NR4A2

Functionⁱ

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	260 – 335	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	263 – 283	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	299 – 323	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

beta-catenin binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22988876
- 24115276
DNA binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
glucocorticoid receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
retinoid X receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
canonical Wnt signaling pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24115276
cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
cellular response to extracellular stimulus
Source: MGI
Inferred from direct assayⁱ
- 7877627
cellular response to oxidative stress Source: Ensembl
central nervous system neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
central nervous system projection neuron axonogenesis Source: Ensembl
dopamine biosynthetic process Source: Ensembl
dopaminergic neuron differentiation Source: UniProtKB
fat cell differentiation Source: UniProtKB
general adaptation syndrome Source: Ensembl
habenula development Source: Ensembl
midbrain dopaminergic neuron differentiation
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
negative regulation of apoptotic signaling pathway
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 19429166
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 18463503
neuron maturation Source: Ensembl
neuron migration
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425
positive regulation of catalytic activity Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: UniProtKB
post-embryonic development Source: Ensembl
regulation of dopamine metabolic process Source: Ensembl
regulation of respiratory gaseous exchange Source: Ensembl
response to amphetamine Source: Ensembl
response to hypoxia Source: Ensembl
signal transduction
Source: ProtInc
Non-traceable author statementⁱ
- 7877627
transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 17184956
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkⁱ	P43354
SIGNORⁱ	P43354

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 4 group A member 2 Alternative name(s): Immediate-early response protein NOT Orphan nuclear receptor NURR1 Transcriptionally-inducible nuclear receptor
Gene namesⁱ	Name:NR4A2 Synonyms:NOT, NURR1, TINUR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153234.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7981 NR4A2
MIMⁱ	601828 gene
neXtProtⁱ	NX_P43354

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4929
GeneReviewsⁱ	NR4A2
MalaCards human disease database More...MalaCardsⁱ	NR4A2
Open Targets More...OpenTargetsⁱ	ENSG00000153234
PharmGKBⁱ	PA31762

Chemistry databases

ChEMBLⁱ	CHEMBL5002

ChEMBLⁱ

CHEMBL5002

Polymorphism and mutation databases

BioMutaⁱ	NR4A2
DMDMⁱ	1171750

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053718	1 – 598	Nuclear receptor subfamily 4 group A member 2Add BLAST		598

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P43354
PaxDbⁱ	P43354
PeptideAtlas More...PeptideAtlasⁱ	P43354
PRIDEⁱ	P43354
ProteomicsDBⁱ	55616

PTM databases

iPTMnetⁱ	P43354
PhosphoSitePlusⁱ	P43354
SwissPalmⁱ	P43354

Expressionⁱ

Tissue specificityⁱ

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Developmental stageⁱ

Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.

Gene expression databases

Bgeeⁱ	ENSG00000153234 Expressed in 223 organ(s), highest expression level in female gonad
CleanExⁱ	HS_NR4A2
ExpressionAtlasⁱ	P43354 baseline and differential
Genevisibleⁱ	P43354 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010481 HPA000543

HPAⁱ

CAB010481
HPA000543

Interactionⁱ

Subunit structureⁱ

Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TCEAL5	Q5H9L2	2	EBI-2681738,EBI-2681773

With

Entry

#Exp.

IntAct

Notes

TCEAL5

Q5H9L2

2

EBI-2681738,EBI-2681773

GO - Molecular functionⁱ

beta-catenin binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22988876
- 24115276
glucocorticoid receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425
retinoid X receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16243425

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110983, 16 interactors
IntActⁱ	P43354, 16 interactors
STRINGⁱ	9606.ENSP00000344479

Chemistry databases

BindingDBⁱ

P43354

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	338 – 341	Combined sources	4
Helixⁱ	364 – 374	Combined sources	11
Helixⁱ	392 – 394	Combined sources	3
Helixⁱ	400 – 422	Combined sources	23
Helixⁱ	427 – 429	Combined sources	3
Helixⁱ	432 – 454	Combined sources	23
Turnⁱ	457 – 460	Combined sources	4
Beta strandⁱ	461 – 463	Combined sources	3
Beta strandⁱ	467 – 471	Combined sources	5
Helixⁱ	472 – 475	Combined sources	4
Turnⁱ	476 – 478	Combined sources	3
Helixⁱ	482 – 494	Combined sources	13
Helixⁱ	500 – 511	Combined sources	12
Helixⁱ	521 – 540	Combined sources	20
Helixⁱ	541 – 543	Combined sources	3
Turnⁱ	544 – 547	Combined sources	4
Helixⁱ	551 – 579	Combined sources	29
Helixⁱ	586 – 595	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P43354
SMRⁱ	P43354
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P43354

EvolutionaryTraceⁱ

P43354

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	360 – 595	NR LBDPROSITE-ProRule annotationAdd BLAST		236

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	287 – 314	Bipartite nuclear localization signal (NLS1)Add BLAST	28
Motifⁱ	338 – 350	Nuclear localization signal (NLS1)1 PublicationAdd BLAST	13
Motifⁱ	443 – 452	nuclear export sequence (NES1)	10
Motifⁱ	568 – 577	nuclear export sequence (NES2)	10

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	80 – 138	Gln-richAdd BLAST	59
Compositional biasⁱ	127 – 233	Pro-richAdd BLAST	107
Compositional biasⁱ	346 – 391	Pro-richAdd BLAST	46

Domainⁱ

the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125).1 Publication

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR4 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	263 – 283	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	299 – 323	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4217 Eukaryota ENOG410YWNC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000230925
HOVERGENⁱ	HBG052663
InParanoidⁱ	P43354
KEGG Orthology (KO) More...KOⁱ	K08558
OMAⁱ	CLYQMPH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GUM
PhylomeDBⁱ	P43354
TreeFamⁱ	TF315430

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR003070 Nuc_orph_rcpt IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003073 NURR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01284 NUCLEARECPTR PR01287 NURRNUCRCPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P43354-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE 
        60         70         80         90        100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY 
       110        120        130        140        150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH 
       160        170        180        190        200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV 
       210        220        230        240        250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS 
       260        270        280        290        300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 
       310        320        330        340        350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK 
       360        370        380        390        400
SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT 
       410        420        430        440        450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR 
       460        470        480        490        500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI 
       510        520        530        540        550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN 
       560        570        580        590 
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF

Length:598

Mass (Da):66,591

Last modified:November 1, 1995 - v1

Checksum:ⁱ28D8199AACE3E211

GO

Isoform 2 (identifier: P43354-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-63: Missing.

« Hide

        10         20         30         40         50
MDNYSTGYDV KPPCLYQMPL SGQQSSIKVE DIQMHNYQQH SHLPPQSEEM 
        60         70         80         90        100
MPHSGSVYYK PSSPPTPTTP GFQVQHSPMW DDPGSLHNFH QNYVATTHMI 
       110        120        130        140        150
EQRKTPVSRL SLFSFKQSPP GTPVSSCQMR FDGPLHVPMN PEPAGSHHVV 
       160        170        180        190        200
DGQTFAVPNP IRKPASMGFP GLQIGHASQL LDTQVPSPPS RGSPSNEGLC 
       210        220        230        240        250
AVCGDNAACQ HYGVRTCEGC KGFFKRTVQK NAKYVCLANK NCPVDKRRRN 
       260        270        280        290        300
RCQYCRFQKC LAVGMVKEVV RTDSLKGRRG RLPSKPKSPQ EPSPPSPPVS 
       310        320        330        340        350
LISALVRAHV DSNPAMTSLD YSRFQANPDY QMSGDDTQHI QQFYDLLTGS 
       360        370        380        390        400
MEIIRGWAEK IPGFADLPKA DQDLLFESAF LELFVLRLAY RSNPVEGKLI 
       410        420        430        440        450
FCNGVVLHRL QCVRGFGEWI DSIVEFSSNL QNMNIDISAF SCIAALAMVT 
       460        470        480        490        500
ERHGLKEPKR VEELQNKIVN CLKDHVTFNN GGLNRPNYLS KLLGKLPELR 
       510        520        530 
TLCTQGLQRI FYLKLEDLVP PPAIIDKLFL DTLPF

Show »

Length:535

Mass (Da):59,809

Checksum:ⁱ41CB735EE1982523

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W6I3	F8W6I3_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 2	NR4A2	553	Annotation score:
C9J8W4	C9J8W4_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 2	NR4A2	490	Annotation score:
E9PBQ4	E9PBQ4_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 2	NR4A2	392	Annotation score:
H7BZ00	H7BZ00_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 2	NR4A2	150	Annotation score:
C9IYM5	C9IYM5_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 2	NR4A2	258	Annotation score:
C9JWQ1	C9JWQ1_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 2	NR4A2	106	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	465	C → W in AAB33999 (PubMed:7706727).Curated		1
Sequence conflictⁱ	468	V → W in AAB33999 (PubMed:7706727).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056057	1 – 63	Missing in isoform 2. 2 PublicationsAdd BLAST		63

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X75918 mRNA Translation: CAA53518.1 AB017586 Genomic DNA Translation: BAA75666.1 AB019433 Genomic DNA Translation: BAA77328.1 AK291456 mRNA Translation: BAF84145.1 AC074099 Genomic DNA Translation: AAY24203.1 CH471058 Genomic DNA Translation: EAX11454.1 CH471058 Genomic DNA Translation: EAX11455.1 BC009288 mRNA Translation: AAH09288.1 BC066890 mRNA Translation: AAH66890.1 S77154 mRNA Translation: AAB33999.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2201.1 [P43354-1] CCDS86887.1 [P43354-2]
PIRⁱ	A57040
NCBI Reference Sequences More...RefSeqⁱ	NP_006177.1, NM_006186.3 [P43354-1] XP_005246679.1, XM_005246622.3 XP_016859708.1, XM_017004219.1 [P43354-1]
UniGeneⁱ	Hs.563344

Genome annotation databases

Ensemblⁱ	ENST00000339562; ENSP00000344479; ENSG00000153234 [P43354-1] ENST00000409572; ENSP00000386747; ENSG00000153234 [P43354-1] ENST00000426264; ENSP00000389986; ENSG00000153234 [P43354-2]
GeneIDⁱ	4929
KEGGⁱ	hsa:4929
UCSC genome browser More...UCSCⁱ	uc002tyx.5 human [P43354-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43354	Uncharacterized protein		SHEEP		610	UniRef100_P43354
Nuclear receptor related 1		HUMAN		598
NR4A2 isoform 1		PANTR		598
NR4A2 isoform 1		PONAB		598
Nuclear receptor subfamily 4 group A member 2		SAIBB		598
+22

Protein	Similar proteins		Species	Score	Length	Source
P43354	Nuclear receptor subfamily 4 group A member 2		MOUSE		598	UniRef90_Q06219
Nuclear receptor subfamily 4 group A member 2		RAT		598
Nuclear receptor subfamily 4 group A member 2		BOVIN		598
Nuclear receptor subfamily 4 group A member 2		PONAB		598
Nuclear receptor subfamily 4 group A member 2		XENTR		591
+255

Protein	Similar proteins		Species	Score	Length	Source
P43354	Nuclear receptor subfamily 4 group A member 2		MOUSE		598	UniRef50_Q06219
Nuclear receptor subfamily 4 group A member 2		RAT		598
Nuclear receptor subfamily 4 group A member 2		PONAB		598
Nuclear receptor subfamily 4 group A member 2		BOVIN		598
Nuclear receptor subfamily 4 group A member 2		XENTR		591
+335

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X75918 mRNA Translation: CAA53518.1 AB017586 Genomic DNA Translation: BAA75666.1 AB019433 Genomic DNA Translation: BAA77328.1 AK291456 mRNA Translation: BAF84145.1 AC074099 Genomic DNA Translation: AAY24203.1 CH471058 Genomic DNA Translation: EAX11454.1 CH471058 Genomic DNA Translation: EAX11455.1 BC009288 mRNA Translation: AAH09288.1 BC066890 mRNA Translation: AAH66890.1 S77154 mRNA Translation: AAB33999.1
CCDSⁱ	CCDS2201.1 [P43354-1] CCDS86887.1 [P43354-2]
PIRⁱ	A57040
RefSeqⁱ	NP_006177.1, NM_006186.3 [P43354-1] XP_005246679.1, XM_005246622.3 XP_016859708.1, XM_017004219.1 [P43354-1]
UniGeneⁱ	Hs.563344

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1OVL	X-ray	2.20	A/B/C/D/E/F	328-598	[»]
ProteinModelPortalⁱ	P43354
SMRⁱ	P43354
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110983, 16 interactors
IntActⁱ	P43354, 16 interactors
STRINGⁱ	9606.ENSP00000344479

Chemistry databases

BindingDBⁱ	P43354
ChEMBLⁱ	CHEMBL5002

PTM databases

iPTMnetⁱ	P43354
PhosphoSitePlusⁱ	P43354
SwissPalmⁱ	P43354

Polymorphism and mutation databases

BioMutaⁱ	NR4A2
DMDMⁱ	1171750

Proteomic databases

MaxQBⁱ	P43354
PaxDbⁱ	P43354
PeptideAtlasⁱ	P43354
PRIDEⁱ	P43354
ProteomicsDBⁱ	55616

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4929
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000339562; ENSP00000344479; ENSG00000153234 [P43354-1] ENST00000409572; ENSP00000386747; ENSG00000153234 [P43354-1] ENST00000426264; ENSP00000389986; ENSG00000153234 [P43354-2]
GeneIDⁱ	4929
KEGGⁱ	hsa:4929
UCSCⁱ	uc002tyx.5 human [P43354-1]

Organism-specific databases

CTDⁱ	4929
DisGeNETⁱ	4929
EuPathDBⁱ	HostDB:ENSG00000153234.13
GeneCardsⁱ	NR4A2
GeneReviewsⁱ	NR4A2
HGNCⁱ	HGNC:7981 NR4A2
HPAⁱ	CAB010481 HPA000543
MalaCardsⁱ	NR4A2
MIMⁱ	601828 gene
neXtProtⁱ	NX_P43354
OpenTargetsⁱ	ENSG00000153234
PharmGKBⁱ	PA31762
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4217 Eukaryota ENOG410YWNC LUCA
GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000230925
HOVERGENⁱ	HBG052663
InParanoidⁱ	P43354
KOⁱ	K08558
OMAⁱ	CLYQMPH
OrthoDBⁱ	EOG091G0GUM
PhylomeDBⁱ	P43354
TreeFamⁱ	TF315430

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkⁱ	P43354
SIGNORⁱ	P43354

Miscellaneous databases

ChiTaRSⁱ	NR4A2 human
EvolutionaryTraceⁱ	P43354
GeneWikiⁱ	Nuclear_receptor_related-1_protein
GenomeRNAiⁱ	4929
Protein Ontology More...PROⁱ	PR:P43354
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153234 Expressed in 223 organ(s), highest expression level in female gonad
CleanExⁱ	HS_NR4A2
ExpressionAtlasⁱ	P43354 baseline and differential
Genevisibleⁱ	P43354 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR003070 Nuc_orph_rcpt IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003073 NURR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01284 NUCLEARECPTR PR01287 NURRNUCRCPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR4A2_HUMAN
Accessionⁱ	P43354Primary (citable) accession number: P43354 Secondary accession number(s): Q16311, Q53RZ2, Q6NXU0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P43354 (NR4A2_HUMAN)

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Nuclear receptor subfamily 4 group A member 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Nucleus

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Nucleus

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Keywords - Cellular componenti

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

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Gene expression databases

Organism-specific databases

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GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

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Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ