Nuclear receptor subfamily 4 group A member 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: ParkinsonsUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
  • "The regulation and deregulation of Wnt signaling by PARK genes in health and disease."
    Berwick D.C., Harvey K.
    J Mol Cell Biol 6:3-12(2014) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease."
    Jankovic J., Chen S., Le W.D.
    Prog Neurobiol 77:128-138(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• glucocorticoid receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease."
    Jankovic J., Chen S., Le W.D.
    Prog Neurobiol 77:128-138(2005) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKB
• retinoid X receptor binding Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease."
    Jankovic J., Chen S., Le W.D.
    Prog Neurobiol 77:128-138(2005) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: ARUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• adult locomotory behavior Source: Ensembl
• canonical Wnt signaling pathway Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The regulation and deregulation of Wnt signaling by PARK genes in health and disease."
    Berwick D.C., Harvey K.
    J Mol Cell Biol 6:3-12(2014) [PubMed] [Europe PMC] [Abstract]
• cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
• cellular response to extracellular stimulus Source: MGIInferred from direct assayⁱ
  • Ref.1

    "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
    Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A.
    Mol. Endocrinol. 8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• cellular response to oxidative stress Source: Ensembl
• central nervous system neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• central nervous system projection neuron axonogenesis Source: Ensembl
• dopamine biosynthetic process Source: Ensembl
• dopaminergic neuron differentiation Source: UniProtKB
• fat cell differentiation Source: UniProtKB
• general adaptation syndrome Source: Ensembl
• habenula development Source: Ensembl
• midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease."
    Jankovic J., Chen S., Le W.D.
    Prog Neurobiol 77:128-138(2005) [PubMed] [Europe PMC] [Abstract]
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
  • "The regulation and deregulation of Wnt signaling by PARK genes in health and disease."
    Berwick D.C., Harvey K.
    J Mol Cell Biol 6:3-12(2014) [PubMed] [Europe PMC] [Abstract]
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic signaling pathway Source: ParkinsonsUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Characterisation of a novel NR4A2 mutation in Parkinson's disease brain."
    Sleiman P.M., Healy D.G., Muqit M.M., Yang Y.X., Van Der Brug M., Holton J.L., Revesz T., Quinn N.P., Bhatia K., Diss J.K., Lees A.J., Cookson M.R., Latchman D.S., Wood N.W.
    Neurosci Lett 457:75-79(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Nurr1 transcriptionally regulates the expression of alpha-synuclein."
    Yang Y.X., Latchman D.S.
    Neuroreport 19:867-871(2008) [PubMed] [Europe PMC] [Abstract]
• neuron maturation Source: Ensembl
• neuron migration Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease."
    Jankovic J., Chen S., Le W.D.
    Prog Neurobiol 77:128-138(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of catalytic activity Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• post-embryonic development Source: Ensembl
• regulation of dopamine metabolic process Source: Ensembl
• regulation of respiratory gaseous exchange Source: Ensembl
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to amphetamine Source: Ensembl
• response to hypoxia Source: Ensembl
• signal transduction Source: ProtInc <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
    Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A.
    Mol. Endocrinol. 8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Induction of tyrosine hydroxylase expression by the transcription factor Pitx3."
    Messmer K., Remington M.P., Skidmore F., Fishman P.S.
    Int. J. Dev. Neurosci. 25:29-37(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
  • "The regulation and deregulation of Wnt signaling by PARK genes in health and disease."
    Berwick D.C., Harvey K.
    J Mol Cell Biol 6:3-12(2014) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKB
• retinoid X receptor binding Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease."
    Jankovic J., Chen S., Le W.D.
    Prog Neurobiol 77:128-138(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE 
        60         70         80         90        100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY 
       110        120        130        140        150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH 
       160        170        180        190        200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV 
       210        220        230        240        250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS 
       260        270        280        290        300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 
       310        320        330        340        350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK 
       360        370        380        390        400
SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT 
       410        420        430        440        450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR 
       460        470        480        490        500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI 
       510        520        530        540        550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN 
       560        570        580        590 
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF   

        10         20         30         40         50
MDNYSTGYDV KPPCLYQMPL SGQQSSIKVE DIQMHNYQQH SHLPPQSEEM 
        60         70         80         90        100
MPHSGSVYYK PSSPPTPTTP GFQVQHSPMW DDPGSLHNFH QNYVATTHMI 
       110        120        130        140        150
EQRKTPVSRL SLFSFKQSPP GTPVSSCQMR FDGPLHVPMN PEPAGSHHVV 
       160        170        180        190        200
DGQTFAVPNP IRKPASMGFP GLQIGHASQL LDTQVPSPPS RGSPSNEGLC 
       210        220        230        240        250
AVCGDNAACQ HYGVRTCEGC KGFFKRTVQK NAKYVCLANK NCPVDKRRRN 
       260        270        280        290        300
RCQYCRFQKC LAVGMVKEVV RTDSLKGRRG RLPSKPKSPQ EPSPPSPPVS 
       310        320        330        340        350
LISALVRAHV DSNPAMTSLD YSRFQANPDY QMSGDDTQHI QQFYDLLTGS 
       360        370        380        390        400
MEIIRGWAEK IPGFADLPKA DQDLLFESAF LELFVLRLAY RSNPVEGKLI 
       410        420        430        440        450
FCNGVVLHRL QCVRGFGEWI DSIVEFSSNL QNMNIDISAF SCIAALAMVT 
       460        470        480        490        500
ERHGLKEPKR VEELQNKIVN CLKDHVTFNN GGLNRPNYLS KLLGKLPELR 
       510        520        530 
TLCTQGLQRI FYLKLEDLVP PPAIIDKLFL DTLPF                 

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families