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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

ALDH3B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.2 Publications

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase family 3 member B2 (ALDH3B2), Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1), Aldehyde dehydrogenase, mitochondrial (ALDH2)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NADBy similarity6

GO - Molecular functioni

  • 3-chloroallyl aldehyde dehydrogenase activity Source: ProtInc
  • aldehyde dehydrogenase (NAD) activity Source: Ensembl
  • aldehyde dehydrogenase [NAD(P)+] activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.5 2681
ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-6798695 Neutrophil degranulation
UniPathwayi
UPA00780;UER00768

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 7
Gene namesi
Name:ALDH3B1
Synonyms:ALDH7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000006534.15
HGNCiHGNC:410 ALDH3B1
MIMi600466 gene
neXtProtiNX_P43353

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221
OpenTargetsiENSG00000006534
PharmGKBiPA24699

Chemistry databases

ChEMBLiCHEMBL3542434
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiALDH3B1
DMDMi1169285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564811 – 465Aldehyde dehydrogenase family 3 member B1Add BLAST465
PropeptideiPRO_0000424193466 – 468Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Lipidationi463S-palmitoyl cysteine1 Publication1
Modified residuei465Cysteine methyl esterCurated1
Lipidationi465S-geranylgeranyl cysteine1 Publication1

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiP43353
MaxQBiP43353
PeptideAtlasiP43353
PRIDEiP43353
ProteomicsDBi55614
55615 [P43353-2]

PTM databases

iPTMnetiP43353
PhosphoSitePlusiP43353
SwissPalmiP43353

Expressioni

Tissue specificityi

Highest expression in kidney and lung.

Gene expression databases

BgeeiENSG00000006534 Expressed in 227 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_ALDH3B1
ExpressionAtlasiP43353 baseline and differential
GenevisibleiP43353 HS

Organism-specific databases

HPAiHPA038525

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi106723, 45 interactors
IntActiP43353, 17 interactors

Structurei

3D structure databases

ProteinModelPortaliP43353
SMRiP43353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002825
HOVERGENiHBG050483
InParanoidiP43353
KOiK00129
OMAiAPTIFMD
OrthoDBiEOG091G05HC
PhylomeDBiP43353

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ
60 70 80 90 100
DLHKSAFESE VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI IAPWNYPLNL TLVPLVGALA AGNCVVLKPS EISKNVEKIL
160 170 180 190 200
AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR FDYIFFTGSP RVGKIVMTAA
210 220 230 240 250
AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA GQTCVAPDYV
260 270 280 290 300
LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC
310 320 330 340 350
GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE
360 370 380 390 400
AIEFINRREK PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL
410 420 430 440 450
PFGGVGASGM GRYHGKFSFD TFSHHRACLL RSPGMEKLNA LRYPPQSPRR
460
LRMLLVAMEA QGCSCTLL
Length:468
Mass (Da):51,840
Last modified:November 1, 1995 - v1
Checksum:i30BEEB982395D2F7
GO
Isoform 2 (identifier: P43353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-91: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,683
Checksum:i8B8E5587616158B4
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X2D4A0A087X2D4_HUMAN
Aldehyde dehydrogenase family 3 mem...
ALDH3B1
351Annotation score:
A0A087X192A0A087X192_HUMAN
Aldehyde dehydrogenase family 3 mem...
ALDH3B1
211Annotation score:
A0A087WTE0A0A087WTE0_HUMAN
Aldehyde dehydrogenase family 3 mem...
ALDH3B1
66Annotation score:
Q9BUJ8Q9BUJ8_HUMAN
ALDH3B1 protein
ALDH3B1
230Annotation score:
A0A087WU54A0A087WU54_HUMAN
Aldehyde dehydrogenase family 3 mem...
ALDH3B1
71Annotation score:
A0A087WUF8A0A087WUF8_HUMAN
Aldehyde dehydrogenase family 3 mem...
ALDH3B1
169Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01404055 – 91Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10868 mRNA Translation: AAA83428.1
EF411198 mRNA Translation: ABN58743.1
BT009832 mRNA Translation: AAP88834.1
AK291505 mRNA Translation: BAF84194.1
CH471076 Genomic DNA Translation: EAW74680.1
BC013584 mRNA Translation: AAH13584.1
BC014168 mRNA Translation: AAH14168.2
BC033099 mRNA Translation: AAH33099.1
CCDSiCCDS73335.1 [P43353-1]
CCDS73336.1 [P43353-2]
PIRiI38669
RefSeqiNP_000685.1, NM_000694.3 [P43353-1]
NP_001025181.1, NM_001030010.2 [P43353-2]
NP_001154945.1, NM_001161473.2 [P43353-1]
NP_001276987.1, NM_001290058.1
NP_001276988.1, NM_001290059.1
UniGeneiHs.523841

Genome annotation databases

EnsembliENST00000342456; ENSP00000473990; ENSG00000006534 [P43353-1]
ENST00000614849; ENSP00000478486; ENSG00000006534 [P43353-1]
ENST00000617288; ENSP00000481604; ENSG00000006534 [P43353-2]
GeneIDi221
KEGGihsa:221
UCSCiuc031xti.2 human [P43353-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10868 mRNA Translation: AAA83428.1
EF411198 mRNA Translation: ABN58743.1
BT009832 mRNA Translation: AAP88834.1
AK291505 mRNA Translation: BAF84194.1
CH471076 Genomic DNA Translation: EAW74680.1
BC013584 mRNA Translation: AAH13584.1
BC014168 mRNA Translation: AAH14168.2
BC033099 mRNA Translation: AAH33099.1
CCDSiCCDS73335.1 [P43353-1]
CCDS73336.1 [P43353-2]
PIRiI38669
RefSeqiNP_000685.1, NM_000694.3 [P43353-1]
NP_001025181.1, NM_001030010.2 [P43353-2]
NP_001154945.1, NM_001161473.2 [P43353-1]
NP_001276987.1, NM_001290058.1
NP_001276988.1, NM_001290059.1
UniGeneiHs.523841

3D structure databases

ProteinModelPortaliP43353
SMRiP43353
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106723, 45 interactors
IntActiP43353, 17 interactors

Chemistry databases

ChEMBLiCHEMBL3542434
DrugBankiDB00157 NADH

PTM databases

iPTMnetiP43353
PhosphoSitePlusiP43353
SwissPalmiP43353

Polymorphism and mutation databases

BioMutaiALDH3B1
DMDMi1169285

Proteomic databases

EPDiP43353
MaxQBiP43353
PeptideAtlasiP43353
PRIDEiP43353
ProteomicsDBi55614
55615 [P43353-2]

Protocols and materials databases

DNASUi221
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342456; ENSP00000473990; ENSG00000006534 [P43353-1]
ENST00000614849; ENSP00000478486; ENSG00000006534 [P43353-1]
ENST00000617288; ENSP00000481604; ENSG00000006534 [P43353-2]
GeneIDi221
KEGGihsa:221
UCSCiuc031xti.2 human [P43353-1]

Organism-specific databases

CTDi221
DisGeNETi221
EuPathDBiHostDB:ENSG00000006534.15
GeneCardsiALDH3B1
HGNCiHGNC:410 ALDH3B1
HPAiHPA038525
MIMi600466 gene
neXtProtiNX_P43353
OpenTargetsiENSG00000006534
PharmGKBiPA24699
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002825
HOVERGENiHBG050483
InParanoidiP43353
KOiK00129
OMAiAPTIFMD
OrthoDBiEOG091G05HC
PhylomeDBiP43353

Enzyme and pathway databases

UniPathwayi
UPA00780;UER00768

BRENDAi1.2.1.5 2681
ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiALDH3B1 human
GeneWikiiALDH3B1
GenomeRNAii221
PROiPR:P43353
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006534 Expressed in 227 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_ALDH3B1
ExpressionAtlasiP43353 baseline and differential
GenevisibleiP43353 HS

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAL3B1_HUMAN
AccessioniPrimary (citable) accession number: P43353
Secondary accession number(s): A3FMP9
, Q53XL5, Q8N515, Q96CK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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