
Mass (Da):48,129
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB399ABF47B4C49B
GO
Isoform 2 (identifier: P43364-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:394
Mass (Da):44,276
Checksum:i36D7A81D8749D896
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E962G5E962_HUMAN
Melanoma antigen family A, 11, isof...
MAGEA11 hCG_1644200
400Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2X2C9J2X2_HUMAN
Melanoma-associated antigen 11
MAGEA11
295Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA68870 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08077557S → P Found in a family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1557362265Ensembl.1
Natural variantiVAR_053497191S → R. Corresponds to variant dbSNP:rs2233049Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0185761 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U10686 Genomic DNA Translation: AAA68870.1 Sequence problems.
AY747607 mRNA Translation: AAW71787.1
AK127849 mRNA Translation: BAC87161.1
BC004479 mRNA Translation: AAH04479.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48180.1 [P43364-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38660

NCBI Reference Sequences

More...RefSeqi		NP_001011544.1, NM_001011544.1
NP_005357.2, NM_005366.4 [P43364-1]
XP_016885010.1, XM_017029521.1
XP_016885011.1, XM_017029522.1 [P43364-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355220; ENSP00000347358; ENSG00000185247 [P43364-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4110

UCSC genome browser

More...UCSCi		uc004fdq.4, human [P43364-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10686 Genomic DNA Translation: AAA68870.1 Sequence problems.
AY747607 mRNA Translation: AAW71787.1
AK127849 mRNA Translation: BAC87161.1
BC004479 mRNA Translation: AAH04479.2
CCDSiCCDS48180.1 [P43364-1]
PIRiI38660
RefSeqiNP_001011544.1, NM_001011544.1
NP_005357.2, NM_005366.4 [P43364-1]
XP_016885010.1, XM_017029521.1
XP_016885011.1, XM_017029522.1 [P43364-2]

3D structure databases

SMRiP43364
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110284, 139 interactors
IntActiP43364, 113 interactors
MINTiP43364
STRINGi9606.ENSP00000347358

Protein family/group databases

MoonDBiP43364, Predicted

PTM databases

iPTMnetiP43364
PhosphoSitePlusiP43364

Polymorphism and mutation databases

BioMutaiMAGEA11
DMDMi97536722

Proteomic databases

MassIVEiP43364
MaxQBiP43364
PaxDbiP43364
PeptideAtlasiP43364
PRIDEiP43364
ProteomicsDBi55626 [P43364-1]
55627 [P43364-2]
TopDownProteomicsiP43364-1 [P43364-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30628, 219 antibodies

The DNASU plasmid repository

More...DNASUi		4110

Genome annotation databases

EnsembliENST00000355220; ENSP00000347358; ENSG00000185247 [P43364-1]
GeneIDi4110
KEGGihsa:4110
UCSCiuc004fdq.4, human [P43364-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4110
DisGeNETi4110
EuPathDBiHostDB:ENSG00000185247.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAGEA11
HGNCiHGNC:6798, MAGEA11
HPAiENSG00000185247, Tissue enhanced (epididymis, testis)
MIMi300344, gene
neXtProtiNX_P43364
OpenTargetsiENSG00000185247
PharmGKBiPA30544

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4562, Eukaryota
GeneTreeiENSGT00940000164167
InParanoidiP43364
OMAiYEEHYSV
OrthoDBi1195799at2759
PhylomeDBiP43364
TreeFamiTF328505

Enzyme and pathway databases

PathwayCommonsiP43364
SIGNORiP43364

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4110, 4 hits in 470 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAGEA11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4110
PharosiP43364, Tbio

Protein Ontology

More...PROi		PR:P43364
RNActiP43364, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185247, Expressed in corpus epididymis and 36 other tissues
ExpressionAtlasiP43364, baseline and differential
GenevisibleiP43364, HS

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR030099, MAGEA11
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 1 hit
PTHR11736:SF146, PTHR11736:SF146, 1 hit
PfamiView protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838, MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGAB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43364
Secondary accession number(s): Q5ETU4, Q6ZRZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 16, 2006
Last modified: December 2, 2020
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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