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Protein

T-cell leukemia homeobox protein 1

Gene

Tlx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi203 – 262HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • animal organ formation Source: MGI
  • cell fate commitment Source: MGI
  • central nervous system development Source: MGI
  • lymph node development Source: MGI
  • neuron differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • spleen development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox TLX-1
Homeobox protein Hox-11
Gene namesi
Name:Tlx1
Synonyms:Hox11, Tlx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98769 Tlx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493341 – 332T-cell leukemia homeobox protein 1Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP43345

PTM databases

PhosphoSitePlusiP43345

Expressioni

Tissue specificityi

Expressed in various embryonic tissues, including branchial arches, some component of the nervous system and spleen.

Gene expression databases

CleanExiMM_TLX1

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP43345
SMRiP43345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG036206
InParanoidiP43345
PhylomeDBiP43345

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P43345-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHLGPHHLH PGHAEPISFG IEQILNSPDQ GGCMGPNSRL QDGDYGLGCL
60 70 80 90 100
VPGAYTYGGG GSAAGAGAGG TGAYGAGGPG GPGGPAGGGG GACSMGPLPG
110 120 130 140 150
SYNVNMDLAG GPGPGGDGGG GGAARRALSA AGVIRVPAHR PLAGAVAHPQ
160 170 180 190 200
PLATGLPTVP SVPAVPGVNN LTGLTFPWME SNRRYTKDRF TGLPYQNRTP
210 220 230 240 250
PKKKKPRTSF TRLQICELEK RFHRQKYLAS AERAALAKAL KMTDAQVKTW
260 270 280 290 300
FQNRRTKWRR QTAEEREAES EQANRILLQL QQEAFQKSLA QPLPADPLCV
310 320 330
HNSSLFALQN LQPWSDDSTK ITSVTSVASA CE
Length:332
Mass (Da):34,644
Last modified:November 1, 1995 - v1
Checksum:i79FC71E2E44E6F82
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QX99Q9QX99_MOUSE
T-cell leukemia homeobox protein 1
Tlx1 Hox11, mCG_16921
333Annotation score:
G3UXB9G3UXB9_MOUSE
T-cell leukemia homeobox protein 1
Tlx1
91Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70632, S70756, S70629 Genomic DNA Translation: AAB30542.1
UniGeneiMm.391203

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70632, S70756, S70629 Genomic DNA Translation: AAB30542.1
UniGeneiMm.391203

3D structure databases

ProteinModelPortaliP43345
SMRiP43345
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiP43345

Proteomic databases

PRIDEiP43345

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98769 Tlx1

Phylogenomic databases

HOVERGENiHBG036206
InParanoidiP43345
PhylomeDBiP43345

Miscellaneous databases

PROiPR:P43345
SOURCEiSearch...

Gene expression databases

CleanExiMM_TLX1

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLX1_MOUSE
AccessioniPrimary (citable) accession number: P43345
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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