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Entry version 173 (31 Jul 2019)
Sequence version 1 (01 Nov 1995)
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Protein

DNA repair protein RAD52 homolog

Gene

RAD52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi152 – 1565

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-5685938 HDR through Single Strand Annealing (SSA)

SIGNOR Signaling Network Open Resource

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SIGNORi
P43351

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein RAD52 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD52
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9824 RAD52

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600392 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P43351

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi55R → A: Abolishes ssDNA-binding. 1 Publication1
Mutagenesisi65Y → A: Moderately defective in both ss and dsDNA-binding. 1 Publication1
Mutagenesisi152K → A: Abolishes ssDNA-binding. 1 Publication1
Mutagenesisi153R → A: Moderately defective in both ss and dsDNA-binding. 1 Publication1
Mutagenesisi156R → A: Moderately defective in both ss and dsDNA-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5893

Open Targets

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OpenTargetsi
ENSG00000002016

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34180

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2362978

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAD52

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1172823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001738811 – 418DNA repair protein RAD52 homologAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104Phosphotyrosine; by ABL11 Publication1
Modified residuei199PhosphoserineCombined sources1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei335PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P43351

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43351

PeptideAtlas

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PeptideAtlasi
P43351

PRoteomics IDEntifications database

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PRIDEi
P43351

ProteomicsDB human proteome resource

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ProteomicsDBi
55613 [P43351-1]
86502
86503
86504

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P43351

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P43351

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000002016 Expressed in 173 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43351 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P43351 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028957

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The full-length protein forms heptameric rings.

Interacts with ABL1.

Interacts with RPA2; the interaction is direct and associates RAD52 with the RPA complex.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111830, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P43351

Database of interacting proteins

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DIPi
DIP-333N

Protein interaction database and analysis system

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IntActi
P43351, 43 interactors

Molecular INTeraction database

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MINTi
P43351

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351284

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43351

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P43351

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni221 – 280Mediates interaction with RPA21 PublicationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RAD52 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4141 Eukaryota
COG5055 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008766

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000237354

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43351

KEGG Orthology (KO)

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KOi
K10873

Identification of Orthologs from Complete Genome Data

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OMAi
VESEATY

Database of Orthologous Groups

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OrthoDBi
742922at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43351

TreeFam database of animal gene trees

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TreeFami
TF101221

Family and domain databases

Database of protein disorder

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DisProti
DP00437

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.390.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004585 DNA_recomb/repair_Rad52
IPR041247 Rad52_fam
IPR007232 Rad52_Rad59_Rad22
IPR042525 Rad52_Rad59_Rad22_sf

The PANTHER Classification System

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PANTHERi
PTHR12132 PTHR12132, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF04098 Rad52_Rad22, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00607 rad52, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform alpha (identifier: P43351-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGTEEAILG GRDSHPAAGG GSVLCFGQCQ YTAEEYQAIQ KALRQRLGPE
60 70 80 90 100
YISSRMAGGG QKVCYIEGHR VINLANEMFG YNGWAHSITQ QNVDFVDLNN
110 120 130 140 150
GKFYVGVCAF VRVQLKDGSY HEDVGYGVSE GLKSKALSLE KARKEAVTDG
160 170 180 190 200
LKRALRSFGN ALGNCILDKD YLRSLNKLPR QLPLEVDLTK AKRQDLEPSV
210 220 230 240 250
EEARYNSCRP NMALGHPQLQ QVTSPSRPSH AVIPADQDCS SRSLSSSAVE
260 270 280 290 300
SEATHQRKLR QKQLQQQFRE RMEKQQVRVS TPSAEKSEAA PPAPPVTHST
310 320 330 340 350
PVTVSEPLLE KDFLAGVTQE LIKTLEDNSE KWAVTPDAGD GVVKPSSRAD
360 370 380 390 400
PAQTSDTLAL NNQMVTQNRT PHSVCHQKPQ AKSGSWDLQT YSADQRTTGN
410
WESHRKSQDM KKRKYDPS
Length:418
Mass (Da):46,169
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E1BBCAF0B9CD4AF
GO
Isoform beta (identifier: P43351-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-226: SFGNALGNCI...PQLQQVTSPS → LPLLGVSGRI...SGQRLPEITK
     227-418: Missing.

Note: Unable to interact with isoform alpha, may act as dominant negative.
Show »
Length:226
Mass (Da):24,540
Checksum:i8B0E3FC5773B46FE
GO
Isoform gamma (identifier: P43351-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-139: DGSYHEDVGYGVSEGLKSKALSL → VRGWSRPAARKDQWVVGEGWFIS
     140-418: Missing.

Note: Unable to interact with isoform alpha, may act as dominant negative.
Show »
Length:139
Mass (Da):15,350
Checksum:iDFA2F7994CACC1DF
GO
Isoform delta (identifier: P43351-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-118: DFVDLNNGKFYVGVCAFVRVQLKDG → GEYALQQWGLLHCPAPAESLLWVRR
     119-418: Missing.

Note: Unable to interact with isoform alpha, may act as dominant negative.
Show »
Length:118
Mass (Da):12,943
Checksum:iC3341B828BE835A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX32F5GX32_HUMAN
DNA repair protein RAD52 homolog
RAD52
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1K5F5H1K5_HUMAN
DNA repair protein RAD52 homolog
RAD52
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PF95E9PF95_HUMAN
DNA repair protein RAD52 homolog
RAD52
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX95F5GX95_HUMAN
DNA repair protein RAD52 homolog
RAD52
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100N → K in AAA87554 (PubMed:7797537).Curated1
Sequence conflicti418S → SY in AAA87554 (PubMed:7797537).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01921870R → W1 PublicationCorresponds to variant dbSNP:rs11571421Ensembl.1
Natural variantiVAR_019219221Q → E1 PublicationCorresponds to variant dbSNP:rs4987206Ensembl.1
Natural variantiVAR_019220287S → N1 PublicationCorresponds to variant dbSNP:rs11571463Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04774994 – 118DFVDL…QLKDG → GEYALQQWGLLHCPAPAESL LWVRR in isoform delta. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_047750117 – 139DGSYH…KALSL → VRGWSRPAARKDQWVVGEGW FIS in isoform gamma. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_047751119 – 418Missing in isoform delta. 2 PublicationsAdd BLAST300
Alternative sequenceiVSP_047752140 – 418Missing in isoform gamma. 2 PublicationsAdd BLAST279
Alternative sequenceiVSP_047753157 – 226SFGNA…VTSPS → LPLLGVSGRILYSLFSVHSV MCAGGLPTPTASAQTAPSSP CSSAVLRYAQEFWECTWKLY SGQRLPEITK in isoform beta. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_047754227 – 418Missing in isoform beta. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12134 mRNA Translation: AAA85793.1
L33262 mRNA Translation: AAB05203.1
U27516 mRNA Translation: AAA87554.1
AF125948 mRNA Translation: AAD24575.1
AF125949 mRNA Translation: AAD24576.1
AF125950 mRNA Translation: AAD24577.1
AK292160 mRNA Translation: BAF84849.1
AK312026 mRNA Translation: BAG34963.1
AY527412 Genomic DNA Translation: AAS00097.1
AC004803 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88943.1
CH471116 Genomic DNA Translation: EAW88945.1
CH471116 Genomic DNA Translation: EAW88946.1
CH471116 Genomic DNA Translation: EAW88949.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS76501.1 [P43351-2]
CCDS8507.2 [P43351-1]

Protein sequence database of the Protein Information Resource

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PIRi
A57518

NCBI Reference Sequences

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RefSeqi
NP_001284348.1, NM_001297419.1 [P43351-1]
NP_001284349.1, NM_001297420.1 [P43351-2]
NP_602296.2, NM_134424.3 [P43351-1]
XP_005253777.1, XM_005253720.4 [P43351-1]
XP_005253778.1, XM_005253721.2 [P43351-1]
XP_011519292.1, XM_011520990.2 [P43351-1]
XP_011519293.1, XM_011520991.2 [P43351-1]
XP_016875258.1, XM_017019769.1 [P43351-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358495; ENSP00000351284; ENSG00000002016 [P43351-1]
ENST00000430095; ENSP00000387901; ENSG00000002016 [P43351-1]
ENST00000461568; ENSP00000436008; ENSG00000002016 [P43351-3]
ENST00000468231; ENSP00000434703; ENSG00000002016 [P43351-3]
ENST00000541619; ENSP00000438965; ENSG00000002016 [P43351-4]
ENST00000544742; ENSP00000443254; ENSG00000002016 [P43351-4]
ENST00000545564; ENSP00000440268; ENSG00000002016 [P43351-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5893

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5893

UCSC genome browser

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UCSCi
uc001qiv.2 human [P43351-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12134 mRNA Translation: AAA85793.1
L33262 mRNA Translation: AAB05203.1
U27516 mRNA Translation: AAA87554.1
AF125948 mRNA Translation: AAD24575.1
AF125949 mRNA Translation: AAD24576.1
AF125950 mRNA Translation: AAD24577.1
AK292160 mRNA Translation: BAF84849.1
AK312026 mRNA Translation: BAG34963.1
AY527412 Genomic DNA Translation: AAS00097.1
AC004803 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88943.1
CH471116 Genomic DNA Translation: EAW88945.1
CH471116 Genomic DNA Translation: EAW88946.1
CH471116 Genomic DNA Translation: EAW88949.1
CCDSiCCDS76501.1 [P43351-2]
CCDS8507.2 [P43351-1]
PIRiA57518
RefSeqiNP_001284348.1, NM_001297419.1 [P43351-1]
NP_001284349.1, NM_001297420.1 [P43351-2]
NP_602296.2, NM_134424.3 [P43351-1]
XP_005253777.1, XM_005253720.4 [P43351-1]
XP_005253778.1, XM_005253721.2 [P43351-1]
XP_011519292.1, XM_011520990.2 [P43351-1]
XP_011519293.1, XM_011520991.2 [P43351-1]
XP_016875258.1, XM_017019769.1 [P43351-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H2IX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-209[»]
1KN0X-ray2.85A/B/C/D/E/F/G/H/I/J/K1-212[»]
5JRBX-ray2.40A/B/C/D/E/F/G/H/I/J/K1-212[»]
5XRZX-ray3.60A/B/C/D/E/F/G/H/I/J/K1-212[»]
5XS0X-ray3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V1-212[»]
SMRiP43351
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111830, 45 interactors
CORUMiP43351
DIPiDIP-333N
IntActiP43351, 43 interactors
MINTiP43351
STRINGi9606.ENSP00000351284

Chemistry databases

ChEMBLiCHEMBL2362978

PTM databases

iPTMnetiP43351
PhosphoSitePlusiP43351

Polymorphism and mutation databases

BioMutaiRAD52
DMDMi1172823

Proteomic databases

EPDiP43351
PaxDbiP43351
PeptideAtlasiP43351
PRIDEiP43351
ProteomicsDBi55613 [P43351-1]
86502
86503
86504

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5893
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358495; ENSP00000351284; ENSG00000002016 [P43351-1]
ENST00000430095; ENSP00000387901; ENSG00000002016 [P43351-1]
ENST00000461568; ENSP00000436008; ENSG00000002016 [P43351-3]
ENST00000468231; ENSP00000434703; ENSG00000002016 [P43351-3]
ENST00000541619; ENSP00000438965; ENSG00000002016 [P43351-4]
ENST00000544742; ENSP00000443254; ENSG00000002016 [P43351-4]
ENST00000545564; ENSP00000440268; ENSG00000002016 [P43351-2]
GeneIDi5893
KEGGihsa:5893
UCSCiuc001qiv.2 human [P43351-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5893
DisGeNETi5893

GeneCards: human genes, protein and diseases

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GeneCardsi
RAD52
HGNCiHGNC:9824 RAD52
HPAiHPA028957
MIMi600392 gene
neXtProtiNX_P43351
OpenTargetsiENSG00000002016
PharmGKBiPA34180

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4141 Eukaryota
COG5055 LUCA
GeneTreeiENSGT00390000008766
HOGENOMiHOG000237354
InParanoidiP43351
KOiK10873
OMAiVESEATY
OrthoDBi742922at2759
PhylomeDBiP43351
TreeFamiTF101221

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
SIGNORiP43351

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RAD52 human
EvolutionaryTraceiP43351

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RAD52

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5893

Protein Ontology

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PROi
PR:P43351

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000002016 Expressed in 173 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP43351 baseline and differential
GenevisibleiP43351 HS

Family and domain databases

DisProtiDP00437
Gene3Di3.30.390.80, 1 hit
InterProiView protein in InterPro
IPR004585 DNA_recomb/repair_Rad52
IPR041247 Rad52_fam
IPR007232 Rad52_Rad59_Rad22
IPR042525 Rad52_Rad59_Rad22_sf
PANTHERiPTHR12132 PTHR12132, 2 hits
PfamiView protein in Pfam
PF04098 Rad52_Rad22, 1 hit
TIGRFAMsiTIGR00607 rad52, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD52_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43351
Secondary accession number(s): Q13205
, Q9Y5T7, Q9Y5T8, Q9Y5T9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 31, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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