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Protein

Melanoma-associated antigen 6

Gene

MAGEA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.2 Publications

Caution

In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specific for MAGEA3 and MAGEA6.Curated

Keywordsi

Molecular functionTumor antigen
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 6
Alternative name(s):
Cancer/testis antigen 1.6
Short name:
CT1.6
MAGE-6 antigen
MAGE3B antigen
Gene namesi
Name:MAGEA6
Synonyms:MAGE6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000197172.10
HGNCiHGNC:6804 MAGEA6
MIMi300176 gene
neXtProtiNX_P43360

Pathology & Biotechi

Organism-specific databases

DisGeNETi4105
OpenTargetsiENSG00000197172
PharmGKBiPA30550

Polymorphism and mutation databases

BioMutaiMAGEA6
DMDMi1170860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567061 – 314Melanoma-associated antigen 6Add BLAST314

Proteomic databases

EPDiP43360
MaxQBiP43360
PaxDbiP43360
PeptideAtlasiP43360
PRIDEiP43360
ProteomicsDBi55622

PTM databases

iPTMnetiP43360
PhosphoSitePlusiP43360

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Gene expression databases

BgeeiENSG00000197172
CleanExiHS_MAGEA6
ExpressionAtlasiP43360 baseline and differential
GenevisibleiP43360 HS

Interactioni

Subunit structurei

Interacts with TRIM28.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110279, 49 interactors
IntActiP43360, 114 interactors
MINTiP43360
STRINGi9606.ENSP00000329199

Structurei

3D structure databases

ProteinModelPortaliP43360
SMRiP43360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 308MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 43Poly-Ser4

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43360
OMAiCIRAANA
OrthoDBiEOG091G0TJ0
PhylomeDBiP43360
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030097 MAGEA3/MAGEA6
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF60 PTHR11736:SF60, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P43360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL
60 70 80 90 100
GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD
110 120 130 140 150
LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI
160 170 180 190 200
FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG
210 220 230 240 250
FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF
260 270 280 290 300
VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS
310
YPLLHEWALR EGEE
Length:314
Mass (Da):34,891
Last modified:November 1, 1995 - v1
Checksum:i29B83C7FA6E50263
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053493152S → I2 PublicationsCorresponds to variant dbSNP:rs7056365Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10691 Genomic DNA Translation: AAA68875.1
U10339 mRNA Translation: AAA19006.1
D32076 mRNA Translation: BAA06842.1
EU161101 mRNA Translation: ABW06860.1
BX640600 mRNA Translation: CAE45706.1
BC041599 mRNA Translation: AAH41599.1
BC067731 mRNA Translation: AAH67731.1
CCDSiCCDS76050.1
PIRiJC2360
RefSeqiNP_005354.1, NM_005363.3
NP_787064.1, NM_175868.2
UniGeneiHs.441113

Genome annotation databases

EnsembliENST00000329342; ENSP00000329199; ENSG00000197172
ENST00000616035; ENSP00000480637; ENSG00000197172
GeneIDi4105
KEGGihsa:4105
UCSCiuc033fan.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGA6_HUMAN
AccessioniPrimary (citable) accession number: P43360
Secondary accession number(s): A8IF93, Q6NW44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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