UniProtKB - P43358 (MAGA4_HUMAN)
Protein
Melanoma-associated antigen 4
Gene
MAGEA4
Organism
Homo sapiens (Human)
Status
Functioni
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
Keywordsi
Molecular function | Tumor antigen |
Enzyme and pathway databases
PathwayCommonsi | P43358 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen 4Alternative name(s): Cancer/testis antigen 1.4 Short name: CT1.4 MAGE-4 antigen MAGE-41 antigen MAGE-X2 antigen |
Gene namesi | Name:MAGEA4 Synonyms:MAGE4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6802, MAGEA4 |
MIMi | 300175, gene |
neXtProti | NX_P43358 |
VEuPathDBi | HostDB:ENSG00000147381.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4103 |
OpenTargetsi | ENSG00000147381 |
PharmGKBi | PA30548 |
Miscellaneous databases
Pharosi | P43358, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296022 |
Genetic variation databases
BioMutai | MAGEA4 |
DMDMi | 322510046 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156704 | 1 – 317 | Melanoma-associated antigen 4Add BLAST | 317 |
Proteomic databases
EPDi | P43358 |
jPOSTi | P43358 |
MassIVEi | P43358 |
MaxQBi | P43358 |
PaxDbi | P43358 |
PeptideAtlasi | P43358 |
PRIDEi | P43358 |
ProteomicsDBi | 55620 |
PTM databases
iPTMneti | P43358 |
PhosphoSitePlusi | P43358 |
Expressioni
Tissue specificityi
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
Gene expression databases
Bgeei | ENSG00000147381, Expressed in testis and 52 other tissues |
ExpressionAtlasi | P43358, baseline and differential |
Genevisiblei | P43358, HS |
Organism-specific databases
HPAi | ENSG00000147381, Group enriched (placenta, testis) |
Interactioni
Binary interactionsi
Hide detailsP43358
Protein-protein interaction databases
BioGRIDi | 110277, 44 interactors |
IntActi | P43358, 36 interactors |
MINTi | P43358 |
STRINGi | 9606.ENSP00000353379 |
Miscellaneous databases
RNActi | P43358, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P43358 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43358 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 110 – 309 | MAGEPROSITE-ProRule annotationAdd BLAST | 200 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 44 | Poly-Ser | 4 |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000166837 |
HOGENOMi | CLU_039582_1_2_1 |
InParanoidi | P43358 |
OMAi | VNFTCWR |
OrthoDBi | 1195799at2759 |
PhylomeDBi | P43358 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR021072, MAGE_N IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR030098, MAGEA4/MAGEA5 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 1 hit PTHR11736:SF48, PTHR11736:SF48, 1 hit |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit PF12440, MAGE_N, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit SM01392, MAGE_N, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P43358-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT
60 70 80 90 100
LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP
110 120 130 140 150
DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV
160 170 180 190 200
IFGKASESLK MIFGIDVKEV DPASNTYTLV TCLGLSYDGL LGNNQIFPKT
210 220 230 240 250
GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD
260 270 280 290 300
WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI
310
AYPSLREAAL LEEEEGV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JK50 | C9JK50_HUMAN | Melanoma-associated antigen 4 | MAGEA4 | 230 | Annotation score: | ||
C9JIR1 | C9JIR1_HUMAN | Melanoma-associated antigen 4 | MAGEA4 | 241 | Annotation score: | ||
C9J9C2 | C9J9C2_HUMAN | Melanoma-associated antigen 4 | MAGEA4 | 217 | Annotation score: | ||
C9JZJ5 | C9JZJ5_HUMAN | Melanoma-associated antigen 4 | MAGEA4 | 171 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | S → L in BAA06841 (PubMed:7642112).Curated | 1 | |
Sequence conflicti | 48 | P → L in BAA06841 (PubMed:7642112).Curated | 1 | |
Sequence conflicti | 53 | E → K in BAA06841 (PubMed:7642112).Curated | 1 | |
Sequence conflicti | 61 | G → D in BAA06841 (PubMed:7642112).Curated | 1 | |
Sequence conflicti | 95 – 96 | GP → EA in BAA06841 (PubMed:7642112).Curated | 2 | |
Sequence conflicti | 307 | E → Q in AAA19007 (PubMed:8037761).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076262 | 137 | L → Q1 PublicationCorresponds to variant dbSNP:rs1224431639Ensembl. | 1 | |
Natural variantiVAR_036582 | 153 | G → D in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_004284 | 173 | A → T4 PublicationsCorresponds to variant dbSNP:rs1047251Ensembl. | 1 | |
Natural variantiVAR_078319 | 230 | G → E1 PublicationCorresponds to variant dbSNP:rs773875619Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10687 Genomic DNA Translation: AAA68871.1 U10688 Genomic DNA Translation: AAA68872.1 U10340 mRNA Translation: AAA19007.1 D32075 mRNA Translation: BAA06841.1 D32077 mRNA Translation: BAA06843.1 AF274855 Genomic DNA No translation available. BC017723 mRNA Translation: AAH17723.1 |
CCDSi | CCDS14702.1 |
PIRi | I38661 |
RefSeqi | NP_001011548.1, NM_001011548.1 NP_001011549.1, NM_001011549.1 NP_001011550.1, NM_001011550.1 NP_002353.3, NM_002362.4 XP_005274735.1, XM_005274678.3 XP_005274736.1, XM_005274679.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10687 Genomic DNA Translation: AAA68871.1 U10688 Genomic DNA Translation: AAA68872.1 U10340 mRNA Translation: AAA19007.1 D32075 mRNA Translation: BAA06841.1 D32077 mRNA Translation: BAA06843.1 AF274855 Genomic DNA No translation available. BC017723 mRNA Translation: AAH17723.1 |
CCDSi | CCDS14702.1 |
PIRi | I38661 |
RefSeqi | NP_001011548.1, NM_001011548.1 NP_001011549.1, NM_001011549.1 NP_001011550.1, NM_001011550.1 NP_002353.3, NM_002362.4 XP_005274735.1, XM_005274678.3 XP_005274736.1, XM_005274679.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I4F | X-ray | 1.40 | C | 230-239 | [»] | |
2WA0 | X-ray | 2.30 | A | 101-317 | [»] | |
6TRN | X-ray | 1.35 | C | 230-239 | [»] | |
6TRO | X-ray | 3.00 | C | 230-239 | [»] | |
SMRi | P43358 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110277, 44 interactors |
IntActi | P43358, 36 interactors |
MINTi | P43358 |
STRINGi | 9606.ENSP00000353379 |
Chemistry databases
ChEMBLi | CHEMBL4296022 |
PTM databases
iPTMneti | P43358 |
PhosphoSitePlusi | P43358 |
Genetic variation databases
BioMutai | MAGEA4 |
DMDMi | 322510046 |
Proteomic databases
EPDi | P43358 |
jPOSTi | P43358 |
MassIVEi | P43358 |
MaxQBi | P43358 |
PaxDbi | P43358 |
PeptideAtlasi | P43358 |
PRIDEi | P43358 |
ProteomicsDBi | 55620 |
Protocols and materials databases
Antibodypediai | 17051, 360 antibodies |
CPTCi | P43358, 3 antibodies |
DNASUi | 4103 |
Genome annotation databases
Organism-specific databases
CTDi | 4103 |
DisGeNETi | 4103 |
GeneCardsi | MAGEA4 |
HGNCi | HGNC:6802, MAGEA4 |
HPAi | ENSG00000147381, Group enriched (placenta, testis) |
MIMi | 300175, gene |
neXtProti | NX_P43358 |
OpenTargetsi | ENSG00000147381 |
PharmGKBi | PA30548 |
VEuPathDBi | HostDB:ENSG00000147381.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000166837 |
HOGENOMi | CLU_039582_1_2_1 |
InParanoidi | P43358 |
OMAi | VNFTCWR |
OrthoDBi | 1195799at2759 |
PhylomeDBi | P43358 |
TreeFami | TF328505 |
Enzyme and pathway databases
PathwayCommonsi | P43358 |
Miscellaneous databases
BioGRID-ORCSi | 4103, 4 hits in 498 CRISPR screens |
ChiTaRSi | MAGEA4, human |
EvolutionaryTracei | P43358 |
GeneWikii | MAGEA4 |
GenomeRNAii | 4103 |
Pharosi | P43358, Tbio |
PROi | PR:P43358 |
RNActi | P43358, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147381, Expressed in testis and 52 other tissues |
ExpressionAtlasi | P43358, baseline and differential |
Genevisiblei | P43358, HS |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR021072, MAGE_N IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR030098, MAGEA4/MAGEA5 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 1 hit PTHR11736:SF48, PTHR11736:SF48, 1 hit |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit PF12440, MAGE_N, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit SM01392, MAGE_N, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGA4_HUMAN | |
Accessioni | P43358Primary (citable) accession number: P43358 Secondary accession number(s): Q14798 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants