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Entry version 164 (07 Oct 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Melanoma-associated antigen 6

Gene

MAGEA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.2 Publications

Caution

In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specific for MAGEA3 and MAGEA6.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P43360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen 6
Alternative name(s):
Cancer/testis antigen 1.6
Short name:
CT1.6
MAGE-6 antigen
MAGE3B antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEA6
Synonyms:MAGE6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197172.10

Human Gene Nomenclature Database

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HGNCi
HGNC:6804, MAGEA6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300176, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P43360

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4105

Open Targets

More...
OpenTargetsi
ENSG00000197172

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30550

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P43360, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MAGEA6

Domain mapping of disease mutations (DMDM)

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DMDMi
1170860

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567061 – 314Melanoma-associated antigen 6Add BLAST314

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43360

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43360

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43360

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43360

PeptideAtlas

More...
PeptideAtlasi
P43360

PRoteomics IDEntifications database

More...
PRIDEi
P43360

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55622

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43360

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43360

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197172, Expressed in testis and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43360, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43360, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197172, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIM28.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P43360
With#Exp.IntAct
ACOT7 [O00154]3EBI-1045155,EBI-948905
ACOT7 - isoform 4 [O00154-4]3EBI-1045155,EBI-12007918
ACTN3 [Q08043]3EBI-1045155,EBI-2880652
AKAP9 - isoform 2 [Q99996-2]3EBI-1045155,EBI-9641546
ANKRD26P1 [Q6NSI1]3EBI-1045155,EBI-10250923
APOA4 [P06727]3EBI-1045155,EBI-1222447
ARFIP1 [P53367]3EBI-1045155,EBI-2808808
ATP6V1G1 [O75348]3EBI-1045155,EBI-711802
ATPAF2 [Q8N5M1]9EBI-1045155,EBI-1166928
BCL7B [Q9BQE9]6EBI-1045155,EBI-2560588
BET1 [O15155]3EBI-1045155,EBI-749204
BFSP2 [Q13515]3EBI-1045155,EBI-10229433
BOLA3 [Q53S33]3EBI-1045155,EBI-12086950
C1orf216 [Q8TAB5]3EBI-1045155,EBI-747505
CAMTA2 - isoform 5 [O94983-5]3EBI-1045155,EBI-10176008
CBFA2T2 - isoform 4 [O43439-4]3EBI-1045155,EBI-11954144
CCDC146 [Q8IYE0]3EBI-1045155,EBI-10749669
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-1045155,EBI-10247802
CCDC185 [Q8N715]3EBI-1045155,EBI-740814
CCDC24 [Q8N4L8]3EBI-1045155,EBI-1104933
CTF1 [Q16619]3EBI-1045155,EBI-10238077
CTF1 - isoform 2 [Q16619-2]3EBI-1045155,EBI-12276476
DLGAP3 [O95886]3EBI-1045155,EBI-1752541
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-1045155,EBI-12000556
DNTTIP1 [Q9H147]3EBI-1045155,EBI-2795449
ELMOD3 [Q96FG2]3EBI-1045155,EBI-10285740
EXOC5 [O00471]6EBI-1045155,EBI-949824
FAM214A [Q32MH5]3EBI-1045155,EBI-2866142
FRMPD1 [Q5SYB0]3EBI-1045155,EBI-10245120
GADD45GIP1 [Q8TAE8]3EBI-1045155,EBI-372506
GCSH [P23434]3EBI-1045155,EBI-715444
GFOD1 [Q9NXC2]6EBI-1045155,EBI-8799578
HAUS1 [Q96CS2]3EBI-1045155,EBI-2514791
HNRNPM [P52272]3EBI-1045155,EBI-486809
IQUB [Q8NA54]3EBI-1045155,EBI-10220600
KIF27 [Q86VH2]3EBI-1045155,EBI-7950718
KLHL38 [Q2WGJ6]6EBI-1045155,EBI-6426443
LCORL [Q8N3X6]3EBI-1045155,EBI-7138654
LCORL - isoform 3 [Q8N3X6-3]3EBI-1045155,EBI-12111580
LIN37 [Q96GY3]6EBI-1045155,EBI-748884
LIN52 [Q52LA3]3EBI-1045155,EBI-1389456
LSM2 [Q9Y333]6EBI-1045155,EBI-347416
MCRS1 [Q96EZ8]3EBI-1045155,EBI-348259
MED21 [A0A0S2Z545]3EBI-1045155,EBI-16431233
MGC50722 [Q8IVT4]3EBI-1045155,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-1045155,EBI-10172526
MIPOL1 [Q8TD10]6EBI-1045155,EBI-2548751
MORN3 [Q6PF18]6EBI-1045155,EBI-9675802
MSGN1 [A6NI15]3EBI-1045155,EBI-11991020
NCK2 [O43639]6EBI-1045155,EBI-713635
NOSTRIN - isoform 3 [Q8IVI9-3]3EBI-1045155,EBI-12280006
PCBD2 [Q9H0N5]3EBI-1045155,EBI-634289
PDE4D [Q08499]3EBI-1045155,EBI-1642831
RASSF10 [A6NK89]3EBI-1045155,EBI-6912267
RASSF4 [Q9H2L5]6EBI-1045155,EBI-2933362
RCOR3 [Q9P2K3]3EBI-1045155,EBI-743428
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-1045155,EBI-1504830
REX1BD [Q96EN9]3EBI-1045155,EBI-745810
RPL37A [P61513]6EBI-1045155,EBI-356793
RUSC1 [Q9BVN2]3EBI-1045155,EBI-6257312
S100A14 [Q9HCY8]3EBI-1045155,EBI-751842
S100A9 [P06702]3EBI-1045155,EBI-1055001
SH2D4A [Q9H788]6EBI-1045155,EBI-747035
SMARCD1 [Q96GM5]3EBI-1045155,EBI-358489
SNAP47 [Q5SQN1]3EBI-1045155,EBI-10244848
SNX4 [O95219]3EBI-1045155,EBI-724909
STAMBPL1 [Q96FJ0]6EBI-1045155,EBI-745021
STX5 [Q13190]3EBI-1045155,EBI-714206
TRIM26 [Q12899]4EBI-1045155,EBI-2341136
TRIM28 [Q13263]2EBI-1045155,EBI-78139
TSPYL6 [Q8N831]3EBI-1045155,EBI-12023322
TULP3 [O75386]7EBI-1045155,EBI-5357290
TXNDC9 [O14530]4EBI-1045155,EBI-707554
XRCC4 [Q13426]3EBI-1045155,EBI-717592
ZNF76 [P36508]3EBI-1045155,EBI-7254550
Q6ZRV73EBI-1045155,EBI-17900348
Q9BS573EBI-1045155,EBI-12418810

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110279, 86 interactors

Protein interaction database and analysis system

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IntActi
P43360, 77 interactors

Molecular INTeraction database

More...
MINTi
P43360

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480637

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P43360, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43360

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini109 – 308MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 43Poly-Ser4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164672

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039582_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43360

KEGG Orthology (KO)

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KOi
K24127

Identification of Orthologs from Complete Genome Data

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OMAi
WSHSEDE

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43360

TreeFam database of animal gene trees

More...
TreeFami
TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR030097, MAGEA3/MAGEA6
IPR002190, MHD_dom

The PANTHER Classification System

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PANTHERi
PTHR11736, PTHR11736, 1 hit
PTHR11736:SF60, PTHR11736:SF60, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838, MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P43360-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL
60 70 80 90 100
GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD
110 120 130 140 150
LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI
160 170 180 190 200
FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG
210 220 230 240 250
FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF
260 270 280 290 300
VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS
310
YPLLHEWALR EGEE
Length:314
Mass (Da):34,891
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29B83C7FA6E50263
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETG4E7ETG4_HUMAN
Melanoma-associated antigen 6
MAGEA6
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUF2E7EUF2_HUMAN
Melanoma-associated antigen 6
MAGEA6
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053493152S → I2 PublicationsCorresponds to variant dbSNP:rs7056365Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10691 Genomic DNA Translation: AAA68875.1
U10339 mRNA Translation: AAA19006.1
D32076 mRNA Translation: BAA06842.1
EU161101 mRNA Translation: ABW06860.1
BX640600 mRNA Translation: CAE45706.1
BC041599 mRNA Translation: AAH41599.1
BC067731 mRNA Translation: AAH67731.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS76050.1

Protein sequence database of the Protein Information Resource

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PIRi
JC2360

NCBI Reference Sequences

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RefSeqi
NP_005354.1, NM_005363.3
NP_787064.1, NM_175868.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329342; ENSP00000329199; ENSG00000197172
ENST00000616035; ENSP00000480637; ENSG00000197172

Database of genes from NCBI RefSeq genomes

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GeneIDi
4105

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4105

UCSC genome browser

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UCSCi
uc033fan.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10691 Genomic DNA Translation: AAA68875.1
U10339 mRNA Translation: AAA19006.1
D32076 mRNA Translation: BAA06842.1
EU161101 mRNA Translation: ABW06860.1
BX640600 mRNA Translation: CAE45706.1
BC041599 mRNA Translation: AAH41599.1
BC067731 mRNA Translation: AAH67731.1
CCDSiCCDS76050.1
PIRiJC2360
RefSeqiNP_005354.1, NM_005363.3
NP_787064.1, NM_175868.2

3D structure databases

SMRiP43360
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110279, 86 interactors
IntActiP43360, 77 interactors
MINTiP43360
STRINGi9606.ENSP00000480637

PTM databases

iPTMnetiP43360
PhosphoSitePlusiP43360

Polymorphism and mutation databases

BioMutaiMAGEA6
DMDMi1170860

Proteomic databases

jPOSTiP43360
MassIVEiP43360
MaxQBiP43360
PaxDbiP43360
PeptideAtlasiP43360
PRIDEiP43360
ProteomicsDBi55622

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30735, 160 antibodies

The DNASU plasmid repository

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DNASUi
4105

Genome annotation databases

EnsembliENST00000329342; ENSP00000329199; ENSG00000197172
ENST00000616035; ENSP00000480637; ENSG00000197172
GeneIDi4105
KEGGihsa:4105
UCSCiuc033fan.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4105
DisGeNETi4105
EuPathDBiHostDB:ENSG00000197172.10

GeneCards: human genes, protein and diseases

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GeneCardsi
MAGEA6
HGNCiHGNC:6804, MAGEA6
HPAiENSG00000197172, Tissue enriched (testis)
MIMi300176, gene
neXtProtiNX_P43360
OpenTargetsiENSG00000197172
PharmGKBiPA30550

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4562, Eukaryota
GeneTreeiENSGT00940000164672
HOGENOMiCLU_039582_1_2_1
InParanoidiP43360
KOiK24127
OMAiWSHSEDE
OrthoDBi1195799at2759
PhylomeDBiP43360
TreeFamiTF328505

Enzyme and pathway databases

PathwayCommonsiP43360

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4105, 6 hits in 468 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4105
PharosiP43360, Tbio

Protein Ontology

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PROi
PR:P43360
RNActiP43360, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197172, Expressed in testis and 27 other tissues
ExpressionAtlasiP43360, baseline and differential
GenevisibleiP43360, HS

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR030097, MAGEA3/MAGEA6
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 1 hit
PTHR11736:SF60, PTHR11736:SF60, 1 hit
PfamiView protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838, MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGA6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43360
Secondary accession number(s): A8IF93, Q6NW44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 7, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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