nudL

Functionⁱ

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.UniRule annotation

Cofactorⁱ

Mn²⁺UniRule annotation, Mg²⁺UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	83	Magnesium or manganeseUniRule annotation		1
Metal bindingⁱ	87	Magnesium or manganeseUniRule annotation		1

GO - Molecular functionⁱ

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Source: EcoCyc
Inferred from direct assayⁱ
- 21119630
magnesium ion binding Source: UniProtKB-UniRule
manganese ion binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

nucleoside diphosphate metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG12693-MONOMER MetaCyc:EG12693-MONOMER

BioCycⁱ

EcoCyc:EG12693-MONOMER
MetaCyc:EG12693-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Uncharacterized Nudix hydrolase NudLUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesⁱ	Name:nudLUniRule annotation Synonyms:yeaB Ordered Locus Names:b1813, JW1802
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12693 nudL

EcoGeneⁱ

EG12693 nudL

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057145	1 – 192	Uncharacterized Nudix hydrolase NudLAdd BLAST		192

Proteomic databases

PaxDbⁱ	P43337
PRIDEⁱ	P43337

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4263367, 35 interactors
Database of interacting proteins More...DIPⁱ	DIP-11783N
IntActⁱ	P43337, 5 interactors
STRINGⁱ	316385.ECDH10B_1951

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P43337
SMRⁱ	P43337
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	29 – 160	Nudix hydrolaseUniRule annotationAdd BLAST		132

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	67 – 89	Nudix boxAdd BLAST		23

Sequence similaritiesⁱ

Belongs to the Nudix hydrolase family. PCD1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105P8F Bacteria COG0494 LUCA
HOGENOMⁱ	HOG000250455
InParanoidⁱ	P43337
PhylomeDBⁱ	P43337

Family and domain databases

HAMAPⁱ	MF_01592 Nudix_NudL, 1 hit
InterProⁱ	View protein in InterPro IPR015797 NUDIX_hydrolase-like_dom_sf IPR000086 NUDIX_hydrolase_dom IPR000059 NUDIX_hydrolase_NudL_CS IPR023735 Nudix_NudL
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00293 NUDIX, 1 hit
SUPFAMⁱ	SSF55811 SSF55811, 1 hit
PROSITEⁱ	View protein in PROSITE PS51462 NUDIX, 1 hit PS01293 NUDIX_COA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P43337-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEYRSLTLDD FLSRFQLLRP QINRETLNHR QAAVLIPIVR RPQPGLLLTQ 
        60         70         80         90        100
RSIHLRKHAG QVAFPGGAVD DTDASAIAAA LREAEEEVAI PPSAVEVIGV 
       110        120        130        140        150
LPPVDSVTGY QVTPVVGIIP PDLPYRASED EVSAVFEMPL AQALHLGRYH 
       160        170        180        190 
PLDIYRRGDS HRVWLSWYEQ YFVWGMTAGI IRELALQIGV KP

Length:192

Mass (Da):21,436

Last modified:November 1, 1995 - v1

Checksum:ⁱA4CAEC50B1767ECF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC74883.1 AP009048 Genomic DNA Translation: BAA15620.1 K02673 Genomic DNA No translation available. M28695 Genomic DNA No translation available.
PIRⁱ	E64942
NCBI Reference Sequences More...RefSeqⁱ	NP_416327.1, NC_000913.3 WP_000456715.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74883; AAC74883; b1813 BAA15620; BAA15620; BAA15620
GeneIDⁱ	946330
KEGGⁱ	ecj:JW1802 eco:b1813
PATRICⁱ	fig\|1411691.4.peg.439

Protein	Similar proteins		Species	Score	Length	Source
P43337	Uncharacterized Nudix hydrolase NudL		ECOBW		192	UniRef100_C4ZZG9
Uncharacterized Nudix hydrolase NudL		ECODH		192
Uncharacterized Nudix hydrolase NudL		ECOLC		192
Coenzyme A pyrophosphatase		Shigella sp.		192
Uncharacterized Nudix hydrolase NudL		ECOLX		192
+22

Protein	Similar proteins		Species	Score	Length	Source
P43337	Uncharacterized Nudix hydrolase NudL		SHIFL		192	UniRef90_Q83L76
Uncharacterized Nudix hydrolase NudL		ECO24		192
Uncharacterized Nudix hydrolase NudL		ECO27		192
Uncharacterized Nudix hydrolase NudL		ECO45		192
Uncharacterized Nudix hydrolase NudL		ECO55		192
+494

Protein	Similar proteins		Species	Score	Length	Source
P43337	Uncharacterized Nudix hydrolase NudL		CITK8		192	UniRef50_A8AFP5
Uncharacterized Nudix hydrolase NudL		CROS8		192
Uncharacterized Nudix hydrolase NudL		ECOSM		192
Uncharacterized Nudix hydrolase NudL		ECO24		192
Uncharacterized Nudix hydrolase NudL		SHISS		192
+1774

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC74883.1 AP009048 Genomic DNA Translation: BAA15620.1 K02673 Genomic DNA No translation available. M28695 Genomic DNA No translation available.
PIRⁱ	E64942
RefSeqⁱ	NP_416327.1, NC_000913.3 WP_000456715.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P43337
SMRⁱ	P43337
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4263367, 35 interactors
DIPⁱ	DIP-11783N
IntActⁱ	P43337, 5 interactors
STRINGⁱ	316385.ECDH10B_1951

Proteomic databases

PaxDbⁱ	P43337
PRIDEⁱ	P43337

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74883; AAC74883; b1813 BAA15620; BAA15620; BAA15620
GeneIDⁱ	946330
KEGGⁱ	ecj:JW1802 eco:b1813
PATRICⁱ	fig\|1411691.4.peg.439

Organism-specific databases

EchoBASEⁱ	EB2556
EcoGeneⁱ	EG12693 nudL

Phylogenomic databases

eggNOGⁱ	ENOG4105P8F Bacteria COG0494 LUCA
HOGENOMⁱ	HOG000250455
InParanoidⁱ	P43337
PhylomeDBⁱ	P43337

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG12693-MONOMER MetaCyc:EG12693-MONOMER

BioCycⁱ

EcoCyc:EG12693-MONOMER
MetaCyc:EG12693-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P43337

PROⁱ

PR:P43337

Family and domain databases

HAMAPⁱ	MF_01592 Nudix_NudL, 1 hit
InterProⁱ	View protein in InterPro IPR015797 NUDIX_hydrolase-like_dom_sf IPR000086 NUDIX_hydrolase_dom IPR000059 NUDIX_hydrolase_NudL_CS IPR023735 Nudix_NudL
Pfamⁱ	View protein in Pfam PF00293 NUDIX, 1 hit
SUPFAMⁱ	SSF55811 SSF55811, 1 hit
PROSITEⁱ	View protein in PROSITE PS51462 NUDIX, 1 hit PS01293 NUDIX_COA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUDL_ECOLI
Accessionⁱ	P43337Primary (citable) accession number: P43337
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P43337 (NUDL_ECOLI)

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Uncharacterized Nudix hydrolase NudL

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ