Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P43358 (MAGA4_HUMAN)

Entry version 171 (10 Feb 2021)
Sequence version 2 (08 Feb 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Melanoma-associated antigen 4

Gene

MAGEA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P43358

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen 4
Alternative name(s):
Cancer/testis antigen 1.4
Short name:
CT1.4
MAGE-4 antigen
MAGE-41 antigen
MAGE-X2 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEA4
Synonyms:MAGE4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6802, MAGEA4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300175, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P43358

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147381.11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4103

Open Targets

More...OpenTargetsi		ENSG00000147381

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30548

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P43358, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4296022

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAGEA4

Domain mapping of disease mutations (DMDM)

More...DMDMi		322510046

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567041 – 317Melanoma-associated antigen 4Add BLAST317

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P43358

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P43358

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P43358

MaxQB - The MaxQuant DataBase

More...MaxQBi		P43358

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P43358

PeptideAtlas

More...PeptideAtlasi		P43358

PRoteomics IDEntifications database

More...PRIDEi		P43358

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55620

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43358

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P43358

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147381, Expressed in testis and 52 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P43358, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P43358, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147381, Group enriched (placenta, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110277, 44 interactors

Protein interaction database and analysis system

More...IntActi		P43358, 36 interactors

Molecular INTeraction database

More...MINTi		P43358

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353379

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43358, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43358

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P43358

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 309MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 44Poly-Ser4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4562, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000166837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039582_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43358

Identification of Orthologs from Complete Genome Data

More...OMAi		VNFTCWR

Database of Orthologous Groups

More...OrthoDBi		1195799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P43358

TreeFam database of animal gene trees

More...TreeFami		TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR030098, MAGEA4/MAGEA5
IPR002190, MHD_dom

The PANTHER Classification System

More...PANTHERi		PTHR11736, PTHR11736, 1 hit
PTHR11736:SF48, PTHR11736:SF48, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50838, MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P43358-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT 
        60         70         80         90        100
LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP 
       110        120        130        140        150
DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV 
       160        170        180        190        200
IFGKASESLK MIFGIDVKEV DPASNTYTLV TCLGLSYDGL LGNNQIFPKT 
       210        220        230        240        250
GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD 
       260        270        280        290        300
WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI 
       310 
AYPSLREAAL LEEEEGV
Length:317
Mass (Da):34,899
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6AA2EE306963E7D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JK50C9JK50_HUMAN
Melanoma-associated antigen 4
MAGEA4
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIR1C9JIR1_HUMAN
Melanoma-associated antigen 4
MAGEA4
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9C2C9J9C2_HUMAN
Melanoma-associated antigen 4
MAGEA4
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZJ5C9JZJ5_HUMAN
Melanoma-associated antigen 4
MAGEA4
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3S → L in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti48P → L in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti53E → K in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti61G → D in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti95 – 96GP → EA in BAA06841 (PubMed:7642112).Curated2
Sequence conflicti307E → Q in AAA19007 (PubMed:8037761).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076262137L → Q1 PublicationCorresponds to variant dbSNP:rs1224431639Ensembl.1
Natural variantiVAR_036582153G → D in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_004284173A → T4 PublicationsCorresponds to variant dbSNP:rs1047251Ensembl.1
Natural variantiVAR_078319230G → E1 PublicationCorresponds to variant dbSNP:rs773875619Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U10687 Genomic DNA Translation: AAA68871.1
U10688 Genomic DNA Translation: AAA68872.1
U10340 mRNA Translation: AAA19007.1
D32075 mRNA Translation: BAA06841.1
D32077 mRNA Translation: BAA06843.1
AF274855 Genomic DNA No translation available.
BC017723 mRNA Translation: AAH17723.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14702.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38661

NCBI Reference Sequences

More...RefSeqi		NP_001011548.1, NM_001011548.1
NP_001011549.1, NM_001011549.1
NP_001011550.1, NM_001011550.1
NP_002353.3, NM_002362.4
XP_005274735.1, XM_005274678.3
XP_005274736.1, XM_005274679.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000276344; ENSP00000276344; ENSG00000147381
ENST00000360243; ENSP00000353379; ENSG00000147381
ENST00000370335; ENSP00000359360; ENSG00000147381
ENST00000370340; ENSP00000359365; ENSG00000147381
ENST00000393920; ENSP00000377497; ENSG00000147381
ENST00000393921; ENSP00000377498; ENSG00000147381

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4103

UCSC genome browser

More...UCSCi		uc004ffa.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10687 Genomic DNA Translation: AAA68871.1
U10688 Genomic DNA Translation: AAA68872.1
U10340 mRNA Translation: AAA19007.1
D32075 mRNA Translation: BAA06841.1
D32077 mRNA Translation: BAA06843.1
AF274855 Genomic DNA No translation available.
BC017723 mRNA Translation: AAH17723.1
CCDSiCCDS14702.1
PIRiI38661
RefSeqiNP_001011548.1, NM_001011548.1
NP_001011549.1, NM_001011549.1
NP_001011550.1, NM_001011550.1
NP_002353.3, NM_002362.4
XP_005274735.1, XM_005274678.3
XP_005274736.1, XM_005274679.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I4FX-ray1.40C230-239[»]
2WA0X-ray2.30A101-317[»]
6TRNX-ray1.35C230-239[»]
6TROX-ray3.00C230-239[»]
SMRiP43358
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110277, 44 interactors
IntActiP43358, 36 interactors
MINTiP43358
STRINGi9606.ENSP00000353379

Chemistry databases

ChEMBLiCHEMBL4296022

PTM databases

iPTMnetiP43358
PhosphoSitePlusiP43358

Genetic variation databases

BioMutaiMAGEA4
DMDMi322510046

Proteomic databases

EPDiP43358
jPOSTiP43358
MassIVEiP43358
MaxQBiP43358
PaxDbiP43358
PeptideAtlasiP43358
PRIDEiP43358
ProteomicsDBi55620

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17051, 360 antibodies

The CPTC Antibody Portal

More...CPTCi		P43358, 3 antibodies

The DNASU plasmid repository

More...DNASUi		4103

Genome annotation databases

EnsembliENST00000276344; ENSP00000276344; ENSG00000147381
ENST00000360243; ENSP00000353379; ENSG00000147381
ENST00000370335; ENSP00000359360; ENSG00000147381
ENST00000370340; ENSP00000359365; ENSG00000147381
ENST00000393920; ENSP00000377497; ENSG00000147381
ENST00000393921; ENSP00000377498; ENSG00000147381
GeneIDi4103
KEGGihsa:4103
UCSCiuc004ffa.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4103
DisGeNETi4103

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAGEA4
HGNCiHGNC:6802, MAGEA4
HPAiENSG00000147381, Group enriched (placenta, testis)
MIMi300175, gene
neXtProtiNX_P43358
OpenTargetsiENSG00000147381
PharmGKBiPA30548
VEuPathDBiHostDB:ENSG00000147381.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4562, Eukaryota
GeneTreeiENSGT00940000166837
HOGENOMiCLU_039582_1_2_1
InParanoidiP43358
OMAiVNFTCWR
OrthoDBi1195799at2759
PhylomeDBiP43358
TreeFamiTF328505

Enzyme and pathway databases

PathwayCommonsiP43358

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4103, 4 hits in 498 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAGEA4, human
EvolutionaryTraceiP43358

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAGEA4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4103
PharosiP43358, Tbio

Protein Ontology

More...PROi		PR:P43358
RNActiP43358, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147381, Expressed in testis and 52 other tissues
ExpressionAtlasiP43358, baseline and differential
GenevisibleiP43358, HS

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR030098, MAGEA4/MAGEA5
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 1 hit
PTHR11736:SF48, PTHR11736:SF48, 1 hit
PfamiView protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838, MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGA4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43358
Secondary accession number(s): Q14798
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 8, 2011
Last modified: February 10, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again