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Protein

Melanoma-associated antigen 10

Gene

MAGEA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 10
Alternative name(s):
Cancer/testis antigen 1.10
Short name:
CT1.10
MAGE-10 antigen
Gene namesi
Name:MAGEA10
Synonyms:MAGE10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000124260.11
HGNCiHGNC:6797 MAGEA10
MIMi300343 gene
neXtProtiNX_P43363

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4109
OpenTargetsiENSG00000124260
PharmGKBiPA30543

Polymorphism and mutation databases

BioMutaiMAGEA10
DMDMi317373386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567091 – 369Melanoma-associated antigen 10Add BLAST369

Proteomic databases

EPDiP43363
MaxQBiP43363
PaxDbiP43363
PeptideAtlasiP43363
PRIDEiP43363
ProteomicsDBi55625
TopDownProteomicsiP43363

PTM databases

iPTMnetiP43363
PhosphoSitePlusiP43363

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for spermatogonia, spermatocytes and placenta.1 Publication

Gene expression databases

BgeeiENSG00000124260 Expressed in 12 organ(s), highest expression level in chorionic villus
CleanExiHS_MAGEA10
ExpressionAtlasiP43363 baseline and differential
GenevisibleiP43363 HS

Organism-specific databases

HPAiHPA003333
HPA070780

Interactioni

Protein-protein interaction databases

BioGridi110283, 43 interactors
IntActiP43363, 11 interactors
STRINGi9606.ENSP00000244096

Structurei

3D structure databases

ProteinModelPortaliP43363
SMRiP43363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 333MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 62Poly-Ser9

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43363
OMAiDGMEHFI
OrthoDBiEOG091G0TJ0
PhylomeDBiP43363
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030102 MAGEA10
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF19 PTHR11736:SF19, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P43363-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVEEDASS STSTSSSFPS
60 70 80 90 100
SFPSSSSSSS SSCYPLIPST PEEVSADDET PNPPQSAQIA CSSPSVVASL
110 120 130 140 150
PLDQSDEGSS SQKEESPSTL QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ
160 170 180 190 200
MKEPITKAEI LESVIRNYED HFPLLFSEAS ECMLLVFGID VKEVDPTGHS
210 220 230 240 250
FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIVFIEGYC TPEEVIWEAL
260 270 280 290 300
NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP
310 320 330 340 350
RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD
360
TTAMASASSS ATGSFSYPE
Length:369
Mass (Da):40,780
Last modified:January 11, 2011 - v2
Checksum:i64FC72BBAF6F2DE6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J958C9J958_HUMAN
Melanoma-associated antigen 10
MAGEA10
184Annotation score:
C9J9A2C9J9A2_HUMAN
Melanoma-associated antigen 10
MAGEA10
161Annotation score:
J3QRD7J3QRD7_HUMAN
Melanoma-associated antigen 10
MAGEA10
71Annotation score:
J3KT71J3KT71_HUMAN
Melanoma-associated antigen 10
MAGEA10
58Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024528166R → K2 PublicationsCorresponds to variant dbSNP:rs210585Ensembl.1
Natural variantiVAR_053496234V → I2 PublicationsCorresponds to variant dbSNP:rs210586Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10685 Genomic DNA Translation: AAA68869.1
AC116666 Genomic DNA No translation available.
BC004105 mRNA Translation: AAH04105.1
CCDSiCCDS14705.1
PIRiI38659
RefSeqiNP_001011543.2, NM_001011543.2
NP_001238757.1, NM_001251828.1
NP_066386.2, NM_021048.4
UniGeneiHs.18048

Genome annotation databases

EnsembliENST00000244096; ENSP00000244096; ENSG00000124260
ENST00000370323; ENSP00000359347; ENSG00000124260
GeneIDi4109
KEGGihsa:4109
UCSCiuc004ffk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10685 Genomic DNA Translation: AAA68869.1
AC116666 Genomic DNA No translation available.
BC004105 mRNA Translation: AAH04105.1
CCDSiCCDS14705.1
PIRiI38659
RefSeqiNP_001011543.2, NM_001011543.2
NP_001238757.1, NM_001251828.1
NP_066386.2, NM_021048.4
UniGeneiHs.18048

3D structure databases

ProteinModelPortaliP43363
SMRiP43363
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110283, 43 interactors
IntActiP43363, 11 interactors
STRINGi9606.ENSP00000244096

PTM databases

iPTMnetiP43363
PhosphoSitePlusiP43363

Polymorphism and mutation databases

BioMutaiMAGEA10
DMDMi317373386

Proteomic databases

EPDiP43363
MaxQBiP43363
PaxDbiP43363
PeptideAtlasiP43363
PRIDEiP43363
ProteomicsDBi55625
TopDownProteomicsiP43363

Protocols and materials databases

DNASUi4109
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244096; ENSP00000244096; ENSG00000124260
ENST00000370323; ENSP00000359347; ENSG00000124260
GeneIDi4109
KEGGihsa:4109
UCSCiuc004ffk.4 human

Organism-specific databases

CTDi4109
DisGeNETi4109
EuPathDBiHostDB:ENSG00000124260.11
GeneCardsiMAGEA10
HGNCiHGNC:6797 MAGEA10
HPAiHPA003333
HPA070780
MIMi300343 gene
neXtProtiNX_P43363
OpenTargetsiENSG00000124260
PharmGKBiPA30543
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43363
OMAiDGMEHFI
OrthoDBiEOG091G0TJ0
PhylomeDBiP43363
TreeFamiTF328505

Miscellaneous databases

GenomeRNAii4109
PROiPR:P43363
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124260 Expressed in 12 organ(s), highest expression level in chorionic villus
CleanExiHS_MAGEA10
ExpressionAtlasiP43363 baseline and differential
GenevisibleiP43363 HS

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030102 MAGEA10
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF19 PTHR11736:SF19, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAGAA_HUMAN
AccessioniPrimary (citable) accession number: P43363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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