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Protein

Melanoma-associated antigen 1

Gene

MAGEA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTumor antigen
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 1
Alternative name(s):
Antigen MZ2-E
Cancer/testis antigen 1.1
Short name:
CT1.1
MAGE-1 antigen
Gene namesi
Name:MAGEA1
Synonyms:MAGE1, MAGE1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198681.6
HGNCiHGNC:6796 MAGEA1
MIMi300016 gene
neXtProtiNX_P43355

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi163D → A: Abolishes HLA-A1 binding. 1 Publication1
Mutagenesisi169Y → A: Abolishes HLA-A1 binding. 1 Publication1

Organism-specific databases

DisGeNETi4100
OpenTargetsiENSG00000198681
PharmGKBiPA30542

Polymorphism and mutation databases

BioMutaiMAGEA1
DMDMi1170855

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567011 – 309Melanoma-associated antigen 1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP43355
MaxQBiP43355
PaxDbiP43355
PeptideAtlasiP43355
PRIDEiP43355
ProteomicsDBi55617

PTM databases

iPTMnetiP43355
PhosphoSitePlusiP43355

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.

Gene expression databases

BgeeiENSG00000198681 Expressed in 14 organ(s), highest expression level in material anatomical entity
CleanExiHS_MAGEA1
GenevisibleiP43355 HS

Organism-specific databases

HPAiCAB002620

Interactioni

Subunit structurei

Interacts with SNW1 and HDCA1.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110274, 92 interactors
CORUMiP43355
DIPiDIP-54794N
IntActiP43355, 41 interactors
MINTiP43355
STRINGi9606.ENSP00000349085

Structurei

3D structure databases

ProteinModelPortaliP43355
SMRiP43355
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43355

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 301MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 36Poly-Ser4

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43355
OMAiVRFFFPS
OrthoDBiEOG091G0TJ0
PhylomeDBiP43355
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030093 MAGEA1
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF49 PTHR11736:SF49, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P43355-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG
60 70 80 90 100
STDPPQSPQG ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA
110 120 130 140 150
VITKKVADLV GFLLLKYRAR EPVTKAEMLE SVIKNYKHCF PEIFGKASES
160 170 180 190 200
LQLVFGIDVK EADPTGHSYV LVTCLGLSYD GLLGDNQIMP KTGFLIIVLV
210 220 230 240 250
MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT QDLVQEKYLE
260 270 280 290 300
YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA

ALREEEEGV
Length:309
Mass (Da):34,342
Last modified:November 1, 1995 - v1
Checksum:i544EEB1F9F4E9D33
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00428332T → A Probable polymorphism. 3 PublicationsCorresponds to variant dbSNP:rs2008160Ensembl.1
Natural variantiVAR_05349163A → T. Corresponds to variant dbSNP:rs2233044Ensembl.1
Natural variantiVAR_01173772R → Q. Corresponds to variant dbSNP:rs2008144Ensembl.1
Natural variantiVAR_036581278K → T in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77481 Genomic DNA Translation: AAA03229.1
AY148486 mRNA Translation: AAN62752.1
BT009789 mRNA Translation: AAP88791.1
AK314979 mRNA Translation: BAG37478.1
U82670 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72885.1
BC017555 mRNA Translation: AAH17555.1
CCDSiCCDS76051.1
PIRiJC2358
RefSeqiNP_004979.3, NM_004988.4
UniGeneiHs.72879

Genome annotation databases

EnsembliENST00000356661; ENSP00000349085; ENSG00000198681
GeneIDi4100
KEGGihsa:4100
UCSCiuc004fhf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77481 Genomic DNA Translation: AAA03229.1
AY148486 mRNA Translation: AAN62752.1
BT009789 mRNA Translation: AAP88791.1
AK314979 mRNA Translation: BAG37478.1
U82670 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72885.1
BC017555 mRNA Translation: AAH17555.1
CCDSiCCDS76051.1
PIRiJC2358
RefSeqiNP_004979.3, NM_004988.4
UniGeneiHs.72879

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W72X-ray2.15C/F161-169[»]
3BO8X-ray1.80C161-169[»]
ProteinModelPortaliP43355
SMRiP43355
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110274, 92 interactors
CORUMiP43355
DIPiDIP-54794N
IntActiP43355, 41 interactors
MINTiP43355
STRINGi9606.ENSP00000349085

PTM databases

iPTMnetiP43355
PhosphoSitePlusiP43355

Polymorphism and mutation databases

BioMutaiMAGEA1
DMDMi1170855

Proteomic databases

EPDiP43355
MaxQBiP43355
PaxDbiP43355
PeptideAtlasiP43355
PRIDEiP43355
ProteomicsDBi55617

Protocols and materials databases

DNASUi4100
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356661; ENSP00000349085; ENSG00000198681
GeneIDi4100
KEGGihsa:4100
UCSCiuc004fhf.3 human

Organism-specific databases

CTDi4100
DisGeNETi4100
EuPathDBiHostDB:ENSG00000198681.6
GeneCardsiMAGEA1
H-InvDBiHIX0017126
HGNCiHGNC:6796 MAGEA1
HPAiCAB002620
MIMi300016 gene
neXtProtiNX_P43355
OpenTargetsiENSG00000198681
PharmGKBiPA30542
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43355
OMAiVRFFFPS
OrthoDBiEOG091G0TJ0
PhylomeDBiP43355
TreeFamiTF328505

Miscellaneous databases

EvolutionaryTraceiP43355
GeneWikiiMAGEA1
GenomeRNAii4100
PROiPR:P43355
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198681 Expressed in 14 organ(s), highest expression level in material anatomical entity
CleanExiHS_MAGEA1
GenevisibleiP43355 HS

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030093 MAGEA1
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF49 PTHR11736:SF49, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAGA1_HUMAN
AccessioniPrimary (citable) accession number: P43355
Secondary accession number(s): B2RC81, O00346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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