Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 173 (17 Jun 2020)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Melanoma-associated antigen 2

Gene

MAGEA2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen
Biological processTranscription, Transcription regulation, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen 2
Alternative name(s):
Cancer/testis antigen 1.2
Short name:
CT1.2
MAGE-2 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEA2
Synonyms:MAGE2, MAGEA2A
AND
Name:MAGEA2B
Synonyms:MAGE2, MAGEA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183305.13
HostDB:ENSG00000268606.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6800 MAGEA2
HGNC:19340 MAGEA2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300173 gene
300549 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43356

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi170V → D: Improves ability to bind to HLA-A1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
266740
4101

Open Targets

More...
OpenTargetsi
ENSG00000183305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30546

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P43356 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGEA2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1170856

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567021 – 314Melanoma-associated antigen 2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43356

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43356

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43356

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43356

PeptideAtlas

More...
PeptideAtlasi
P43356

PRoteomics IDEntifications database

More...
PRIDEi
P43356

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55618

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1497

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43356

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43356

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183305 Expressed in testis and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P43356 baseline

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43356 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183305 Tissue enriched (testis)
ENSG00000268606 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIM28 and UBE2H.

Interacts with HDAC3.

Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110275, 6 interactors
129334, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-61231N

Protein interaction database and analysis system

More...
IntActi
P43356, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000485541

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P43356 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43356

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini109 – 308MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 43Poly-Ser4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562 Eukaryota
ENOG4111S70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039582_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43356

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTEHIYV

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43356

TreeFam database of animal gene trees

More...
TreeFami
TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11736 PTHR11736, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01454 MAGE, 2 hits
PF12440 MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838 MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P43356-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL
60 70 80 90 100
GEVPAADSPS PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD
110 120 130 140 150
LESEFQAAIS RKMVELVHFL LLKYRAREPV TKAEMLESVL RNCQDFFPVI
160 170 180 190 200
FSKASEYLQL VFGIEVVEVV PISHLYILVT CLGLSYDGLL GDNQVMPKTG
210 220 230 240 250
LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA HPRKLLMQDL
260 270 280 290 300
VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS
310
YPPLHERALR EGEE
Length:314
Mass (Da):35,055
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i844F16335A2BECE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC03E9PC03_HUMAN
Melanoma-associated antigen 2
MAGEA2B
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER35E7ER35_HUMAN
Melanoma-associated antigen 2
MAGEA2B
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EP80E7EP80_HUMAN
Melanoma-associated antigen 2
MAGEA2B
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQY6E7EQY6_HUMAN
Melanoma-associated antigen 2
MAGEA2B
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZT8A0A087WZT8_HUMAN
Melanoma-associated antigen 2
MAGEA2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENJ0E7ENJ0_HUMAN
Melanoma-associated antigen 2
MAGEA2 MAGEA2B
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A060B9A060_HUMAN
Melanoma-associated antigen 2
MAGEA2B
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L18920 Genomic DNA Translation: AAA17729.1
AK290443 mRNA Translation: BAF83132.1
U82671 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99429.1
BC108720 mRNA Translation: AAI08721.1
BC112158 mRNA Translation: AAI12159.1
BC112160 mRNA Translation: AAI12161.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS76046.1
CCDS76049.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I68889

NCBI Reference Sequences

More...
RefSeqi
NP_001269430.1, NM_001282501.1
NP_001269431.1, NM_001282502.1
NP_001269433.1, NM_001282504.1
NP_001269434.1, NM_001282505.1
NP_001308329.1, NM_001321400.1
NP_001308330.1, NM_001321401.1
NP_001308331.1, NM_001321402.1
NP_001308332.1, NM_001321403.1
NP_001308333.1, NM_001321404.1
NP_005352.1, NM_005361.3
NP_705692.1, NM_153488.4
NP_786884.1, NM_175742.2
NP_786885.1, NM_175743.2
XP_016884895.1, XM_017029406.1
XP_016885008.1, XM_017029519.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331220; ENSP00000333487; ENSG00000183305
ENST00000370293; ENSP00000359316; ENSG00000183305
ENST00000595583; ENSP00000470872; ENSG00000268606
ENST00000598543; ENSP00000469919; ENSG00000268606
ENST00000611557; ENSP00000480738; ENSG00000268606
ENST00000611674; ENSP00000480491; ENSG00000268606
ENST00000620710; ENSP00000484290; ENSG00000268606
ENST00000623438; ENSP00000485391; ENSG00000268606
ENST00000623806; ENSP00000485541; ENSG00000268606

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
266740
4101

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:266740
hsa:4101

UCSC genome browser

More...
UCSCi
uc004fgg.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18920 Genomic DNA Translation: AAA17729.1
AK290443 mRNA Translation: BAF83132.1
U82671 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99429.1
BC108720 mRNA Translation: AAI08721.1
BC112158 mRNA Translation: AAI12159.1
BC112160 mRNA Translation: AAI12161.1
CCDSiCCDS76046.1
CCDS76049.1
PIRiI68889
RefSeqiNP_001269430.1, NM_001282501.1
NP_001269431.1, NM_001282502.1
NP_001269433.1, NM_001282504.1
NP_001269434.1, NM_001282505.1
NP_001308329.1, NM_001321400.1
NP_001308330.1, NM_001321401.1
NP_001308331.1, NM_001321402.1
NP_001308332.1, NM_001321403.1
NP_001308333.1, NM_001321404.1
NP_005352.1, NM_005361.3
NP_705692.1, NM_153488.4
NP_786884.1, NM_175742.2
NP_786885.1, NM_175743.2
XP_016884895.1, XM_017029406.1
XP_016885008.1, XM_017029519.1

3D structure databases

SMRiP43356
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110275, 6 interactors
129334, 13 interactors
DIPiDIP-61231N
IntActiP43356, 24 interactors
STRINGi9606.ENSP00000485541

PTM databases

GlyConnecti1497
iPTMnetiP43356
PhosphoSitePlusiP43356

Polymorphism and mutation databases

BioMutaiMAGEA2B
DMDMi1170856

Proteomic databases

jPOSTiP43356
MassIVEiP43356
MaxQBiP43356
PaxDbiP43356
PeptideAtlasiP43356
PRIDEiP43356
ProteomicsDBi55618

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30741 44 antibodies
73570 100 antibodies

The DNASU plasmid repository

More...
DNASUi
266740
4101

Genome annotation databases

EnsembliENST00000331220; ENSP00000333487; ENSG00000183305
ENST00000370293; ENSP00000359316; ENSG00000183305
ENST00000595583; ENSP00000470872; ENSG00000268606
ENST00000598543; ENSP00000469919; ENSG00000268606
ENST00000611557; ENSP00000480738; ENSG00000268606
ENST00000611674; ENSP00000480491; ENSG00000268606
ENST00000620710; ENSP00000484290; ENSG00000268606
ENST00000623438; ENSP00000485391; ENSG00000268606
ENST00000623806; ENSP00000485541; ENSG00000268606
GeneIDi266740
4101
KEGGihsa:266740
hsa:4101
UCSCiuc004fgg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
266740
4101
DisGeNETi266740
4101
EuPathDBiHostDB:ENSG00000183305.13
HostDB:ENSG00000268606.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAGEA2
MAGEA2B
HGNCiHGNC:6800 MAGEA2
HGNC:19340 MAGEA2B
HPAiENSG00000183305 Tissue enriched (testis)
ENSG00000268606 Tissue enriched (testis)
MIMi300173 gene
300549 gene
neXtProtiNX_P43356
OpenTargetsiENSG00000183305
PharmGKBiPA30546

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00940000164673
HOGENOMiCLU_039582_1_1_1
InParanoidiP43356
OMAiPTEHIYV
OrthoDBi1195799at2759
PhylomeDBiP43356
TreeFamiTF328505

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
266740 4 hits in 399 CRISPR screens
4101 53 hits in 397 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAGEA2B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAGEA2
PharosiP43356 Tbio

Protein Ontology

More...
PROi
PR:P43356
RNActiP43356 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183305 Expressed in testis and 35 other tissues
ExpressionAtlasiP43356 baseline
GenevisibleiP43356 HS

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 2 hits
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43356
Secondary accession number(s): A8K328, Q32NC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 17, 2020
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again