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UniProtKB - P43337 (NUDL_ECOLI)
Protein
Uncharacterized Nudix hydrolase NudL
Gene
nudL
Organism
Escherichia coli (strain K12)
Status
Functioni
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
UniRule annotationCofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 83 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 87 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- CoA pyrophosphatase activity Source: InterPro
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: EcoCyc
- magnesium ion binding Source: UniProtKB-UniRule
- manganese ion binding Source: UniProtKB-UniRule
GO - Biological processi
- nucleoside diphosphate metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12693-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized Nudix hydrolase NudLUniRule annotation (EC:3.6.1.-UniRule annotation) |
Gene namesi | Name:nudLUniRule annotation Synonyms:yeaB Ordered Locus Names:b1813, JW1802 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057145 | 1 – 192 | Uncharacterized Nudix hydrolase NudLAdd BLAST | 192 |
Proteomic databases
jPOSTi | P43337 |
PaxDbi | P43337 |
PRIDEi | P43337 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263367, 35 interactors |
DIPi | DIP-11783N |
IntActi | P43337, 5 interactors |
STRINGi | 511145.b1813 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 160 | Nudix hydrolaseUniRule annotationAdd BLAST | 132 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 67 – 89 | Nudix boxAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0494, Bacteria |
HOGENOMi | CLU_040940_5_2_6 |
InParanoidi | P43337 |
OMAi | YYIWGAT |
PhylomeDBi | P43337 |
Family and domain databases
CDDi | cd03426, CoAse, 1 hit |
HAMAPi | MF_01592, Nudix_NudL, 1 hit |
InterProi | View protein in InterPro IPR045121, CoAse IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom IPR000059, NUDIX_hydrolase_NudL_CS IPR023735, Nudix_NudL |
PANTHERi | PTHR12992, PTHR12992, 1 hit |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
SUPFAMi | SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit PS01293, NUDIX_COA, 1 hit |
i Sequence
Sequence statusi: Complete.
P43337-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYRSLTLDD FLSRFQLLRP QINRETLNHR QAAVLIPIVR RPQPGLLLTQ
60 70 80 90 100
RSIHLRKHAG QVAFPGGAVD DTDASAIAAA LREAEEEVAI PPSAVEVIGV
110 120 130 140 150
LPPVDSVTGY QVTPVVGIIP PDLPYRASED EVSAVFEMPL AQALHLGRYH
160 170 180 190
PLDIYRRGDS HRVWLSWYEQ YFVWGMTAGI IRELALQIGV KP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74883.1 AP009048 Genomic DNA Translation: BAA15620.1 K02673 Genomic DNA No translation available. M28695 Genomic DNA No translation available. |
PIRi | E64942 |
RefSeqi | NP_416327.1, NC_000913.3 WP_000456715.1, NZ_SSZK01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC74883; AAC74883; b1813 BAA15620; BAA15620; BAA15620 |
GeneIDi | 946330 |
KEGGi | ecj:JW1802 eco:b1813 |
PATRICi | fig|1411691.4.peg.439 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74883.1 AP009048 Genomic DNA Translation: BAA15620.1 K02673 Genomic DNA No translation available. M28695 Genomic DNA No translation available. |
PIRi | E64942 |
RefSeqi | NP_416327.1, NC_000913.3 WP_000456715.1, NZ_SSZK01000001.1 |
3D structure databases
AlphaFoldDBi | P43337 |
SMRi | P43337 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263367, 35 interactors |
DIPi | DIP-11783N |
IntActi | P43337, 5 interactors |
STRINGi | 511145.b1813 |
Proteomic databases
jPOSTi | P43337 |
PaxDbi | P43337 |
PRIDEi | P43337 |
Genome annotation databases
EnsemblBacteriai | AAC74883; AAC74883; b1813 BAA15620; BAA15620; BAA15620 |
GeneIDi | 946330 |
KEGGi | ecj:JW1802 eco:b1813 |
PATRICi | fig|1411691.4.peg.439 |
Organism-specific databases
EchoBASEi | EB2556 |
Phylogenomic databases
eggNOGi | COG0494, Bacteria |
HOGENOMi | CLU_040940_5_2_6 |
InParanoidi | P43337 |
OMAi | YYIWGAT |
PhylomeDBi | P43337 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12693-MONOMER |
Miscellaneous databases
PROi | PR:P43337 |
Family and domain databases
CDDi | cd03426, CoAse, 1 hit |
HAMAPi | MF_01592, Nudix_NudL, 1 hit |
InterProi | View protein in InterPro IPR045121, CoAse IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom IPR000059, NUDIX_hydrolase_NudL_CS IPR023735, Nudix_NudL |
PANTHERi | PTHR12992, PTHR12992, 1 hit |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
SUPFAMi | SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit PS01293, NUDIX_COA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NUDL_ECOLI | |
Accessioni | P43337Primary (citable) accession number: P43337 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families